- For upcoming "Termine/Events" and "News" of the current month: see teasers on the right
- For past "Termine/Events" of the current and former months: click here or see below
- For "Termine/Events" and "News" of the last years: click on Archiv/Archive:
PharMetrX Industry 1 module in November
From 04 – 08 November 2019, the PharMetrX Industry Module 1 (the “I1 module”) entitled “Drug discovery & development – Walking along the value chain” will take place for the PharMetrX PhD Student Years 2018 and 2019 and will kindly be hosted by the PharMetrX Industry partners Boehringer Ingelheim (Biberach an der Riss) and AbbVie (Ludwigshafen). For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de
Guest visit of Dr. Joachim Grevel, UK
On the 29 October 2019, Dr. Joachim Grevel, an expert in pharmacometric modelling and simulation, from BAST Inc. (Loughborough, UK) will visit our group. During his visit, he will give a presentation entitled “Treatment effectiveness, the patient’s perspective”, providing insights into modelling approaches to objectively evaluate the benefit of treatment regimens with consideration of multiple treatment end points e.g. toxicity or efficacy. We will further discuss the possibility of integrating these approaches into some of our ongoing projects.
Presentations at Iberoamerican Pharmacometrics Network Congress 2019
A member of our working group, Dr. Robin Michelet, will present his work at the annual meeting of Iberoamerican Pharmacometrics Network (RedIF) in Havanna, Cuba. The main topic of the meeting, which takes place from 27-30 October this year is “Pharmacometrics in the Developing World: Translational M&S and Virtual Bioequivalence”.
Presentations at ACoP10
Franziska Kluwe, doctoral student of our working group, and Lena Klopp-Schulze, former doctoral student of our working group, will present their work at the 10th American Conference on Pharmacometrics (ACoP10), 20-23 October 2019, at the Rosen Shingle Creek Hotel in Orlando, FL. ACoP is the annual scientific meeting of the International Society of Pharmacometrics (ISoP). The theme of ACoP10 is “Modeling without Borders”. This theme was chosen to highlight ISoP’s 2019 objectives of “globalization and collaboration” of pharmacometrics groups, methods, tools and its impact on Global Health. Franziska’s poster was selected to be presented during the newly established poster walk session, 20 October 2019 8.00 PM, to highlight and recognize significant and thought-provoking accomplishments in pharmacometrics.
Defence of Master thesis
The defence of the Master thesis by Claas Hedtfeld on “Investigation of growth and kill behaviour of Escherichia coli under levofloxacin exposure in the static in vitro infection model” will take place in room 404A in the Institute of Pharmacy, Kelchstr. 31, 12169 Berlin, on Tuesday, 15 Oct 2019, at 14:30. Guests are welcome!
BCP Graduate Center officially opened!
On 10 October, the Department of Biology, Chemistry and Pharmacy celebrated the opening ceremony of its new graduate center. Among other alumni, a former PhD student of our group, Dr. Eva Göbgen, gave insights in her work in a presentation, followed by a plenary discussion.
Presentation at ESMO 2019
Anna Mueller-Schoell, doctoral student of our Department, will present her joint work with Dr. Lena Klopp Schulze (former doctoral student of the working group) on “Patient-tailored tamoxifen dosing based on an increased quantitative understanding of its complex pharmacokinetics: A novel integrative modelling approach “ at the ESMO Annual Meeting, 27 September-01 October 2019, in Barcelona, Spain. The European Society for Medical Oncology (ESMO) is the leading European professional organisation for medical oncology. The theme of this year’s annual meeting is “Translating science into better patient care”.
PharMetrX A4 module
From 16–20 September 2019, the PharMetrX A4 module “Introduction to Systems Biology” will take place at the University of Potsdam. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
Presentations at CESAR Annual Meeting 2019
Three PhD students of our working group, Francis Williams Ojara, Anna Mueller-Schoell and Yomna M Nassar, and Prof. Charlotte Kloft will attend this year’s annual meeting of the Central European Society for Anticancer Drug Research (CESAR) in Oldenburg. The students will present their PhD work at the meeting. The main topic of the meeting this year is “From bench to real world data”. Together with Prof. Jaehde, Prof. Kloftwill host a session on “Model-informed Therapeutic Drug Monitoring: benefit for the patient – The CESAR consortium” on Friday, 13 September 2019.
Presentations at DPhG Annual Meeting 2019
Five PhD students of our working group, David Busse, Luis Ilia, Anna Mueller-Schoell, Josefine Schulz and Johanna Seeger will present their work at the Annual meeting of the German Pharmaceutical Society (DPhG) in Heidelberg. The main topic of the meeting this year is “Pharmaceutical Research: From basic research to medical applications”. Charlotte Kloft will host a session together with Thorsten Lehr(Saarland University) on “Challenges and opportunities in model based dose adaptation” on Wednesday, 4 September.
Apply now! Application period for doctoral studies in PharMetrX now open
Are you about to finish or have you just finished your studies in pharmacy, pharmaceutical sciences, mathematics, bioinformatics, or some related field? The PharMetrX program (www.PharMetrX.de) calls for applications for the:
PharMetrX Research+ Program: You are looking for a PhD +++ in a fascinating and prosperous research area +++ within two truly trans-disciplinary research groups +++ supervised by leading experts in their fields +++ with an industry mentor +++ in the vibrant Berlin/Potsdam area +++ supported by a specifically tailored training program of academic and industrial modules +++ embedded into a network of peers +++ supported a 3.5 year competitive fellowship?
PharMetrX Training+ Program: You have already started your PhD in the field of pharmacometrics (or will do so soon) and are looking +++ for a specifically tailored training program of compact modules that convey the foundations in pharmacokinetics & pharmacodynamics, systems biology, statistics etc. +++ and a network of peers to exchange with?
The application period is open from 15 July – 15 September 2019.
PhD student awarded “Best Abstract award” at CESAR Annual Meeting
Anna Mueller-Schoell, doctoral student at our Department, was awarded the “Best abstract award for young scientists” for her work on “Assessing the impact of non-adherence on endoxifen target attainment in tamoxifen breast cancer therapy using a modelling & simulation framework” at the Central European Society for Anticancer Drug Research (CESAR) Annual Meeting 2019.
PharMetrX A3 module
From 19–23 August 2019, the PharMetrX A3 module “Introduction to population analysis” will take place at our Institute. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
Are you interested in learning more about the fascinating field of “pharmacometrics” and the Graduate Research Training Program “PharMetrX”? On 12 August 2019 from 13:00 to 17:00, members of our working group will give an introduction into pharmacometrics and provide an exciting overview about the PharMetrX program. Students from all semesters, other subjects or universities are welcome. Prior registration is required, please contact josefine.schulz[at]fu-berlin.de.
Attendance at Uppsala PMX Summer School
Viktoria Stachanow, PhD student at our working group, will attend the 9th annual Uppsala Pharmacometrics Summer School (UPSS) taking place from 12 – 23 August 2019 at the Uppsala University, Sweden. Beside lectures, hands-on sessions and group works, Viktoria will present parts of her current research work.
Off-site meeting of our Department
From 8-10 August 2019, our working group will retreat to the green areas north of Berlin to discuss the future directions of our Dept. Strategic discussions, critical reflection on the past years and brainstorming for the coming years will be alternated with team-building and social activities. We hope to return to the institute as a freshly energised team full of new ideas.
New scientific publication of Department
The original research article “Development of a dosing algorithm for meropenem in critically ill patients based on a population pharmacokinetic/pharmacodynamic analysis “ by Ehmann, Zoller, Minichmayr, Scharf, Huisinga, Zander and Kloft has been accepted in the International Journal of Antimicrobial Agents, and is now available online.
PhD student of Dept. received the “CIMT poster award”
Anna Mueller-Schoell, PhD student of our department, was awarded the “CIMT poster award” in the category cellular therapy for her work on “CAR-T cell therapy: Investigating clinical challenges using a modelling & simulation framework” at the 17th Annual Meeting of the Association for Cancer Immunotherapy (CIMT) 2019 in Mainz, Germany. Click below to see a short video of her describing her work.
Visit to Prof. Holdenrieder’s group, TU Munich
On 26 July 2019, two doctoral students of our group Francis Williams Ojara and Anna Müller-Schöll will visit Prof. Stefan Holdenrieder’s working group at the Institute of Laboratory Medicine, German Heart Centre, Technical University of Munich. The students will get introduced to different laboratory methods for analysing clinical samples to e.g. quantify biomarkers which are subsequently used in modelling and simulation projects to better describe disease processes and treatment-response relationships. Discussion on ongoing collaborations between the Department of Clinical Pharmacy, Freie Universität Berlin, and the Institute of Laboratory Medicine, German Heart Centre, Technical University of Munich will also be undertaken.
Visit to Grünenthal in Aachen
On 19 July 2019, Ferdinand Weinelt, doctoral student of our Dept. and enrolled in the Graduate Research Training program PharMetrX, will visit his industry mentor Dr. Jan Freijer and the Grünenthal pharmacometrics team in Aachen. Besides individual meetings with team members, Ferdinand will present parts of his research.
Scientific meeting with Pharm. Technology Dept.
On 4 July at 18:00, our working group and the working groups of Professor Bodmeier and Professor Müller from the pharmaceutical technology department will look behind the scenes of the other working groups in order to foster our scientific exchange. Afterwards, we will have a joint “Kelchstraße barbeque”.
The AK Kloft is glad to welcome a new member
In July 2019, a new doctoral student Yomna M. Nassar will join our Department. Her doctoral thesis project will be in the area of pharmacometrics of anticancer drugs.
Participation of the Department at the “Long Night of Science” (LNdW)
During the “Long Night of Science” (Lange Nacht der Wissenschaften, LNdW) Johanna Seeger, Ferdinand Weinelt and multiple undergraduate Pharmacy students presented different aspects of our research to interested visitors at the Institute of Pharmacy. Our group further contributed to a successful night with two interactive presentations, one by Johanna Seeger concerning “Facts & Myths in antibiotic drug therapy” and one by Prof. Kloft with the tile “From mouse to man – how to to translate and scale results from animal trials?”
Visit of Prof. Mikus, Univ. Hospital Heidelberg
On 19 June 2019, Prof. Gerd Mikus from the University Hospital Heidelberg will visit our Department to discuss ongoing collaborations and projects between the Department of Clinical Pharmacy, Freie Universität Berlin, and the Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, as well as insights into the research and teaching concept at our Department.
Inaugural lecture of Hon. Prof. Martin Schulz
On 19 June at 17:00, our newly appointed honorary professor, Prof. Dr. Martin Schulz, will give his inaugural lecture on “Non-adherence in cardiovascular medicine – so what?” in the Big Lecture Hall of the Botanical Museum in Berlin. We are looking forward to new insights in this highly relevant topic and many future lectures and collaboration. An interesting article can be found here.
Contribution at ESDPPP 2019
From 28 – 30 May 2019, the 17th Congress of the European Society For Developmental Perinatal And Paediatric Pharmacology (ESDPPP) congress takes place in Basel, Switzerland. Viktoria Stachanow will give a poster presentation on her work on optimisation of hydrocortisone replacement therapy. Young physicians, pharmacists, pharmacometricians and many other scientists will join the ESDPPP congress in order to present and discuss their latest research results.
Presentation at CIMT Annual Meeting 2019
Anna Müller-Schöll will present her scientific work on CAR-T cells at the 17th Annual Meeting of the Association for Cancer Immunotherapy in Mainz, Germany. The three-day conference is the largest meeting in Europe focussing on cancer immunotherapy research and development.
23rd PK/PD Expert Meeting in Friedrichroda
From 09-11 May 2019, the 23rd PK/PD Expert Meeting will take placeunder the auspices of AGAH in Friedrichroda. Presentations and associated discussions will focus on the topics “Insight in chronobiology and its impact on PK/PD and drug development”, “Make man transparent: application of imaging techniques in biodistribution and pharmacodynamics” and “Oncolytic virus therapy - fighting cancer with good bugs”. From our Department, Prof. Dr. Charlotte Kloft, Dr. Robin Michlet and the PhD students Ana-Marija Grišić, Franziska Kluwe, Francis Williams Ojara, Viktoria Stachanow, Anna Müller-Schöll and David Busse will attend the meeting. For more information: see www.pkpd-expertentreffen.de
8th PharMetrX Symposium at SocraTec
On 09 May 2019, the 8th PharMetrx-Symposium 2019 will take place at SocraTec R&D GmbH, Clinical Pharmacology Unit. Three PharMetrX Research+ doctoral students, Franziska Kluwe, Francis Ojara and Sabine Stübler, will present their scientific work. For more detailed information on the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
Visit of Prof. Derendorf, Dr. Mayer and Dr. Sturm
On 08 May 2019, Prof. Hartmut Derendorf from the University of Florida and Dr. Sonja Mayer and Dr. Christoph Sturm from the Bavarian Pharmacy Chamber (Bayrische Landesapothekerkammer) will visit our Department to discuss the evolvement and current developments in the field of Clinical Pharmacy research and teaching.
Inaugural lecture Hon. Prof. Martin Schulz
In April 2019, Prof. Dr. Martin Schulz, Chair of the Drug Commission of German Pharmacists (Arzneimittelkommission der Deutschen Apotheker, AMK), and outstanding expert in medication adherence, medication safety and pharmacoepidemiology, was appointed Honorary Professor by the Freie Universität Berlin. On 19 June 2019, Prof. Dr. Schulz gave his inaugural lecture with the title "Non-adherence to cardiovascular drugs - so what?"in the Big Lecture Hall of the Botanical Museum in Berlin. Despite the hot temperatures on this summer day, the lecture was highly frequented and well perceived.
PhD student of Dept. received the “Alan Forrest Young Investigator Award”
Sebastian Franck, PhD student of our Department, was awarded the “Alan Forrest Young Investigator Award” for an excellent presentation entitled “Boosting the immune system to enhance amoxicillin activity: Insights provided by semi-mechanistic PK/PD modelling” at the Young Investigator Session of the International Society of Anti-infective Pharmacology (ISAP) annual meeting 2019 in Rotterdam, The Netherlands.
Our former PhD student awarded the “Hanse-Doctoral prize”
Dr. rer. nat. Iris Minichmayr, a former PhD student of our Department who defended her thesis in 2018 at Freie Universitaet Berlin, was awarded the “Hanse-Doctoral prize for Clinical Research in Intensive Care and Emergency Medicine 2019” by theScientific Association for the Promotion of Clinically Applied Research in Intensive Care Medicine for her outstanding her doctoral thesis “Pharmacometrics-based evaluation of antibiotic target site exposure to improve dosing regimens in special populations” accomplished at our Department.
Contribution at ECCMID and ISAP annual meeting 2019
From 12 – 16 April 2019, the ISAP annual meeting and the 29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) takes place in Rotterdam and Amsterdam, Netherlands. Five members of our department, Johanna Seeger, Sebastian Franck, Luis Ilia, Dr. Robin Michelet and Ferdinand Weinelt will present their work during ECCMID as paper posters or ePoster talks. The world’s leading experts will join the most important congress in infectious diseases, infection control and clinical microbiology to present and discuss the latest results.
Honorary professorship awarded to Prof. Martin Schulz
We are happy to announce that on 10 April 2019, a honorary professorship was conferred to Prof. Dr. Martin Schulz, Chair of the Drug Commission of German Pharmacists (Arzneimittelkommission der Deutschen Apotheker, AMK), and outstanding expert in medication adherence, medication safety and pharmacoepidemiology. We are looking forward to strengthen the fruitful collaborations in research and teaching between Prof Schulz, our Dept, Institute and University.
PharMetrX I2 module (“Industry internship”) at Boehringer Ingelheim
As part of the structured PhD program PharMetrX, Franziska Kluwe, doctoral student in the area of pharmacometrics, will join the pharmacometrics team at Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß/Germany, as an intern from February to April 2019.
For more information about PharMetrX and the I2 module, please visit: https://www.pharmetrx.de/training/curriculum/intership-industry-partners.html.
PharMetrX Module Curriculum: A2 module
From 25-29 March 2019, the PharMetrX A2 module “Introduction to physiologically-based pharmacokinetics” will take place at the Universitaet Potsdam. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
Oral presentation at Digestive Disease Week 2019
Our work entitled “Infliximab clearance is decreased during 2nd and 3rd trimesters of pregnancy in inflammatory bowel disease” performed in collaboration with Herlev Hospital (Denmark) and Sheba Medical Centre (Israel) has been selected for oral presentation at the Digestive Disease Week in San Diego, CA, USA. The presentation will take place on 18 May 2019 as part of the session “The Pregnant Patient: Therapy and Diagnostics”.
PharMetrX Module Curriculum: Kick-off
From 11 – 15 March 2019, the PharMetrX Module Curriculum for the new PhD student year of our program will start with the A1 module “Introduction to pharmacokinetics and pharmacodynamics” taking place at our Institute. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de
Presentations at AMR Conference 2019, Berlin
The Senior Scientist of our working group, Dr. Robin Michelet, will present the results of the joint “COMBINATORIALS” research consortium project at the 12th Conference on Life Sciences on Novel Antimicrobials & AMR Diagnostics in Berlin. The topic of his oral presentation is “Applying the general pharmacodynamic interaction model on high-throughput combinatorial data in order to identify drug combinations that can overcome multi-drug-resistance”.
New scientific publication of Department
The manuscript, “High voriconazole target-site exposure after approved sequence dosing due to nonlinear pharmacokinetics assessed by long-term microdialysis” by Kirbs et al. has been published in the Eur. J. Pharm. Sci (doi: 10.1016/j.ejps.2019.02.001). A key component of the analysis was the evaluation of the relationship between CYP2C19 genotype-predicted phenotype and voriconazole clearance.
The AK Kloft is glad to welcome a new member
In March 2019, a new doctoral student Alix Demaris will join our Department. Her doctoral thesis project will be in the area of pharmacometrics of monoclonal antibodies.
PBPK workshop using PK-Sim and MoBi
Jointly with SGS Exprimo our Department will organise a 2-day workshop on the use of the open source software PK-Sim and MoBi. The event will take place in the Institute of Pharmacy from 21–22 February 2019. A combination of lectures, demos and hands-on sessions will be used as teaching methods during the workshop featuring examples including predictions of human dose and drug-drug interactions (DDI).
Scientific workshop with Prof. Meibohm, UTHSC
On 22 January 2019, Prof. Bernd Meibohm from the University of Tennessee Health Science Center, Memphis, TN, USA, will visit our Department again for a scientific workshop. The workshop will comprise of lectures given by Prof. Meibohm and presentations of PhD students. Prof. Meibohm’s research is focused on the investigation of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs with special emphasis on PK/PD relations of macromolecular drugs.