Springe direkt zu Inhalt

Recent Research

Dimos et al in Microbial Cell Factories

Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol

Bergfort et al. in Nature Communications

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR" recruits C9ORF78 to regulate alternative splicing

Jehle et al. in Molecular Systems Biology

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein–protein interactions

Bergfort et al. in Nucleic Acids Research

The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling

Mittermeier et al. in Molecular Microbiology

A non-native C-terminal extension of the β’ subunit compromises RNA polymerase and Rho functions

Said & Wahl in Transcription

Transcription complexes as RNA chaperones

Dimos and Helmer in Acta Cryst. D

CryoEM analysis of small plant biocatalysts at sub-2 A°
resolution

He et al in Epilepsia

The molecular and phenotypic spectrum of CLCN4-related epilepsy

Lan et al. in Nature Communication

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Grass et al. in PNAS

Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility

Absmeier et al. in JBC

Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

Reichenbach et al. in Advanced Biology

Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes

Knaus in Stem Cell Rev and Rep

ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC
Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the
Drug Candidate Saracatinib

Geertsema in Nature Biotechnology

Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus

Li in Nature Communications

Directed manipulation of membrane proteins by fluorescent magnetic nanoparticles

Pei in Nature Communications

The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling

Roske in Nucleic Acids Research

A skipping rope translocation mechanism in a widespread family of DNA repair helicases

Loll in JACS

Loll in JACS: The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol

Said in Science

Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ

Preussner in EMBO Reports

Neumann in EMBO Reports
Neumann, Heyd, Preußner - Alternative splicing coupled mRNA decay shapes
the temperature‐dependent transcriptome

Stricker in Journal of Cachexia, Sarcopenia and Muscle

Stricker in Journal of Cachexia, Sarcopenia and Muscle: Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis

Hiepen in Cells

Hiepen, Mendes, Knaus in Cells:
"It Takes Two to Tango:
Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology"

Huang in Molecular Cell

Huang - Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

Freund in Brain

Freund in Brain
Syntaxin-1B mutations reveal clear molecular disease mechanisms that translate into distinct neurophysiological phenotypes

Knaus in Bone

Knaus in Bone
BMP signalling in a mechanical context – Implications for bone biology

Meinke in eLife

Meinke et al, in eLife
Srsf10 and the minor spliceosome control
tissue-specific and dynamic SR protein expression

Haltenhof in Molecular Cell

Tom Haltenhof et al. in Molecular Cell: A conserved kinase-based body
temperature sensor globally controls alternative splicing and gene
expression

Knaus in MBC of the cell

Knaus-AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells

Hiepen in PLOS Biology

Hiepen-BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Chakrabarti in Nature Communications

Chakrabarti - Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Loll in Beilstein J Org Chem

Loll - Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

Wahl in Nucleic Acids Research

Wahl - Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis

Freund in Structure

Freund - Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

Stauber in eLIFE

Stauber - A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

DeBortoli in Nucleic Acids Research

F. De Bortoli - Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39

Neumann in Journal of Cell Science

A. Neumann - Genome-wide identification of
alternative splicing events that regulate protein transport across the
secretory pathway

Sticht in Biophysical Journal

J. Sticht - FBP21’s C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase

Driller in Nature Communications

R. Driller - Towards a comprehensive understanding of the
structural dynamics of a bacterial diterpene
synthase during catalysis

Stricker in Stem Cell Research

S. Stricker - Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

Loll in Nature Communications

B. Loll - Molecular insights into antibiotic resistance - how a binding protein traps albicidin

Stricker in Development

S. Stricker - Genome-wide strategies identify downstream target genes of connective tissue-associated transcription factors

Stricker in PLoS ONE

Sigmar Stricker - Cooperation of BMP and IHH signaling in interdigital cell fate determination

Wollenhaupt in Biophysical Journal

Jan Wollenhaupt - Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2

Loll in ChemBioChem

B. Loll: Ketonization of Proline Residues in the Peptide Chains of Actinomycins by a 4-Oxoproline Synthase

Loll in ChemCatChem

B. Loll: Rhodococcus erythropolis Oleate Hydratase: a New Member in the Oleate Hydratase Family Tree

Image Credits