Publications
'Hypothermia in a syringe' through RBM3 ASOs
A splicing-based mechanism that increases expression of the broadly neuroprotective protein RBM3 in hypothermia may form the basis for a new therapeutic concept in neurodegenerative diseases. Online access: https://www.embopress.org/doi/full/10.15252/emmm.202217157
CLKs are on the Cover of Molecular Cell!
https://www.cell.com/molcel/issue?pii=S1097276519X00088
https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30049-6
We show that CLKs act as evolutionarily conserved body temperature sensor that globally controls alternative splicing and gene expression. Among many functional implications we suggest a connection to temperature-dependent sex determination in reptiles. Isn't that hot? This drawing by the first author Tom Haltenhof summarizes the main findings. The style is adapted from a mural of the artist Gerhard Richter. Science meets Arts!
Image Credit: Tom Haltenhof