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Recent Research

Dimos et al in Microbial Cell Factories

Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol

Bergfort et al. in Nature Communications

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR" recruits C9ORF78 to regulate alternative splicing

Jehle et al. in Molecular Systems Biology

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein–protein interactions

Bergfort et al. in Nucleic Acids Research

The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling

Mittermeier et al. in Molecular Microbiology

A non-native C-terminal extension of the β’ subunit compromises RNA polymerase and Rho functions

Said & Wahl in Transcription

Transcription complexes as RNA chaperones

Dimos and Helmer in Acta Cryst. D

CryoEM analysis of small plant biocatalysts at sub-2 A°
resolution

He et al in Epilepsia

The molecular and phenotypic spectrum of CLCN4-related epilepsy

Lan et al. in Nature Communication

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Grass et al. in PNAS

Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility

Absmeier et al. in JBC

Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

Reichenbach et al. in Advanced Biology

Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes

Knaus in Stem Cell Rev and Rep

ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC
Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the
Drug Candidate Saracatinib

Geertsema in Nature Biotechnology

Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus

Li in Nature Communications

Directed manipulation of membrane proteins by fluorescent magnetic nanoparticles

Pei in Nature Communications

The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling

Roske in Nucleic Acids Research

A skipping rope translocation mechanism in a widespread family of DNA repair helicases

Loll in JACS

Loll in JACS: The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol

Said in Science

Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ

Preussner in EMBO Reports

Neumann in EMBO Reports
Neumann, Heyd, Preußner - Alternative splicing coupled mRNA decay shapes
the temperature‐dependent transcriptome

Stricker in Journal of Cachexia, Sarcopenia and Muscle

Stricker in Journal of Cachexia, Sarcopenia and Muscle: Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis

Hiepen in Cells

Hiepen, Mendes, Knaus in Cells:
"It Takes Two to Tango:
Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology"

Huang in Molecular Cell

Huang - Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

Freund in Brain

Freund in Brain
Syntaxin-1B mutations reveal clear molecular disease mechanisms that translate into distinct neurophysiological phenotypes

Knaus in Bone

Knaus in Bone
BMP signalling in a mechanical context – Implications for bone biology

Meinke in eLife

Meinke et al, in eLife
Srsf10 and the minor spliceosome control
tissue-specific and dynamic SR protein expression

Haltenhof in Molecular Cell

Tom Haltenhof et al. in Molecular Cell: A conserved kinase-based body
temperature sensor globally controls alternative splicing and gene
expression

Knaus in MBC of the cell

Knaus-AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells

Hiepen in PLOS Biology

Hiepen-BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Chakrabarti in Nature Communications

Chakrabarti - Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Loll in Beilstein J Org Chem

Loll - Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

Wahl in Nucleic Acids Research

Wahl - Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis

Freund in Structure

Freund - Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

Stauber in eLIFE

Stauber - A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

DeBortoli in Nucleic Acids Research

F. De Bortoli - Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39

Neumann in Journal of Cell Science

A. Neumann - Genome-wide identification of
alternative splicing events that regulate protein transport across the
secretory pathway

Sticht in Biophysical Journal

J. Sticht - FBP21’s C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase

Driller in Nature Communications

R. Driller - Towards a comprehensive understanding of the
structural dynamics of a bacterial diterpene
synthase during catalysis

Stricker in Stem Cell Research

S. Stricker - Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

Loll in Nature Communications

B. Loll - Molecular insights into antibiotic resistance - how a binding protein traps albicidin

Stricker in Development

S. Stricker - Genome-wide strategies identify downstream target genes of connective tissue-associated transcription factors

Stricker in PLoS ONE

Sigmar Stricker - Cooperation of BMP and IHH signaling in interdigital cell fate determination

Wollenhaupt in Biophysical Journal

Jan Wollenhaupt - Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2

Loll in ChemBioChem

B. Loll: Ketonization of Proline Residues in the Peptide Chains of Actinomycins by a 4-Oxoproline Synthase

Loll in ChemCatChem

B. Loll: Rhodococcus erythropolis Oleate Hydratase: a New Member in the Oleate Hydratase Family Tree