2023

1. Zuo, J., A.A. Hasan, C.F. Hocher, P. Kalk, B. Kleuser, B.K. Krämer, and B. Hocher, Inverse correlation of intact PTH, oxidized PTH as well as non-oxidized PTH with 25-hydroxyvitamin D3 in kidney transplant recipients. Front Endocrinol (Lausanne), 2023. 14: p. 1178166.

2. Zoicas, I., C. Mühle, F. Schumacher, B. Kleuser, and J. Kornhuber, Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism. Cells, 2023. 12(10).

3. Zabihi, F., Z. Tu, S. Kaessmeyer, F. Schumacher, F. Rancan, B. Kleuser, C. Boettcher, K. Ludwig, J. Plendl, S. Hedtrich, A. Vogt, and R. Haag, Efficient skin interactions of graphene derivatives: challenge, opportunity or both? Nanoscale Adv, 2023. 5(21): p. 5923-5931.

4. Wohlleben, W., A. Mehling, and R. Landsiedel, Lessons Learned from the Grouping of Chemicals to Assess Risks to Human Health. Angew Chem Int Ed Engl, 2023. 62(22): p. e202210651.

5. Wilhelmi, P., V. Giri, F.M. Zickgraf, V. Haake, S. Henkes, P. Driemert, P. Michaelis, W. Busch, S. Scholz, B. Flick, M. Barenys, B. Birk, H. Kamp, R. Landsiedel, and D. Funk-Weyer, A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. Chem Biol Interact, 2023. 382: p. 110565.

6. Tran, P.T., P. Tawornchat, B. Kleuser, S.B. Lohan, J. Schleusener, M.C. Meinke, and M.E. Darvin, Red- and Near-Infrared-Excited Autofluorescence as a Marker for Acute Oxidative Stress in Skin Exposed to Cigarette Smoke Ex Vivo and In Vivo. Antioxidants (Basel), 2023. 12(5).

7. Ramirez-Hincapie, S., B. Birk, P. Ternes, V. Giri, F.M. Zickgraf, V. Haake, M. Herold, H. Kamp, P. Driemert, R. Landsiedel, E. Richling, D. Funk-Weyer, and B. van Ravenzwaay, Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin. Arch Toxicol, 2023. 97(11): p. 2903-2917.

8. Ramirez-Hincapie, S., B. Birk, P. Ternes, V. Giri, V. Haake, M. Herold, F.M. Zickgraf, A. Verlohner, H.A. Huener, H. Kamp, P. Driemert, R. Landsiedel, E. Richling, D. Funk-Weyer, and B. van Ravenzwaay, A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity. Cell Biol Toxicol, 2023.

9. Otte, J.C., H.M. Hollnagel, C. Nagel, R.F. Gerhardt, W. Wohlleben, N. Vallotton, D. Schowanek, G. Sanders, J.M. Frasca, T. Mahale, M. Pemberton, B. Hidding, and R. Landsiedel, Three-tiered approach for standard information requirements for polymers requiring registration under REACH. Regul Toxicol Pharmacol, 2023. 144: p. 105495.

10. Nieschalke, K., N. Bergau, S. Jessel, A. Seidel, S. Baldermann, M. Schreiner, K. Abraham, A. Lampen, B.H. Monien, B. Kleuser, H. Glatt, and F. Schumacher, Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans. Chem Res Toxicol, 2023. 36(11): p. 1753-1767.

11. Kolle, S.N., M. Flach, M. Kleber, D.A. Basketter, B. Wareing, A. Mehling, L. Hareng, N. Watzek, S. Bade, D. Funk-Weyer, and R. Landsiedel, Plant extracts, polymers and new approach methods: Practical experience with skin sensitization assessment. Regul Toxicol Pharmacol, 2023. 138: p. 105330.

12. Kleuser, B., F. Schumacher, and E. Gulbins, New Therapeutic Options in Pulmonal Diseases: Sphingolipids and Modulation of Sphingolipid Metabolism. Handb Exp Pharmacol, 2023.

13. Kleuser, B. and W. Bäumer, Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases. Int J Mol Sci, 2023. 24(2).

14. Keller, J.G., M. Persson, P. Müller, L. Ma-Hock, K. Werle, J. Arts, R. Landsiedel, and W. Wohlleben, Corrigendum to variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity [NanoImpact 23 (2021) 100341]. NanoImpact, 2023. 29: p. 100455.

15. Dimitrijevic, D., E. Fabian, D. Funk-Weyer, and R. Landsiedel, Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma. Biochem Biophys Res Commun, 2023. 651: p. 114-120.

16. Chen, X., D. Delić, Y. Cao, L. Shen, Q. Shao, Z. Zhang, H. Wu, A.A. Hasan, C. Reichetzeder, M.M.S. Gaballa, B.K. Krämer, T. Klein, L. Yin, B. He, S. Morgera, and B. Hocher, Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system. Am J Physiol Cell Physiol, 2023. 324(4): p. C951-c962.

17. Braakhuis, H.M., E.R. Gremmer, A. Bannuscher, B. Drasler, S. Keshavan, B. Rothen-Rutishauser, B. Birk, A. Verlohner, R. Landsiedel, K. Meldrum, S.H. Doak, M.J.D. Clift, J.S. Erdem, O.A.H. Foss, S. Zienolddiny-Narui, T. Serchi, E. Moschini, P. Weber, S. Burla, P. Kumar, O. Schmid, E. Zwart, J.P. Vermeulen, and R.J. Vandebriel, Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact, 2023. 31: p. 100466.

18. Bloch, D., P. Diel, B. Epe, M. Hellwig, A. Lampen, A. Mally, D. Marko, M.A. Villar Fernández, S. Guth, A. Roth, R. Marchan, A. Ghallab, C. Cadenas, P. Nell, N. Vartak, C. van Thriel, A. Luch, S. Schmeisser, M. Herzler, R. Landsiedel, M. Leist, P. Marx-Stoelting, T. Tralau, and J.G. Hengstler, Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Arch Toxicol, 2023. 97(11): p. 3005-3017.

2022

19. Zuo, J., L. Chaykovska, C. Chu, X. Chen, A.A. Hasan, B.K. Krämer, M. Tepel, and B. Hocher, Head-to-Head Comparison of Oxidative Stress Biomarkers for All-Cause Mortality in Hemodialysis Patients. Antioxidants (Basel), 2022. 11(10).

20. Zhang, X., L. Liu, M.M.S. Gaballa, A.A. Hasan, Y. Xiong, L. Xie, T. Klein, D. Delic, B. Kleuser, B.K. Krämer, J. Li, and B. Hocher, Impact of Salt Intake and Renin-Angiotensin-Aldosterone System Blockade on Lung Severe Acute Respiratory Syndrome Coronavirus 2 Host Factors. Kidney Blood Press Res, 2022. 47(9): p. 565-575.

21. Zhang, X., A.A. Hasan, H. Wu, M.M.S. Gaballa, S. Zeng, L. Liu, L. Xie, T. Jung, T. Grune, B.K. Krämer, B. Kleuser, J. Li, and B. Hocher, High-fat, sucrose and salt-rich diet during rat spermatogenesis lead to the development of chronic kidney disease in the female offspring of the F2 generation. Faseb j, 2022. 36(4): p. e22259.

22. Zeng, S., D. Delic, C. Chu, Y. Xiong, T. Luo, X. Chen, M.M.S. Gaballa, Y. Xue, X. Chen, Y. Cao, A.A. Hasan, K. Stadermann, S. Frankenreiter, L. Yin, B.K. Krämer, T. Klein, and B. Hocher, Antifibrotic effects of low dose SGLT2 Inhibition with empagliflozin in comparison to Ang II receptor blockade with telmisartan in 5/6 nephrectomised rats on high salt diet. Biomed Pharmacother, 2022. 146: p. 112606.

23. Xiong, Y., D. Delic, S. Zeng, X. Chen, C. Chu, A.A. Hasan, B.K. Krämer, T. Klein, L. Yin, and B. Hocher, Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker. BMC Nephrol, 2022. 23(1): p. 117.

24. Westhölter, D., F. Schumacher, N. Wülfinghoff, S. Sutharsan, S. Strassburg, B. Kleuser, P.A. Horn, S. Reuter, E. Gulbins, C. Taube, and M. Welsner, CFTR modulator therapy alters plasma sphingolipid profiles in people with cystic fibrosis. J Cyst Fibros, 2022. 21(4): p. 713-720.

25. Weber, A.G., B. Birk, C. Müller, S. Schneider, B. van Ravenzwaay, D. Funk-Weyer, and R. Landsiedel, The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles. Chem Biol Interact, 2022. 351: p. 109709.

26. Tran, P.T., B. Beidoun, S.B. Lohan, R. Talbi, B. Kleuser, M. Seifert, K. Jung, G. Sandig, and M.C. Meinke, Establishment of a method to expose and measure pollution in excised porcine skin with electron paramagnetic resonance spectroscopy. Ecotoxicol Environ Saf, 2022. 247: p. 114258.

27. Schumacher, F., M.J. Edwards, C. Mühle, A. Carpinteiro, G.C. Wilson, B. Wilker, M. Soddemann, S. Keitsch, N. Scherbaum, B.W. Müller, U.E. Lang, C. Linnemann, B. Kleuser, C.P. Müller, J. Kornhuber, and E. Gulbins, Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice. J Biol Chem, 2022. 298(8): p. 102185.

28. Schumacher, F., A. Carpinteiro, M.J. Edwards, G.C. Wilson, S. Keitsch, M. Soddemann, B. Wilker, B. Kleuser, K.A. Becker, C.P. Müller, J. Kornhuber, and E. Gulbins, Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. J Mol Med (Berl), 2022. 100(10): p. 1493-1508.

29. Schulz, J., R. Michelet, J.F. Joseph, M. Zeitlinger, F. Schumacher, G. Mikus, and C. Kloft, A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications. J Pharm Biomed Anal, 2022. 210: p. 114551.

30. Radbruch, M., H. Pischon, F. Du, R. Haag, F. Schumacher, B. Kleuser, L. Mundhenk, and A.D. Gruber, Biodegradable core-multishell nanocarrier: Topical tacrolimus delivery for treatment of dermatitis. J Control Release, 2022. 349: p. 917-928.

31. Putra, S.E.D., C. Reichetzeder, K. von Websky, C. Neuber, H. Halle, B. Kleuser, B.K. Krämer, and B. Hocher, Association between placental global DNA methylation and blood pressure during human pregnancy. J Hypertens, 2022. 40(5): p. 1002-1009.

32. Péricat, D., S.A. Leon-Icaza, M. Sanchez Rico, C. Mühle, I. Zoicas, F. Schumacher, R. Planès, R. Mazars, G. Gros, A. Carpinteiro, K.A. Becker, J. Izopet, N. Strub-Wourgaft, P. Sjö, O. Neyrolles, B. Kleuser, F. Limosin, E. Gulbins, J. Kornhuber, E. Meunier, N. Hoertel, and C. Cougoule, Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model. Int J Mol Sci, 2022. 23(21).

33. Oesch, F., N. Honarvar, E. Fabian, L. Finch, S. Hindle, K. Wiench, and R. Landsiedel, Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione. Arch Toxicol, 2022. 96(9): p. 2573-2587.

34. Neuhaus, W., B. Reininger-Gutmann, B. Rinner, R. Plasenzotti, D. Wilflingseder, J. De Kock, T. Vanhaecke, V. Rogiers, D. Jírová, K. Kejlová, L.E. Knudsen, R.N. Nielsen, B. Kleuser, V. Kral, C. Thöne-Reineke, T. Hartung, G. Pallocca, C. Rovida, M. Leist, S. Hippenstiel, A. Lang, I. Retter, S. Krämer, P. Jedlicka, K. Ameli, E. Fritsche, J. Tigges, E. Kuchovská, M. Buettner, A. Bleich, N. Baumgart, J. Baumgart, M.W. Meinhardt, R. Spanagel, S. Chourbaji, B. Kränzlin, B. Seeger, M. von Köckritz-Blickwede, J.M. Sánchez-Morgado, V. Galligioni, D. Ruiz-Pérez, D. Movia, A. Prina-Mello, A. Ahluwalia, V. Chiono, A.C. Gutleb, M. Schmit, B. van Golen, L. van Weereld, A. Kienhuis, E. van Oort, J. van der Valk, A. Smith, J. Roszak, M. Stępnik, Z. Sobańska, E. Reszka, I.A.S. Olsson, N.H. Franco, B. Sevastre, H. Kandarova, S. Capdevila, J. Johansson, E. Svensk, C.R. Cederroth, J. Sandström, I. Ragan, N. Bubalo, J. Kurreck, and H. Spielmann, The Current Status and Work of Three Rs Centres and Platforms in Europe. Altern Lab Anim, 2022. 50(6): p. 381-413.

35. Neuhaus, W., B. Reininger-Gutmann, B. Rinner, R. Plasenzotti, D. Wilflingseder, J. De Kock, T. Vanhaecke, V. Rogiers, D. Jírová, K. Kejlová, L.E. Knudsen, R.N. Nielsen, B. Kleuser, V. Kral, C. Thöne-Reineke, T. Hartung, G. Pallocca, M. Leist, S. Hippenstiel, A. Lang, I. Retter, S. Krämer, P. Jedlicka, K. Ameli, E. Fritsche, J. Tigges, M. Buettner, A. Bleich, N. Baumgart, J. Baumgart, M.W. Meinhardt, R. Spanagel, S. Chourbaji, B. Kränzlin, B. Seeger, M. von Köckritz-Blickwede, J.M. Sánchez-Morgado, V. Galligioni, D. Ruiz-Pérez, D. Movia, A. Prina-Mello, A. Ahluwalia, V. Chiono, A.C. Gutleb, M. Schmit, B. van Golen, L. van Weereld, A. Kienhuis, E. van Oort, J. van der Valk, A. Smith, J. Roszak, M. Stępnik, Z. Sobańska, I.A.S. Olsson, N.H. Franco, B. Sevastre, H. Kandarova, S. Capdevila, J. Johansson, C.R. Cederroth, J. Sandström, I. Ragan, N. Bubalo, and H. Spielmann, The Rise of Three Rs Centres and Platforms in Europe. Altern Lab Anim, 2022. 50(2): p. 90-120.

36. Mohamud Yusuf, A., N. Hagemann, X. Zhang, M. Zafar, T. Hussner, C. Bromkamp, C. Martiny, T. Tertel, V. Börger, F. Schumacher, F.A. Solari, M. Hasenberg, C. Kleinschnitz, T.R. Doeppner, B. Kleuser, A. Sickmann, M. Gunzer, B. Giebel, R. Kolesnick, E. Gulbins, and D.M. Hermann, Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. Basic Res Cardiol, 2022. 117(1): p. 43.

37. Lu, Y.P., H.W. Wu, T. Zhu, X.T. Li, J. Zuo, A.A. Hasan, C. Reichetzeder, D. Delic, B. Yard, T. Klein, B.K. Krämer, Z.Y. Zhang, X.H. Wang, L.H. Yin, Y. Dai, Z.H. Zheng, and B. Hocher, Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy. Biomed Pharmacother, 2022. 156: p. 113947.

38. Landsiedel, R., N. Honarvar, S.B. Seiffert, B. Oesch, and F. Oesch, Genotoxicity testing of nanomaterials. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2022. 14(6): p. e1833.

39. Landsiedel, R., D. Hahn, R. Ossig, S. Ritz, L. Sauer, R. Buesen, S. Rehm, W. Wohlleben, S. Groeters, V. Strauss, S. Sperber, H. Wami, U. Dobrindt, K. Prior, D. Harmsen, B. van Ravenzwaay, and J. Schnekenburger, Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects. Part Fibre Toxicol, 2022. 19(1): p. 21.

40. Landsiedel, R., B. Birk, and D. Funk-Weyer, The Evolution of Regulatory Toxicology: Where is the Gardener? Altern Lab Anim, 2022. 50(4): p. 255-262.

41. Kyriakoudi, S., A. Theodoulou, L. Potamiti, F. Schumacher, M. Zachariou, R. Papacharalambous, B. Kleuser, M.I. Panayiotidis, A. Drousiotou, and P.P. Petrou, Stbd1-deficient mice display insulin resistance associated with enhanced hepatic ER-mitochondria contact. Biochimie, 2022. 200: p. 172-183.

42. Kadow, S., F. Schumacher, M. Kramer, G. Hessler, R. Scholtysik, S. Oubari, P. Johansson, A. Hüttmann, H.C. Reinhardt, B. Kleuser, M. Zoratti, A. Mattarei, I. Szabò, E. Gulbins, and A. Carpinteiro, Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma. Cancers (Basel), 2022. 14(8).

43. Hose, M., A. Günther, E. Naser, F. Schumacher, T. Schönberger, J. Falkenstein, A. Papadamakis, B. Kleuser, K.A. Becker, E. Gulbins, A. Haimovitz-Friedman, J. Buer, A.M. Westendorf, and W. Hansen, Cell-intrinsic ceramides determine T cell function during melanoma progression. Elife, 2022. 11.

44. Holle, J., H. Bartolomaeus, U. Löber, F. Behrens, T.U.P. Bartolomaeus, H. Anandakumar, M.I. Wimmer, D.L. Vu, M. Kuhring, U. Brüning, A. Maifeld, S. Geisberger, S. Kempa, F. Schumacher, B. Kleuser, P. Bufler, U. Querfeld, S. Kitschke, D. Engler, L.D. Kuhrt, O. Drechsel, K.U. Eckardt, S.K. Forslund, A. Thürmer, V. McParland, J.A. Kirwan, N. Wilck, and D. Müller, Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance. J Am Soc Nephrol, 2022. 33(12): p. 2259-2275.

45. Hochrein, S.M., H. Wu, M. Eckstein, L. Arrigoni, J.S. Herman, F. Schumacher, C. Gerecke, M. Rosenfeldt, D. Grün, B. Kleuser, G. Gasteiger, W. Kastenmüller, B. Ghesquière, J. Van den Bossche, E.D. Abel, and M. Vaeth, The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. Cell Metab, 2022. 34(4): p. 516-532.e11.

46. Hocher, B., Y.P. Lu, C. Reichetzeder, X. Zhang, O. Tsuprykov, J. Rahnenführer, L. Xie, J. Li, L. Hu, B.K. Krämer, and A.A. Hasan, Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself. Diabetologia, 2022. 65(7): p. 1222-1236.

47. Hashemi Arani, F., S. Kadow, M. Kramer, S. Keitsch, L. Kirchhoff, F. Schumacher, B. Kleuser, P.M. Rath, E. Gulbins, and A. Carpinteiro, Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp. Int J Mol Sci, 2022. 23(24).

48. Hasan, A.A., C.F. Hocher, B. Kleuser, B.K. Krämer, and B. Hocher, Biological Activity of Different Forms of Oxidized Parathyroid Hormone. Int J Mol Sci, 2022. 23(20).

49. Günther, A., M. Hose, H. Abberger, F. Schumacher, Y. Veith, B. Kleuser, K. Matuschewski, K.S. Lang, E. Gulbins, J. Buer, A.M. Westendorf, and W. Hansen, The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis. Elife, 2022. 11.

50. Gerecke, C., C. Egea Rodrigues, T. Homann, and B. Kleuser, The Role of Ten-Eleven Translocation Proteins in Inflammation. Front Immunol, 2022. 13: p. 861351.

51. Gabbert, S., M. Mathea, S.N. Kolle, and R. Landsiedel, Accounting for Precision Uncertainty of Toxicity Testing: Methods to Define Borderline Ranges and Implications for Hazard Assessment of Chemicals. Risk Anal, 2022. 42(2): p. 224-238.

52. Eder, S., C. Hollmann, P. Mandasari, P. Wittmann, F. Schumacher, B. Kleuser, J. Fink, J. Seibel, J. Schneider-Schaulies, C. Stigloher, N. Beyersdorf, and S. Dembski, Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations. J Funct Biomater, 2022. 13(3).

53. Dimitrijevic, D., E. Fabian, B. Nicol, D. Funk-Weyer, and R. Landsiedel, Toward Realistic Dosimetry In Vitro: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an In Silico Mass Balance Model. Chem Res Toxicol, 2022. 35(11): p. 1962-1973.

54. Chu, C., D. Delić, J. Alber, M. Feger, Y. Xiong, T. Luo, A.A. Hasan, S. Zeng, M.M.S. Gaballa, X. Chen, L. Yin, T. Klein, S. Elitok, B.K. Krämer, M. Föller, and B. Hocher, Head-to-head comparison of two SGLT-2 inhibitors on AKI outcomes in a rat ischemia-reperfusion model. Biomed Pharmacother, 2022. 153: p. 113357.

55. Chu, C., X. Chen, A.A. Hasan, A. Szakallova, B.K. Krämer, M. Tepel, and B. Hocher, Angiopoietin-2 predicts all-cause mortality in male but not female end-stage kidney disease patients on hemodialysis. Nephrol Dial Transplant, 2022. 37(7): p. 1348-1356.

56. Carstens, H., K. Kalka, R. Verhaegh, F. Schumacher, M. Soddemann, B. Wilker, S. Keitsch, C. Sehl, B. Kleuser, M. Hübler, U. Rauen, A.K. Becker, A. Koch, E. Gulbins, and M. Kamler, Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs. PLoS One, 2022. 17(7): p. e0271620.

57. Bernacchioni, C., R. Squecco, T. Gamberi, V. Ghini, F. Schumacher, M. Mannelli, R. Garella, E. Idrizaj, F. Cencetti, E. Puliti, P. Bruni, P. Turano, T. Fiaschi, and C. Donati, S1P Signalling Axis Is Necessary for Adiponectin-Directed Regulation of Electrophysiological Properties and Oxidative Metabolism in C2C12 Myotubes. Cells, 2022. 11(4).

58. Bannuscher, A., O. Schmid, B. Drasler, A. Rohrbasser, H.M. Braakhuis, K. Meldrum, E.P. Zwart, E.R. Gremmer, B. Birk, M. Rissel, R. Landsiedel, E. Moschini, S.J. Evans, P. Kumar, S. Orak, A. Doryab, J.S. Erdem, T. Serchi, R.J. Vandebriel, F.R. Cassee, S.H. Doak, A. Petri-Fink, S. Zienolddiny, M.J.D. Clift, and B. Rothen-Rutishauser, An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact, 2022. 28: p. 100439.

2021

59. Zeng, S., A.A. Hasan, C. Chu, Y. Xiong, J.G. Hocher, S. Elitok, B.K. Krämer, and B. Hocher, Osteoprotegerin is an independent risk factor predicting death in stable renal transplant recipients. Clin Nephrol, 2021. 96(3): p. 129-137.

60. Wigger, D., F. Schumacher, S. Schneider-Schaulies, and B. Kleuser, Sphingosine 1-phosphate metabolism and insulin signaling. Cell Signal, 2021. 82: p. 109959.

61. Wiese, T., F. Dennstädt, C. Hollmann, S. Stonawski, C. Wurst, J. Fink, E. Gorte, P. Mandasari, K. Domschke, L. Hommers, B. Vanhove, F. Schumacher, B. Kleuser, J. Seibel, J. Rohr, M. Buttmann, A. Menke, J. Schneider-Schaulies, and N. Beyersdorf, Inhibition of acid sphingomyelinase increases regulatory T cells in humans. Brain Commun, 2021. 3(2): p. fcab020.

62. Wetzel, A., B. Scholtka, F. Schumacher, H. Rawel, B. Geisendörfer, and B. Kleuser, Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis. Int J Mol Sci, 2021. 22(10).

63. Wardelmann, K., M. Rath, J.P. Castro, S. Blümel, M. Schell, R. Hauffe, F. Schumacher, T. Flore, K. Ritter, A. Wernitz, T. Hosoi, K. Ozawa, B. Kleuser, J. Weiß, A. Schürmann, and A. Kleinridders, Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants (Basel), 2021. 10(5).

64. Ulrey, A., S. Kolle, R. Landsiedel, and E. Hill, How a GIVIMP certification program can increase confidence in in vitro methods. Altex, 2021. 38(2): p. 316-318.

65. Stratmann, H., W. Wohlleben, M. Wiemann, A. Vennemann, N. End, U. Veith, L. Ma-Hock, and R. Landsiedel, Classes of organic pigments meet tentative PSLT criteria and lack toxicity in short-term inhalation studies. Regul Toxicol Pharmacol, 2021. 124: p. 104988.

66. Stepanovska Tanturovska, B., A. Zivkovic, F. Imeri, T. Homann, B. Kleuser, H. Stark, and A. Huwiler, ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P(1) Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 2021. 26(17).

67. Spohner, A.K., K. Jakobi, S. Trautmann, D. Thomas, F. Schumacher, B. Kleuser, D. Lütjohann, K. El-Hindi, S. Grösch, J. Pfeilschifter, J.D. Saba, and D. Meyer Zu Heringdorf, Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Int J Mol Sci, 2021. 22(19).

68. Seibel, J., S. Schneider-Schaulies, and B. Kleuser, Editorial: Sphingolipids in Infection Control. Front Cell Dev Biol, 2021. 9: p. 697290.

69. Schneider-Schaulies, S., F. Schumacher, D. Wigger, M. Schöl, T. Waghmare, J. Schlegel, J. Seibel, and B. Kleuser, Sphingolipids: Effectors and Achilles Heals in Viral Infections? Cells, 2021. 10(9).

70. Prakash, H., D. Upadhyay, O.R. Bandapalli, A. Jain, and B. Kleuser, Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease. Prostaglandins Other Lipid Mediat, 2021. 152: p. 106504.

71. Peters, S., L. Kaiser, J. Fink, F. Schumacher, V. Perschin, J. Schlegel, M. Sauer, C. Stigloher, B. Kleuser, J. Seibel, and A. Schubert-Unkmeir, Click-correlative light and electron microscopy (click-AT-CLEM) for imaging and tracking azido-functionalized sphingolipids in bacteria. Sci Rep, 2021. 11(1): p. 4300.

72. Oesch, F., N. Honarvar, E. Fabian, F.I. Berger, and R. Landsiedel, N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity. Arch Toxicol, 2021. 95(10): p. 3143-3159.

73. Oesch, F., D. Fruth, J.G. Hengstler, E. Fabian, F.I. Berger, and R. Landsiedel, Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat. Arch Toxicol, 2021. 95(12): p. 3717-3744.

74. Natsch, A., R. Landsiedel, and S.N. Kolle, A triangular approach for the validation of new approach methods for skin sensitization. Altex, 2021. 38(4): p. 669-677.

75. Ma-Hock, L., U.G. Sauer, E. Ruggiero, J.G. Keller, W. Wohlleben, and R. Landsiedel, The Use of Nanomaterial In Vivo Organ Burden Data for In Vitro Dose Setting. Small, 2021. 17(15): p. e2005725.

76. Kolle, S.N. and R. Landsiedel, Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh. Handb Exp Pharmacol, 2021. 265: p. 3-27.

77. Keller, J.G., M. Wiemann, S. Gröters, K. Werle, A. Vennemann, R. Landsiedel, and W. Wohlleben, Aerogels are not regulated as nanomaterials, but can be assessed by tiered testing and grouping strategies for nanomaterials. Nanoscale Adv, 2021. 3(13): p. 3881-3893.

78. Keller, J.G., D.F. Quevedo, L. Faccani, A.L. Costa, R. Landsiedel, K. Werle, and W. Wohlleben, Dosimetry in vitro - exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods. Nanotoxicology, 2021. 15(1): p. 21-34.

79. Keller, J.G., M. Persson, P. Müller, L. Ma-Hock, K. Werle, J. Arts, R. Landsiedel, and W. Wohlleben, Variation in dissolution behavior among different nanoforms and its implication for grouping approaches in inhalation toxicity. NanoImpact, 2021. 23: p. 100341.

80. Keller, J.G., U.M. Graham, J. Koltermann-Jülly, R. Gelein, L. Ma-Hock, R. Landsiedel, M. Wiemann, G. Oberdörster, A. Elder, and W. Wohlleben, Author Correction: Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulphate. Sci Rep, 2021. 11(1): p. 8813.

81. Kalinichenko, L.S., L. Abdel-Hafiz, A.L. Wang, C. Mühle, N. Rösel, F. Schumacher, B. Kleuser, I. Smaga, M. Frankowska, M. Filip, G. Schaller, T. Richter-Schmidinger, B. Lenz, E. Gulbins, J. Kornhuber, A.W.C. Oliveira, M. Barros, J.P. Huston, and C.P. Müller, Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and Memory. Cereb Cortex, 2021. 31(2): p. 1316-1333.

82. Janer, G., R. Landsiedel, and W. Wohlleben, Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH. Nanotoxicology, 2021. 15(2): p. 145-166.

83. Janer, G., D. Ag-Seleci, J.A. Sergent, R. Landsiedel, and W. Wohlleben, Creating sets of similar nanoforms with the ECETOC NanoApp: real-life case studies. Nanotoxicology, 2021. 15(8): p. 1016-1034.

84. Imeri, F., B. Stepanovska Tanturovska, A. Zivkovic, G. Enzmann, S. Schwalm, J. Pfeilschifter, T. Homann, B. Kleuser, B. Engelhardt, H. Stark, and A. Huwiler, Novel compounds with dual S1P receptor agonist and histamine H(3) receptor antagonist activities act protective in a mouse model of multiple sclerosis. Neuropharmacology, 2021. 186: p. 108464.

85. Garcia de Lomana, M., A.G. Weber, B. Birk, R. Landsiedel, J. Achenbach, K.J. Schleifer, M. Mathea, and J. Kirchmair, In Silico Models to Predict the Perturbation of Molecular Initiating Events Related to Thyroid Hormone Homeostasis. Chem Res Toxicol, 2021. 34(2): p. 396-411.

86. Garcia de Lomana, M., A. Morger, U. Norinder, R. Buesen, R. Landsiedel, A. Volkamer, J. Kirchmair, and M. Mathea, ChemBioSim: Enhancing Conformal Prediction of In Vivo Toxicity by Use of Predicted Bioactivities. J Chem Inf Model, 2021. 61(7): p. 3255-3272.

87. Fink, J., F. Schumacher, J. Schlegel, P. Stenzel, D. Wigger, M. Sauer, B. Kleuser, and J. Seibel, Azidosphinganine enables metabolic labeling and detection of sphingolipid de novo synthesis. Org Biomol Chem, 2021. 19(10): p. 2203-2212.

88. Ebenezer, D.L., R. Ramchandran, P. Fu, L.A. Mangio, V. Suryadevara, A.W. Ha, E. Berdyshev, P.P. Van Veldhoven, S.J. Kron, F. Schumacher, B. Kleuser, and V. Natarajan, Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell Biochem Biophys, 2021. 79(3): p. 575-592.

89. Chu, C., S. Zeng, A.A. Hasan, C.F. Hocher, B.K. Krämer, and B. Hocher, Comparison of infection risks and clinical outcomes in patients with and without SARS-CoV-2 lung infection under renin-angiotensin-aldosterone system blockade: Systematic review and meta-analysis. Br J Clin Pharmacol, 2021. 87(6): p. 2475-2492.

90. Chu, C., S. Elitok, S. Zeng, Y. Xiong, C.F. Hocher, A.A. Hasan, B.K. Krämer, and B. Hocher, C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival. BMC Nephrol, 2021. 22(1): p. 125.

91. Carstens, H., K. Kalka, R. Verhaegh, F. Schumacher, M. Soddemann, B. Wilker, S. Keitsch, C. Sehl, B. Kleuser, T. Wahlers, G. Reiner, A. Koch, U. Rauen, E. Gulbins, and M. Kamler, Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs. Sci Rep, 2021. 11(1): p. 18607.

92. Beckmann, N., F. Schumacher, B. Kleuser, E. Gulbins, V. Nomellini, and C.C. Caldwell, Burn Injury Impairs Neutrophil Chemotaxis Through Increased Ceramide. Shock, 2021. 56(1): p. 125-132.

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