Aktuelles
- Für kommende "Termine/Events" und "News" des aktuellen Monats: siehe Teaser auf der rechten Seite
- Für vergangene "Termine/Events" des aktuellen Monats bzw. früherer Monate: hier klicken oder siehe unten
- Für "Termine/Events" und "News" der letzten Jahre: auf Archiv/Archive klicken
Juni 2025
Upcoming at PAGE 2025 in Thessaloniki with contributions from us
The 33rd Population Approach Group Europe (PAGE) meeting will take place in Thessaloniki, Greece in 3-6 June 2025. We are excited to announce that two of our doctoral students, Fenja Klima and Zrinka Duvnjak, have been selected for oral presentations:
Fenja Klima will present “Development of efficient CAR-T cell clinical study designs: Towards understanding of novel anticancer therapies through optimal experimental design.” Zrinka Duvnjak will present “Dosing regimen optimisation of vedolizumab during pregnancy through physiologically-motivated sequential population modelling of albumin trends and vedolizumab pharmacokinetics”.
Additionally, 5 doctoral students from us, Davide Bindellini, Marian Klose, Mgambi Gideon Gamba, Miriam Happ, Yersultan Mirasbekov, will present posters on their latest research projects and Prof. Kloft will chair a session on “Bispecific antibodies & antibody PBPK”.
PharMetrX PhD Student joins Boehringer Ingelheim for a 3-month internship in Biberach a.d.R.
Another doctoral student, Miriam Happ, is taking part in our PharMetrX I2 module. Miriam is joining one member of our PharMetrX Industry Partner Consortium, Boehringer Ingelheim, for a 3-month internshipin the Department of Preclinical PKPD Modelling in Biberach an der Riß. We wish her a successful start and insightful experiences!
Networking Summer BBQ at Kelchstraße
On 24 June, a joint summer BBQ with the 2 other research groups at Kelchstraße (AG Lauster, AG Seidlitz) will take place. We are looking forward to the next casual get-together and scientific exchange.
Welcome to our new PharMetrX PhD students Elsa Smith and Katharina Braun!
We are thrilled to welcome two new doctoral researchers to the PharMetrX Research+ program:
Elsa Smith joined us in March 2025 and will contribute to the oncology research focus. Her PhD project explores the dynamics of CAR-T cell therapy, aiming to deepen our mechanistic understanding of this living drug product and its complex interactions with the disease and immune system. With a strong academic background in pharmacology from University College London and the University of Edinburgh, we are excited to have her on board!
Katharina Braun, pharmacist since June 2024, began her PhD journey after gaining interdisciplinary experience at Boehringer Ingelheim. Her research will focus on Model-Informed Precision Dosing (MIPD), optimizing antibiotic and oncologic therapies in close collaboration with clinical partners, such as the Charité. We look forward to her contributions in improving model-informed Therapeutic Drug Monitoring and supporting individualised treatments.
A warm welcome to you both – we're excited to have you as part of the PharMetrX community!
Visiting PhD student Federico Herrero Hervás joins AK Kloft
We are pleased to welcome Federico Herrero Hervás, PhD student from the Complutense University of Madrid and Universitaet Paderborn, to our Department for a research stay. Federico’s project focuses on nonlinear parabolic partial differential equations, particularly Keller–Segel models and nonlinear diffusion, with a strong interest in existence, asymptotics, and numerical methods. During his stay, he will learn about pharmacometrics and contribute to a PK/PD model for model-informed clinical decision making in high-dose methotrexate therapy. A warm welcome, Federico!
Mai 2025
14th Annual PharMetrX Symposium
On Thursday, 15 May 2025, we look forward to the 14th PharMetrX Symposium, the annual event for intensive scientific exchange. The agenda includes presentations by PhD students from our working groups: Fenja Klima, Johannes Tillil, and Zrinka Duvnjak. This year, the full-day event will be hosted at AbbVie in Ludwigshafen. For further details on the scientific program and the meeting, please visit https://www.pharmetrx.de/event/14th-pharmetrx-symposium.html
Attendance at the 27th PK/PD Expert Meeting
From 15–17 May 2025, several PhD students from our working group, together with Prof. Charlotte Kloft, will join the 27th Pharmacokinetics/Pharmacodynamics (PK/PD) Expert Meeting organised by the AGAH (Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V.) in Bad Dürkheim/Pfalz. The Saturday session on Rare Diseases has been organised by us including a talk on innovative methodological approached by Mats Karlsson, Uppsala University. For further details on the scientific program and the meeting, please visit www.pkpd-expertentreffen.de.
New publication on quantification of fosfomycin in bacterial growth medium
The manuscript on “Development and validation of an LC-MS/MS assay for quantification of fosfomycin in Mueller-Hinton broth for application in profiling antibacterial efficacy against clinical bacterial isolates” by N. Zimmermann, F. Schumacher, F. Bredendiek and C. Kloft has been accepted in the Journal of Chromatography B and is now available online. Great work! https://www.sciencedirect.com/science/article/pii/S1570023225001138?via%3Dihub
April 2025
Defence of Anja Lehmann
On 28 April 2025, Anja Lehmann, doctoral student co-supervised by us and Dr. Christoph Hethey, will defend her thesis on “Physiologically-based pharmacokinetic modeling of pyrrolizidine alkaloids and their cytochrome P450 3A4-mediated interaction”. She did her thesis at “Bundesinstitut für Risikobewertung (BfR)” and is PharMetrX Training+ student. Good luck Anja!
Two PharMetrX PhD students join Novo Nordisk for a 3 month internship in Denmark
The doctoral students Malin Andersson and Fenja Klima are joining one member of our PharMetrX Industry Partner Consortium, Novo Nordisk, Department of Pharmacometrics, for a 3-month internship. This PharMetrX I2 module will take place in Copenhagen, Denmark from February – April 2025. We wish them many new learnings and exciting experiences!
März 2025
PharMetrX A2 module
From 31 March to 04 April 2025, the PharMetrX A2 module “Introduction to physiologically-based pharmacokinetics” of the Module Curriculum of our doctoral program will take place at the University of Potsdam. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
PharMetrX Module Curriculum: Kick-off
On 10 March 2025, the PharMetrX Module Curriculum for the new doctoral student year of our PhD program will kick off with the A1 module “Introduction to pharmacokinetics and pharmacodynamics” taking place at our Institute from 10 – 14 March 2025. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de
Nicole Zimmermann will continue as a scientist in our group
We are pleased to announce that Nicole Zimmermann will continue as scientific employee in our working group. Nicole brings strong experience from her research work in the infection lab and integrated her results into a computer modelling and simulation research framework. Her research focussed on understanding combination therapy in the field of antiinfectives. She will also continue to support our teaching activities for undergraduate students at our institute. We are very happy to continuously have her in our team!
Februar 2025
Machine learning meets pharmacometrics - Pumas-AI workshop at FU Berlin
From 03 – 05 February 2025, the “Nonlinear Mixed Effects Modeling Workflows using Pumas” workshop by Pumas-AI Inc will take place in collaboration with the FU Berlin. Over three days, the attendees will engage in hands-on sessions guided by experts from Pumas-AI Inc., focusing on essential modelling techniques, population PK, PKPD analyses, and advanced data handling. A glimpse into DeepPumas will highlight the powerful integration of machine learning with pharmacometrics. The event will take place online and is free for students. We look forward to an inspiring, interactive event!
Scientific workshop with Prof. Meibohm, UTHSC/USA
On 10 February 2025, Prof. Bernd Meibohm from the University of Tennessee Health Science Center, Memphis, TN, USA, will visit our Department again for a scientific workshop. He will give insights about new aspects of PK/PD of therapeutic proteins and three members of our working group or University Potsdam, Zrinka Duvnjak, Dr. Niklas Hartung and Johannes Tillil will present their research.
PharMetrX Module Curriculum: Kick-off
On 10 March 2025, the PharMetrX Module Curriculum for the new doctoral student year of our PhD program will kick off with the A1 module “Introduction to pharmacokinetics and pharmacodynamics” taking place at our Institute from 10 – 14 March 2025. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de
Presentations at the 20th Congress of ECCO (European Crohn’s and Colitis Organisation)
The upcoming ECCO Congress, themed Sustainability in IBD and Beyond, will take place in Berlin from 20-22 February 2025.
At this event, our doctoral student Zrinka Duvnjak will present her research as a poster titled "Supporting Vedolizumab Treatment Throughout Pregnancy: Insights from a Population Pharmacokinetic Model."
Additionally, Prof. Kloft will give a short oral presentation on the topic "Hospitalised Severe Ulcerative Colitis Patients Treated with Rescue Infliximab Risk Treatment Failure Due to Underexposure Caused by High Drug Clearance."
The AK Kloft is glad to welcoming a new intern!
In February 2025, Sara Salehian joined our Department for an eight-week research project. Sara obtained her Masters in Pharmacy at Cyprus International University and is currently enrolled in the Master program Pharmaceutical Research at our University. During her internship, she will develop a mathematical model for levofloxacin resistance. A warm WELCOME
Januar 2025
Our Contributions to Faculty Day 2025
On 16 January 2025, our working group will participate in the Department of Biology, Chemistry, and Pharmacy's biannually Faculty Day at Arnimallee 22. Starting at 16:15. The event will bring together the faculty’s diverse research groups for exciting talks and a poster session, where we will present our latest findings and ongoing projects.
This gathering is a good opportunity for scientific exchange and networking, especially for undergraduate students in their final year, interested in our field and considering thesis topics. We look forward to sharing insights from our work and connecting with colleagues and students for an inspiring afternoon of academic dialogue and collaboration.
First insights into clinical application of aztreonam–avibactam in treating carbapenem-resistant enterobacterales in a critically ill patient. See our latest article!
The research article “First Clinical Application of Aztreonam–Avibactam in Treating Carbapenem-Resistant Enterobacterales: Insights from Therapeutic Drug Monitoring and Pharmacokinetic Simulations“ by O. Hölsken, K. Sponheuer (Charité—Universitätsmedizin Berlin), further colleagues and F. Weber, and C. Kloft has been published in the Journal of Personalized Medicine, and is now available online.