2023

1: Hengstler JG, Bolt H, Heinrich U, Hartwig A, Landsiedel R. In memoriam Thomas Gebel. Arch Toxicol. 2023 Mar 14. doi: 10.1007/s00204-023-03473-9. Epub ahead of print. PMID: 36917353.

2: Dimitrijevic D, Fabian E, Funk-Weyer D, Landsiedel R. Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma. Biochem Biophys Res Commun. 2023 Apr 9;651:114-120. doi: 10.1016/j.bbrc.2023.02.021. Epub 2023 Feb 10. PMID: 36812744.

3: Keller JG, Persson M, Müller P, Ma-Hock L, Werle K, Arts J, Landsiedel R, Wohlleben W. Corrigendum to variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity [NanoImpact 23 (2021) 100341]. NanoImpact. 2023 Jan;29:100455. doi: 10.1016/j.impact.2023.100455. Epub 2023 Feb 17. Erratum for: NanoImpact. 2021 Jul;23:100341. PMID: 36801377.

4: Chen X, Delić D, Cao Y, Shen L, Shao Q, Zhang Z, Wu H, Hasan AA, Reichetzeder C, Gaballa MMS, Krämer BK, Klein T, Yin L, He B, Morgera S, Hocher B. Reno-protective Effects of Empagliflozin are linked to Activation of the Tubuloglomerular Feedback Mechanism and Blunting of the Complement System. Am J Physiol Cell Physiol. 2023 Feb 13. doi: 10.1152/ajpcell.00528.2022. Epub ahead of print. PMID: 36779666.

5: Kleuser B, Bäumer W. Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases. Int J Mol Sci. 2023 Jan 11;24(2):1456. doi: 10.3390/ijms24021456. PMID: 36674974; PMCID: PMC9863039.

6: Kolle SN, Flach M, Kleber M, Basketter DA, Wareing B, Mehling A, Hareng L, Watzek N, Bade S, Funk-Weyer D, Landsiedel R. Plant extracts, polymers and new approach methods: Practical experience with skin sensitization assessment. Regul Toxicol Pharmacol. 2023 Feb;138:105330. doi: 10.1016/j.yrtph.2022.105330. Epub 2023 Jan 1. PMID: 36599391.

2022

7: Hashemi Arani F, Kadow S, Kramer M, Keitsch S, Kirchhoff L, Schumacher F, Kleuser B, Rath PM, Gulbins E, Carpinteiro A. Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp. Int J Mol Sci. 2022 Dec 7;23(24):15510. doi: 10.3390/ijms232415510. PMID: 36555152; PMCID: PMC9779773.

8: Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Rovida C, Leist M,
Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Kuchovská E, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stępnik M, Sobańska Z, Reszka E, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Svensk E, Cederroth CR, Sandström J, Ragan I, Bubalo N, Kurreck J, Spielmann H. The Current Status and Work of Three Rs Centres and Platforms in Europe. Altern Lab Anim. 2022 Nov;50(6):381-413. doi: 10.1177/02611929221140909. PMID: 36458800.

9: Hose M, Günther A, Naser E, Schumacher F, Schönberger T, Falkenstein J, Papadamakis A, Kleuser B, Becker KA, Gulbins E, Haimovitz-Friedman A, Buer J, Westendorf AM, Hansen W. Cell-intrinsic ceramides determine T cell function during melanoma progression. Elife. 2022 Nov 25;11:e83073. doi: 10.7554/eLife.83073. PMID: 36426850; PMCID: PMC9699697.

10: Landsiedel R, Honarvar N, Seiffert SB, Oesch B, Oesch F. Genotoxicity testing of nanomaterials. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Nov;14(6):e1833. doi: 10.1002/wnan.1833. PMID: 36416021.

11: Lu YP, Wu HW, Zhu T, Li XT, Zuo J, Hasan AA, Reichetzeder C, Delic D, Yard B, Klein T, Krämer BK, Zhang ZY, Wang XH, Yin LH, Dai Y, Zheng ZH, Hocher B. Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy. Biomed Pharmacother. 2022 Dec;156:113947. doi: 10.1016/j.biopha.2022.113947. Epub 2022 Oct 31. PMID: 36411661.

12: Bannuscher A, Schmid O, Drasler B, Rohrbasser A, Braakhuis HM, Meldrum K, Zwart EP, Gremmer ER, Birk B, Rissel M, Landsiedel R, Moschini E, Evans SJ, Kumar P, Orak S, Doryab A, Erdem JS, Serchi T, Vandebriel RJ, Cassee FR, Doak SH, Petri-Fink A, Zienolddiny S, Clift MJD, Rothen-Rutishauser B. An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact. 2022 Oct;28:100439. doi: 10.1016/j.impact.2022.100439. Epub 2022 Nov 17. PMID: 36402283.

13: Péricat D, Leon-Icaza SA, Sanchez Rico M, Mühle C, Zoicas I, Schumacher F, Planès R, Mazars R, Gros G, Carpinteiro A, Becker KA, Izopet J, Strub-Wourgaft N, Sjö P, Neyrolles O, Kleuser B, Limosin F, Gulbins E, Kornhuber J, Meunier E, Hoertel N, Cougoule C. Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model. Int J Mol Sci. 2022 Nov 7;23(21):13623. doi: 10.3390/ijms232113623. PMID: 36362409; PMCID: PMC9657171.

14: Tran PT, Beidoun B, Lohan SB, Talbi R, Kleuser B, Seifert M, Jung K, Sandig G, Meinke MC. Establishment of a method to expose and measure pollution in excised porcine skin with electron paramagnetic resonance spectroscopy. Ecotoxicol Environ Saf. 2022 Dec 1;247:114258. doi: 10.1016/j.ecoenv.2022.114258. Epub 2022 Nov 4. PMID: 36343452.

15: Hasan AA, Hocher CF, Kleuser B, Krämer BK, Hocher B. Biological Activity of Different Forms of Oxidized Parathyroid Hormone. Int J Mol Sci. 2022 Oct 13;23(20):12228. doi: 10.3390/ijms232012228. PMID: 36293083; PMCID: PMC9603367.

16: Zuo J, Chaykovska L, Chu C, Chen X, Hasan AA, Krämer BK, Tepel M, Hocher B. Head-to-Head Comparison of Oxidative Stress Biomarkers for All-Cause Mortality
in Hemodialysis Patients. Antioxidants (Basel). 2022 Oct 2;11(10):1975. doi: 10.3390/antiox11101975. PMID: 36290698; PMCID: PMC9598936.

17: Dimitrijevic D, Fabian E, Nicol B, Funk-Weyer D, Landsiedel R. Toward Realistic Dosimetry In Vitro: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an In Silico Mass Balance Model. Chem Res Toxicol. 2022 Nov 21;35(11):1962-1973. doi: 10.1021/acs.chemrestox.2c00128. Epub 2022 Oct 20. PMID: 36264934; PMCID: PMC9682521.

18: Wohlleben W, Mehling A, Landsiedel R. Lessons Learned from the Grouping of Chemicals to Assess Risks to Human Health. Angew Chem Int Ed Engl. 2022 Oct 18:e202210651. doi: 10.1002/anie.202210651. Epub ahead of print. PMID: 36254879.

19: Günther A, Hose M, Abberger H, Schumacher F, Veith Y, Kleuser B, Matuschewski K, Lang KS, Gulbins E, Buer J, Westendorf AM, Hansen W. The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis. Elife. 2022 Sep 12;11:e77975. doi: 10.7554/eLife.77975. PMID: 36094170; PMCID: PMC9499531.

20: Schumacher F, Carpinteiro A, Edwards MJ, Wilson GC, Keitsch S, Soddemann M, Wilker B, Kleuser B, Becker KA, Müller CP, Kornhuber J, Gulbins E. Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. J Mol Med (Berl). 2022 Oct;100(10):1493-1508. doi: 10.1007/s00109-022-02250-y. Epub 2022 Aug 31. PMID: 36045177; PMCID: PMC9470690.

21: Mohamud Yusuf A, Hagemann N, Zhang X, Zafar M, Hussner T, Bromkamp C, Martiny C, Tertel T, Börger V, Schumacher F, Solari FA, Hasenberg M, Kleinschnitz C, Doeppner TR, Kleuser B, Sickmann A, Gunzer M, Giebel B, Kolesnick R, Gulbins E, Hermann DM. Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. Basic Res Cardiol. 2022 Dec;117(1):43. doi: 10.1007/s00395-022-00950-7. Epub 2022 Aug 29. PMID: 36038749; PMCID: PMC9424180.

22: Eder S, Hollmann C, Mandasari P, Wittmann P, Schumacher F, Kleuser B, Fink J, Seibel J, Schneider-Schaulies J, Stigloher C, Beyersdorf N, Dembski S. Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations. J Funct Biomater. 2022 Aug 2;13(3):111. doi: 10.3390/jfb13030111. PMID: 35997449; PMCID: PMC9397063.

23: Holle J, Bartolomaeus H, Löber U, Behrens F, Bartolomaeus TUP, Anandakumar H, Wimmer MI, Vu DL, Kuhring M, Brüning U, Maifeld A, Geisberger S, Kempa S, Schumacher F, Kleuser B, Bufler P, Querfeld U, Kitschke S, Engler D, Kuhrt LD, Drechsel O, Eckardt KU, Forslund SK, Thürmer A, McParland V, Kirwan JA, Wilck N, Müller D. Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance. J Am Soc Nephrol. 2022 Dec;33(12):2259-2275. doi: 10.1681/ASN.2022030378. Epub 2022 Aug 19. PMID: 35985814; PMCID: PMC9731629.

24: Radbruch M, Pischon H, Du F, Haag R, Schumacher F, Kleuser B, Mundhenk L, Gruber AD. Biodegradable core-multishell nanocarrier: Topical tacrolimus delivery for treatment of dermatitis. J Control Release. 2022 Sep;349:917-928. doi: 10.1016/j.jconrel.2022.07.025. Epub 2022 Aug 8. PMID: 35905785.

25: Zhang X, Liu L, Gaballa MMS, Hasan AA, Xiong Y, Xie L, Klein T, Delic D, Kleuser B, Krämer BK, Li J, Hocher B. Impact of Salt Intake and Renin-Angiotensin-Aldosterone System Blockade on Lung Severe Acute Respiratory Syndrome Coronavirus 2 Host Factors. Kidney Blood Press Res. 2022;47(9):565-575. doi: 10.1159/000525368. Epub 2022 Jul 25. PMID: 35878596.

26: Carstens H, Kalka K, Verhaegh R, Schumacher F, Soddemann M, Wilker B, Keitsch S, Sehl C, Kleuser B, Hübler M, Rauen U, Becker AK, Koch A, Gulbins E, Kamler M. Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs. PLoS One. 2022 Jul 21;17(7):e0271620. doi: 10.1371/journal.pone.0271620. PMID: 35862397; PMCID: PMC9302828.

27: Chu C, Delić D, Alber J, Feger M, Xiong Y, Luo T, Hasan AA, Zeng S, Gaballa MMS, Chen X, Yin L, Klein T, Elitok S, Krämer BK, Föller M, Hocher B. Head-to-head comparison of two SGLT-2 inhibitors on AKI outcomes in a rat ischemia-reperfusion model. Biomed Pharmacother. 2022 Sep;153:113357. doi: 10.1016/j.biopha.2022.113357. Epub 2022 Jul 2. PMID: 35792391.

28: Schumacher F, Edwards MJ, Mühle C, Carpinteiro A, Wilson GC, Wilker B, Soddemann M, Keitsch S, Scherbaum N, Müller BW, Lang UE, Linnemann C, Kleuser B, Müller CP, Kornhuber J, Gulbins E. Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice. J Biol Chem. 2022 Aug;298(8):102185. doi: 10.1016/j.jbc.2022.102185. Epub 2022 Jun 24. PMID: 35753355; PMCID: PMC9304786.

29: Landsiedel R, Birk B, Funk-Weyer D. The Evolution of Regulatory Toxicology: Where is the Gardener? Altern Lab Anim. 2022 Jul;50(4):255-262. doi: 10.1177/02611929221107617. Epub 2022 Jun 24. PMID: 35749778.

30: Oesch F, Honarvar N, Fabian E, Finch L, Hindle S, Wiench K, Landsiedel R. Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione. Arch Toxicol. 2022 Sep;96(9):2573-2587. doi: 10.1007/s00204-022-03322-1. Epub 2022 Jun 15. PMID: 35704047; PMCID: PMC9325804.

31: Kyriakoudi S, Theodoulou A, Potamiti L, Schumacher F, Zachariou M, Papacharalambous R, Kleuser B, Panayiotidis MI, Drousiotou A, Petrou PP. Stbd1-deficient mice display insulin resistance associated with enhanced hepatic ER-mitochondria contact. Biochimie. 2022 Sep;200:172-183. doi: 10.1016/j.biochi.2022.06.003. Epub 2022 Jun 9. PMID: 35691532.

32: Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stępnik M, Sobańska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandström J, Ragan I, Bubalo N, Spielmann H. The Rise of Three Rs Centres and Platforms in Europe. Altern Lab Anim. 2022 Mar;50(2):90-120. doi: 10.1177/02611929221099165. Epub 2022 May 16. PMID: 35578444.

33: Keller JG, Persson M, Müller P, Ma-Hock L, Werle K, Arts J, Landsiedel R, Wohlleben W. Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity. NanoImpact. 2021 Jul;23:100341. doi: 10.1016/j.impact.2021.100341. Epub 2021 Jul 12. Erratum in: NanoImpact. 2023 Jan;29:100455. PMID: 35559842.

34: Hocher B, Lu YP, Reichetzeder C, Zhang X, Tsuprykov O, Rahnenführer J, Xie L, Li J, Hu L, Krämer BK, Hasan AA. Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself. Diabetologia. 2022 Jul;65(7):1222-1236. doi: 10.1007/s00125-022-05700-x. Epub 2022 Apr 30. PMID: 35488925; PMCID: PMC9174141.

35: Kadow S, Schumacher F, Kramer M, Hessler G, Scholtysik R, Oubari S, Johansson P, Hüttmann A, Reinhardt HC, Kleuser B, Zoratti M, Mattarei A, Szabò I, Gulbins E, Carpinteiro A. Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma. Cancers (Basel). 2022 Apr 13;14(8):1955. doi: 10.3390/cancers14081955. PMID: 35454865; PMCID: PMC9032553.

36: Gerecke C, Egea Rodrigues C, Homann T, Kleuser B. The Role of Ten-Eleven Translocation Proteins in Inflammation. Front Immunol. 2022 Mar 21;13:861351. doi: 10.3389/fimmu.2022.861351. PMID: 35386689; PMCID: PMC8977485.

37: Xiong Y, Delic D, Zeng S, Chen X, Chu C, Hasan AA, Krämer BK, Klein T, Yin L, Hocher B. Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker. BMC Nephrol. 2022 Mar 24;23(1):117. doi: 10.1186/s12882-022-02747-1. PMID: 35331159; PMCID: PMC8942812.

38: Landsiedel R, Hahn D, Ossig R, Ritz S, Sauer L, Buesen R, Rehm S, Wohlleben W, Groeters S, Strauss V, Sperber S, Wami H, Dobrindt U, Prior K, Harmsen D, van Ravenzwaay B, Schnekenburger J. Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects. Part Fibre Toxicol. 2022 Mar 23;19(1):21. doi: 10.1186/s12989-022-00459-w. PMID: 35321750; PMCID: PMC8941749.

39: Hochrein SM, Wu H, Eckstein M, Arrigoni L, Herman JS, Schumacher F, Gerecke C, Rosenfeldt M, Grün D, Kleuser B, Gasteiger G, Kastenmüller W, Ghesquière B, Van den Bossche J, Abel ED, Vaeth M. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. Cell Metab. 2022 Apr 5;34(4):516-532.e11. doi: 10.1016/j.cmet.2022.02.015. Epub 2022 Mar 21. PMID: 35316657; PMCID: PMC9019065.

40: Zhang X, Hasan AA, Wu H, Gaballa MMS, Zeng S, Liu L, Xie L, Jung T, Grune T, Krämer BK, Kleuser B, Li J, Hocher B. High-fat, sucrose and salt-rich diet during rat spermatogenesis lead to the development of chronic kidney disease in the female offspring of the F2 generation. FASEB J. 2022 Apr;36(4):e22259. doi: 10.1096/fj.202101789RR. PMID: 35294083.

41: Putra SED, Reichetzeder C, von Websky K, Neuber C, Halle H, Kleuser B, Krämer BK, Hocher B. Association between placental global DNA methylation and blood pressure during human pregnancy. J Hypertens. 2022 May 1;40(5):1002-1009. doi: 10.1097/HJH.0000000000003103. Epub 2022 Feb 25. PMID: 35221324.

42: Bernacchioni C, Squecco R, Gamberi T, Ghini V, Schumacher F, Mannelli M, Garella R, Idrizaj E, Cencetti F, Puliti E, Bruni P, Turano P, Fiaschi T, Donati C. S1P Signalling Axis Is Necessary for Adiponectin Directed Regulation of Electrophysiological Properties and Oxidative Metabolism in C2C12 Myotubes. Cells. 2022 Feb 17;11(4):713. doi: 10.3390/cells11040713. PMID: 35203362; PMCID: PMC8869893.

43: Westhölter D, Schumacher F, Wülfinghoff N, Sutharsan S, Strassburg S, Kleuser B, Horn PA, Reuter S, Gulbins E, Taube C, Welsner M. CFTR modulator therapy alters plasma sphingolipid profiles in people with cystic fibrosis. J Cyst Fibros. 2022 Jul;21(4):713-720. doi: 10.1016/j.jcf.2022.02.005. Epub 2022 Feb 12. PMID: 35168870.

44: Schulz J, Michelet R, Joseph JF, Zeitlinger M, Schumacher F, Mikus G, Kloft C. A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications. J Pharm Biomed Anal. 2022 Feb 20;210:114551. doi: 10.1016/j.jpba.2021.114551. Epub 2021 Dec 24. PMID: 34999435.

45: Zeng S, Delic D, Chu C, Xiong Y, Luo T, Chen X, Gaballa MMS, Xue Y, Chen X, Cao Y, Hasan AA, Stadermann K, Frankenreiter S, Yin L, Krämer BK, Klein T, Hocher B. Antifibrotic effects of low dose SGLT2 Inhibition with empagliflozin in comparison to Ang II receptor blockade with telmisartan in 5/6 nephrectomised rats on high salt diet. Biomed Pharmacother. 2022 Feb;146:112606. doi: 10.1016/j.biopha.2021.112606. Epub 2021 Dec 28. PMID: 34968924.

46: Chu C, Chen X, Hasan AA, Szakallova A, Krämer BK, Tepel M, Hocher B. Angiopoietin-2 predicts all-cause mortality in male but not female end-stage kidney disease patients on hemodialysis. Nephrol Dial Transplant. 2022 Jun 23;37(7):1348-1356. doi: 10.1093/ndt/gfab332. PMID: 34792167; PMCID: PMC9217660.

47: Weber AG, Birk B, Müller C, Schneider S, van Ravenzwaay B, Funk-Weyer D, Landsiedel R. The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles. Chem Biol Interact. 2022 Jan 5;351:109709. doi: 10.1016/j.cbi.2021.109709. Epub 2021 Oct 16. PMID: 34662569.

2021

48: Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Int J Mol Sci. 2021 Sep 30;22(19):10617. doi: 10.3390/ijms221910617. PMID: 34638955; PMCID: PMC8508615.

49: Oesch F, Fruth D, Hengstler JG, Fabian E, Berger FI, Landsiedel R. Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat. Arch Toxicol. 2021 Dec;95(12):3717-3744. doi: 10.1007/s00204-021-03151-8. Epub 2021 Sep 30. PMID: 34595563; PMCID: PMC8536644.

50: Schneider-Schaulies S, Schumacher F, Wigger D, Schöl M, Waghmare T, Schlegel J, Seibel J, Kleuser B. Sphingolipids: Effectors and Achilles Heals in Viral Infections? Cells. 2021 Aug 24;10(9):2175. doi: 10.3390/cells10092175. PMID: 34571822; PMCID: PMC8466362.

51: Carstens H, Kalka K, Verhaegh R, Schumacher F, Soddemann M, Wilker B, Keitsch S, Sehl C, Kleuser B, Wahlers T, Reiner G, Koch A, Rauen U, Gulbins E, Kamler M. Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs. Sci Rep. 2021 Sep 20;11(1):18607. doi: 10.1038/s41598-021-97708-3. PMID: 34545108; PMCID: PMC8452622.

52: Stepanovska Tanturovska B, Zivkovic A, Imeri F, Homann T, Kleuser B, Stark H, Huwiler A. ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules. 2021 Aug 24;26(17):5134. doi: 10.3390/molecules26175134. PMID: 34500564; PMCID: PMC8433829.

53: Natsch A, Landsiedel R, Kolle SN. A triangular approach for the validation of new approach methods for skin sensitization. ALTEX. 2021;38(4):669-677. doi: 10.14573/altex.2105111. Epub 2021 Jul 8. PMID: 34247252.

54: Janer G, Ag-Seleci D, Sergent JA, Landsiedel R, Wohlleben W. Creating sets of similar nanoforms with the ECETOC NanoApp: real-life case studies. Nanotoxicology. 2021 Oct;15(8):1016-1034. doi: 10.1080/17435390.2021.1946186. Epub 2021 Jul 9. PMID: 34242099.

55: Seibel J, Schneider-Schaulies S, Kleuser B. Editorial: Sphingolipids in Infection Control. Front Cell Dev Biol. 2021 Jun 21;9:697290. doi: 10.3389/fcell.2021.697290. PMID: 34235157; PMCID: PMC8255667.

56: Stratmann H, Wohlleben W, Wiemann M, Vennemann A, End N, Veith U, Ma-Hock L, Landsiedel R. Classes of organic pigments meet tentative PSLT criteria and lack toxicity in short-term inhalation studies. Regul Toxicol Pharmacol. 2021 Aug;124:104988. doi: 10.1016/j.yrtph.2021.104988. Epub 2021 Jul 2. PMID: 34224799.

57: Garcia de Lomana M, Morger A, Norinder U, Buesen R, Landsiedel R, Volkamer A, Kirchmair J, Mathea M. ChemBioSim: Enhancing Conformal Prediction of In Vivo Toxicity by Use of Predicted Bioactivities. J Chem Inf Model. 2021 Jul 26;61(7):3255-3272. doi: 10.1021/acs.jcim.1c00451. Epub 2021 Jun 21. PMID: 34153183; PMCID: PMC8317154.

58: Oesch F, Honarvar N, Fabian E, Berger FI, Landsiedel R. N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity. Arch Toxicol. 2021 Oct;95(10):3143-3159. doi: 10.1007/s00204-021-03081-5. Epub 2021 Jun 6. PMID: 34091723.

59: Ebenezer DL, Ramchandran R, Fu P, Mangio LA, Suryadevara V, Ha AW, Berdyshev E, Van Veldhoven PP, Kron SJ, Schumacher F, Kleuser B, Natarajan V. Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell Biochem Biophys. 2021 Sep;79(3):575-592. doi: 10.1007/s12013-021-01005-9. Epub 2021 Jun 3. PMID: 34085165; PMCID: PMC9128239.

60: Wetzel A, Scholtka B, Schumacher F, Rawel H, Geisendörfer B, Kleuser B. Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis. Int J Mol Sci. 2021 May 19;22(10):5329. doi: 10.3390/ijms22105329. PMID: 34069352; PMCID: PMC8158689.

61: Zeng S, Hasan AA, Chu C, Xiong Y, Hocher JG, Elitok S, Krämer BK, Hocher B. Osteoprotegerin is an independent risk factor predicting death in stable renal transplant recipients. Clin Nephrol. 2021 Sep;96(3):129-137. doi: 10.5414/CN110470. PMID: 34042584.

62: Keller JG, Wiemann M, Gröters S, Werle K, Vennemann A, Landsiedel R, Wohlleben W. Aerogels are not regulated as nanomaterials, but can be assessed by tiered testing and grouping strategies for nanomaterials. Nanoscale Adv. 2021 May 19;3(13):3881-3893. doi: 10.1039/d1na00044f. PMID: 36133012; PMCID: PMC9419173.

63: Wardelmann K, Rath M, Castro JP, Blümel S, Schell M, Hauffe R, Schumacher F, Flore T, Ritter K, Wernitz A, Hosoi T, Ozawa K, Kleuser B, Weiß J, Schürmann A, Kleinridders A. Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants (Basel). 2021 Apr 30;10(5):711. doi: 10.3390/antiox10050711. PMID: 33946318; PMCID: PMC8145035.

64: Wiese T, Dennstädt F, Hollmann C, Stonawski S, Wurst C, Fink J, Gorte E, Mandasari P, Domschke K, Hommers L, Vanhove B, Schumacher F, Kleuser B, Seibel J, Rohr J, Buttmann M, Menke A, Schneider Schaulies J, Beyersdorf N. Inhibition of acid sphingomyelinase increases regulatory T cells in humans. Brain Commun. 2021 Mar 5;3(2):fcab020. doi: 10.1093/braincomms/fcab020. PMID: 33898989; PMCID: PMC8054263.

65: Keller JG, Graham UM, Koltermann-Jülly J, Gelein R, Ma-Hock L, Landsiedel R, Wiemann M, Oberdörster G, Elder A, Wohlleben W. Author Correction: Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulphate. Sci Rep. 2021 Apr 19;11(1):8813. doi: 10.1038/s41598-021-82185-5. Erratum for: Sci Rep. 2020 Jan 16;10(1):458. PMID: 33875670; PMCID: PMC8055969.

66: Ulrey A, Kolle S, Landsiedel R, Hill E. How a GIVIMP certification program can increase confidence in in vitro methods. ALTEX. 2021;38(2):316-318. doi: 10.14573/altex.2102261. PMID: 33871038.

67: Chu C, Elitok S, Zeng S, Xiong Y, Hocher CF, Hasan AA, Krämer BK, Hocher B. C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival. BMC Nephrol. 2021 Apr 8;22(1):125. doi: 10.1186/s12882-021-02329-7. PMID: 33832449; PMCID: PMC8033679.

68: Wigger D, Schumacher F, Schneider-Schaulies S, Kleuser B. Sphingosine 1-phosphate metabolism and insulin signaling. Cell Signal. 2021 Jun;82:109959. doi: 10.1016/j.cellsig.2021.109959. Epub 2021 Feb 22. PMID: 33631318.

69: Peters S, Kaiser L, Fink J, Schumacher F, Perschin V, Schlegel J, Sauer M, Stigloher C, Kleuser B, Seibel J, Schubert-Unkmeir A. Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria. Sci Rep. 2021 Feb 22;11(1):4300. doi: 10.1038/s41598-021-83813-w. PMID: 33619350; PMCID: PMC7900124.

70: Ma-Hock L, Sauer UG, Ruggiero E, Keller JG, Wohlleben W, Landsiedel R. The Use of Nanomaterial In Vivo Organ Burden Data for In Vitro Dose Setting. Small. 2021 Apr;17(15):e2005725. doi: 10.1002/smll.202005725. Epub 2021 Feb 15. PMID: 33586349.

71: Fink J, Schumacher F, Schlegel J, Stenzel P, Wigger D, Sauer M, Kleuser B, Seibel J. Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis. Org Biomol Chem. 2021 Mar 18;19(10):2203-2212. doi: 10.1039/d0ob02592e. PMID: 33496698.

72: Imeri F, Stepanovska Tanturovska B, Zivkovic A, Enzmann G, Schwalm S, Pfeilschifter J, Homann T, Kleuser B, Engelhardt B, Stark H, Huwiler A. Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology. 2021 Mar 15;186:108464. doi: 10.1016/j.neuropharm.2021.108464. Epub 2021 Jan 16. PMID: 33460688.

73: Morger A, Mathea M, Achenbach JH, Wolf A, Buesen R, Schleifer KJ, Landsiedel R, Volkamer A. KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development. J Cheminform. 2020 Apr 14;12(1):24. doi: 10.1186/s13321-020-00422-x. PMID: 33431007; PMCID: PMC7157991.

74: Janer G, Landsiedel R, Wohlleben W. Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH. Nanotoxicology. 2021 Mar;15(2):145-166. doi: 10.1080/17435390.2020.1842933. Epub 2020 Dec 15. PMID: 33320695.

75: Beckmann N, Schumacher F, Kleuser B, Gulbins E, Nomellini V, Caldwell CC. Burn Injury Impairs Neutrophil Chemotaxis Through Increased Ceramide. Shock. 2021 Jul 1;56(1):125-132. doi: 10.1097/SHK.0000000000001693. PMID: 33273368.

76: Chu C, Zeng S, Hasan AA, Hocher CF, Krämer BK, Hocher B. Comparison of infection risks and clinical outcomes in patients with and without SARS-CoV-2 lung infection under renin-angiotensin-aldosterone system blockade: Systematic review and meta-analysis. Br J Clin Pharmacol. 2021 Jun;87(6):2475-2492. doi: 10.1111/bcp.14660. Epub 2020 Dec 18. PMID: 33217033; PMCID: PMC7753617.

77: Garcia de Lomana M, Weber AG, Birk B, Landsiedel R, Achenbach J, Schleifer KJ, Mathea M, Kirchmair J. In Silico Models to Predict the Perturbation of Molecular Initiating Events Related to Thyroid Hormone Homeostasis. Chem Res Toxicol. 2021 Feb 15;34(2):396-411. doi: 10.1021/acs.chemrestox.0c00304. Epub 2020 Nov 13. PMID: 33185102; PMCID: PMC7887800.

78: Prakash H, Upadhyay D, Bandapalli OR, Jain A, Kleuser B. Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106504. doi: 10.1016/j.prostaglandins.2020.106504. Epub 2020 Nov 2. PMID: 33147503; PMCID: PMC7605809.

79: Kolle SN, Landsiedel R. Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh. Handb Exp Pharmacol. 2021;265:3-27. doi: 10.1007/164_2020_368. PMID: 33136188.

80: Keller JG, Quevedo DF, Faccani L, Costa AL, Landsiedel R, Werle K, Wohlleben W. Dosimetry in vitro - exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods. Nanotoxicology. 2021 Feb;15(1):21-34. doi: 10.1080/17435390.2020.1836281. Epub 2020 Oct 26. PMID: 33100120.

81: Kalinichenko LS, Abdel-Hafiz L, Wang AL, Mühle C, Rösel N, Schumacher F, Kleuser B, Smaga I, Frankowska M, Filip M, Schaller G, Richter-Schmidinger T, Lenz B, Gulbins E, Kornhuber J, Oliveira AWC, Barros M, Huston JP, Müller CP. Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory. Cereb Cortex. 2021 Jan 5;31(2):1316-1333. doi: 10.1093/cercor/bhaa298. PMID: 33043975.

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