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Annual Christmas party of our working group
According to our long-standing tradition, our Department will have our famous annual Christmas party on 7 December 2022 to look back at a wonderful and successful year and to enjoy a Christmas dinner and mulled wine together.
PharMetrX PhD program: Personal interviews
From 21 - 22 November 2022 the personal interviews with the selected candidates to enter as doctoral students the PharMetrX Research+ PhD program (www.PharMetrX.de) will take place at the Freie Universität Berlin. The start of the PharMetrX module curriculum and PharMetrX network is in March 2023.
We are looking forward to welcoming and getting to know this year's candidates!
Defence of doctoral thesis
The defence of the doctoral thesis of David Busse on “Towards precision dosing in morbidly obese patients: Complementary pharmacometric approaches to characterise antibiotic target-site exposure “ will take place in Arnimallee 22, 14195 Berlin (room A.006), on Thursday, 23 Nov 2022, at 16:00. Guests are welcome!
As a hybrid event, it will be possible to join online: See link attached.
New article on our research about the clinical implementation of TDM for oral anticancer drugs
Curious about our research on Therapeutic Drug Monitoring (TDM) for oral anticancer drugs? Then check out this report in Pharmazeutische Zeitung on the work that was recently presented by Fenja Klima at the DPhG (Deutsche Pharmazeutische Gesellschaft) Annual Meeting in Marburg.
Visit at the Netherlands Cancer Institute (NKI)
From 07 – 09 November 2022, our doctoral student Fenja Klima had the opportunity to visit the Netherlands Cancer Institute in Amsterdam, Netherlands, and got new insights into state-of-the-art anticancer therapy and the implementation of TDM clinical practice there.
Guest talk on “Pharmpy”
On 28 October 2022, Rikard Nordgren and Stella Belin from Uppsala University, Sweden, will give us an online guest talk on “Pharmpy”, a new tool for pharmacometrics and automated model development. We are looking forward to it!
We will be at the 46th ISOBM Congress
From 13 – 17 October 2022, the 46th International Society Oncology and Biomarkers (ISOBM) Congress takes place in Bled, Slovenia. From our Department, Prof. Dr. Charlotte Kloft, has been invited to give an oral presentation on “Biomarker monitoring and pharmacometric modelling to optimise anticancer therapy”.
Contributions to SUP Fall Meeting
On 13 October 2022, the Stockholm Uppsala Pharmacometrics (SUP) Fall meetingwill take take place in Uppsala, Sweden, with the theme PBPK/mechanistic PK. From our working group Ayatallah Saleh will attend and Linda Aulin will present ongoing translational work on the FAIR project.
New article on microdialysis of the antifungal voriconazole and its metabolite
Our research article “Microdialysis of drug and drug metabolite: a comprehensive in vitro analysis for voriconazole and voriconazole N-oxide“ by Schulz et al. has been published in the Journal Pharmaceutical Research.
New article on quantification of drug-drug interaction studies
Our manuscript “Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion“ by Nassar et al. has been accepted in Clinical Pharmacokinetics, and is now available online (https://doi.org/10.1007/s40262-022-01175-6).
Presentation at RedIF 2022 in Porto Alegre
From 03 to 07 October 2022, the fourth “Iberoamerican Pharmacometrics Network (RedIF) meeting” will take place in Porto Alegre, Brazil. Dr. Robin Michelet from our working group will present the ongoing work on FAIR to a global audience in a talk as part of the symposium on Pharmacometric applications in infectious diseases.
PharMetrX Module Curriculum continues with A4 module
From 26 – 30 Sep 2022, the PharMetrX A4 module “Introduction to Systems Biology” will take place at the University of Potsdam. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrX.de
First interprofessional “TEAM Summer School”
From 22 to 24 September 2022, the first “TEAM Summer School” will take place at Freie Universität Berlin. Our Summer School will focus on the recognition, treatment and prevention of depression in an interprofessional setting. Students of pharmacy and medicine will participate in workshops and study together various different aspects of depression and pharmacotherapy thereof. If you are interested, do not hesitate to visit our website for more information and registration: https://www.bcp.fu-berlin.de/pharmazie/faecher/klinische_pharmazie/arbeitsgruppe_kloft/lehre/TEAM-Summer_School/index.html
Contributions to DPhG Annual Meeting 2022
From 13 – 16 September 2022, theDeutsche Pharmazeutische Gesellschaft (DPhG) - Jahrestagung 2022 / German Pharmaceutical Society - Annual meeting 2022 takes place in Marburg. Four members of our Department, Amrei Konrad, Felix Müller, Fenja Klima and Franz Weber will represent our group through poster presentations. We are looking forward to an exciting scientific exchange!
Best young investigators presentations award at the 9th IMS
During the successful 9th International Microdialysis Symposium organised by our working group in Berlin, high quality work were presented by young investigators. We would like to congratulate Laura van Smeden and Davide Bindellini, who received the award for best young investigator oral presentations, and Frida Bällgren and Felix Müller who received the award for best young investigators poster presentations. Congratulations to all of them for their great work!
9th International microdialysis symposium 2022
From 7-9 September the 9th International Microdialysis Symposium took place in Berlin. The event was organised by our working group and we are delighted by the successful realisation.
PharMetrX Module Curriculum continues with A5 module
From 29 Aug – 02 Sep 2022, the PharMetrX A5 module “Introduction to Statistics and Data Analysis” will take place at the University of Potsdam. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrX.de.
Summer BBQ at Kelchstr.
On 9 August 2022, our Department will enjoy the lovely season together through a summer BBQ.
PharMetrX Module Curriculum continues with A3 module
From 01 – 05 Aug 2022, the PharMetrX A3 module “Introduction to Population Analysis” will take place at the FU Berlin. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
Apply now! Application period for doctoral studies in PharMetrX now open
Are you about to finish or have you just finished your studies in pharmacy, pharmaceutical sciences, mathematics, bioinformatics, or some related field? The PharMetrX program (www.PharMetrX.de) calls for applications for the:
PharMetrX Research+ Program: You are looking for a PhD +++ in a fascinating and prosperous research area +++ within two truly transdisciplinary research groups +++ supervised by leading experts in their fields +++ with an industry mentor +++ in the vibrant Berlin/Potsdam area +++ supported by a specifically tailored training program of academic and industrial modules +++ embedded into a network of peers +++ supported by a 3.5 year competitive fellowship
PharMetrX Training+ Program: You have already started your PhD in the field of pharmacometrics (or will do so soon) and are looking +++ for a specifically tailored training program of compact academic and industrial modules conveying the foundations in pharmacokinetics and pharmacodynamics, systems biology, statistics, methodological approaches of modelling & simulation and much more +++ and a network of peers to exchange with
The application period is open from 15 July – 15 September 2022.
Successful defense of doctoral thesis of Josefine Schulz
Josefine Schulz successfully defended her doctoral thesis entitled “Towards the elucidation of voriconazole pharmacokinetics: quantitative insights into distribution and metabolism processes in humans” on 11 July 2022. Congratulations!
The AK Kloft is glad to welcome a new member
In July 2022, Malin Andersson joined our Department as a doctoral student. She studied pharmacy at University of Gothenburg, Sweden, and she will have her PhD project in the area of antiinfectives, involving both experimental and modelling approaches. A warm WELCOME!
We participate in the 12th Scientific Symposium “Young scientists present” of our Institute
On 08 July 2022, our Institute of Pharmacy together with the DPhG (German Pharmaceutical Society, Deutsche Pharmazeutische Gesellschaft Landesgruppe Berlin-Brandenburg), hosts the 12th Scientific Symposium as biyearly event „Der Wissenschaftliche Nachwuchs stellt sich vor – Young scientists present”. 9 young scientists of our and many of the other research groups of the Institute of Pharmacy will present their research in talks and on posters to foster exchange between all research groups at the Institute and attract new master, diploma and doctoral students. We are looking forward to an exciting event and to seeing as many of you there!
Scientific workshop with Prof. Meibohm, UTHSC/USA
On 05 July 2022, Prof. Bernd Meibohm from the University of Tennessee Health Science Center, Memphis, TN, USA, will visit our Department again for a scientific workshop. He will give insights about new aspects of PK/PD of therapeutic proteins. In addition, three members of our working group, Linda Aulin, Davide Bindellini and Alix Démaris will present their research.
Contributions to annual PAGE 2022 meeting
From 28 June to 1 July 2022, the 30th Population Approach Group Europe (PAGE) meeting takes place in Ljubljana, Slovenia. From our Department, Alix Démaris will represent our group through an oral presentation andour young scientists Linda Aulin, Davide Bindellini, Yomna Nassar, Ayatallah Saleh and Ella Widigson through poster presentations.
The core program of the 9th International Microdialysis Symposium is online
The core program of the 9th International Microdialysis Symposium (IMS) is online!The abstract deadline is extended to 1st of July and the Early Bird registration to 15th of July. For more information, visit the official IMS 2022 website.
FAIR annual meeting in Nice/France
From 15 – 16 June 2022, the annual meeting of the FAIR project takes place in Nice, France. From our Department, Prof. Dr. Charlotte Kloft, Dr. Robin Michelet, and Linda Aulin will attend.
We will be at ‘Lung In Vitro event 2022’ (LIVe2022)
From 13 – 14 June 2022, the Lung In Vitro event 2022 – (LIVe2022) takes place in Nice, France. From our Department, Prof. Dr. Charlotte Kloft, Dr. Robin Michelet, and Linda Aulin will represent our group through an oral presentation.
Research Exchange Day with Uppsala University
On 10 June 2022, a research Exchange Day will be organised together with Uppsala University, Sweden. From our group, PhD students Alix Démaris, Fenja Klima and Yomna Nassar will present their research. We are looking forward to fruitful discussion and exchange!
11th PharMetrX Symposium
On 02 May 2022, the 11th PharMetrX Symposium 2022 will take place (online). Two PharMetrX Research+ doctoral students, Alix Démaris and Daniel Seeler, will present their scientific work. For more detailed information on the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de
The AK Kloft is glad to welcome a new member
In May 2022, a new guest visitor as ERASMUS+ student, Zrinka Duvnjak joined our Department. Zrinka Duvnjak studied pharmacy and obtained her masters at the University of Zagreb, Croatia. She will have her 5-monthsinternship project in the area of modelling and simulation. A warm WELCOME!
The AK Kloft is glad to welcome a new AvH guest researcher
On the 9th of May 2022, Prof. Dr. Stephan Schmidt joined as Alexander-von-Humboldt Research Fellow our Department as a guest researcher. He is an Associate Professor in the Department of Pharmaceutics and Director of the Center for Pharmacometrics and Systems Pharmacology at the University of Florida, US. In our group Prof. Dr. Schmidt will focus on QSP and mechanistic modelling.
A warm WELCOME!
24th PK/PD Expert Meeting
From 28-30 April 2022, the 24th PK/PD Expert Meeting will take place at Saarland University, Saarbrücken. Presentations and associated discussions will focus on the topics “Machine learning: From Buzzword to Useful Tool in Clinical Pharmacology?”, “Precision Dosing - Bringing Models to Patients” and “Neglected majorities - What do we have to consider?”. From our Department, Prof. Dr. Charlotte Kloft, Dr. Robin Michelet and the PhD students Alix Démaris, Ayatallah Saleh will attend the meeting. For more information: see www.pkpd-expertentreffen.de
Quantitative Systems Pharmacology Conference 2022 (QSPC2022)
From 20 – 22 April 2022, the Quantitative Systems Pharmacology Conference 2022 (QSPC2022) takes place in Leiden, the Netherlands. One member of our Department, Linda Aulin represents our group through a poster presentations.
New article on cortisol concentrations monitoring in paediatric patients
The research article “Exploring dried blood spot cortisol concentrations as an alternative for monitoring pediatric adrenal insufficiency patients: A model-based analysis“ by Stachanow et al. has been accepted in Frontiers in Pharmacology, and is now available online.
32nd Congress of Clinical Microbiology & Infectious Diseases (ECCMID)
From 23 - 26 April 2022, the 32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) takes place in Lisbon, Portugal. Two members of our Department, Nicole Zimmermann and Malin Andersson will represent our group through poster presentations.
Contributions and symposium at WCoP 2022
From 29 March – 1 April 2022, the 3rd World Conference on Pharmacometrics (WCoP) takes place in Cape Town, South-Africa. Two members of our Department, Dr. Robin Michelet and Prof. Charlotte Kloft will represent our group. They will co-chair a symposium entitled “Training of the next generation of pharmacometric talents around the world: Competencies – Barriers – Opportunities” together with Dr. Stefanie Hennig, Humboldt Research Fellow at our Department.
Pharmacy students joining for a “Schnuppertag”
On 23 March and 4 April, five undergraduate pharmacy students are joining our Department for a short internship, a so-called “Schnuppertag”. They will be getting insight in our working group, research projects and the methodology platform we are using. If you are also interested, please contact Amrei Konrad (firstname.lastname@example.org) for further information
Presentation at ASCPT Annual Meeting 2022
A member of our working group, Anna Mc Laughlin, will present a late-breaking abstract on tamoxifen breast cancer therapy at the American Society for Clinical Pharmacology & Therapeutics (ASCPT) 2022 Annual Meeting, which takes place online. The main topic of the meeting, which takes place from 16-18 March 2022, is “Disruptive innovation”.
PharMetrX Module Curriculum: Kick-off
On 14 March 2021, the PharMetrX Module Curriculum for the new doctoral student year of our PhD program will kick off with the A1 module "Introduction to pharmacokinetics and pharmacodynamics" taking place online from 14 - 21 March 2022. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
The AK Kloft is glad to welcome a new member
Mid of March 2022, Ella Widigson joined our Department, also being enrolled in our PharMetrX program. Ella studied pharmacy and obtained her M.Sc. atUniversity of Gothenburg, Gothenburg, Sweden. Her doctoral thesis project will focus on pharmacometrics modelling approached of biologics in the area of inflammatory diseases. A warm WELCOME!
New article on metabolism of the antifungal voriconazole
The research article “Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism“ by Schulz et al. has been published in the Journal Pharmaceutics and is available online.
The AK Kloft is glad to welcome a new member
In March 2022, Fenja Klima joined our Department, also being enrolled in our PharMetrX program. Fenja studied pharmacy at University of Freiburg, Freiburg, Germany. She will have her doctoral thesis project in the area of pharmacometrics of anticancer drugs. A warm WELCOME!
Report on successful joint IPSF & PharMetrX Clinical Skills Event
An article about the Clinical Skills Event (CSE) in November 2021 in collaboration with the International Pharmaceutical Students' Federation (IPSF) is now available in the latest issue of the “Grüne Hand Brief” published by the Federal Association of Pharmacy Students in Germany (BPhD e. V.).The CSE aimed to raise awareness of the importance of the pharmacist's role in clinical patient care. Different teams competed in a friendly environment by demonstrating their skills in clinical pharmacy related project tasks to work out dosing regimens in antibiotic therapy and present their recommendation to the ‘Antibiotic Stewardship team’. Follow-up events are already planned!
New article on meropenem pharmacokinetics in obese and nonobese patiens
The research article “Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients “ by Busse et al. has been accepted in Clinical Pharmacokinetics, and is now available online.
Ethics committee approval for collaboration project
The proposal to the ethics committee for the evaluation of the interprofessional teaching project in collaboration with Charité – Universitätsmedizin Berlin has been accepted.
New article on a model informed dosing tool in antibiotic therapy
The research article “Development of a Model-Informed Dosing Tool to Optimise Initial Antibiotic Dosing—A Translational Example for Intensive Care Units“ by Weinelt et al. has been accepted in Pharmaceutics, and is now available online.
Successful defense of two master theses
Malin Andersson and Ella Widigson successfully defended their master theses, supervised by Prof. Kloft and members of our working group, at University of Gothenburg. Congratulations!
Two abstracts accepted for poster presentation at ECCMID conference
The research abstracts of Nicole Zimmermann and Malin Andersson have been accepted for poster presentation at ECCMID conference in Lisbon and online, 23 – 26 April 2022. Malin Andersson won a travel grant for her excellent abstract. Congratulations!
New article on the optimisation of meropenem therapy in critically ill
The research article “Combination of pharmacokinetic and pathogen susceptibility information to optimize meropenem treatment of gram-negative infections in critically ill patients“ by Liebchen et al. has been accepted in Antimicrobial Agents and Chemotherapy, and is now available online.
New article on review of cost-effectiveness of oral anticancer drugs
The research article “Cost-effectiveness of oral anti-cancer drugs and associated individualised dosing approaches in cancer patients: Protocol for a systematic review and meta-analysis“ by van Dyk et al. has been accepted in the British Medical Journal and is now available online.
New article on evaluating prediction methods for glomerular filtration
Our manuscript “Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and nonobese patients” by Busse et al. has been accepted in the British Journal of Clinical Pharmacology and is now available online.
New article on a LC-MS/MS assay for voriconazole and its N-oxide metabolite
Our manuscript “A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications” by Schulz et al. has been accepted in the Journal of Pharmaceutical and Biomedical Analysis and is now available online.
New article on the ON-TARGET study protocol
The manuscript “Developing a nationwide infrastructure for Therapeutic Drug Monitoring of targeted oral anticancer drugs: The ON-TARGET study protocol“ by Mc Laughlin et al. has been accepted in the journal Cancers and is now available online.
PharMetrX at virtual ALARM job fair in Göteborg
PharMetrX at the ALARM job fair 2022 of the University of Gothenburg (GU): We are excited to talk to Pharmacy students of all semesters about our research projects and encourage applying to our do a PhD thesis with us within the Research, Training and Network Graduate Programme! The AK Kloft, represented by Davide Bindellini and Johanna Melin, a current and a former PharMetrX Research+ PhD student, is looking forward to getting in touch with the GU students on the 18 January 2022!
New Berlin University Alliance project proposal approved
AK Kloft is proud to announce that the project proposal entitled “GlobalResist – Forecasting antibiotic resistance evolution – a new approach to address a major issue in global health” has been approved for funding as part of the Grand Challenge Initiative on Global Health of the Berlin University Alliance. For this project, the AK Kloft partners with colleagues from FU, Charité and Technische Universität Berlin to develop a wide-ranging approach to predicting antibiotic resistance, intricately linking different disciplines.