Eine vollständige Liste der Publikationen finden Sie unter diesem Link

Pubmed

2025

1. Zimmermann, N., F. Schumacher, F. Bredendiek, and C. Kloft, Development and validation of an LC-MS/MS assay for quantification of fosfomycin in Mueller-Hinton broth for application in profiling antibacterial efficacy against clinical bacterial isolates. J Chromatogr B Analyt Technol Biomed Life Sci, 2025. 1256: p. 124561.

2. Zhang, X., M.M.S. Gaballa, A.A. Hasan, Y. Liu, J.G. Hocher, X. Chen, L. Liu, J. Li, D. Wigger, C. Reichetzeder, S. Elitok, B. Kleuser, B.K. Krämer, and B. Hocher, Effects of High-Salt Intake on Glucose Metabolism, Liver Function, and the Microbiome in Rats: Influence of ACE Inhibitors and Angiotensin II Receptor Blockers. Am J Physiol Cell Physiol, 2025.

3. Wu, Y., F. Schnitker, Y. Liu, S. Keitsch, F. Caicci, F. Schumacher, A. Riehle, B. Pollmeier, J. Kehrmann, B. Kleuser, M. Kamler, I. Szabo, H. Grassmé, and E. Gulbins, Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections. J Mol Med (Berl), 2025.

4. Werner, F., F. Schumacher, C. Mühle, W. Adler, C. Schug, E. Schäflein, E. Morawa, B. Kleuser, J. Kornhuber, Y. Erim, and C. Rhein, Psychosomatic - psychotherapeutic treatment of stress-related disorders impacts the sphingolipid metabolism towards increased sphingosine and sphingosine-1-phosphate levels. Eur Arch Psychiatry Clin Neurosci, 2025.

5. Sharma, M., E. Huber, E. Arnesdotter, H.P. Behrsing, A. Bettmann, D. Brandwein, S. Constant, R. Date, A. Deshpande, E. Fabian, A. Gupta, R. Gutierrez, A.C. Gutleb, M.M. Hargrove, M. Hollings, V. Hutter, A.M. Jarabek, Y. Kaluzhny, R. Landsiedel, L. Milchak, R.A. Moyer, J.R. Murray, K. Page, M. Patel, S.N. Pearson, E.J. Petersen, E. Reinke, N. Roldan, C. Roper, J.B. Scaglione, R.S. Settivari, A.O. Stucki, S. Verstraelen, J.L. Wallace, S. McCullough, and A.J. Clippinger, Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA). Arch Toxicol, 2025. 99(1): p. 57-66.

6. Sehgal, R., M. Jähnert, M. Lazaratos, T. Speckmann, F. Schumacher, B. Kleuser, M. Ouni, W. Jonas, and A. Schürmann, Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction. J Lipid Res, 2025. 66(4): p. 100767.

7. Göpfert, A., D.M. Schuster, C. Rülker, M. Eichenlaub, B. Tokovenko, M. Dammann, D. Funk-Weyer, N. Honarvar, and R. Landsiedel, The transgenic MutaMouse hepatocyte mutation assay in vitro: Mutagenicity and mutation spectra of six substances with different mutagenic mechanisms. Mutat Res Genet Toxicol Environ Mutagen, 2025. 901: p. 503836.

8. Chestnykh, D., C. Mühle, F. Schumacher, L.S. Kalinichenko, S. Löber, P. Gmeiner, C. Alzheimer, S. von Hörsten, B. Kleuser, S. Uebe, A.B. Ekici, E. Gulbins, J. Kornhuber, H.K. Jin, J.S. Bae, A. Lourdusamy, and C.P. Müller, Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia. Mol Psychiatry, 2025.

9. Blum, J., M. Brüll, J.G. Hengstler, D.R. Dietrich, A.J. Gruber, M. Dipalo, U. Kraushaar, I. Mangas, A. Terron, E. Fritsche, P. Marx-Stoelting, B. Hardy, A. Schepky, S. Escher, T. Hartung, R. Landsiedel, A. Odermatt, M. Sachana, K. Koch, A. Dönmez, S. Masjosthusmann, K. Bothe, S. Schildknecht, M. Beilmann, J.B. Beltman, S. Fitzpatrick, A. Mangerich, M. Rehm, S. Tangianu, F.M. Zickgraf, H. Kamp, G. Burger, B. van de Water, N. Kleinstreuer, A. White, and M. Leist, The long way from raw data to NAM-based information: Overview on data layers and processing steps. Altex, 2025. 42(1): p. 167-180.

10. Behrens, F., J. Holle, C.Y. Chen, L.F. Ginsbach, B.C. Krause, U. Bruning, F.L. Kriegel, T. Kaiser, I.A. Szijártó, H. Anandakumar, K. Lehmann, F. Schumacher, P. Durek, F.F. Heinrich, D. Lodka, C. Hoffmann, A.A. Borchardt, L. Peters, L. Michalick, U. Querfeld, P. Bufler, A. Luch, B. Kleuser, J.A. Kirwan, S.K. Forslund, J. Thumfahrt, D. Müller, N. Wilck, M.F. Mashreghi, U. Löber, H. Bartolomaeus, W.M. Kuebler, and S. Simmons, Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease. J Extracell Vesicles, 2025. 14(3): p. e70062.

11. Alcolea-Rodriguez, V., F.C. Simeone, V.I. Dumit, L. Faccani, V. Toledo, A. Haase, N. Coca-López, R. Portela, and M.A. Bañares, A refined dose metric for nanotoxicology based on surface site reactivity for oxidative potential of engineered nanomaterials. Nanoscale Adv, 2025.

2024

12. Zabihi, F., M. Cherri, X. Guo, F. Rancan, F. Schumacher, E. Mohammadifar, B. Kleuser, W. Bäumer, M. Schirner, A. Vogt, and R. Haag, Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates. Pharmaceuticals (Basel), 2024. 17(1).

13. Wu, Y., A. Riehle, B. Pollmeier, S. Kadow, F. Schumacher, M. Drab, B. Kleuser, E. Gulbins, and H. Grassmé, Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice. Tuberculosis (Edinb), 2024. 147: p. 102493.

14. Wimmer, M.I., H. Bartolomaeus, H. Anandakumar, C.Y. Chen, V. Vecera, S. Kedziora, S. Kamboj, F. Schumacher, S. Pals, A. Rauch, J. Meisel, O. Potapenko, A. Yarritu, T.U.P. Bartolomaeus, M. Samaan, A. Thiele, L. Stürzbecher, S.Y. Geisberger, B. Kleuser, P.J. Oefner, N. Haase, U. Löber, W. Gronwald, S.K. Forslund-Startceva, D.N. Müller, and N. Wilck, Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension. Acta Physiol (Oxf), 2024. 240(11): p. e14226.

15. Wilhelmi, P., V. Haake, F.M. Zickgraf, V. Giri, P. Ternes, P. Driemert, J. Nöth, S. Scholz, M. Barenys, B. Flick, B. Birk, H. Kamp, R. Landsiedel, and D. Funk-Weyer, Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish. Arch Toxicol, 2024. 98(3): p. 943-956.

16. Wareing, B., A. Aktalay Hippchen, S.N. Kolle, B. Birk, D. Funk-Weyer, and R. Landsiedel, Limitations and Modifications of Skin Sensitization NAMs for Testing Inorganic Nanomaterials. Toxics, 2024. 12(8).

17. Vogel, A., J. Tentschert, R. Pieters, F. Bennet, H. Dirven, A. van den Berg, E. Lenssen, M. Rietdijk, D. Broßell, and A. Haase, Towards a risk assessment framework for micro- and nanoplastic particles for human health. Part Fibre Toxicol, 2024. 21(1): p. 48.

18. Tran, P.T., J. Schleusener, B. Kleuser, K. Jung, M.C. Meinke, and S.B. Lohan, Evidence of the protective effect of anti-pollution products against oxidative stress in skin ex vivo using EPR spectroscopy and autofluorescence measurements. Eur J Pharm Biopharm, 2024. 197: p. 114211.

19. Thoma, T., L. Ma-Hock, S. Schneider, N. Honarvar, S. Treumann, S. Groeters, V. Strauss, H. Marxfeld, D. Funk-Weyer, S. Seiffert, W. Wohlleben, M. Dammann, K. Wiench, N. Lombaert, C. Spirlet, M. Vasquez, N. Dewhurst, and R. Landsiedel, Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms. Part Fibre Toxicol, 2024. 21(1): p. 24.

20. Thiel, A., F. Drews, M. Pirritano, F. Schumacher, V. Michaelis, M. Schwarz, S. Franzenburg, T. Schwerdtle, B. Michalke, A.P. Kipp, B. Kleuser, M. Simon, and J. Bornhorst, Transcriptomics pave the way into mechanisms of cobalt and nickel toxicity: Nrf2-mediated cellular responses in liver carcinoma cells. Redox Biol, 2024. 75: p. 103290.

21. Stobernack, T., N. Dommershausen, V. Alcolea-Rodríguez, R. Ledwith, M.A. Bañares, A. Haase, M. Pink, and V.I. Dumit, Advancing Nanomaterial Toxicology Screening Through Efficient and Cost-Effective Quantitative Proteomics. Small Methods, 2024. 8(12): p. e2400420.

22. Schöl, M., R. Schempp, T. Hennig, D. Wigger, F. Schumacher, B. Kleuser, C. Stigloher, M. van Ham, L. Jänsch, S. Schneider-Schaulies, L. Dölken, and E. Avota, Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells. Front Immunol, 2024. 15: p. 1435701.

23. Schempp, R., J. Eilts, M. Schöl, M.F. Grijalva Yépez, A. Fekete, D. Wigger, F. Schumacher, B. Kleuser, M. van Ham, L. Jänsch, M. Sauer, and E. Avota, The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. Int J Mol Sci, 2024. 25(6).

24. Rühling, M., L. Kersting, F. Wagner, F. Schumacher, D. Wigger, D.A. Helmerich, T. Pfeuffer, R. Elflein, C. Kappe, M. Sauer, C. Arenz, B. Kleuser, T. Rudel, M. Fraunholz, and J. Seibel, Trifunctional sphingomyelin derivatives enable nanoscale resolution of sphingomyelin turnover in physiological and infection processes via expansion microscopy. Nat Commun, 2024. 15(1): p. 7456.

25. Prell, A., D. Wigger, A. Huwiler, F. Schumacher, and B. Kleuser, The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells. J Lipid Res, 2024. 65(10): p. 100631.

26. Mandasari, P., C. Hollmann, R.H. Zaidi, S. Löw, J. Schrama, D. Wigger, F. Schumacher, B. Kleuser, and N. Beyersdorf, Acid ceramidase expression reduces IFNγ secretion by mouse CD4(+) T cells and is crucial for maintaining B-cell numbers in mice. Front Immunol, 2024. 15: p. 1309846.

27. Lortzing, V., G. Valsamakis, F. Jantzen, J. Hundacker, L.R. Paniagua Voirol, F. Schumacher, B. Kleuser, and M. Hilker, Plant defensive responses to insect eggs are inducible by general egg-associated elicitors. Sci Rep, 2024. 14(1): p. 1076.

28. Liu, L., Z. Karim, N. Schlörer, X. de la Torre, F. Botrè, C. Zoschke, and M.K. Parr, Biotransformation of anabolic androgenic steroids in human skin cells. J Steroid Biochem Mol Biol, 2024. 237: p. 106444.

29. Liu, H., G. Yin, M.S. Kohlhepp, F. Schumacher, J. Hundertmark, M.I.A. Hassan, F. Heymann, T. Puengel, B. Kleuser, A.S. Mosig, F. Tacke, and A. Guillot, Dissecting Acute Drug-Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver-On-A-Chip Model. Adv Sci (Weinh), 2024. 11(30): p. e2403516.

30. Li, M., A.A. Hasan, C. Chu, J.G. Hocher, Y. Liu, X. Zhang, X. Chen, B. Yard, B.K. Krämer, and B. Hocher, Only bioactive forms of PTH (n-oxPTH and Met18(ox)-PTH) inhibit synthesis of sclerostin - evidence from in vitro and human studies. Pflugers Arch, 2024. 476(6): p. 889-899.

31. Ledwith, R., T. Stobernack, A. Bergert, A. Bahl, M. Pink, A. Haase, and V.I. Dumit, Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines. Arch Toxicol, 2024. 98(12): p. 4021-4031.

32. Kleuser, B., F. Schumacher, and E. Gulbins, New Therapeutic Options in Pulmonal Diseases: Sphingolipids and Modulation of Sphingolipid Metabolism. Handb Exp Pharmacol, 2024. 284: p. 289-312.

33. Kirmpaki, M.A., E.M. Saied, F. Schumacher, K. Prause, B. Kleuser, and C. Arenz, Live-Cell Identification of Inhibitors of the Lipid Transfer Protein CERT Using Nanoluciferase Bioluminescence Resonance Energy Transfer (NanoBRET). Angew Chem Int Ed Engl, 2024. 63(52): p. e202413562.

34. Jacobs, M.N., S. Hoffmann, H.M. Hollnagel, P. Kern, S.N. Kolle, A. Natsch, and R. Landsiedel, Avoiding a reproducibility crisis in regulatory toxicology-on the fundamental role of ring trials. Arch Toxicol, 2024. 98(7): p. 2047-2063.

35. Holzapfel, R., A. Prell, F. Schumacher, V. Perschin, J.P. Friedmann Angeli, B. Kleuser, C. Stigloher, and G. Fazeli, Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Eur J Cell Biol, 2024. 103(2): p. 151411.

36. Holle, J., V. McParland, H. Anandakumar, F. Gerritzmann, F. Behrens, F. Schumacher, J. Thumfart, K.U. Eckardt, B. Kleuser, H. Bartolomaeus, and N. Wilck, Gut dysbiosis contributes to TMAO accumulation in CKD. Nephrol Dial Transplant, 2024. 39(11): p. 1923-1926.

37. Hindrichs, C., T. Walk, S. Melching-Kollmuss, R. Landsiedel, H. Kamp, and D. Funk-Weyer, A Novel and Fast Online-SPE-LC-MS/MS Method to Quantify Thyroid Hormone Metabolites in Rat Plasma. Chem Res Toxicol, 2024. 37(1): p. 33-41.

38. Hindrichs, C., T. Walk, R. Landsiedel, H. Kamp, S. Schneider, S. Melching-Kollmuss, and D. Funk-Weyer, Thyroid Hormone Metabolites Quantified in Pup and Adult Rat Cerebellum, Cortex and Whole-Brain Samples Using an Automated Online SPE-LC-MS/MS Method. Metabolites, 2024. 14(1).

39. Haßmann, U., S. Amann, N. Babayan, S. Fankhauser, T. Hofmaier, T. Jakl, M. Nendza, H. Stopper, S.M. Stefan, and R. Landsiedel, Predictive, integrative, and regulatory aspects of AI-driven computational toxicology - Highlights of the German Pharm-Tox Summit (GPTS) 2024. Toxicology, 2024. 509: p. 153975.

40. Glatt, H., S.Y. Weißenberg, A. Ehlers, A. Lampen, A. Seidel, F. Schumacher, W. Engst, and W. Meinl, Formation of DNA Adducts by 1-Methoxy-3-indolylmethylalcohol, a Breakdown Product of a Glucosinolate, in the Mouse: Impact of the SULT1A1 Status-Wild-Type, Knockout or Humanised. Int J Mol Sci, 2024. 25(7).

41. Germer, G., L. Schwartze, J. García-Miller, R. Balansin-Rigon, L.J. Groth, I. Rühl, P. Patoka, C. Zoschke, and E. Rühl, Label-free mapping of cetuximab in multi-layered tumor oral mucosa models by atomic force-microscopy-based infrared spectroscopy. Analyst, 2024. 149(7): p. 2122-2130.

42. Emecheta, E.E., P.M. Pfohl, W. Wohlleben, A. Haase, and A. Roloff, Desorption of Polycyclic Aromatic Hydrocarbons from Microplastics in Human Gastrointestinal Fluid Simulants-Implications for Exposure Assessment. ACS Omega, 2024. 9(23): p. 24281-24290.

43. Dumit, V.I., Y.C. Liu, A. Bahl, P. Kohonen, R.C. Grafström, P. Nymark, C. Müller-Graf, A. Haase, and M. Pink, Meta-Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure-Activity Relationship of Carbon Materials with Different Morphologies. Adv Sci (Weinh), 2024. 11(9): p. e2306268.

44. Dubau, M., T. Tripetchr, L. Mahmoud, V. Kral, and B. Kleuser, Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach. J Tissue Eng, 2024. 15: p. 20417314241291848.

45. Chen, X., D. Delić, Y. Cao, Z. Zhang, H. Wu, A.A. Hasan, M.M.S. Gaballa, L. Yin, B.K. Krämer, T. Klein, X. Shi, B. He, L. Shen, and B. Hocher, Renal and cardiac effects of the PDE9 inhibitor BAY 73-6691 in 5/6 nephrectomized rats. Pflugers Arch, 2024. 476(5): p. 755-767.

46. Chen, H., J. Yao, L. Hu, Y. Liu, J.G. Hocher, X. Zhang, A.A. Hasan, G. Lin, F. Gong, and B. Hocher, Vitamin D binding protein correlate with estrogen increase after administration of human chorionic gonadotropin but do not affect ovulation, embryo, or pregnancy outcomes. Front Endocrinol (Lausanne), 2024. 15: p. 1401975.

47. Burgum, M.J., C. Ulrich, N. Partosa, S.J. Evans, C. Gomes, S.B. Seiffert, R. Landsiedel, N. Honarvar, and S.H. Doak, Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices. Mutagenesis, 2024. 39(3): p. 205-217.

48. Brandão, F., C. Costa, M.J. Bessa, E. Dumortier, F. Debacq-Chainiaux, R. Hubaux, M. Salmon, J. Laloy, M.S. Stan, A. Hermenean, S. Gharbia, A. Dinischiotu, A. Bannuscher, B. Hellack, A. Haase, S. Fraga, and J.P. Teixeira, Correction: Brandão et al. Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO(2) NM). Nanomaterials 2021, 11, 1502. Nanomaterials (Basel), 2024. 14(23).

49. Batliner, M., F. Schumacher, D. Wigger, W. Vivas, A. Prell, I. Fohmann, T. Köhler, R. Schempp, A. Riedel, M. Vaeth, A. Fekete, B. Kleuser, O. Kurzai, and N.E. Nieuwenhuizen, The Candida albicans quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells. mBio, 2024. 15(8): p. e0073224.

50. Bahl, A., S. Halappanavar, W. Wohlleben, P. Nymark, P. Kohonen, H. Wallin, U. Vogel, and A. Haase, Bioinformatics and machine learning to support nanomaterial grouping. Nanotoxicology, 2024. 18(4): p. 373-400.

51. Alcolea-Rodriguez, V., V.I. Dumit, R. Ledwith, R. Portela, M.A. Bañares, and A. Haase, Differentially Induced Autophagy by Engineered Nanomaterial Treatment Has an Impact on Cellular Homeostasis and Cytotoxicity. Nano Lett, 2024. 24(38): p. 11793-11799.

2023

52. Zuo, J., A.A. Hasan, C.F. Hocher, P. Kalk, B. Kleuser, B.K. Krämer, and B. Hocher, Inverse correlation of intact PTH, oxidized PTH as well as non-oxidized PTH with 25-hydroxyvitamin D3 in kidney transplant recipients. Front Endocrinol (Lausanne), 2023. 14: p. 1178166.

53. Zoicas, I., C. Mühle, F. Schumacher, B. Kleuser, and J. Kornhuber, Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism. Cells, 2023. 12(10).

54. Zhang, X., C. Reichetzeder, Y. Liu, J.G. Hocher, A.A. Hasan, G. Lin, B. Kleuser, L. Hu, and B. Hocher, Parental sex-dependent effects of either maternal or paternal eNOS deficiency on the offspring's phenotype without transmission of the parental eNOS deficiency to the offspring. Front Physiol, 2023. 14: p. 1306178.

55. Zabihi, F., Z. Tu, S. Kaessmeyer, F. Schumacher, F. Rancan, B. Kleuser, C. Boettcher, K. Ludwig, J. Plendl, S. Hedtrich, A. Vogt, and R. Haag, Efficient skin interactions of graphene derivatives: challenge, opportunity or both? Nanoscale Adv, 2023. 5(21): p. 5923-5931.

56. Wohlleben, W., A. Mehling, and R. Landsiedel, Lessons Learned from the Grouping of Chemicals to Assess Risks to Human Health. Angew Chem Int Ed Engl, 2023. 62(22): p. e202210651.

57. Wilhelmi, P., V. Giri, F.M. Zickgraf, V. Haake, S. Henkes, P. Driemert, P. Michaelis, W. Busch, S. Scholz, B. Flick, M. Barenys, B. Birk, H. Kamp, R. Landsiedel, and D. Funk-Weyer, A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. Chem Biol Interact, 2023. 382: p. 110565.

58. Tran, P.T., P. Tawornchat, B. Kleuser, S.B. Lohan, J. Schleusener, M.C. Meinke, and M.E. Darvin, Red- and Near-Infrared-Excited Autofluorescence as a Marker for Acute Oxidative Stress in Skin Exposed to Cigarette Smoke Ex Vivo and In Vivo. Antioxidants (Basel), 2023. 12(5).

59. Ramirez-Hincapie, S., B. Birk, P. Ternes, V. Giri, F.M. Zickgraf, V. Haake, M. Herold, H. Kamp, P. Driemert, R. Landsiedel, E. Richling, D. Funk-Weyer, and B. van Ravenzwaay, Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin. Arch Toxicol, 2023. 97(11): p. 2903-2917.

60. Ramirez-Hincapie, S., B. Birk, P. Ternes, V. Giri, V. Haake, M. Herold, F.M. Zickgraf, A. Verlohner, H.A. Huener, H. Kamp, P. Driemert, R. Landsiedel, E. Richling, D. Funk-Weyer, and B. van Ravenzwaay, A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity. Cell Biol Toxicol, 2023. 39(6): p. 2899-2917.

61. Otte, J.C., H.M. Hollnagel, C. Nagel, R.F. Gerhardt, W. Wohlleben, N. Vallotton, D. Schowanek, G. Sanders, J.M. Frasca, T. Mahale, M. Pemberton, B. Hidding, and R. Landsiedel, Three-tiered approach for standard information requirements for polymers requiring registration under REACH. Regul Toxicol Pharmacol, 2023. 144: p. 105495.

62. Nieschalke, K., N. Bergau, S. Jessel, A. Seidel, S. Baldermann, M. Schreiner, K. Abraham, A. Lampen, B.H. Monien, B. Kleuser, H. Glatt, and F. Schumacher, Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans. Chem Res Toxicol, 2023. 36(11): p. 1753-1767.

63. Murphy, F.A., H.J. Johnston, S. Dekkers, E.A.J. Bleeker, A.G. Oomen, T.F. Fernandes, K. Rasmussen, P. Jantunen, H. Rauscher, N. Hunt, L. di Cristo, H.M. Braakhuis, A. Haase, D. Hristozov, W. Wohlleben, S. Sabella, and V. Stone, How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms. Altex, 2023. 40(1): p. 125-140.

64. Kolle, S.N., M. Flach, M. Kleber, D.A. Basketter, B. Wareing, A. Mehling, L. Hareng, N. Watzek, S. Bade, D. Funk-Weyer, and R. Landsiedel, Plant extracts, polymers and new approach methods: Practical experience with skin sensitization assessment. Regul Toxicol Pharmacol, 2023. 138: p. 105330.

65. Kleuser, B. and W. Bäumer, Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases. Int J Mol Sci, 2023. 24(2).

66. Keller, J.G., M. Persson, P. Müller, L. Ma-Hock, K. Werle, J. Arts, R. Landsiedel, and W. Wohlleben, Corrigendum to variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity [NanoImpact 23 (2021) 100341]. NanoImpact, 2023. 29: p. 100455.

67. Höper, T., I. Karkossa, V.I. Dumit, M. von Bergen, K. Schubert, and A. Haase, A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways. Toxicol Appl Pharmacol, 2023. 475: p. 116650.

68. Fohmann, I., A. Weinmann, F. Schumacher, S. Peters, A. Prell, C. Weigel, S. Spiegel, B. Kleuser, and A. Schubert-Unkmeir, Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells. PLoS Pathog, 2023. 19(11): p. e1011842.

69. Dimitrijevic, D., E. Fabian, D. Funk-Weyer, and R. Landsiedel, Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma. Biochem Biophys Res Commun, 2023. 651: p. 114-120.

70. Chen, X., D. Delić, Y. Cao, L. Shen, Q. Shao, Z. Zhang, H. Wu, A.A. Hasan, C. Reichetzeder, M.M.S. Gaballa, B.K. Krämer, T. Klein, L. Yin, B. He, S. Morgera, and B. Hocher, Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system. Am J Physiol Cell Physiol, 2023. 324(4): p. C951-c962.

71. Brandão, F., C. Costa, M.J. Bessa, V. Valdiglesias, B. Hellack, A. Haase, S. Fraga, and J.P. Teixeira, Multiparametric in vitro genotoxicity assessment of different variants of amorphous silica nanomaterials in rat alveolar epithelial cells. Nanotoxicology, 2023. 17(6-7): p. 511-528.

72. Braakhuis, H.M., E.R. Gremmer, A. Bannuscher, B. Drasler, S. Keshavan, B. Rothen-Rutishauser, B. Birk, A. Verlohner, R. Landsiedel, K. Meldrum, S.H. Doak, M.J.D. Clift, J.S. Erdem, O.A.H. Foss, S. Zienolddiny-Narui, T. Serchi, E. Moschini, P. Weber, S. Burla, P. Kumar, O. Schmid, E. Zwart, J.P. Vermeulen, and R.J. Vandebriel, Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 2023. 31: p. 100466.

73. Bloch, D., P. Diel, B. Epe, M. Hellwig, A. Lampen, A. Mally, D. Marko, M.A. Villar Fernández, S. Guth, A. Roth, R. Marchan, A. Ghallab, C. Cadenas, P. Nell, N. Vartak, C. van Thriel, A. Luch, S. Schmeisser, M. Herzler, R. Landsiedel, M. Leist, P. Marx-Stoelting, T. Tralau, and J.G. Hengstler, Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol, 2023. 97(11): p. 3005-3017.

74. Bahl, A., C. Ibrahim, K. Plate, A. Haase, J. Dengjel, P. Nymark, and V.I. Dumit, PROTEOMAS: a workflow enabling harmonized proteomic meta-analysis and proteomic signature mapping. J Cheminform, 2023. 15(1): p. 34.

2022

75. Zuo, J., L. Chaykovska, C. Chu, X. Chen, A.A. Hasan, B.K. Krämer, M. Tepel, and B. Hocher, Head-to-Head Comparison of Oxidative Stress Biomarkers for All-Cause Mortality in Hemodialysis Patients. Antioxidants (Basel), 2022. 11(10).

76. Zhang, X., L. Liu, M.M.S. Gaballa, A.A. Hasan, Y. Xiong, L. Xie, T. Klein, D. Delic, B. Kleuser, B.K. Krämer, J. Li, and B. Hocher, Impact of Salt Intake and Renin-Angiotensin-Aldosterone System Blockade on Lung Severe Acute Respiratory Syndrome Coronavirus 2 Host Factors. Kidney Blood Press Res, 2022. 47(9): p. 565-575.

77. Zhang, X., A.A. Hasan, H. Wu, M.M.S. Gaballa, S. Zeng, L. Liu, L. Xie, T. Jung, T. Grune, B.K. Krämer, B. Kleuser, J. Li, and B. Hocher, High-fat, sucrose and salt-rich diet during rat spermatogenesis lead to the development of chronic kidney disease in the female offspring of the F2 generation. Faseb j, 2022. 36(4): p. e22259.

78. Zeng, S., D. Delic, C. Chu, Y. Xiong, T. Luo, X. Chen, M.M.S. Gaballa, Y. Xue, X. Chen, Y. Cao, A.A. Hasan, K. Stadermann, S. Frankenreiter, L. Yin, B.K. Krämer, T. Klein, and B. Hocher, Antifibrotic effects of low dose SGLT2 Inhibition with empagliflozin in comparison to Ang II receptor blockade with telmisartan in 5/6 nephrectomised rats on high salt diet. Biomed Pharmacother, 2022. 146: p. 112606.

79. Xiong, Y., D. Delic, S. Zeng, X. Chen, C. Chu, A.A. Hasan, B.K. Krämer, T. Klein, L. Yin, and B. Hocher, Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker. BMC Nephrol, 2022. 23(1): p. 117.

80. Westhölter, D., F. Schumacher, N. Wülfinghoff, S. Sutharsan, S. Strassburg, B. Kleuser, P.A. Horn, S. Reuter, E. Gulbins, C. Taube, and M. Welsner, CFTR modulator therapy alters plasma sphingolipid profiles in people with cystic fibrosis. J Cyst Fibros, 2022. 21(4): p. 713-720.

81. Weber, A.G., B. Birk, C. Müller, S. Schneider, B. van Ravenzwaay, D. Funk-Weyer, and R. Landsiedel, The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles. Chem Biol Interact, 2022. 351: p. 109709.

82. Verdon, R., V. Stone, F. Murphy, E. Christopher, H. Johnston, S. Doak, U. Vogel, A. Haase, and A. Kermanizadeh, The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment. Part Fibre Toxicol, 2022. 19(1): p. 32.

83. Tschiche, H.R., F.S. Bierkandt, O. Creutzenberg, V. Fessard, R. Franz, R. Greiner, C. Gruber-Traub, K.H. Haas, A. Haase, A. Hartwig, B. Hesse, K. Hund-Rinke, P. Iden, C. Kromer, K. Loeschner, D. Mutz, A. Rakow, K. Rasmussen, H. Rauscher, H. Richter, J. Schoon, O. Schmid, C. Som, L.M. Spindler, G.E.M. Tovar, P. Westerhoff, W. Wohlleben, A. Luch, and P. Laux, Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities. NanoImpact, 2022. 28: p. 100416.

84. Tran, P.T., B. Beidoun, S.B. Lohan, R. Talbi, B. Kleuser, M. Seifert, K. Jung, G. Sandig, and M.C. Meinke, Establishment of a method to expose and measure pollution in excised porcine skin with electron paramagnetic resonance spectroscopy. Ecotoxicol Environ Saf, 2022. 247: p. 114258.

85. Schumacher, F., M.J. Edwards, C. Mühle, A. Carpinteiro, G.C. Wilson, B. Wilker, M. Soddemann, S. Keitsch, N. Scherbaum, B.W. Müller, U.E. Lang, C. Linnemann, B. Kleuser, C.P. Müller, J. Kornhuber, and E. Gulbins, Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice. J Biol Chem, 2022. 298(8): p. 102185.

86. Schumacher, F., A. Carpinteiro, M.J. Edwards, G.C. Wilson, S. Keitsch, M. Soddemann, B. Wilker, B. Kleuser, K.A. Becker, C.P. Müller, J. Kornhuber, and E. Gulbins, Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. J Mol Med (Berl), 2022. 100(10): p. 1493-1508.

87. Schulz, J., R. Michelet, J.F. Joseph, M. Zeitlinger, F. Schumacher, G. Mikus, and C. Kloft, A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications. J Pharm Biomed Anal, 2022. 210: p. 114551.

88. Radbruch, M., H. Pischon, F. Du, R. Haag, F. Schumacher, B. Kleuser, L. Mundhenk, and A.D. Gruber, Biodegradable core-multishell nanocarrier: Topical tacrolimus delivery for treatment of dermatitis. J Control Release, 2022. 349: p. 917-928.

89. Putra, S.E.D., C. Reichetzeder, K. von Websky, C. Neuber, H. Halle, B. Kleuser, B.K. Krämer, and B. Hocher, Association between placental global DNA methylation and blood pressure during human pregnancy. J Hypertens, 2022. 40(5): p. 1002-1009.

90. Péricat, D., S.A. Leon-Icaza, M. Sanchez Rico, C. Mühle, I. Zoicas, F. Schumacher, R. Planès, R. Mazars, G. Gros, A. Carpinteiro, K.A. Becker, J. Izopet, N. Strub-Wourgaft, P. Sjö, O. Neyrolles, B. Kleuser, F. Limosin, E. Gulbins, J. Kornhuber, E. Meunier, N. Hoertel, and C. Cougoule, Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model. Int J Mol Sci, 2022. 23(21).

91. Oesch, F., N. Honarvar, E. Fabian, L. Finch, S. Hindle, K. Wiench, and R. Landsiedel, Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione. Arch Toxicol, 2022. 96(9): p. 2573-2587.

92. Neuhaus, W., B. Reininger-Gutmann, B. Rinner, R. Plasenzotti, D. Wilflingseder, J. De Kock, T. Vanhaecke, V. Rogiers, D. Jírová, K. Kejlová, L.E. Knudsen, R.N. Nielsen, B. Kleuser, V. Kral, C. Thöne-Reineke, T. Hartung, G. Pallocca, C. Rovida, M. Leist, S. Hippenstiel, A. Lang, I. Retter, S. Krämer, P. Jedlicka, K. Ameli, E. Fritsche, J. Tigges, E. Kuchovská, M. Buettner, A. Bleich, N. Baumgart, J. Baumgart, M.W. Meinhardt, R. Spanagel, S. Chourbaji, B. Kränzlin, B. Seeger, M. von Köckritz-Blickwede, J.M. Sánchez-Morgado, V. Galligioni, D. Ruiz-Pérez, D. Movia, A. Prina-Mello, A. Ahluwalia, V. Chiono, A.C. Gutleb, M. Schmit, B. van Golen, L. van Weereld, A. Kienhuis, E. van Oort, J. van der Valk, A. Smith, J. Roszak, M. Stępnik, Z. Sobańska, E. Reszka, I.A.S. Olsson, N.H. Franco, B. Sevastre, H. Kandarova, S. Capdevila, J. Johansson, E. Svensk, C.R. Cederroth, J. Sandström, I. Ragan, N. Bubalo, J. Kurreck, and H. Spielmann, The Current Status and Work of Three Rs Centres and Platforms in Europe. Altern Lab Anim, 2022. 50(6): p. 381-413.

93. Neuhaus, W., B. Reininger-Gutmann, B. Rinner, R. Plasenzotti, D. Wilflingseder, J. De Kock, T. Vanhaecke, V. Rogiers, D. Jírová, K. Kejlová, L.E. Knudsen, R.N. Nielsen, B. Kleuser, V. Kral, C. Thöne-Reineke, T. Hartung, G. Pallocca, M. Leist, S. Hippenstiel, A. Lang, I. Retter, S. Krämer, P. Jedlicka, K. Ameli, E. Fritsche, J. Tigges, M. Buettner, A. Bleich, N. Baumgart, J. Baumgart, M.W. Meinhardt, R. Spanagel, S. Chourbaji, B. Kränzlin, B. Seeger, M. von Köckritz-Blickwede, J.M. Sánchez-Morgado, V. Galligioni, D. Ruiz-Pérez, D. Movia, A. Prina-Mello, A. Ahluwalia, V. Chiono, A.C. Gutleb, M. Schmit, B. van Golen, L. van Weereld, A. Kienhuis, E. van Oort, J. van der Valk, A. Smith, J. Roszak, M. Stępnik, Z. Sobańska, I.A.S. Olsson, N.H. Franco, B. Sevastre, H. Kandarova, S. Capdevila, J. Johansson, C.R. Cederroth, J. Sandström, I. Ragan, N. Bubalo, and H. Spielmann, The Rise of Three Rs Centres and Platforms in Europe. Altern Lab Anim, 2022. 50(2): p. 90-120.

94. Mohamud Yusuf, A., N. Hagemann, X. Zhang, M. Zafar, T. Hussner, C. Bromkamp, C. Martiny, T. Tertel, V. Börger, F. Schumacher, F.A. Solari, M. Hasenberg, C. Kleinschnitz, T.R. Doeppner, B. Kleuser, A. Sickmann, M. Gunzer, B. Giebel, R. Kolesnick, E. Gulbins, and D.M. Hermann, Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. Basic Res Cardiol, 2022. 117(1): p. 43.

95. Lu, Y.P., H.W. Wu, T. Zhu, X.T. Li, J. Zuo, A.A. Hasan, C. Reichetzeder, D. Delic, B. Yard, T. Klein, B.K. Krämer, Z.Y. Zhang, X.H. Wang, L.H. Yin, Y. Dai, Z.H. Zheng, and B. Hocher, Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy. Biomed Pharmacother, 2022. 156: p. 113947.

96. Landsiedel, R., N. Honarvar, S.B. Seiffert, B. Oesch, and F. Oesch, Genotoxicity testing of nanomaterials. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2022. 14(6): p. e1833.

97. Landsiedel, R., D. Hahn, R. Ossig, S. Ritz, L. Sauer, R. Buesen, S. Rehm, W. Wohlleben, S. Groeters, V. Strauss, S. Sperber, H. Wami, U. Dobrindt, K. Prior, D. Harmsen, B. van Ravenzwaay, and J. Schnekenburger, Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects. Part Fibre Toxicol, 2022. 19(1): p. 21.

98. Landsiedel, R., B. Birk, and D. Funk-Weyer, The Evolution of Regulatory Toxicology: Where is the Gardener? Altern Lab Anim, 2022. 50(4): p. 255-262.

99. Kyriakoudi, S., A. Theodoulou, L. Potamiti, F. Schumacher, M. Zachariou, R. Papacharalambous, B. Kleuser, M.I. Panayiotidis, A. Drousiotou, and P.P. Petrou, Stbd1-deficient mice display insulin resistance associated with enhanced hepatic ER-mitochondria contact. Biochimie, 2022. 200: p. 172-183.

100. Kadow, S., F. Schumacher, M. Kramer, G. Hessler, R. Scholtysik, S. Oubari, P. Johansson, A. Hüttmann, H.C. Reinhardt, B. Kleuser, M. Zoratti, A. Mattarei, I. Szabò, E. Gulbins, and A. Carpinteiro, Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma. Cancers (Basel), 2022. 14(8).

101. Jeliazkova, N., E. Bleeker, R. Cross, A. Haase, G. Janer, W. Peijnenburg, M. Pink, H. Rauscher, C. Svendsen, G. Tsiliki, A. Zabeo, D. Hristozov, V. Stone, and W. Wohlleben, How can we justify grouping of nanoforms for hazard assessment? Concepts and tools to quantify similarity. NanoImpact, 2022. 25: p. 100366.

102. Hose, M., A. Günther, E. Naser, F. Schumacher, T. Schönberger, J. Falkenstein, A. Papadamakis, B. Kleuser, K.A. Becker, E. Gulbins, A. Haimovitz-Friedman, J. Buer, A.M. Westendorf, and W. Hansen, Cell-intrinsic ceramides determine T cell function during melanoma progression. Elife, 2022. 11.

103. Holle, J., H. Bartolomaeus, U. Löber, F. Behrens, T.U.P. Bartolomaeus, H. Anandakumar, M.I. Wimmer, D.L. Vu, M. Kuhring, U. Brüning, A. Maifeld, S. Geisberger, S. Kempa, F. Schumacher, B. Kleuser, P. Bufler, U. Querfeld, S. Kitschke, D. Engler, L.D. Kuhrt, O. Drechsel, K.U. Eckardt, S.K. Forslund, A. Thürmer, V. McParland, J.A. Kirwan, N. Wilck, and D. Müller, Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance. J Am Soc Nephrol, 2022. 33(12): p. 2259-2275.

104. Hochrein, S.M., H. Wu, M. Eckstein, L. Arrigoni, J.S. Herman, F. Schumacher, C. Gerecke, M. Rosenfeldt, D. Grün, B. Kleuser, G. Gasteiger, W. Kastenmüller, B. Ghesquière, J. Van den Bossche, E.D. Abel, and M. Vaeth, The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. Cell Metab, 2022. 34(4): p. 516-532.e11.

105. Hocher, B., Y.P. Lu, C. Reichetzeder, X. Zhang, O. Tsuprykov, J. Rahnenführer, L. Xie, J. Li, L. Hu, B.K. Krämer, and A.A. Hasan, Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself. Diabetologia, 2022. 65(7): p. 1222-1236.

106. Hashemi Arani, F., S. Kadow, M. Kramer, S. Keitsch, L. Kirchhoff, F. Schumacher, B. Kleuser, P.M. Rath, E. Gulbins, and A. Carpinteiro, Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp. Int J Mol Sci, 2022. 23(24).

107. Hasan, A.A., C.F. Hocher, B. Kleuser, B.K. Krämer, and B. Hocher, Biological Activity of Different Forms of Oxidized Parathyroid Hormone. Int J Mol Sci, 2022. 23(20).

108. Günther, A., M. Hose, H. Abberger, F. Schumacher, Y. Veith, B. Kleuser, K. Matuschewski, K.S. Lang, E. Gulbins, J. Buer, A.M. Westendorf, and W. Hansen, The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis. Elife, 2022. 11.

109. Grafström, R., A. Haase, P. Kohonen, N. Jeliazkova, and P. Nymark, Reply to: Prospects and challenges for FAIR toxicogenomics data. Nat Nanotechnol, 2022. 17(1): p. 19-20.

110. Gerecke, C., C. Egea Rodrigues, T. Homann, and B. Kleuser, The Role of Ten-Eleven Translocation Proteins in Inflammation. Front Immunol, 2022. 13: p. 861351.

111. Gabbert, S., M. Mathea, S.N. Kolle, and R. Landsiedel, Accounting for Precision Uncertainty of Toxicity Testing: Methods to Define Borderline Ranges and Implications for Hazard Assessment of Chemicals. Risk Anal, 2022. 42(2): p. 224-238.

112. Eder, S., C. Hollmann, P. Mandasari, P. Wittmann, F. Schumacher, B. Kleuser, J. Fink, J. Seibel, J. Schneider-Schaulies, C. Stigloher, N. Beyersdorf, and S. Dembski, Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations. J Funct Biomater, 2022. 13(3).

113. Dimitrijevic, D., E. Fabian, B. Nicol, D. Funk-Weyer, and R. Landsiedel, Toward Realistic Dosimetry In Vitro: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an In Silico Mass Balance Model. Chem Res Toxicol, 2022. 35(11): p. 1962-1973.

114. Di Cristo, L., G. Janer, S. Dekkers, M. Boyles, A. Giusti, J.G. Keller, W. Wohlleben, H. Braakhuis, L. Ma-Hock, A.G. Oomen, A. Haase, V. Stone, F. Murphy, H.J. Johnston, and S. Sabella, Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure. Nanotoxicology, 2022. 16(3): p. 310-332.

115. Chu, C., D. Delić, J. Alber, M. Feger, Y. Xiong, T. Luo, A.A. Hasan, S. Zeng, M.M.S. Gaballa, X. Chen, L. Yin, T. Klein, S. Elitok, B.K. Krämer, M. Föller, and B. Hocher, Head-to-head comparison of two SGLT-2 inhibitors on AKI outcomes in a rat ischemia-reperfusion model. Biomed Pharmacother, 2022. 153: p. 113357.

116. Chu, C., X. Chen, A.A. Hasan, A. Szakallova, B.K. Krämer, M. Tepel, and B. Hocher, Angiopoietin-2 predicts all-cause mortality in male but not female end-stage kidney disease patients on hemodialysis. Nephrol Dial Transplant, 2022. 37(7): p. 1348-1356.

117. Carstens, H., K. Kalka, R. Verhaegh, F. Schumacher, M. Soddemann, B. Wilker, S. Keitsch, C. Sehl, B. Kleuser, M. Hübler, U. Rauen, A.K. Becker, A. Koch, E. Gulbins, and M. Kamler, Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs. PLoS One, 2022. 17(7): p. e0271620.

118. Bernacchioni, C., R. Squecco, T. Gamberi, V. Ghini, F. Schumacher, M. Mannelli, R. Garella, E. Idrizaj, F. Cencetti, E. Puliti, P. Bruni, P. Turano, T. Fiaschi, and C. Donati, S1P Signalling Axis Is Necessary for Adiponectin-Directed Regulation of Electrophysiological Properties and Oxidative Metabolism in C2C12 Myotubes. Cells, 2022. 11(4).

119. Bannuscher, A., O. Schmid, B. Drasler, A. Rohrbasser, H.M. Braakhuis, K. Meldrum, E.P. Zwart, E.R. Gremmer, B. Birk, M. Rissel, R. Landsiedel, E. Moschini, S.J. Evans, P. Kumar, S. Orak, A. Doryab, J.S. Erdem, T. Serchi, R.J. Vandebriel, F.R. Cassee, S.H. Doak, A. Petri-Fink, S. Zienolddiny, M.J.D. Clift, and B. Rothen-Rutishauser, An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 2022. 28: p. 100439.

120. Ag Seleci, D., G. Tsiliki, K. Werle, D.A. Elam, O. Okpowe, K. Seidel, X. Bi, P. Westerhoff, E. Innes, M. Boyles, M. Miller, A. Giusti, F. Murphy, A. Haase, V. Stone, and W. Wohlleben, Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays. NanoImpact, 2022. 26: p. 100390.

2021

121. Zeng, S., A.A. Hasan, C. Chu, Y. Xiong, J.G. Hocher, S. Elitok, B.K. Krämer, and B. Hocher, Osteoprotegerin is an independent risk factor predicting death in stable renal transplant recipients. Clin Nephrol, 2021. 96(3): p. 129-137.

122. Wigger, D., F. Schumacher, S. Schneider-Schaulies, and B. Kleuser, Sphingosine 1-phosphate metabolism and insulin signaling. Cell Signal, 2021. 82: p. 109959.

123. Wiese, T., F. Dennstädt, C. Hollmann, S. Stonawski, C. Wurst, J. Fink, E. Gorte, P. Mandasari, K. Domschke, L. Hommers, B. Vanhove, F. Schumacher, B. Kleuser, J. Seibel, J. Rohr, M. Buttmann, A. Menke, J. Schneider-Schaulies, and N. Beyersdorf, Inhibition of acid sphingomyelinase increases regulatory T cells in humans. Brain Commun, 2021. 3(2): p. fcab020.

124. Wetzel, A., B. Scholtka, F. Schumacher, H. Rawel, B. Geisendörfer, and B. Kleuser, Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis. Int J Mol Sci, 2021. 22(10).

125. Wardelmann, K., M. Rath, J.P. Castro, S. Blümel, M. Schell, R. Hauffe, F. Schumacher, T. Flore, K. Ritter, A. Wernitz, T. Hosoi, K. Ozawa, B. Kleuser, J. Weiß, A. Schürmann, and A. Kleinridders, Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants (Basel), 2021. 10(5).

126. Ulrey, A., S. Kolle, R. Landsiedel, and E. Hill, How a GIVIMP certification program can increase confidence in in vitro methods. Altex, 2021. 38(2): p. 316-318.

127. Stratmann, H., W. Wohlleben, M. Wiemann, A. Vennemann, N. End, U. Veith, L. Ma-Hock, and R. Landsiedel, Classes of organic pigments meet tentative PSLT criteria and lack toxicity in short-term inhalation studies. Regul Toxicol Pharmacol, 2021. 124: p. 104988.

128. Stepanovska Tanturovska, B., A. Zivkovic, F. Imeri, T. Homann, B. Kleuser, H. Stark, and A. Huwiler, ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P(1) Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 2021. 26(17).

129. Spohner, A.K., K. Jakobi, S. Trautmann, D. Thomas, F. Schumacher, B. Kleuser, D. Lütjohann, K. El-Hindi, S. Grösch, J. Pfeilschifter, J.D. Saba, and D. Meyer Zu Heringdorf, Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Int J Mol Sci, 2021. 22(19).

130. Seibel, J., S. Schneider-Schaulies, and B. Kleuser, Editorial: Sphingolipids in Infection Control. Front Cell Dev Biol, 2021. 9: p. 697290.

131. Schneider-Schaulies, S., F. Schumacher, D. Wigger, M. Schöl, T. Waghmare, J. Schlegel, J. Seibel, and B. Kleuser, Sphingolipids: Effectors and Achilles Heals in Viral Infections? Cells, 2021. 10(9).

132. Schäfer-Korting, M. and C. Zoschke, How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development. Handb Exp Pharmacol, 2021. 265: p. 29-56.

133. Prakash, H., D. Upadhyay, O.R. Bandapalli, A. Jain, and B. Kleuser, Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease. Prostaglandins Other Lipid Mediat, 2021. 152: p. 106504.

134. Pfuhler, S., R. Pirow, T.R. Downs, A. Haase, N. Hewitt, A. Luch, M. Merkel, C. Petrick, A. Said, M. Schäfer-Korting, and K. Reisinger, Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays. Mutagenesis, 2021. 36(1): p. 19-35.

135. Peters, S., L. Kaiser, J. Fink, F. Schumacher, V. Perschin, J. Schlegel, M. Sauer, C. Stigloher, B. Kleuser, J. Seibel, and A. Schubert-Unkmeir, Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria. Sci Rep, 2021. 11(1): p. 4300.

136. Oesch, F., N. Honarvar, E. Fabian, F.I. Berger, and R. Landsiedel, N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity. Arch Toxicol, 2021. 95(10): p. 3143-3159.

137. Oesch, F., D. Fruth, J.G. Hengstler, E. Fabian, F.I. Berger, and R. Landsiedel, Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat. Arch Toxicol, 2021. 95(12): p. 3717-3744.

138. Natsch, A., R. Landsiedel, and S.N. Kolle, A triangular approach for the validation of new approach methods for skin sensitization. Altex, 2021. 38(4): p. 669-677.

139. Murphy, F., S. Dekkers, H. Braakhuis, L. Ma-Hock, H. Johnston, G. Janer, L. di Cristo, S. Sabella, N.R. Jacobsen, A.G. Oomen, A. Haase, T. Fernandes, and V. Stone, An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma hazard. NanoImpact, 2021. 22: p. 100314.

140. Mohamed, A., V. Korzhikov-Vlakh, N. Zhang, A. Said, I. Pilipenko, M. Schäfer-Korting, C. Zoschke, and T. Tennikova, Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility. Pharmaceutics, 2021. 13(6).

141. Ma-Hock, L., U.G. Sauer, E. Ruggiero, J.G. Keller, W. Wohlleben, and R. Landsiedel, The Use of Nanomaterial In Vivo Organ Burden Data for In Vitro Dose Setting. Small, 2021. 17(15): p. e2005725.

142. Kolle, S.N. and R. Landsiedel, Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh. Handb Exp Pharmacol, 2021. 265: p. 3-27.

143. Keller, J.G., M. Wiemann, S. Gröters, K. Werle, A. Vennemann, R. Landsiedel, and W. Wohlleben, Aerogels are not regulated as nanomaterials, but can be assessed by tiered testing and grouping strategies for nanomaterials. Nanoscale Adv, 2021. 3(13): p. 3881-3893.

144. Keller, J.G., D.F. Quevedo, L. Faccani, A.L. Costa, R. Landsiedel, K. Werle, and W. Wohlleben, Dosimetry in vitro - exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods. Nanotoxicology, 2021. 15(1): p. 21-34.

145. Keller, J.G., M. Persson, P. Müller, L. Ma-Hock, K. Werle, J. Arts, R. Landsiedel, and W. Wohlleben, Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity. NanoImpact, 2021. 23: p. 100341.

146. Keller, J.G., U.M. Graham, J. Koltermann-Jülly, R. Gelein, L. Ma-Hock, R. Landsiedel, M. Wiemann, G. Oberdörster, A. Elder, and W. Wohlleben, Author Correction: Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulphate. Sci Rep, 2021. 11(1): p. 8813.

147. Karkossa, I., A. Bannuscher, B. Hellack, W. Wohlleben, J. Laloy, M.S. Stan, A. Dinischiotu, M. Wiemann, A. Luch, A. Haase, M. von Bergen, and K. Schubert, Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects. Sci Total Environ, 2021. 801: p. 149538.

148. Kalinichenko, L.S., L. Abdel-Hafiz, A.L. Wang, C. Mühle, N. Rösel, F. Schumacher, B. Kleuser, I. Smaga, M. Frankowska, M. Filip, G. Schaller, T. Richter-Schmidinger, B. Lenz, E. Gulbins, J. Kornhuber, A.W.C. Oliveira, M. Barros, J.P. Huston, and C.P. Müller, Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory. Cereb Cortex, 2021. 31(2): p. 1316-1333.

149. Kah, M., L.J. Johnston, R.S. Kookana, W. Bruce, A. Haase, V. Ritz, J. Dinglasan, S. Doak, H. Garelick, and V. Gubala, Comprehensive framework for human health risk assessment of nanopesticides. Nat Nanotechnol, 2021. 16(9): p. 955-964.

150. Jeliazkova, N., M.D. Apostolova, C. Andreoli, F. Barone, A. Barrick, C. Battistelli, C. Bossa, A. Botea-Petcu, A. Châtel, I. De Angelis, M. Dusinska, N. El Yamani, D. Gheorghe, A. Giusti, P. Gómez-Fernández, R. Grafström, M. Gromelski, N.R. Jacobsen, V. Jeliazkov, K.A. Jensen, N. Kochev, P. Kohonen, N. Manier, E. Mariussen, A. Mech, J.M. Navas, V. Paskaleva, A. Precupas, T. Puzyn, K. Rasmussen, P. Ritchie, I.R. Llopis, E. Rundén-Pran, R. Sandu, N. Shandilya, S. Tanasescu, A. Haase, and P. Nymark, Towards FAIR nanosafety data. Nat Nanotechnol, 2021. 16(6): p. 644-654.

151. Janer, G., R. Landsiedel, and W. Wohlleben, Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH. Nanotoxicology, 2021. 15(2): p. 145-166.

152. Janer, G., D. Ag-Seleci, J.A. Sergent, R. Landsiedel, and W. Wohlleben, Creating sets of similar nanoforms with the ECETOC NanoApp: real-life case studies. Nanotoxicology, 2021. 15(8): p. 1016-1034.

153. Imeri, F., B. Stepanovska Tanturovska, A. Zivkovic, G. Enzmann, S. Schwalm, J. Pfeilschifter, T. Homann, B. Kleuser, B. Engelhardt, H. Stark, and A. Huwiler, Novel compounds with dual S1P receptor agonist and histamine H(3) receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 2021. 186: p. 108464.

154. Höper, T., K. Siewert, V.I. Dumit, M. von Bergen, K. Schubert, and A. Haase, The Contact Allergen NiSO(4) Triggers a Distinct Molecular Response in Primary Human Dendritic Cells Compared to Bacterial LPS. Front Immunol, 2021. 12: p. 644700.

155. Hering, H., C. Zoschke, F. König, M. Kühn, A. Luch, and I. Schreiver, Phototoxic versus photoprotective effects of tattoo pigments in reconstructed human skin models: In vitro phototoxicity testing of tattoo pigments: 3D versus 2D. Toxicology, 2021. 460: p. 152872.

156. Gimeno-Benito, I., A. Giusti, S. Dekkers, A. Haase, and G. Janer, A review to support the derivation of a worst-case dermal penetration value for nanoparticles. Regul Toxicol Pharmacol, 2021. 119: p. 104836.

157. Garcia de Lomana, M., A.G. Weber, B. Birk, R. Landsiedel, J. Achenbach, K.J. Schleifer, M. Mathea, and J. Kirchmair, In Silico Models to Predict the Perturbation of Molecular Initiating Events Related to Thyroid Hormone Homeostasis. Chem Res Toxicol, 2021. 34(2): p. 396-411.

158. Garcia de Lomana, M., A. Morger, U. Norinder, R. Buesen, R. Landsiedel, A. Volkamer, J. Kirchmair, and M. Mathea, ChemBioSim: Enhancing Conformal Prediction of In Vivo Toxicity by Use of Predicted Bioactivities. J Chem Inf Model, 2021. 61(7): p. 3255-3272.

159. Fink, J., F. Schumacher, J. Schlegel, P. Stenzel, D. Wigger, M. Sauer, B. Kleuser, and J. Seibel, Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis. Org Biomol Chem, 2021. 19(10): p. 2203-2212.

160. Ebenezer, D.L., R. Ramchandran, P. Fu, L.A. Mangio, V. Suryadevara, A.W. Ha, E. Berdyshev, P.P. Van Veldhoven, S.J. Kron, F. Schumacher, B. Kleuser, and V. Natarajan, Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell Biochem Biophys, 2021. 79(3): p. 575-592.

161. Di Cristo, L., A.G. Oomen, S. Dekkers, C. Moore, W. Rocchia, F. Murphy, H.J. Johnston, G. Janer, A. Haase, V. Stone, and S. Sabella, Grouping Hypotheses and an Integrated Approach to Testing and Assessment of Nanomaterials Following Oral Ingestion. Nanomaterials (Basel), 2021. 11(10).

162. Chu, C., S. Zeng, A.A. Hasan, C.F. Hocher, B.K. Krämer, and B. Hocher, Comparison of infection risks and clinical outcomes in patients with and without SARS-CoV-2 lung infection under renin-angiotensin-aldosterone system blockade: Systematic review and meta-analysis. Br J Clin Pharmacol, 2021. 87(6): p. 2475-2492.

163. Chu, C., S. Elitok, S. Zeng, Y. Xiong, C.F. Hocher, A.A. Hasan, B.K. Krämer, and B. Hocher, C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival. BMC Nephrol, 2021. 22(1): p. 125.

164. Carstens, H., K. Kalka, R. Verhaegh, F. Schumacher, M. Soddemann, B. Wilker, S. Keitsch, C. Sehl, B. Kleuser, T. Wahlers, G. Reiner, A. Koch, U. Rauen, E. Gulbins, and M. Kamler, Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs. Sci Rep, 2021. 11(1): p. 18607.

165. Brandão, F., C. Costa, M.J. Bessa, E. Dumortier, F. Debacq-Chainiaux, R. Hubaux, M. Salmon, J. Laloy, M.S. Stan, A. Hermenean, S. Gharbia, A. Dinischiotu, A. Bannuscher, B. Hellack, A. Haase, S. Fraga, and J.P. Teixeira, Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO(2) NM). Nanomaterials (Basel), 2021. 11(6).

166. Beckmann, N., F. Schumacher, B. Kleuser, E. Gulbins, V. Nomellini, and C.C. Caldwell, Burn Injury Impairs Neutrophil Chemotaxis Through Increased Ceramide. Shock, 2021. 56(1): p. 125-132.

1. Zimmermann, N., F. Schumacher, F. Bredendiek, and C. Kloft, Development and validation of an LC-MS/MS assay for quantification of fosfomycin in Mueller-Hinton broth for application in profiling antibacterial efficacy against clinical bacterial isolates. J Chromatogr B Analyt Technol Biomed Life Sci, 2025. 1256: p. 124561.

2. Zhang, X., M.M.S. Gaballa, A.A. Hasan, Y. Liu, J.G. Hocher, X. Chen, L. Liu, J. Li, D. Wigger, C. Reichetzeder, S. Elitok, B. Kleuser, B.K. Krämer, and B. Hocher, Effects of High-Salt Intake on Glucose Metabolism, Liver Function, and the Microbiome in Rats: Influence of ACE Inhibitors and Angiotensin II Receptor Blockers. Am J Physiol Cell Physiol, 2025.

3. Wu, Y., F. Schnitker, Y. Liu, S. Keitsch, F. Caicci, F. Schumacher, A. Riehle, B. Pollmeier, J. Kehrmann, B. Kleuser, M. Kamler, I. Szabo, H. Grassmé, and E. Gulbins, Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections. J Mol Med (Berl), 2025.

4. Werner, F., F. Schumacher, C. Mühle, W. Adler, C. Schug, E. Schäflein, E. Morawa, B. Kleuser, J. Kornhuber, Y. Erim, and C. Rhein, Psychosomatic - psychotherapeutic treatment of stress-related disorders impacts the sphingolipid metabolism towards increased sphingosine and sphingosine-1-phosphate levels. Eur Arch Psychiatry Clin Neurosci, 2025.

5. Sharma, M., E. Huber, E. Arnesdotter, H.P. Behrsing, A. Bettmann, D. Brandwein, S. Constant, R. Date, A. Deshpande, E. Fabian, A. Gupta, R. Gutierrez, A.C. Gutleb, M.M. Hargrove, M. Hollings, V. Hutter, A.M. Jarabek, Y. Kaluzhny, R. Landsiedel, L. Milchak, R.A. Moyer, J.R. Murray, K. Page, M. Patel, S.N. Pearson, E.J. Petersen, E. Reinke, N. Roldan, C. Roper, J.B. Scaglione, R.S. Settivari, A.O. Stucki, S. Verstraelen, J.L. Wallace, S. McCullough, and A.J. Clippinger, Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA). Arch Toxicol, 2025. 99(1): p. 57-66.

6. Sehgal, R., M. Jähnert, M. Lazaratos, T. Speckmann, F. Schumacher, B. Kleuser, M. Ouni, W. Jonas, and A. Schürmann, Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction. J Lipid Res, 2025. 66(4): p. 100767.

7. Göpfert, A., D.M. Schuster, C. Rülker, M. Eichenlaub, B. Tokovenko, M. Dammann, D. Funk-Weyer, N. Honarvar, and R. Landsiedel, The transgenic MutaMouse hepatocyte mutation assay in vitro: Mutagenicity and mutation spectra of six substances with different mutagenic mechanisms. Mutat Res Genet Toxicol Environ Mutagen, 2025. 901: p. 503836.

8. Chestnykh, D., C. Mühle, F. Schumacher, L.S. Kalinichenko, S. Löber, P. Gmeiner, C. Alzheimer, S. von Hörsten, B. Kleuser, S. Uebe, A.B. Ekici, E. Gulbins, J. Kornhuber, H.K. Jin, J.S. Bae, A. Lourdusamy, and C.P. Müller, Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia. Mol Psychiatry, 2025.

9. Blum, J., M. Brüll, J.G. Hengstler, D.R. Dietrich, A.J. Gruber, M. Dipalo, U. Kraushaar, I. Mangas, A. Terron, E. Fritsche, P. Marx-Stoelting, B. Hardy, A. Schepky, S. Escher, T. Hartung, R. Landsiedel, A. Odermatt, M. Sachana, K. Koch, A. Dönmez, S. Masjosthusmann, K. Bothe, S. Schildknecht, M. Beilmann, J.B. Beltman, S. Fitzpatrick, A. Mangerich, M. Rehm, S. Tangianu, F.M. Zickgraf, H. Kamp, G. Burger, B. van de Water, N. Kleinstreuer, A. White, and M. Leist, The long way from raw data to NAM-based information: Overview on data layers and processing steps. Altex, 2025. 42(1): p. 167-180.

10. Behrens, F., J. Holle, C.Y. Chen, L.F. Ginsbach, B.C. Krause, U. Bruning, F.L. Kriegel, T. Kaiser, I.A. Szijártó, H. Anandakumar, K. Lehmann, F. Schumacher, P. Durek, F.F. Heinrich, D. Lodka, C. Hoffmann, A.A. Borchardt, L. Peters, L. Michalick, U. Querfeld, P. Bufler, A. Luch, B. Kleuser, J.A. Kirwan, S.K. Forslund, J. Thumfahrt, D. Müller, N. Wilck, M.F. Mashreghi, U. Löber, H. Bartolomaeus, W.M. Kuebler, and S. Simmons, Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease. J Extracell Vesicles, 2025. 14(3): p. e70062.

11. Alcolea-Rodriguez, V., F.C. Simeone, V.I. Dumit, L. Faccani, V. Toledo, A. Haase, N. Coca-López, R. Portela, and M.A. Bañares, A refined dose metric for nanotoxicology based on surface site reactivity for oxidative potential of engineered nanomaterials. Nanoscale Adv, 2025.

12. Zabihi, F., M. Cherri, X. Guo, F. Rancan, F. Schumacher, E. Mohammadifar, B. Kleuser, W. Bäumer, M. Schirner, A. Vogt, and R. Haag, Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates. Pharmaceuticals (Basel), 2024. 17(1).

13. Wu, Y., A. Riehle, B. Pollmeier, S. Kadow, F. Schumacher, M. Drab, B. Kleuser, E. Gulbins, and H. Grassmé, Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice. Tuberculosis (Edinb), 2024. 147: p. 102493.

14. Wimmer, M.I., H. Bartolomaeus, H. Anandakumar, C.Y. Chen, V. Vecera, S. Kedziora, S. Kamboj, F. Schumacher, S. Pals, A. Rauch, J. Meisel, O. Potapenko, A. Yarritu, T.U.P. Bartolomaeus, M. Samaan, A. Thiele, L. Stürzbecher, S.Y. Geisberger, B. Kleuser, P.J. Oefner, N. Haase, U. Löber, W. Gronwald, S.K. Forslund-Startceva, D.N. Müller, and N. Wilck, Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension. Acta Physiol (Oxf), 2024. 240(11): p. e14226.

15. Wilhelmi, P., V. Haake, F.M. Zickgraf, V. Giri, P. Ternes, P. Driemert, J. Nöth, S. Scholz, M. Barenys, B. Flick, B. Birk, H. Kamp, R. Landsiedel, and D. Funk-Weyer, Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish. Arch Toxicol, 2024. 98(3): p. 943-956.

16. Wareing, B., A. Aktalay Hippchen, S.N. Kolle, B. Birk, D. Funk-Weyer, and R. Landsiedel, Limitations and Modifications of Skin Sensitization NAMs for Testing Inorganic Nanomaterials. Toxics, 2024. 12(8).

17. Vogel, A., J. Tentschert, R. Pieters, F. Bennet, H. Dirven, A. van den Berg, E. Lenssen, M. Rietdijk, D. Broßell, and A. Haase, Towards a risk assessment framework for micro- and nanoplastic particles for human health. Part Fibre Toxicol, 2024. 21(1): p. 48.

18. Tran, P.T., J. Schleusener, B. Kleuser, K. Jung, M.C. Meinke, and S.B. Lohan, Evidence of the protective effect of anti-pollution products against oxidative stress in skin ex vivo using EPR spectroscopy and autofluorescence measurements. Eur J Pharm Biopharm, 2024. 197: p. 114211.

19. Thoma, T., L. Ma-Hock, S. Schneider, N. Honarvar, S. Treumann, S. Groeters, V. Strauss, H. Marxfeld, D. Funk-Weyer, S. Seiffert, W. Wohlleben, M. Dammann, K. Wiench, N. Lombaert, C. Spirlet, M. Vasquez, N. Dewhurst, and R. Landsiedel, Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms. Part Fibre Toxicol, 2024. 21(1): p. 24.

20. Thiel, A., F. Drews, M. Pirritano, F. Schumacher, V. Michaelis, M. Schwarz, S. Franzenburg, T. Schwerdtle, B. Michalke, A.P. Kipp, B. Kleuser, M. Simon, and J. Bornhorst, Transcriptomics pave the way into mechanisms of cobalt and nickel toxicity: Nrf2-mediated cellular responses in liver carcinoma cells. Redox Biol, 2024. 75: p. 103290.

21. Stobernack, T., N. Dommershausen, V. Alcolea-Rodríguez, R. Ledwith, M.A. Bañares, A. Haase, M. Pink, and V.I. Dumit, Advancing Nanomaterial Toxicology Screening Through Efficient and Cost-Effective Quantitative Proteomics. Small Methods, 2024. 8(12): p. e2400420.

22. Schöl, M., R. Schempp, T. Hennig, D. Wigger, F. Schumacher, B. Kleuser, C. Stigloher, M. van Ham, L. Jänsch, S. Schneider-Schaulies, L. Dölken, and E. Avota, Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells. Front Immunol, 2024. 15: p. 1435701.

23. Schempp, R., J. Eilts, M. Schöl, M.F. Grijalva Yépez, A. Fekete, D. Wigger, F. Schumacher, B. Kleuser, M. van Ham, L. Jänsch, M. Sauer, and E. Avota, The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. Int J Mol Sci, 2024. 25(6).

24. Rühling, M., L. Kersting, F. Wagner, F. Schumacher, D. Wigger, D.A. Helmerich, T. Pfeuffer, R. Elflein, C. Kappe, M. Sauer, C. Arenz, B. Kleuser, T. Rudel, M. Fraunholz, and J. Seibel, Trifunctional sphingomyelin derivatives enable nanoscale resolution of sphingomyelin turnover in physiological and infection processes via expansion microscopy. Nat Commun, 2024. 15(1): p. 7456.

25. Prell, A., D. Wigger, A. Huwiler, F. Schumacher, and B. Kleuser, The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells. J Lipid Res, 2024. 65(10): p. 100631.

26. Mandasari, P., C. Hollmann, R.H. Zaidi, S. Löw, J. Schrama, D. Wigger, F. Schumacher, B. Kleuser, and N. Beyersdorf, Acid ceramidase expression reduces IFNγ secretion by mouse CD4(+) T cells and is crucial for maintaining B-cell numbers in mice. Front Immunol, 2024. 15: p. 1309846.

27. Lortzing, V., G. Valsamakis, F. Jantzen, J. Hundacker, L.R. Paniagua Voirol, F. Schumacher, B. Kleuser, and M. Hilker, Plant defensive responses to insect eggs are inducible by general egg-associated elicitors. Sci Rep, 2024. 14(1): p. 1076.

28. Liu, L., Z. Karim, N. Schlörer, X. de la Torre, F. Botrè, C. Zoschke, and M.K. Parr, Biotransformation of anabolic androgenic steroids in human skin cells. J Steroid Biochem Mol Biol, 2024. 237: p. 106444.

29. Liu, H., G. Yin, M.S. Kohlhepp, F. Schumacher, J. Hundertmark, M.I.A. Hassan, F. Heymann, T. Puengel, B. Kleuser, A.S. Mosig, F. Tacke, and A. Guillot, Dissecting Acute Drug-Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver-On-A-Chip Model. Adv Sci (Weinh), 2024. 11(30): p. e2403516.

30. Li, M., A.A. Hasan, C. Chu, J.G. Hocher, Y. Liu, X. Zhang, X. Chen, B. Yard, B.K. Krämer, and B. Hocher, Only bioactive forms of PTH (n-oxPTH and Met18(ox)-PTH) inhibit synthesis of sclerostin - evidence from in vitro and human studies. Pflugers Arch, 2024. 476(6): p. 889-899.

31. Ledwith, R., T. Stobernack, A. Bergert, A. Bahl, M. Pink, A. Haase, and V.I. Dumit, Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines. Arch Toxicol, 2024. 98(12): p. 4021-4031.

32. Kleuser, B., F. Schumacher, and E. Gulbins, New Therapeutic Options in Pulmonal Diseases: Sphingolipids and Modulation of Sphingolipid Metabolism. Handb Exp Pharmacol, 2024. 284: p. 289-312.

33. Kirmpaki, M.A., E.M. Saied, F. Schumacher, K. Prause, B. Kleuser, and C. Arenz, Live-Cell Identification of Inhibitors of the Lipid Transfer Protein CERT Using Nanoluciferase Bioluminescence Resonance Energy Transfer (NanoBRET). Angew Chem Int Ed Engl, 2024. 63(52): p. e202413562.

34. Jacobs, M.N., S. Hoffmann, H.M. Hollnagel, P. Kern, S.N. Kolle, A. Natsch, and R. Landsiedel, Avoiding a reproducibility crisis in regulatory toxicology-on the fundamental role of ring trials. Arch Toxicol, 2024. 98(7): p. 2047-2063.

35. Holzapfel, R., A. Prell, F. Schumacher, V. Perschin, J.P. Friedmann Angeli, B. Kleuser, C. Stigloher, and G. Fazeli, Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Eur J Cell Biol, 2024. 103(2): p. 151411.

36. Holle, J., V. McParland, H. Anandakumar, F. Gerritzmann, F. Behrens, F. Schumacher, J. Thumfart, K.U. Eckardt, B. Kleuser, H. Bartolomaeus, and N. Wilck, Gut dysbiosis contributes to TMAO accumulation in CKD. Nephrol Dial Transplant, 2024. 39(11): p. 1923-1926.

37. Hindrichs, C., T. Walk, S. Melching-Kollmuss, R. Landsiedel, H. Kamp, and D. Funk-Weyer, A Novel and Fast Online-SPE-LC-MS/MS Method to Quantify Thyroid Hormone Metabolites in Rat Plasma. Chem Res Toxicol, 2024. 37(1): p. 33-41.

38. Hindrichs, C., T. Walk, R. Landsiedel, H. Kamp, S. Schneider, S. Melching-Kollmuss, and D. Funk-Weyer, Thyroid Hormone Metabolites Quantified in Pup and Adult Rat Cerebellum, Cortex and Whole-Brain Samples Using an Automated Online SPE-LC-MS/MS Method. Metabolites, 2024. 14(1).

39. Haßmann, U., S. Amann, N. Babayan, S. Fankhauser, T. Hofmaier, T. Jakl, M. Nendza, H. Stopper, S.M. Stefan, and R. Landsiedel, Predictive, integrative, and regulatory aspects of AI-driven computational toxicology - Highlights of the German Pharm-Tox Summit (GPTS) 2024. Toxicology, 2024. 509: p. 153975.

40. Glatt, H., S.Y. Weißenberg, A. Ehlers, A. Lampen, A. Seidel, F. Schumacher, W. Engst, and W. Meinl, Formation of DNA Adducts by 1-Methoxy-3-indolylmethylalcohol, a Breakdown Product of a Glucosinolate, in the Mouse: Impact of the SULT1A1 Status-Wild-Type, Knockout or Humanised. Int J Mol Sci, 2024. 25(7).

41. Germer, G., L. Schwartze, J. García-Miller, R. Balansin-Rigon, L.J. Groth, I. Rühl, P. Patoka, C. Zoschke, and E. Rühl, Label-free mapping of cetuximab in multi-layered tumor oral mucosa models by atomic force-microscopy-based infrared spectroscopy. Analyst, 2024. 149(7): p. 2122-2130.

42. Emecheta, E.E., P.M. Pfohl, W. Wohlleben, A. Haase, and A. Roloff, Desorption of Polycyclic Aromatic Hydrocarbons from Microplastics in Human Gastrointestinal Fluid Simulants-Implications for Exposure Assessment. ACS Omega, 2024. 9(23): p. 24281-24290.

43. Dumit, V.I., Y.C. Liu, A. Bahl, P. Kohonen, R.C. Grafström, P. Nymark, C. Müller-Graf, A. Haase, and M. Pink, Meta-Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure-Activity Relationship of Carbon Materials with Different Morphologies. Adv Sci (Weinh), 2024. 11(9): p. e2306268.

44. Dubau, M., T. Tripetchr, L. Mahmoud, V. Kral, and B. Kleuser, Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach. J Tissue Eng, 2024. 15: p. 20417314241291848.

45. Chen, X., D. Delić, Y. Cao, Z. Zhang, H. Wu, A.A. Hasan, M.M.S. Gaballa, L. Yin, B.K. Krämer, T. Klein, X. Shi, B. He, L. Shen, and B. Hocher, Renal and cardiac effects of the PDE9 inhibitor BAY 73-6691 in 5/6 nephrectomized rats. Pflugers Arch, 2024. 476(5): p. 755-767.

46. Chen, H., J. Yao, L. Hu, Y. Liu, J.G. Hocher, X. Zhang, A.A. Hasan, G. Lin, F. Gong, and B. Hocher, Vitamin D binding protein correlate with estrogen increase after administration of human chorionic gonadotropin but do not affect ovulation, embryo, or pregnancy outcomes. Front Endocrinol (Lausanne), 2024. 15: p. 1401975.

47. Burgum, M.J., C. Ulrich, N. Partosa, S.J. Evans, C. Gomes, S.B. Seiffert, R. Landsiedel, N. Honarvar, and S.H. Doak, Adapting the in vitro micronucleus assay (OECD Test Guideline No. 487) for testing of manufactured nanomaterials: recommendations for best practices. Mutagenesis, 2024. 39(3): p. 205-217.

48. Brandão, F., C. Costa, M.J. Bessa, E. Dumortier, F. Debacq-Chainiaux, R. Hubaux, M. Salmon, J. Laloy, M.S. Stan, A. Hermenean, S. Gharbia, A. Dinischiotu, A. Bannuscher, B. Hellack, A. Haase, S. Fraga, and J.P. Teixeira, Correction: Brandão et al. Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO(2) NM). Nanomaterials 2021, 11, 1502. Nanomaterials (Basel), 2024. 14(23).

49. Batliner, M., F. Schumacher, D. Wigger, W. Vivas, A. Prell, I. Fohmann, T. Köhler, R. Schempp, A. Riedel, M. Vaeth, A. Fekete, B. Kleuser, O. Kurzai, and N.E. Nieuwenhuizen, The Candida albicans quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells. mBio, 2024. 15(8): p. e0073224.

50. Bahl, A., S. Halappanavar, W. Wohlleben, P. Nymark, P. Kohonen, H. Wallin, U. Vogel, and A. Haase, Bioinformatics and machine learning to support nanomaterial grouping. Nanotoxicology, 2024. 18(4): p. 373-400.

51. Alcolea-Rodriguez, V., V.I. Dumit, R. Ledwith, R. Portela, M.A. Bañares, and A. Haase, Differentially Induced Autophagy by Engineered Nanomaterial Treatment Has an Impact on Cellular Homeostasis and Cytotoxicity. Nano Lett, 2024. 24(38): p. 11793-11799.

52. Zuo, J., A.A. Hasan, C.F. Hocher, P. Kalk, B. Kleuser, B.K. Krämer, and B. Hocher, Inverse correlation of intact PTH, oxidized PTH as well as non-oxidized PTH with 25-hydroxyvitamin D3 in kidney transplant recipients. Front Endocrinol (Lausanne), 2023. 14: p. 1178166.

53. Zoicas, I., C. Mühle, F. Schumacher, B. Kleuser, and J. Kornhuber, Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism. Cells, 2023. 12(10).

54. Zhang, X., C. Reichetzeder, Y. Liu, J.G. Hocher, A.A. Hasan, G. Lin, B. Kleuser, L. Hu, and B. Hocher, Parental sex-dependent effects of either maternal or paternal eNOS deficiency on the offspring's phenotype without transmission of the parental eNOS deficiency to the offspring. Front Physiol, 2023. 14: p. 1306178.

55. Zabihi, F., Z. Tu, S. Kaessmeyer, F. Schumacher, F. Rancan, B. Kleuser, C. Boettcher, K. Ludwig, J. Plendl, S. Hedtrich, A. Vogt, and R. Haag, Efficient skin interactions of graphene derivatives: challenge, opportunity or both? Nanoscale Adv, 2023. 5(21): p. 5923-5931.

56. Wohlleben, W., A. Mehling, and R. Landsiedel, Lessons Learned from the Grouping of Chemicals to Assess Risks to Human Health. Angew Chem Int Ed Engl, 2023. 62(22): p. e202210651.

57. Wilhelmi, P., V. Giri, F.M. Zickgraf, V. Haake, S. Henkes, P. Driemert, P. Michaelis, W. Busch, S. Scholz, B. Flick, M. Barenys, B. Birk, H. Kamp, R. Landsiedel, and D. Funk-Weyer, A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. Chem Biol Interact, 2023. 382: p. 110565.

58. Tran, P.T., P. Tawornchat, B. Kleuser, S.B. Lohan, J. Schleusener, M.C. Meinke, and M.E. Darvin, Red- and Near-Infrared-Excited Autofluorescence as a Marker for Acute Oxidative Stress in Skin Exposed to Cigarette Smoke Ex Vivo and In Vivo. Antioxidants (Basel), 2023. 12(5).

59. Ramirez-Hincapie, S., B. Birk, P. Ternes, V. Giri, F.M. Zickgraf, V. Haake, M. Herold, H. Kamp, P. Driemert, R. Landsiedel, E. Richling, D. Funk-Weyer, and B. van Ravenzwaay, Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin. Arch Toxicol, 2023. 97(11): p. 2903-2917.

60. Ramirez-Hincapie, S., B. Birk, P. Ternes, V. Giri, V. Haake, M. Herold, F.M. Zickgraf, A. Verlohner, H.A. Huener, H. Kamp, P. Driemert, R. Landsiedel, E. Richling, D. Funk-Weyer, and B. van Ravenzwaay, A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity. Cell Biol Toxicol, 2023. 39(6): p. 2899-2917.

61. Otte, J.C., H.M. Hollnagel, C. Nagel, R.F. Gerhardt, W. Wohlleben, N. Vallotton, D. Schowanek, G. Sanders, J.M. Frasca, T. Mahale, M. Pemberton, B. Hidding, and R. Landsiedel, Three-tiered approach for standard information requirements for polymers requiring registration under REACH. Regul Toxicol Pharmacol, 2023. 144: p. 105495.

62. Nieschalke, K., N. Bergau, S. Jessel, A. Seidel, S. Baldermann, M. Schreiner, K. Abraham, A. Lampen, B.H. Monien, B. Kleuser, H. Glatt, and F. Schumacher, Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans. Chem Res Toxicol, 2023. 36(11): p. 1753-1767.

63. Murphy, F.A., H.J. Johnston, S. Dekkers, E.A.J. Bleeker, A.G. Oomen, T.F. Fernandes, K. Rasmussen, P. Jantunen, H. Rauscher, N. Hunt, L. di Cristo, H.M. Braakhuis, A. Haase, D. Hristozov, W. Wohlleben, S. Sabella, and V. Stone, How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms. Altex, 2023. 40(1): p. 125-140.

64. Kolle, S.N., M. Flach, M. Kleber, D.A. Basketter, B. Wareing, A. Mehling, L. Hareng, N. Watzek, S. Bade, D. Funk-Weyer, and R. Landsiedel, Plant extracts, polymers and new approach methods: Practical experience with skin sensitization assessment. Regul Toxicol Pharmacol, 2023. 138: p. 105330.

65. Kleuser, B. and W. Bäumer, Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases. Int J Mol Sci, 2023. 24(2).

66. Keller, J.G., M. Persson, P. Müller, L. Ma-Hock, K. Werle, J. Arts, R. Landsiedel, and W. Wohlleben, Corrigendum to variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity [NanoImpact 23 (2021) 100341]. NanoImpact, 2023. 29: p. 100455.

67. Höper, T., I. Karkossa, V.I. Dumit, M. von Bergen, K. Schubert, and A. Haase, A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways. Toxicol Appl Pharmacol, 2023. 475: p. 116650.

68. Fohmann, I., A. Weinmann, F. Schumacher, S. Peters, A. Prell, C. Weigel, S. Spiegel, B. Kleuser, and A. Schubert-Unkmeir, Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells. PLoS Pathog, 2023. 19(11): p. e1011842.

69. Dimitrijevic, D., E. Fabian, D. Funk-Weyer, and R. Landsiedel, Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma. Biochem Biophys Res Commun, 2023. 651: p. 114-120.

70. Chen, X., D. Delić, Y. Cao, L. Shen, Q. Shao, Z. Zhang, H. Wu, A.A. Hasan, C. Reichetzeder, M.M.S. Gaballa, B.K. Krämer, T. Klein, L. Yin, B. He, S. Morgera, and B. Hocher, Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system. Am J Physiol Cell Physiol, 2023. 324(4): p. C951-c962.

71. Brandão, F., C. Costa, M.J. Bessa, V. Valdiglesias, B. Hellack, A. Haase, S. Fraga, and J.P. Teixeira, Multiparametric in vitro genotoxicity assessment of different variants of amorphous silica nanomaterials in rat alveolar epithelial cells. Nanotoxicology, 2023. 17(6-7): p. 511-528.

72. Braakhuis, H.M., E.R. Gremmer, A. Bannuscher, B. Drasler, S. Keshavan, B. Rothen-Rutishauser, B. Birk, A. Verlohner, R. Landsiedel, K. Meldrum, S.H. Doak, M.J.D. Clift, J.S. Erdem, O.A.H. Foss, S. Zienolddiny-Narui, T. Serchi, E. Moschini, P. Weber, S. Burla, P. Kumar, O. Schmid, E. Zwart, J.P. Vermeulen, and R.J. Vandebriel, Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 2023. 31: p. 100466.

73. Bloch, D., P. Diel, B. Epe, M. Hellwig, A. Lampen, A. Mally, D. Marko, M.A. Villar Fernández, S. Guth, A. Roth, R. Marchan, A. Ghallab, C. Cadenas, P. Nell, N. Vartak, C. van Thriel, A. Luch, S. Schmeisser, M. Herzler, R. Landsiedel, M. Leist, P. Marx-Stoelting, T. Tralau, and J.G. Hengstler, Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol, 2023. 97(11): p. 3005-3017.

74. Bahl, A., C. Ibrahim, K. Plate, A. Haase, J. Dengjel, P. Nymark, and V.I. Dumit, PROTEOMAS: a workflow enabling harmonized proteomic meta-analysis and proteomic signature mapping. J Cheminform, 2023. 15(1): p. 34.

75. Zuo, J., L. Chaykovska, C. Chu, X. Chen, A.A. Hasan, B.K. Krämer, M. Tepel, and B. Hocher, Head-to-Head Comparison of Oxidative Stress Biomarkers for All-Cause Mortality in Hemodialysis Patients. Antioxidants (Basel), 2022. 11(10).

76. Zhang, X., L. Liu, M.M.S. Gaballa, A.A. Hasan, Y. Xiong, L. Xie, T. Klein, D. Delic, B. Kleuser, B.K. Krämer, J. Li, and B. Hocher, Impact of Salt Intake and Renin-Angiotensin-Aldosterone System Blockade on Lung Severe Acute Respiratory Syndrome Coronavirus 2 Host Factors. Kidney Blood Press Res, 2022. 47(9): p. 565-575.

77. Zhang, X., A.A. Hasan, H. Wu, M.M.S. Gaballa, S. Zeng, L. Liu, L. Xie, T. Jung, T. Grune, B.K. Krämer, B. Kleuser, J. Li, and B. Hocher, High-fat, sucrose and salt-rich diet during rat spermatogenesis lead to the development of chronic kidney disease in the female offspring of the F2 generation. Faseb j, 2022. 36(4): p. e22259.

78. Zeng, S., D. Delic, C. Chu, Y. Xiong, T. Luo, X. Chen, M.M.S. Gaballa, Y. Xue, X. Chen, Y. Cao, A.A. Hasan, K. Stadermann, S. Frankenreiter, L. Yin, B.K. Krämer, T. Klein, and B. Hocher, Antifibrotic effects of low dose SGLT2 Inhibition with empagliflozin in comparison to Ang II receptor blockade with telmisartan in 5/6 nephrectomised rats on high salt diet. Biomed Pharmacother, 2022. 146: p. 112606.

79. Xiong, Y., D. Delic, S. Zeng, X. Chen, C. Chu, A.A. Hasan, B.K. Krämer, T. Klein, L. Yin, and B. Hocher, Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker. BMC Nephrol, 2022. 23(1): p. 117.

80. Westhölter, D., F. Schumacher, N. Wülfinghoff, S. Sutharsan, S. Strassburg, B. Kleuser, P.A. Horn, S. Reuter, E. Gulbins, C. Taube, and M. Welsner, CFTR modulator therapy alters plasma sphingolipid profiles in people with cystic fibrosis. J Cyst Fibros, 2022. 21(4): p. 713-720.

81. Weber, A.G., B. Birk, C. Müller, S. Schneider, B. van Ravenzwaay, D. Funk-Weyer, and R. Landsiedel, The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles. Chem Biol Interact, 2022. 351: p. 109709.

82. Verdon, R., V. Stone, F. Murphy, E. Christopher, H. Johnston, S. Doak, U. Vogel, A. Haase, and A. Kermanizadeh, The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment. Part Fibre Toxicol, 2022. 19(1): p. 32.

83. Tschiche, H.R., F.S. Bierkandt, O. Creutzenberg, V. Fessard, R. Franz, R. Greiner, C. Gruber-Traub, K.H. Haas, A. Haase, A. Hartwig, B. Hesse, K. Hund-Rinke, P. Iden, C. Kromer, K. Loeschner, D. Mutz, A. Rakow, K. Rasmussen, H. Rauscher, H. Richter, J. Schoon, O. Schmid, C. Som, L.M. Spindler, G.E.M. Tovar, P. Westerhoff, W. Wohlleben, A. Luch, and P. Laux, Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities. NanoImpact, 2022. 28: p. 100416.

84. Tran, P.T., B. Beidoun, S.B. Lohan, R. Talbi, B. Kleuser, M. Seifert, K. Jung, G. Sandig, and M.C. Meinke, Establishment of a method to expose and measure pollution in excised porcine skin with electron paramagnetic resonance spectroscopy. Ecotoxicol Environ Saf, 2022. 247: p. 114258.

85. Schumacher, F., M.J. Edwards, C. Mühle, A. Carpinteiro, G.C. Wilson, B. Wilker, M. Soddemann, S. Keitsch, N. Scherbaum, B.W. Müller, U.E. Lang, C. Linnemann, B. Kleuser, C.P. Müller, J. Kornhuber, and E. Gulbins, Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice. J Biol Chem, 2022. 298(8): p. 102185.

86. Schumacher, F., A. Carpinteiro, M.J. Edwards, G.C. Wilson, S. Keitsch, M. Soddemann, B. Wilker, B. Kleuser, K.A. Becker, C.P. Müller, J. Kornhuber, and E. Gulbins, Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. J Mol Med (Berl), 2022. 100(10): p. 1493-1508.

87. Schulz, J., R. Michelet, J.F. Joseph, M. Zeitlinger, F. Schumacher, G. Mikus, and C. Kloft, A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications. J Pharm Biomed Anal, 2022. 210: p. 114551.

88. Radbruch, M., H. Pischon, F. Du, R. Haag, F. Schumacher, B. Kleuser, L. Mundhenk, and A.D. Gruber, Biodegradable core-multishell nanocarrier: Topical tacrolimus delivery for treatment of dermatitis. J Control Release, 2022. 349: p. 917-928.

89. Putra, S.E.D., C. Reichetzeder, K. von Websky, C. Neuber, H. Halle, B. Kleuser, B.K. Krämer, and B. Hocher, Association between placental global DNA methylation and blood pressure during human pregnancy. J Hypertens, 2022. 40(5): p. 1002-1009.

90. Péricat, D., S.A. Leon-Icaza, M. Sanchez Rico, C. Mühle, I. Zoicas, F. Schumacher, R. Planès, R. Mazars, G. Gros, A. Carpinteiro, K.A. Becker, J. Izopet, N. Strub-Wourgaft, P. Sjö, O. Neyrolles, B. Kleuser, F. Limosin, E. Gulbins, J. Kornhuber, E. Meunier, N. Hoertel, and C. Cougoule, Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model. Int J Mol Sci, 2022. 23(21).

91. Oesch, F., N. Honarvar, E. Fabian, L. Finch, S. Hindle, K. Wiench, and R. Landsiedel, Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione. Arch Toxicol, 2022. 96(9): p. 2573-2587.

92. Neuhaus, W., B. Reininger-Gutmann, B. Rinner, R. Plasenzotti, D. Wilflingseder, J. De Kock, T. Vanhaecke, V. Rogiers, D. Jírová, K. Kejlová, L.E. Knudsen, R.N. Nielsen, B. Kleuser, V. Kral, C. Thöne-Reineke, T. Hartung, G. Pallocca, C. Rovida, M. Leist, S. Hippenstiel, A. Lang, I. Retter, S. Krämer, P. Jedlicka, K. Ameli, E. Fritsche, J. Tigges, E. Kuchovská, M. Buettner, A. Bleich, N. Baumgart, J. Baumgart, M.W. Meinhardt, R. Spanagel, S. Chourbaji, B. Kränzlin, B. Seeger, M. von Köckritz-Blickwede, J.M. Sánchez-Morgado, V. Galligioni, D. Ruiz-Pérez, D. Movia, A. Prina-Mello, A. Ahluwalia, V. Chiono, A.C. Gutleb, M. Schmit, B. van Golen, L. van Weereld, A. Kienhuis, E. van Oort, J. van der Valk, A. Smith, J. Roszak, M. Stępnik, Z. Sobańska, E. Reszka, I.A.S. Olsson, N.H. Franco, B. Sevastre, H. Kandarova, S. Capdevila, J. Johansson, E. Svensk, C.R. Cederroth, J. Sandström, I. Ragan, N. Bubalo, J. Kurreck, and H. Spielmann, The Current Status and Work of Three Rs Centres and Platforms in Europe. Altern Lab Anim, 2022. 50(6): p. 381-413.

93. Neuhaus, W., B. Reininger-Gutmann, B. Rinner, R. Plasenzotti, D. Wilflingseder, J. De Kock, T. Vanhaecke, V. Rogiers, D. Jírová, K. Kejlová, L.E. Knudsen, R.N. Nielsen, B. Kleuser, V. Kral, C. Thöne-Reineke, T. Hartung, G. Pallocca, M. Leist, S. Hippenstiel, A. Lang, I. Retter, S. Krämer, P. Jedlicka, K. Ameli, E. Fritsche, J. Tigges, M. Buettner, A. Bleich, N. Baumgart, J. Baumgart, M.W. Meinhardt, R. Spanagel, S. Chourbaji, B. Kränzlin, B. Seeger, M. von Köckritz-Blickwede, J.M. Sánchez-Morgado, V. Galligioni, D. Ruiz-Pérez, D. Movia, A. Prina-Mello, A. Ahluwalia, V. Chiono, A.C. Gutleb, M. Schmit, B. van Golen, L. van Weereld, A. Kienhuis, E. van Oort, J. van der Valk, A. Smith, J. Roszak, M. Stępnik, Z. Sobańska, I.A.S. Olsson, N.H. Franco, B. Sevastre, H. Kandarova, S. Capdevila, J. Johansson, C.R. Cederroth, J. Sandström, I. Ragan, N. Bubalo, and H. Spielmann, The Rise of Three Rs Centres and Platforms in Europe. Altern Lab Anim, 2022. 50(2): p. 90-120.

94. Mohamud Yusuf, A., N. Hagemann, X. Zhang, M. Zafar, T. Hussner, C. Bromkamp, C. Martiny, T. Tertel, V. Börger, F. Schumacher, F.A. Solari, M. Hasenberg, C. Kleinschnitz, T.R. Doeppner, B. Kleuser, A. Sickmann, M. Gunzer, B. Giebel, R. Kolesnick, E. Gulbins, and D.M. Hermann, Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. Basic Res Cardiol, 2022. 117(1): p. 43.

95. Lu, Y.P., H.W. Wu, T. Zhu, X.T. Li, J. Zuo, A.A. Hasan, C. Reichetzeder, D. Delic, B. Yard, T. Klein, B.K. Krämer, Z.Y. Zhang, X.H. Wang, L.H. Yin, Y. Dai, Z.H. Zheng, and B. Hocher, Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy. Biomed Pharmacother, 2022. 156: p. 113947.

96. Landsiedel, R., N. Honarvar, S.B. Seiffert, B. Oesch, and F. Oesch, Genotoxicity testing of nanomaterials. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2022. 14(6): p. e1833.

97. Landsiedel, R., D. Hahn, R. Ossig, S. Ritz, L. Sauer, R. Buesen, S. Rehm, W. Wohlleben, S. Groeters, V. Strauss, S. Sperber, H. Wami, U. Dobrindt, K. Prior, D. Harmsen, B. van Ravenzwaay, and J. Schnekenburger, Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects. Part Fibre Toxicol, 2022. 19(1): p. 21.

98. Landsiedel, R., B. Birk, and D. Funk-Weyer, The Evolution of Regulatory Toxicology: Where is the Gardener? Altern Lab Anim, 2022. 50(4): p. 255-262.

99. Kyriakoudi, S., A. Theodoulou, L. Potamiti, F. Schumacher, M. Zachariou, R. Papacharalambous, B. Kleuser, M.I. Panayiotidis, A. Drousiotou, and P.P. Petrou, Stbd1-deficient mice display insulin resistance associated with enhanced hepatic ER-mitochondria contact. Biochimie, 2022. 200: p. 172-183.

100. Kadow, S., F. Schumacher, M. Kramer, G. Hessler, R. Scholtysik, S. Oubari, P. Johansson, A. Hüttmann, H.C. Reinhardt, B. Kleuser, M. Zoratti, A. Mattarei, I. Szabò, E. Gulbins, and A. Carpinteiro, Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma. Cancers (Basel), 2022. 14(8).

101. Jeliazkova, N., E. Bleeker, R. Cross, A. Haase, G. Janer, W. Peijnenburg, M. Pink, H. Rauscher, C. Svendsen, G. Tsiliki, A. Zabeo, D. Hristozov, V. Stone, and W. Wohlleben, How can we justify grouping of nanoforms for hazard assessment? Concepts and tools to quantify similarity. NanoImpact, 2022. 25: p. 100366.

102. Hose, M., A. Günther, E. Naser, F. Schumacher, T. Schönberger, J. Falkenstein, A. Papadamakis, B. Kleuser, K.A. Becker, E. Gulbins, A. Haimovitz-Friedman, J. Buer, A.M. Westendorf, and W. Hansen, Cell-intrinsic ceramides determine T cell function during melanoma progression. Elife, 2022. 11.

103. Holle, J., H. Bartolomaeus, U. Löber, F. Behrens, T.U.P. Bartolomaeus, H. Anandakumar, M.I. Wimmer, D.L. Vu, M. Kuhring, U. Brüning, A. Maifeld, S. Geisberger, S. Kempa, F. Schumacher, B. Kleuser, P. Bufler, U. Querfeld, S. Kitschke, D. Engler, L.D. Kuhrt, O. Drechsel, K.U. Eckardt, S.K. Forslund, A. Thürmer, V. McParland, J.A. Kirwan, N. Wilck, and D. Müller, Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance. J Am Soc Nephrol, 2022. 33(12): p. 2259-2275.

104. Hochrein, S.M., H. Wu, M. Eckstein, L. Arrigoni, J.S. Herman, F. Schumacher, C. Gerecke, M. Rosenfeldt, D. Grün, B. Kleuser, G. Gasteiger, W. Kastenmüller, B. Ghesquière, J. Van den Bossche, E.D. Abel, and M. Vaeth, The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. Cell Metab, 2022. 34(4): p. 516-532.e11.

105. Hocher, B., Y.P. Lu, C. Reichetzeder, X. Zhang, O. Tsuprykov, J. Rahnenführer, L. Xie, J. Li, L. Hu, B.K. Krämer, and A.A. Hasan, Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself. Diabetologia, 2022. 65(7): p. 1222-1236.

106. Hashemi Arani, F., S. Kadow, M. Kramer, S. Keitsch, L. Kirchhoff, F. Schumacher, B. Kleuser, P.M. Rath, E. Gulbins, and A. Carpinteiro, Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp. Int J Mol Sci, 2022. 23(24).

107. Hasan, A.A., C.F. Hocher, B. Kleuser, B.K. Krämer, and B. Hocher, Biological Activity of Different Forms of Oxidized Parathyroid Hormone. Int J Mol Sci, 2022. 23(20).

108. Günther, A., M. Hose, H. Abberger, F. Schumacher, Y. Veith, B. Kleuser, K. Matuschewski, K.S. Lang, E. Gulbins, J. Buer, A.M. Westendorf, and W. Hansen, The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis. Elife, 2022. 11.

109. Grafström, R., A. Haase, P. Kohonen, N. Jeliazkova, and P. Nymark, Reply to: Prospects and challenges for FAIR toxicogenomics data. Nat Nanotechnol, 2022. 17(1): p. 19-20.

110. Gerecke, C., C. Egea Rodrigues, T. Homann, and B. Kleuser, The Role of Ten-Eleven Translocation Proteins in Inflammation. Front Immunol, 2022. 13: p. 861351.

111. Gabbert, S., M. Mathea, S.N. Kolle, and R. Landsiedel, Accounting for Precision Uncertainty of Toxicity Testing: Methods to Define Borderline Ranges and Implications for Hazard Assessment of Chemicals. Risk Anal, 2022. 42(2): p. 224-238.

112. Eder, S., C. Hollmann, P. Mandasari, P. Wittmann, F. Schumacher, B. Kleuser, J. Fink, J. Seibel, J. Schneider-Schaulies, C. Stigloher, N. Beyersdorf, and S. Dembski, Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations. J Funct Biomater, 2022. 13(3).

113. Dimitrijevic, D., E. Fabian, B. Nicol, D. Funk-Weyer, and R. Landsiedel, Toward Realistic Dosimetry In Vitro: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an In Silico Mass Balance Model. Chem Res Toxicol, 2022. 35(11): p. 1962-1973.

114. Di Cristo, L., G. Janer, S. Dekkers, M. Boyles, A. Giusti, J.G. Keller, W. Wohlleben, H. Braakhuis, L. Ma-Hock, A.G. Oomen, A. Haase, V. Stone, F. Murphy, H.J. Johnston, and S. Sabella, Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure. Nanotoxicology, 2022. 16(3): p. 310-332.

115. Chu, C., D. Delić, J. Alber, M. Feger, Y. Xiong, T. Luo, A.A. Hasan, S. Zeng, M.M.S. Gaballa, X. Chen, L. Yin, T. Klein, S. Elitok, B.K. Krämer, M. Föller, and B. Hocher, Head-to-head comparison of two SGLT-2 inhibitors on AKI outcomes in a rat ischemia-reperfusion model. Biomed Pharmacother, 2022. 153: p. 113357.

116. Chu, C., X. Chen, A.A. Hasan, A. Szakallova, B.K. Krämer, M. Tepel, and B. Hocher, Angiopoietin-2 predicts all-cause mortality in male but not female end-stage kidney disease patients on hemodialysis. Nephrol Dial Transplant, 2022. 37(7): p. 1348-1356.

117. Carstens, H., K. Kalka, R. Verhaegh, F. Schumacher, M. Soddemann, B. Wilker, S. Keitsch, C. Sehl, B. Kleuser, M. Hübler, U. Rauen, A.K. Becker, A. Koch, E. Gulbins, and M. Kamler, Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs. PLoS One, 2022. 17(7): p. e0271620.

118. Bernacchioni, C., R. Squecco, T. Gamberi, V. Ghini, F. Schumacher, M. Mannelli, R. Garella, E. Idrizaj, F. Cencetti, E. Puliti, P. Bruni, P. Turano, T. Fiaschi, and C. Donati, S1P Signalling Axis Is Necessary for Adiponectin-Directed Regulation of Electrophysiological Properties and Oxidative Metabolism in C2C12 Myotubes. Cells, 2022. 11(4).

119. Bannuscher, A., O. Schmid, B. Drasler, A. Rohrbasser, H.M. Braakhuis, K. Meldrum, E.P. Zwart, E.R. Gremmer, B. Birk, M. Rissel, R. Landsiedel, E. Moschini, S.J. Evans, P. Kumar, S. Orak, A. Doryab, J.S. Erdem, T. Serchi, R.J. Vandebriel, F.R. Cassee, S.H. Doak, A. Petri-Fink, S. Zienolddiny, M.J.D. Clift, and B. Rothen-Rutishauser, An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 2022. 28: p. 100439.

120. Ag Seleci, D., G. Tsiliki, K. Werle, D.A. Elam, O. Okpowe, K. Seidel, X. Bi, P. Westerhoff, E. Innes, M. Boyles, M. Miller, A. Giusti, F. Murphy, A. Haase, V. Stone, and W. Wohlleben, Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays. NanoImpact, 2022. 26: p. 100390.

121. Zeng, S., A.A. Hasan, C. Chu, Y. Xiong, J.G. Hocher, S. Elitok, B.K. Krämer, and B. Hocher, Osteoprotegerin is an independent risk factor predicting death in stable renal transplant recipients. Clin Nephrol, 2021. 96(3): p. 129-137.

122. Wigger, D., F. Schumacher, S. Schneider-Schaulies, and B. Kleuser, Sphingosine 1-phosphate metabolism and insulin signaling. Cell Signal, 2021. 82: p. 109959.

123. Wiese, T., F. Dennstädt, C. Hollmann, S. Stonawski, C. Wurst, J. Fink, E. Gorte, P. Mandasari, K. Domschke, L. Hommers, B. Vanhove, F. Schumacher, B. Kleuser, J. Seibel, J. Rohr, M. Buttmann, A. Menke, J. Schneider-Schaulies, and N. Beyersdorf, Inhibition of acid sphingomyelinase increases regulatory T cells in humans. Brain Commun, 2021. 3(2): p. fcab020.

124. Wetzel, A., B. Scholtka, F. Schumacher, H. Rawel, B. Geisendörfer, and B. Kleuser, Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis. Int J Mol Sci, 2021. 22(10).

125. Wardelmann, K., M. Rath, J.P. Castro, S. Blümel, M. Schell, R. Hauffe, F. Schumacher, T. Flore, K. Ritter, A. Wernitz, T. Hosoi, K. Ozawa, B. Kleuser, J. Weiß, A. Schürmann, and A. Kleinridders, Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants (Basel), 2021. 10(5).

126. Ulrey, A., S. Kolle, R. Landsiedel, and E. Hill, How a GIVIMP certification program can increase confidence in in vitro methods. Altex, 2021. 38(2): p. 316-318.

127. Stratmann, H., W. Wohlleben, M. Wiemann, A. Vennemann, N. End, U. Veith, L. Ma-Hock, and R. Landsiedel, Classes of organic pigments meet tentative PSLT criteria and lack toxicity in short-term inhalation studies. Regul Toxicol Pharmacol, 2021. 124: p. 104988.

128. Stepanovska Tanturovska, B., A. Zivkovic, F. Imeri, T. Homann, B. Kleuser, H. Stark, and A. Huwiler, ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P(1) Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 2021. 26(17).

129. Spohner, A.K., K. Jakobi, S. Trautmann, D. Thomas, F. Schumacher, B. Kleuser, D. Lütjohann, K. El-Hindi, S. Grösch, J. Pfeilschifter, J.D. Saba, and D. Meyer Zu Heringdorf, Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Int J Mol Sci, 2021. 22(19).

130. Seibel, J., S. Schneider-Schaulies, and B. Kleuser, Editorial: Sphingolipids in Infection Control. Front Cell Dev Biol, 2021. 9: p. 697290.

131. Schneider-Schaulies, S., F. Schumacher, D. Wigger, M. Schöl, T. Waghmare, J. Schlegel, J. Seibel, and B. Kleuser, Sphingolipids: Effectors and Achilles Heals in Viral Infections? Cells, 2021. 10(9).

132. Schäfer-Korting, M. and C. Zoschke, How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development. Handb Exp Pharmacol, 2021. 265: p. 29-56.

133. Prakash, H., D. Upadhyay, O.R. Bandapalli, A. Jain, and B. Kleuser, Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease. Prostaglandins Other Lipid Mediat, 2021. 152: p. 106504.

134. Pfuhler, S., R. Pirow, T.R. Downs, A. Haase, N. Hewitt, A. Luch, M. Merkel, C. Petrick, A. Said, M. Schäfer-Korting, and K. Reisinger, Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays. Mutagenesis, 2021. 36(1): p. 19-35.

135. Peters, S., L. Kaiser, J. Fink, F. Schumacher, V. Perschin, J. Schlegel, M. Sauer, C. Stigloher, B. Kleuser, J. Seibel, and A. Schubert-Unkmeir, Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria. Sci Rep, 2021. 11(1): p. 4300.

136. Oesch, F., N. Honarvar, E. Fabian, F.I. Berger, and R. Landsiedel, N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity. Arch Toxicol, 2021. 95(10): p. 3143-3159.

137. Oesch, F., D. Fruth, J.G. Hengstler, E. Fabian, F.I. Berger, and R. Landsiedel, Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat. Arch Toxicol, 2021. 95(12): p. 3717-3744.

138. Natsch, A., R. Landsiedel, and S.N. Kolle, A triangular approach for the validation of new approach methods for skin sensitization. Altex, 2021. 38(4): p. 669-677.

139. Murphy, F., S. Dekkers, H. Braakhuis, L. Ma-Hock, H. Johnston, G. Janer, L. di Cristo, S. Sabella, N.R. Jacobsen, A.G. Oomen, A. Haase, T. Fernandes, and V. Stone, An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma hazard. NanoImpact, 2021. 22: p. 100314.

140. Mohamed, A., V. Korzhikov-Vlakh, N. Zhang, A. Said, I. Pilipenko, M. Schäfer-Korting, C. Zoschke, and T. Tennikova, Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility. Pharmaceutics, 2021. 13(6).

141. Ma-Hock, L., U.G. Sauer, E. Ruggiero, J.G. Keller, W. Wohlleben, and R. Landsiedel, The Use of Nanomaterial In Vivo Organ Burden Data for In Vitro Dose Setting. Small, 2021. 17(15): p. e2005725.

142. Kolle, S.N. and R. Landsiedel, Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh. Handb Exp Pharmacol, 2021. 265: p. 3-27.

143. Keller, J.G., M. Wiemann, S. Gröters, K. Werle, A. Vennemann, R. Landsiedel, and W. Wohlleben, Aerogels are not regulated as nanomaterials, but can be assessed by tiered testing and grouping strategies for nanomaterials. Nanoscale Adv, 2021. 3(13): p. 3881-3893.

144. Keller, J.G., D.F. Quevedo, L. Faccani, A.L. Costa, R. Landsiedel, K. Werle, and W. Wohlleben, Dosimetry in vitro - exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods. Nanotoxicology, 2021. 15(1): p. 21-34.

145. Keller, J.G., M. Persson, P. Müller, L. Ma-Hock, K. Werle, J. Arts, R. Landsiedel, and W. Wohlleben, Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity. NanoImpact, 2021. 23: p. 100341.

146. Keller, J.G., U.M. Graham, J. Koltermann-Jülly, R. Gelein, L. Ma-Hock, R. Landsiedel, M. Wiemann, G. Oberdörster, A. Elder, and W. Wohlleben, Author Correction: Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulphate. Sci Rep, 2021. 11(1): p. 8813.

147. Karkossa, I., A. Bannuscher, B. Hellack, W. Wohlleben, J. Laloy, M.S. Stan, A. Dinischiotu, M. Wiemann, A. Luch, A. Haase, M. von Bergen, and K. Schubert, Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects. Sci Total Environ, 2021. 801: p. 149538.

148. Kalinichenko, L.S., L. Abdel-Hafiz, A.L. Wang, C. Mühle, N. Rösel, F. Schumacher, B. Kleuser, I. Smaga, M. Frankowska, M. Filip, G. Schaller, T. Richter-Schmidinger, B. Lenz, E. Gulbins, J. Kornhuber, A.W.C. Oliveira, M. Barros, J.P. Huston, and C.P. Müller, Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory. Cereb Cortex, 2021. 31(2): p. 1316-1333.

149. Kah, M., L.J. Johnston, R.S. Kookana, W. Bruce, A. Haase, V. Ritz, J. Dinglasan, S. Doak, H. Garelick, and V. Gubala, Comprehensive framework for human health risk assessment of nanopesticides. Nat Nanotechnol, 2021. 16(9): p. 955-964.

150. Jeliazkova, N., M.D. Apostolova, C. Andreoli, F. Barone, A. Barrick, C. Battistelli, C. Bossa, A. Botea-Petcu, A. Châtel, I. De Angelis, M. Dusinska, N. El Yamani, D. Gheorghe, A. Giusti, P. Gómez-Fernández, R. Grafström, M. Gromelski, N.R. Jacobsen, V. Jeliazkov, K.A. Jensen, N. Kochev, P. Kohonen, N. Manier, E. Mariussen, A. Mech, J.M. Navas, V. Paskaleva, A. Precupas, T. Puzyn, K. Rasmussen, P. Ritchie, I.R. Llopis, E. Rundén-Pran, R. Sandu, N. Shandilya, S. Tanasescu, A. Haase, and P. Nymark, Towards FAIR nanosafety data. Nat Nanotechnol, 2021. 16(6): p. 644-654.

151. Janer, G., R. Landsiedel, and W. Wohlleben, Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH. Nanotoxicology, 2021. 15(2): p. 145-166.

152. Janer, G., D. Ag-Seleci, J.A. Sergent, R. Landsiedel, and W. Wohlleben, Creating sets of similar nanoforms with the ECETOC NanoApp: real-life case studies. Nanotoxicology, 2021. 15(8): p. 1016-1034.

153. Imeri, F., B. Stepanovska Tanturovska, A. Zivkovic, G. Enzmann, S. Schwalm, J. Pfeilschifter, T. Homann, B. Kleuser, B. Engelhardt, H. Stark, and A. Huwiler, Novel compounds with dual S1P receptor agonist and histamine H(3) receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 2021. 186: p. 108464.

154. Höper, T., K. Siewert, V.I. Dumit, M. von Bergen, K. Schubert, and A. Haase, The Contact Allergen NiSO(4) Triggers a Distinct Molecular Response in Primary Human Dendritic Cells Compared to Bacterial LPS. Front Immunol, 2021. 12: p. 644700.

155. Hering, H., C. Zoschke, F. König, M. Kühn, A. Luch, and I. Schreiver, Phototoxic versus photoprotective effects of tattoo pigments in reconstructed human skin models: In vitro phototoxicity testing of tattoo pigments: 3D versus 2D. Toxicology, 2021. 460: p. 152872.

156. Gimeno-Benito, I., A. Giusti, S. Dekkers, A. Haase, and G. Janer, A review to support the derivation of a worst-case dermal penetration value for nanoparticles. Regul Toxicol Pharmacol, 2021. 119: p. 104836.

157. Garcia de Lomana, M., A.G. Weber, B. Birk, R. Landsiedel, J. Achenbach, K.J. Schleifer, M. Mathea, and J. Kirchmair, In Silico Models to Predict the Perturbation of Molecular Initiating Events Related to Thyroid Hormone Homeostasis. Chem Res Toxicol, 2021. 34(2): p. 396-411.

158. Garcia de Lomana, M., A. Morger, U. Norinder, R. Buesen, R. Landsiedel, A. Volkamer, J. Kirchmair, and M. Mathea, ChemBioSim: Enhancing Conformal Prediction of In Vivo Toxicity by Use of Predicted Bioactivities. J Chem Inf Model, 2021. 61(7): p. 3255-3272.

159. Fink, J., F. Schumacher, J. Schlegel, P. Stenzel, D. Wigger, M. Sauer, B. Kleuser, and J. Seibel, Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis. Org Biomol Chem, 2021. 19(10): p. 2203-2212.

160. Ebenezer, D.L., R. Ramchandran, P. Fu, L.A. Mangio, V. Suryadevara, A.W. Ha, E. Berdyshev, P.P. Van Veldhoven, S.J. Kron, F. Schumacher, B. Kleuser, and V. Natarajan, Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell Biochem Biophys, 2021. 79(3): p. 575-592.

161. Di Cristo, L., A.G. Oomen, S. Dekkers, C. Moore, W. Rocchia, F. Murphy, H.J. Johnston, G. Janer, A. Haase, V. Stone, and S. Sabella, Grouping Hypotheses and an Integrated Approach to Testing and Assessment of Nanomaterials Following Oral Ingestion. Nanomaterials (Basel), 2021. 11(10).

162. Chu, C., S. Zeng, A.A. Hasan, C.F. Hocher, B.K. Krämer, and B. Hocher, Comparison of infection risks and clinical outcomes in patients with and without SARS-CoV-2 lung infection under renin-angiotensin-aldosterone system blockade: Systematic review and meta-analysis. Br J Clin Pharmacol, 2021. 87(6): p. 2475-2492.

163. Chu, C., S. Elitok, S. Zeng, Y. Xiong, C.F. Hocher, A.A. Hasan, B.K. Krämer, and B. Hocher, C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival. BMC Nephrol, 2021. 22(1): p. 125.

164. Carstens, H., K. Kalka, R. Verhaegh, F. Schumacher, M. Soddemann, B. Wilker, S. Keitsch, C. Sehl, B. Kleuser, T. Wahlers, G. Reiner, A. Koch, U. Rauen, E. Gulbins, and M. Kamler, Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs. Sci Rep, 2021. 11(1): p. 18607.

165. Brandão, F., C. Costa, M.J. Bessa, E. Dumortier, F. Debacq-Chainiaux, R. Hubaux, M. Salmon, J. Laloy, M.S. Stan, A. Hermenean, S. Gharbia, A. Dinischiotu, A. Bannuscher, B. Hellack, A. Haase, S. Fraga, and J.P. Teixeira, Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO(2) NM). Nanomaterials (Basel), 2021. 11(6).

166. Beckmann, N., F. Schumacher, B. Kleuser, E. Gulbins, V. Nomellini, and C.C. Caldwell, Burn Injury Impairs Neutrophil Chemotaxis Through Increased Ceramide. Shock, 2021. 56(1): p. 125-132.