The where, what, and when of membrane protein degradation in neurons

Jin EJ, Kiral FR, Hiesinger PR – 2018

Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo-specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons.

Titel
The where, what, and when of membrane protein degradation in neurons
Verfasser
Jin EJ, Kiral FR, Hiesinger PR
Verlag
Wiley
Schlagwörter
autophagy; endosome; lysosome; membrane degradation; neuronal maintenance
Datum
2018-03
Kennung
doi: 10.1002/dneu.22534
Erschienen in
Developmental Neurobiology, 78(3): 283-297
Sprache
eng
Art
Text
Rechte
© 2017 The Authors; Developmental Neurobiology, Published by Wiley Periodicals, Inc.
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