Role of FoxP2 in proliferation and neurogenesis in the ventricular zone of zebra finches, an area delivering newly born neurons to the song nuclei Area X
Steffen Schulz, Diplomand
So far it is known that FoxP2, a member of the forkhead box transcription factors, is involved in learning and acquisition of speech and song in humans and songbirds like zebra finches, respectively . It is, amongst others, expressed in two song nuclei, HVC in the pallium and Area X in the striatum of the male zebra finch, whereto newly born neurons of the subventricular zone migrate during the sensorimotory learning phase . This neurogenesis persists also in adult males, when the song is already crystallized . To test if the FoxP2 gene may have a main function in regulating neurogenesis and in predefining the morphologic structures of the newly born neurons, knock-down experiments in the subventricular zone will be performed and potential changes in the total amount and in the structure of new cells analysed. Teramitsu I, Kudo LC, London SE, Geschwind DH, White SA: Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. J Neurosci 2004, 24:3152-3163.  Nordeen K W, Nordeen E J: Projection neurons within a vocal motor pathway are born during song learning in zebra finches. Nature. 1988 Jul 14;334(6178):149-51.  Alvarez-Buylla A.: Neurogenesis and plasticity in the CNS of adult birds. Exp. Neurol. 1992 Jan;115(1):110-4.