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Ausgewählte Publikationen


  • Ramesh N, Escher MJF, Mampell MM, Böhme MA, Götz TWB, Goel P, Matkovic T,
    Petzoldt AG, Dickman D, Sigrist SJ.
    Antagonistic interactions between two Neuroligins coordinate pre- and postsynaptic assembly.
    Curr Biol. 2021 Feb 23:S0960-9822(21)00158-5. doi: 10.1016/j.cub.2021.01.093.
    View abstract at Pubmed
  • Fukaya R, Maglione M, Sigrist SJ, Sakaba T.
    Rapid Ca2+ channel accumulation contributes to cAMP-mediated increase in transmission at
    hippocampal mossy fiber synapses.
    Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2016754118. doi: 10.1073/pnas.2016754118.
    View abstract at Pubmed 
  • Wirth A, Wolf B, Huang CK, Glage S, Hofer SJ, Bankstahl M, Bär C, Thum T, Kahl KG, Sigrist SJ, Madeo F,
    Bankstahl JP, Ponimaskin E.
    Novel aspects of age-protection by spermidine supplementation are associated with preserved
    telomere length.
    Geroscience. 2021 Jan 31. doi: 10.1007/s11357-020-00310-0.
    View abstract at Pubmed 


  • Huang S, Sigrist SJ.
    Presynaptic and postsynaptic long-term plasticity in sleep homeostasis.
    Curr Opin Neurobiol. 2020 Dec 14;69:1-10. doi: 10.1016/j.conb.2020.11.010.
    View abstract at Pubmed 
  • Zhao K, Hong H, Zhao L, Huang S, Gao Y, Metwally E, Jiang Y, Sigrist SJ, Zhang YQ.
    Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes.
    Development. 2020 Dec 16;147(24):dev191874. doi: 10.1242/dev.191874.
    View abstract at Pubmed 
  • Petzoldt AG, Götz TWB, Driller JH, Lützkendorf J, Reddy-Alla S, Matkovic-Rachid T, Liu S, Knoche E, Mertel S, Ugorets V, Lehmann M, Ramesh N, Beuschel CB, 
    Kuropka B, Freund C, Stelzl U, Loll B, Liu F, Wahl MC, Sigrist SJ.
    RIM-binding protein couples synaptic vesicle recruitment to release sites.
    J Cell Biol. 2020 Jul 6;219(7):e201902059. doi: 10.1083/jcb.201902059.
    View abstract at Pubmed
  • Huang S, Piao C, Beuschel CB, Götz T, Sigrist SJ
    Presynaptic Active Zone Plasticity Encodes Sleep Need in Drosophila
    Curr Biol. 2020 Feb 27. pii: S0960-9822(20)30019-1. doi: 10.1016/j.cub.2020.01.019.
    View abstract at Pubmed
  • Jennifer Woitkuhn, Anatoli Ender, Christine B. Beuschel, Marta Maglione,Tanja Matkovic-Rachid, Sheng Huang, Martin Lehmann, Joerg R. P. Geiger & Stephan J. Sigrist
    The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses
    J Neurogenet. 2020;1–9. doi:10.1080/01677063.2019.1710146
    View abstract at Pubmed


  • Marta Maglione, Gaga Kochlamazashvili, Tobias Eisenberg, Bence Rácz, Eva Michael, David Toppe, Alexander Stumpf, Alexander Wirth, André Zeug, 
    Franziska E. Müller, Laura Moreno-Velasquez, Rosanna P. Sammons, Sebastian J. Hofer, Frank Madeo, Tanja Maritzen, Nikolaus Maier, 
    Evgeni Ponimaskin, Dietmar Schmitz, Volker Haucke & Stephan J. Sigrist
    Spermidine Protects From Age-Related Synaptic Alterations at Hippocampal Mossy fiber-CA3 Synapses
    Sci Rep 9, 19616 (2019). doi.org/10.1038/s41598-019-56133-3
    View abstract at Pubmed 
  • Bhukel A, Beuschel CB, Maglione M, Lehmann M, Juhász G, Madeo F, Sigrist SJ.
    Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
    Nat Commun. 2019 Mar 21;10(1):1318. doi: 10.1038/s41467-019-09262-2.
    View abstract at Pubmed 
  • Jan H. Driller, Janine Lützkendorf, Harald Depner, Matthias Siebert, Benno Kuropka, Christoph Weise, Chengji Piao, Astrid G. Petzoldt, Martin Lehmann, Ulrich Stelzl, René Zahedi, Albert Sickmann, Christian Freund, Stephan J. Sigrist, Markus C. Wahl
    Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks     
    J Cell Sci. 2019 Mar 18;132(6). pii: jcs225151. doi: 10.1242/jcs.225151.
    View abstract at Pubmed
  • Mathias A. Boehme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G Petzold, Martin Lehmann, Fabian Goettfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter
    Rapid active zone remodeling consolidates presynaptic potentiation                  
    Nat Commun. 2019 Mar 6;10(1):1085. doi: 10.1038/s41467-019-08977-6.
    View abstract at Pubmed


  • Tina Ghelani and Stephan J. Sigrist
    Coupling the Structural and Functional Assembly of Synaptic Release Sites.                        
    Front. Neuroanat. 2018 Oct 16;12:81. doi: 10.3389/fnana.2018.00081. eCollection 2018.                                         View abstract at Pubmed
  • Ramesh N, Sigrist SJ
    The Long and Short of It: A Dwarf Neurexin Suffices for Synapse Assembly
    Neuron. 2018 Oct 10;100(1):6-8. doi: 10.1016/j.neuron.2018.09.035.
    View abstract at Pubmed

  • Vukoja A, Rey U, Petzoldt AG, Ott C, Vollweiter D, Quentin C, Puchkov D, Reynolds E, Lehmann M, Hohensee S, Rosa S, Lipowsky R, Sigrist SJ, Haucke V.
    Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles
    Neuron. 2018 Sep 19;99(6):1216-1232.e7. doi: 10.1016/j.neuron.2018.08.004. Epub 2018 Aug 30.
    View abstract at Pubmed

  • Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, Marta Maglione, Katherine Eyring, Jennifer Woitkuhn, Martin Lehmann, Tanja Matkovic-Rachid, Joerg R.P. Geiger, Alexander M. Walter, Katherine I. Nagel and Stephan J. Sigrist
    Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses
    Cell Reports 23, 1259–1274 May 1, 2018 doi : 10.1016/j.celrep.2018.03.126
    View full text at Cell

  • Stocker B, Bochow C, Damrau C, Mathejczyk T, Wolfenberg H, Colomb J, Weber C, Ramesh N, Duch C, Biserova NM, Sigrist S, Pflüger HJ.
    Structural and Molecular Properties of Insect Type II Motor Axon Terminals
    Front Syst Neurosci. 2018 Mar 19;12:5. doi: 10.3389/fnsys.2018.00005. eCollection 2018.
    View abstract at Pubmed

  • Sigrist S, Ohtsuka T
    The presynaptic active zone: molecules, plasticity and diseases
    Neurosci Res. 2018 Feb;127:1-2. doi: 10.1016/j.neures.2018.01.004.
    View full text at Neuroscience Research

  • Walter AM, Böhme MA, Sigrist SJ.
    Vesicle release site organization at synaptic active zones.
    Neurosci Res. 2018 Feb;127:3-13. doi: 10.1016/j.neures.2017.12.006. Epub 2017 Dec 21. Review.
    View abstract at Pubmed

  • Liang Y, Sigrist SJ.
    Autophagy and proteostasis in the control of synapse aging and disease.
    Curr Opin Neurobiol. 2018 Feb;48:113-121. doi: 10.1016/j.conb.2017.12.006. Epub 2017 Dec 21
    View abstract at Pubmed

  • Hussain A, Pooryasin A, Zhang M, Loschek LF, La Fortezza M, Friedrich AB, Blais CM, Üçpunar HK, Yépez VA, Lehmann M, Gompel N, Gagneur J, Sigrist SJ, Grunwald Kadow IC.
    Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila.
    Elife. 2018 Jan 18;7. pii: e32018. doi: 10.7554/eLife.32018
    View abstract at Pubmed


  • Reddy-Alla S, Böhme MA, Reynolds E, Beis C, Grasskamp AT, Mampell MM, Maglione M, Jusyte M, Rey U, Babikir H, McCarthy AW, Quentin C, Matkovic T, Bergeron DD, Mushtaq Z, Göttfert F, Owald D, Mielke T, Hell SW, Sigrist SJ, Walter AM.
    Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.
    Neuron. 2017 Sep 13;95(6):1350-1364.e12. doi: 10.1016/j.neuron.2017.08.016. Epub 2017 Aug 31.
    View abstract at Pubmed

  • Gehring KB, Heufelder K, Depner H, Kersting I, Sigrist SJ, Eisenhardt D.
    Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body.
    PLoS One. 2017 Apr 24;12(4):e0175894. doi: 10.1371/journal.pone.0175894. eCollection 2017.
    View abstract at Pubmed

  • Van Vactor D, Sigrist SJ.
    Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila.
    Curr Opin Neurobiol. 2017 Apr;43:119-129. doi: 10.1016/j.conb.2017.03.003. Epub 2017 Apr 5. Review.
    View abstract at Pubmed

  • Bhukel A, Madeo F, Sigrist SJ
    Spermidine boosts autophagy to protect from synapse aging.
    .Autophagy. 2017 Feb;13(2):444-445. doi: 10.1080/15548627.2016.1265193. Epub 2016 Dec 27.
    View abstract at Pubmed


  • Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwärzel M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ.
    Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release.
    PLoS Biol. 2016 Sep 29;14(9):e1002563. doi: 10.1371/journal.pbio.1002563. eCollection 2016 Sep.
    View abstract at Pubmed

  • Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C.
    RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
    Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620. Epub 2016 Sep 26
    View abstract at Pubmed

  • Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH, Babikir H, Göttfert F, Robinson IM, O'Kane CJ, Hell SW, Wahl MC, Stelzl U, Loll B, Walter AM, Sigrist SJ.
    Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.
    Nat Neurosci. 2016 Oct;19(10):1311-20. doi: 10.1038/nn.4364. Epub 2016 Aug 15.
    View abstract at Pubmed 

  • Sigrist SJ, Petzoldt AG.
    Neuroscience: Nanocolumns at the heart of the synapse.
    Nature. 2016 Aug 11;536(7615):151-2. Epub 2016 Jul 27.
    View abstract at Pubmed 

  • Petzoldt AG, Lützkendorf J, Sigrist SJ.
    Mechanisms controlling assembly and plasticity of presynaptic active zone scaffolds.
    Curr Opin Neurobiol. 2016 Aug;39:69-76. doi: 10.1016/j.conb.2016.04.009. Epub 2016 Apr 29. Review.
    View abstract at Pubmed


  • Muhammad K, Reddy-Alla S, Driller JH, Schreiner D, Rey U, Böhme MA, Hollmann C, Ramesh N, Depner H, Lützkendorf J, Matkovic T, Götz T, Bergeron DD, Schmoranzer J, Goettfert F, Holt M, Wahl MC, Hell SW, Scheiffele P, Walter AM, Loll B, Sigrist SJ.
    Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.
    Nat Commun. 2015 Oct 16;6:8362. doi: 10.1038/ncomms9362.
    View abstract at Pubmed

  • Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y.
    Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.
    Hum Mol Genet. 2015 Dec 1;24(23):6736-55. doi: 10.1093/hmg/ddv380. Epub 2015 Sep 16.
    View abstract at Pubmed
  • Ullrich A, Böhme MA, Schöneberg J, Depner H, Sigrist SJ, Noé F.
    Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.
    PLoS Comput Biol. 2015 Sep 14;11(9):e1004407. doi: 10.1371/journal.pcbi.1004407. eCollection 2015 Sep.
    View abstract at Pubmed 

  • Siebert M, Böhme MA, Driller JH, Babikir H, Mampell MM, Rey U, Ramesh N, Matkovic T, Holton N, Reddy-Alla S, Göttfert F, Kamin D, Quentin C, Klinedinst S, Andlauer TF, Hell SW, Collins CA, Wahl MC, Loll B, Sigrist SJ.
    A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones.
    Elife 2015 Aug 14;4. doi: 10.7554/eLife.06935.
    View abstract at Pubmed 

  • Schneider J, Zahn J, Maglione M, Sigrist SJ, Marquard J, Chojnacki J, Kräusslich HG, Sahl SJ, Engelhardt J, Hell SW
    Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics.
    Nat Methods. 2015 Sep;12(9):827-30. doi: 10.1038/nmeth.3481. Epub 2015 Jul 27.
    View abstract at Pubmed
  • Böhme MA, Sigrist SJ.
    Lights on for the molecular players of presynaptic plasticity.
    Neuron. 2015 May 6;86(3):603-4. doi: 10.1016/j.neuron.2015.04.021.
    View abstract at Pubmed
  • Lardong JA, Driller JH, Depner H, Weise C, Petzoldt A, Wahl MC, Sigrist SJ, Loll B (2015):
    Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP
    Acta Crystallogr F Struct Biol Commun. 1;71(Pt 1):34-40
    View abstract at Pubmed


  • Petzoldt AG, Sigrist SJ (2014):
    Current Biology 24(22):R1076-80
    View abstract at Pubmed

  • Petzoldt AG, Lee YH, Khorramshahi O, Reynolds E, Plested AJ, Herzel H, Sigrist SJ (2014):
    Gating characteristics control glutamate receptor distribution and trafficking in vivo
    Current Biology 24(17):2059-65
    View abstract at Pubmed

  • Depner H, Lützkendorf J, Babkir HA, Sigrist SJ, Holt MG (2014):
    Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS
    Nature Protocols 9(12):2796-808
    View abstract at Pubmed
  • Andlauer TF, Scholz-Kornehl S, Tian R, Kirchner M, Babikir HA, Depner H, Loll B, Quentin C, Gupta VK, Holt MG, Dipt S, Cressy M, Wahl MC, Fiala A, Selbach M, Schwärzel M, Sigrist SJ (2014):
    Drep-2 is a novel synaptic protein important for learning and memory
    eLife 2014;3:e03895
    View abstract at Pubmed
  • Li L, Tian X, Zhu M, Bulgari D, Böhme MA, Goettfert F, Wichmann C, Sigrist SJ, Levitan ES, Wu C (2014):
    Drosophila Syd-1, Liprin-a, and Protein Phosphatase 2A B' Subunit Wrd Function in a Linear Pathway to Prevent Ectopic Accumulation of Synaptic Materials in Distal Axons.
    J Neuroscience 34(25):8474-87
    View abstract at Pubmed
  • Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. (2014):
    Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
    Cell metabolism 19(3):431-44
    View abstract at Pubmed
  • Jasmin Podufall, Rui Tian, Elena Knoche, Dmytro Puchkov, Alexander M. Walter, Stefanie Rosa, Christine Quentin, Anela Vukoja, Nadja Jung, Andre Lampe, Carolin Wichmann, Mathias Böhme, Harald Depner, Yong Q. Zhang, Jan Schmoranzer, Stephan J. Sigrist, Volker Haucke (2014):
    A Presynaptic Role for the Cytomatrix Protein GITin Synaptic Vesicle Recycling.
    Cell Reports 7(5):1417-25
    View abstract at Pubmed
  • Walter AM, Haucke V, Sigrist SJ (2014):
    Neurotransmission: spontaneous and evoked release filing for divorce.
    Current Biology 24(5):R192-4
    View abstract at Pubmed
  • Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F (2014):
    Spermidine-triggered autophagy ameliorates memory during aging.
    Autophagy 10(1):178-9
    View abstract at Pubmed


  • Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ (2013):
    Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
    Nature Neuroscience 16(10):1453–1460
    View abstract at Pubmed
  • Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickman A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ (2013):
    The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.
    J Cell Biol 202(4):667-83
    View abstract at Pubmed
  • Maglione M, Sigrist SJ (2013):
    Seeing the forest tree by tree: super-resolution light microscopy meets the neurosciences.
    Nature Neuroscience 16(7):790-7
    View abstract at Pubmed
  • Gupta VK, Sigrist SJ (2013):
    Sperm(idine) answers the next generation.
    Cell Cycle 12(4):542-3
    View abstract at Pubmed


  • Müller M, Liu KSY, Sigrist SJ, Davis GW (2012):
    RIM Controls Homeostatic Plasticity through Modulation of the Readily-Releasable Vesicle Pool.
    J Neuroscience, 32(47):16574-85
    View abstract at Pubmed
  • Owald D, Khorramshahi O, Gupta VK, Banovic D, Depner H, Fouquet W, Wichmann C, Mertel S, Eimer S, Reynolds E, Holt M, Aberle H, Sigrist SJ (2012):
    Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.
    Nature Neuroscience, 15(9):1219-26
    View abstract at Pubmed
  • Sigrist SJ, Sabatini BL (2012):
    Optical super-resolution microscopy in neurobiology.
    Curr Opin Neurobiol. 22(1):86-93
    View abstract at Pubmed
  • Abbasi-Moheb L, Mertel S, Gonsior M, Nouri-Vahid L, Kahrizi K, Cirak S, Wieczorek D, Motazacker MM, Esmaeeli-Nieh S, Cremer K, Weißmann R, Tzschach A, Garshasbi M, Abedini SS, Najmabadi H, Ropers HH, Sigrist SJ, Kuss AW (2012):
    Mutations in NSUN2 Cause Autosomal-Recessive Intellectual Disability.
    Am J Hum Genet., 90(5):847-55
    View abstract at Pubmed
  • Jordan-Alvarez S, Fouquet W, Sigrist SJ, Acebes A (2012):
    Presynaptic PI3K activity triggers the formation of glutamate receptors at neuromuscular terminals of Drosophila.
    J Cell Sci., 125(15):3621-9
    View abstract at Pubmed
  • Lampe A, Haucke V, Sigrist SJ, Heilemann M, Schmoranzer J (2012):
    Multi-colour direct STORM with red emitting carbocyanines.
    Biol Cell. 104(4):229-37
    View abstract at Pubmed
  • Thomas U, Sigrist SJ (2012):
    Glutamate Receptors in Synaptic Assembly and Plasticity: Case Studies on Fly NMJs.
    Adv Exp Med Biol. 970(1):3-28.
    View abstract at Pubmed


  • Liu KSY, Siebert M, Mertel M, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, B&u ;ckers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ (2011):
    RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release.
    Science 334(6062):1565-9
    View abstract at Pubmed
  • Wichmann C, Sigrist SJ (2011):
    Dem Innenleben der Synapsen auf der Spur.
    Neuroforum 11(4):144-51
    Download as pdf
  • Miskiewicz K, Jose LE, Bento-Abreu A, Fislage M, Taes I, Kasprowicz J, Swerts J, Sigrist SJ, Versees W, Robberecht W, Verstreken P (2011):
    ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.
    Neuron 72(5):776-88
    View abstract at Pubmed
  • Waites CL, Leal-Ortiz SA, Andlauer TFM, Sigrist SJ, Garner CC (2011):
    Piccolo regulates the dynamic assembly of presynaptic f-actin.
    J Neurosci. 31(40):14250-63
    View abstract at Pubmed
  • Christiansen F, Zube C, Andlauer TFM, Wichmann C, Fouquet W, Owald D, Mertel S, Leiss F, Tavosanis G, Farca Luna AJ, Fiala A, Sigrist SJ (2011):
    Presynapses in Kenyon Cell Dendrites in the Mushroom Body Calyx of Drosophila.
    J Neurosci. 31(26):9696-9707
    View abstract at Pubmed
  • Haucke V, Neher E, Sigrist SJ (2011):
    Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.
    Nat Rev Neurosci. 12(3):127-138
    View abstract at Pubmed
  • Sigrist SJ, Andlauer TFM (2011):
    Fighting the famine with an amine: synaptic strategies for smart search.
    Nature Neuroscience 14(2):124-6
    View abstract at Pubmed
  • Sigrist SJ, Schmitz D (2011):
    Structural and functional plasticity of the cytoplasmic active zone.
    Curr Opin Neurobiol. 21(1):144-50
    View abstract at Pubmed


  • Hallermann S, Kittel RJ, Wichmann C, Weyhersmüller A, Fouquet W, Mertel S, Owald D, Eimer S, Depner H, Schwärzel M, Sigrist SJ, Heckmann M (2010):
    Naked Dense Bodies Provoke Depression.
    J Neuroscience 30(43):14340-14345
    View abstract
  • Kremer MC, Christiansen F, Leiss F, Paehler M, Knapek S, Andlauer TFM, Förstner F, Kloppenburg P, Sigrist SJ, Tavosanis G (2010):
    Structural Long-Term Changes at Mushroom Body Input Synapses.
    Current Biology 20(21):1938-44
    View abstract at Pubmed
  • Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Uçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ, Toyka KV, Heckmann M, Sommer C (2010):
    Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition.
    Brain 133(11):3166-80
    View abstract at Pubmed
  • Wichmann C, Sigrist SJ (2010):
    The Active Zone T-Bar - A Plasticity Module?
    J Neurogenetics 24(3):133-145
    View abstract at Pubmed
  • Banovic D, Khorramshahi O, Owald D, Wichmann C, Riedt T, Fouquet W, Tian R, Sigrist SJ, Aberle H (2010):
    Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions.
    Neuron 66(5):724-738
    View abstract at Pubmed
  • Andlauer TFM, Sigrist SJ (2010):
    In Vivo Imaging of Drosophila Larval Neuromuscular Junctions to Study Synapse Assembly.
    Cold Spring Harbor Laboratory Press - Drosophila Neurobiology Methods: A Laboratory Manual; Chapter 21
    View abstract at CSHL Press
  • Bachmann A, Kobler O, Kittel RJ, Wichmann C, Sierralta J, Sigrist SJ, Gundelfinger ED, Knust E, Thomas U (2010):
    A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.
    J. Neurosci. 30(17):5811-24
    View abstract at Pubmed
  • Owald D, Fouquet W, Schmidt M, Wichmann C, Mertel S, Depner H, Christiansen F, Zube C, Quentin C, Körner J, Urlaub U, Mechtler K, Sigrist SJ (2010):
    A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.
    J. Cell Biol. 188(4):565-579
    View abstract at Pubmed


  • Leiss F, Koper E, Hein I, Fouquet W, Lindner J, Sigrist SJ, Tavosanis G (2009):
    Characterization of dendritic spines in the Drosophila central nervous system.
    Dev Neurobiol. 69(4):221-34
    View abstract at Pubmed
  • Sigrist SJ (2009):
    The Yin and Yang of synaptic active zone assembly.
    Sci Signal. 2(70):pe32
    View abstract at Pubmed
  • Owald D, Sigrist SJ (2009):
    Assembling the presynaptic active zone.
    Curr Opin Neurobiol. 19(3):311-8
    View abstract at Pubmed
  • Raghu SV, Joesch M, Sigrist SJ, Borst A, Reiff DF (2009):
    Synaptic organization of lobula plate tangential cells in Drosophila: Dalpha7 cholinergic receptors.
    J Neurogenet. 23(1-2):200-9
    View abstract at Pubmed


  • Schmid A, Sigrist SJ (2008):
    Analysis of neuromuscular junctions: histology and in vivo imaging.
    Methods Mol Biol. 420:239-251
    View abstract at Pubmed
  • Schmid A, Hallermann S, Kittel RJ, Khorramshahi O, Frölich AM, Quentin C, Rasse TM, Mertel S, Heckmann M, Sigrist SJ (2008):
    Activity-dependent site-specific changes of glutamate receptor composition in vivo.
    Nature Neuroscience 11(6):659-666
    View abstract at Pubmed
  • Ataman B, Ashley J, Gorczyca M, Ramachandran P, Fouquet W, Sigrist SJ, Budnik V (2008):
    Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling.
    Neuron 57(5):705-18
    View abstract at Pubmed


  • Füger P, Behrends LB, Mertel S, Sigrist SJ, Rasse TM (2007):
    Live imaging of synapse development and measuring protein dynamics using two-color fluorescence recovery after photo-bleaching at Drosophila synapses.
    Nature Protocols 2(12):3285-98
    View abstract at Pubmed
  • Besse F, Mertel S, Kittel RJ, Wichmann C, Rasse TM, Sigrist SJ and Ephrussi A (2007):
    The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses. 
    J. Cell Biology 177(5):843-55
    View abstract at Pubmed


  • Schmid A, Qin G, Wichmann C, Kittel RJ, Mertel S, Fouquet W, Schmidt M, Heckmann M, Sigrist SJ (2006):
    Non-NMDA-type glutamate receptors are essential for maturation but not for initial assembly of synapses at Drosophila neuromuscular junctions. 
    J. Neuroscience 26(44):11267-77
    View abstract at Pubmed
  • Swan LE, Schmidt M, Schwarz T, Ponimaskin E, Prange U, Boeckers T, Thomas U, Sigrist SJ (2006):
    Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis. 
    EMBO J. 25(15):3640-51
    View abstract at Pubmed
  • Ataman B, Ashley J, Gorczyca D, Gorczyca M, Mathew D, Wichmann C, Sigrist SJ, Budnik V (2006):
    Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP. 
    PNAS 103(20):7841-6
    View abstract at Pubmed
  • Kittel RJ, Wichmann C, Rasse TM, Fouquet W, Schmidt M, Schmid A, Wagh DA, Pawlu C, Kellner RR, Willig KI, Hell SW, Buchner E, Heckmann M, Sigrist SJ (2006):
    Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release. 
    Science 312(5776):1051-4
    View abstract at Pubmed
  • Wagh DA, Rasse TM, Asan E, Hofbauer A, Schwenkert I, Dürrbeck H, Buchner S, Dabauvalle MC, Schmidt M, Qin G, Wichmann C, Kittel R, Sigrist SJ, Buchner E (2006):
    Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. 
    Neuron 49(6):833-44
    View abstract at Pubmed


  • Rasse TM, Fouquet W, Schmid A, Kittel RJ, Mertel S, Sigrist CB, Schmidt M, Guzman A, Merino C, Qin G, Quentin C, Madeo F, Heckmann M, Sigrist SJ (2005):
    Glutamate receptor dynamics organizing synapse formation in vivo. 
    Nature Neuroscience 8(7):898-905
    View abstract at Pubmed
  • Qin G, Schwarz T, Kittel RJ, Schmid A, Rasse TM, Kappei D, Ponimaskin E, Heckmann M, Sigrist SJ (2005):
    Four different subunits are essential for expressing the synaptic glutamate receptor at neuromuscular junctions of Drosophila. 
    J. Neuroscience 25(12):3209-18
    View abstract at Pubmed


  • Swan LE, Wichmann C, Prange U, Schmid A, Schmidt M, Schwarz T, Ponimaskin E, Madeo F, Vorbrüggen G, Sigrist SJ (2004):
    A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila. 
    Genes Dev. 18(2):223-37
    View abstract at Pubmed

2003 and older

  • Sigrist SJ, Reiff DF, Thiel PR, Steinert JR, Schuster CM (2003):
    Experience-dependent strengthening of Drosophila neuromuscular junctions. 
    J. Neuroscience 23(16):6546-56
    View abstract at Pubmed
  • Sigrist SJ, Thiel PR, Reiff DF, Lachance PE, Lasko P, Schuster CM (2000):
    Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. 
    Nature 405(6790):1062-5
    View abstract at Pubmed