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October 2023
Viktoria Stachanow PhD defense on 31 October
On 31 October 2023, we are looking forward to Viktoria Stachanow’s defense of her PhD thesis entitled “Optimisation of congenital adrenal hyperplasia therapy in paediatric and foetal populations by leveraging pharmacometrics”.
Seminarraum B.-131 (UG), Arnimallee 22, 14195 Berlin
https://fu-berlin.webex.com/meet/charlotte.kloft
Successful annual DPhG meeting in Tübingen!
We look back to a successful and inspiring annual meeting of the German Pharmaceutical Association (Deutsche Pharmazeutische Gesellschaft, DPhG) that took place in Tübingen, Germany (07 – 10 October), covering the topic “Translational Pharmacy – Practice & Perspective”. The AK was broadly represented in the program, with Prof. Kloft giving a plenary lecture with the topic “Translational Pharmacometrics” and being a session chair. Dr. Linda Aulin gave a talk with the topic “Transforming Antimicrobial Therapy”. PhD students Malin Andersson, Fenja Klima, Amrei Konrad and Nicole Zimmermann presented their posters contributions.
We are already looking forward to next year meeting in Münster!
AK contributions at annual DPhG conference
The annual meeting of the German Pharmaceutical Association (Deutsche Pharmazeutische Gesellschaft, DPhG) will take place in Tübingen, Germany, this year from 07 – 10 October. The AK is broadly represented in the program, with Prof. Kloft giving a plenary lecture and being a session chair, Dr. Linda Aulin being an invited speaker, and Malin Andersson, Fenja Klima, Amrei Konrad and Nicole Zimmermann having accepted poster presentations.
https://www.dphg.de/vortraege-und-tagungen/dphg-jahrestagung-2023-annual-meeting-copy
2nd TEAM Summer School
From 04 – 06 October 2023 we will realise the 2nd TEAM Summer School for pharmacy and medicine students from Berlin and all over Germany. In interdisciplinary seminars, workshops and excursions the students will work in matched pairs or all together on the topic “Depression – Detecting | Treating | Preventing. We are beyond excited for some very insightful days!
September 2023
Apply now! – Application period for doctoral studies in PharMetrX now open
Are you about to finish or have you just finished your studies in pharmacy, pharmaceutical sciences, mathematics, bioinformatics, or some related field? The PharMetrX program (www.PharMetrX.de)calls for applications for the:
PharMetrX Research+ Program: You are looking for a PhD +++ in a fascinating and prosperous research area +++ within two truly trans-disciplinary research groups +++ supervised by leading experts in their fields +++ with an industry mentor +++ in the vibrant Berlin/Potsdam area +++ supported by a specifically tailored training program of academic and industrial modules +++ embedded into a network of peers +++ supported by a 3.5 year competitive fellowship?
or
PharMetrX Training+ Program: You have already started your PhD in the field of pharmacometrics (or will do so soon) and are looking +++ for a specifically tailored training program of compact academic and industrial modules conveying the foundations in pharmacokinetics and pharmacodynamics, systems biology, statistics, methodological approaches of modelling & simulation, etc. +++ and a network of peers to exchange with?
The application period is open from 15 July – 15 September 2023.
https://www.pharmetrx.de/apply/index.html
Successful 5th PharMetrX PhD student Network Meeting
We look back to a successful and inspiring 5th PharMetrX PhD student Network Meeting taking place in Berlin last weekend from 8 to 9 September 2023. It was a remarkable opportunity for our growing PharMetrX Graduate Research Training network to meet, discuss, maintain connections and build upon new ones throughout all PhD student years from 2008 – 2023. Many thanks to everyone who made this fantastic event possible and we are already looking forward to the next one in 2 years!
The AK Kloft is glad to welcome a new member
In September 2023, a new master student Abubakar Shakeel will join our department. Abubakar Shakeel studied pharmacy at Uppsala University, Sweden. He will have his master thesis project in the area of modelling and simulation applied towards cortisol replacement therapy optimisation. A warm WELCOME!
5th PharMetrX PhD student Network Meeting
On 8– 9 September 2023, the 5th PharMetrX PhD student Network Meeting will take place. Almost 60 former & present PhD students of the PharMetrX Graduate Research Training Program will meet onsite at our Institute again to discuss “hot topics” in Pharmacometrics and maintain the connections and interactions developed in PharMetrX program and expand these across various PhD student years since 2008. The network meeting will start with a Get-together event on Friday evening, 08 September, and continues with the scientific and networking contents on Saturday, 09 September 2023.
https://www.pharmetrx.de/event/5th-pharmetrx-phd-students-network-meeting.html
PharMetrX A4 module
From 4– 8 September 2023, the PharMetrX A4 module “Introduction to system biology” of the Module Curriculum of our doctoral programwill take place at the Institute of Mathematics, University of Potsdam. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
https://www.pharmetrx.de/training/curriculum/population-analysis.html
August 2023
Paper on new approach for risk assessment of hepatotoxity based on a PBTK modelling approach published
The paper “PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat” by Anja Lehmann et al. was published in Arch. Toxicol. (doi: 10.1007/s00204-023-03453-z) - Congratulations!
PharMetrX A3 module
From 14– 18 August 2023, the PharMetrX A3 module “Introduction to population analysis” of the Module Curriculum of our doctoral programwill take place at our Institute. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
https://www.pharmetrx.de/training/curriculum/population-analysis.html
July 2023
Short Lectures, Award for Good Teaching and Summer Party
On Thursday, July 13 2023, students, faculty and staff of the Department of Biology, Chemistry, Pharmacy are cordially invited to the summer event. It will start at Arnimallee 22 and continue on the lawn between the rear exit of the building at Arnimallee 22 and the building at Fabeckstraße 34/36. For more info you find the link below.
https://www.bcp.fu-berlin.de/en/termine/2023/20230713-sommerfest-preis-fuer-gute-lehre.html
Summer BBQ at Kelchstraße
On 10 July 2023, we will have a summer BBQ at Kelchstraße. We welcome Prof. Lauster’s group as the newest members at Kelchstraße and Prof. Bodmeiers group for a casual get to know and scientific exchange.
PAGE football tournament winners
After a year without a trophy, the ‘PharMetrX & friends’ football team won the annual football tournament during the PAGE conference in A Coruña/Spain this year. Congratulations to everyone in the team and all the enthusiastic supporters!
June 2023
Contributions to annual PAGE meeting 2023
From 28 June to 30 June 2023, the 31st Population Approach Group Europe (PAGE) meeting takes place in A Coruña, Spain. From our Department, we are looking forward to oral presentations by our senior scientist Dr. Robin Michelet and our PhD student Yomna Nassar. In addition, our senior scientist Dr. Linda Aulin and our PhD students Davide Bindellini, Fenja Klima, Felix Müller and Ayatallah Saleh will represent our group through poster presentations.
https://www.page-meeting.org/default.asp?id=48&keuze=program
Lange Nacht der Wissenschaften
On 17 June 2023, the “Lange Nacht der Wissenschaften” („Long Night of Science”) will take place in Berlin from 15:00-23:00. Our group will represent its research and pharmaceutical core competences such as blood pressure monitoring at the Institute of Pharmacy in Königin-Luise-Straße 2-4. Further we also support a registration campaign for bone marrow donations (DMKS). We are looking forward to meet you there!
https://www.langenachtderwissenschaften.de/programm/detail/93939
New insights on voriconazole: paper accepted!
The paper “Towards model-informed precision dosing of voriconazole: Challenging published voriconazole nonlinear mixed-effects models with real-world clinical data” by Franziska Kluwe et al. was accepted by Clinical Pharmacokinetics. Congratulations!
The AK Kloft is glad to welcome new members
On 01 June 2023, two new doctoral students Miriam Happ and Zrinka Duvnjak joined our Department. Miriam will work on model-informed therapy optimisation of advanced therapies and Zrinka will focus on the interplay of monoclonal antibody therapy - disease - immune system.A warm WELCOME!
New group member
Starting from June Isabell Franke will complete a practical internship as part of her apprenticeship as administrative assistant in our group. A warm welcome!
May 2023
Robin Michelet wins “Hans Günter Schäfer Science Award 2023“
Dr. Robin Michelet, senior scientist of our Department, was awarded the “Hans Günter Schäfer Science Award 2023” for young scientists for the research article “Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach” (in Front. Pharmacol. 2023, DOI: 10.3389/fphar.2022.1090554). The prize was donated by the Frankfurt Foundation Quality of Medicines (FFQM, https://frankfurt-foundation.org) and presented at the 25th PK/PD Expert meeting in Nauen on 21 April 2023.
http://pkpd-expertentreffen.de
PubPharm Roadshow at our Institute
On 17 May 2023, the pharmacy-specific literature search platform PubPharm, developed at TU Braunschweig,will be presented on site in a workshop at our Institute. We are looking forward to get to know the different PubPharm functionalities.
The AK Kloft is glad to welcome a new member
On 02 May 2023, a new master student Eman Eldessouki joined our Department. Eman will work on in vitro microdialysis systems with a focus on calibration of microdialysis catheters.A warm WELCOME!
April 2023
Theoretical Methodology Symposium on “Modelling Resistance Evolution”
From 26-28 April 2023, a Theoretical Methodology Symposium on “Modelling Resistance Evolution” will take place at the Max Planck Institute for Evolutionary Biology in Plön, Germany. From our Department, Dr. Linda Aulin, Malin Andersson and Nicole Zimmermann will represent our group through poster presentation. We are looking forward to an insightful scientific exchange. For more information: see link below.
https://workshops.evolbio.mpg.de/event/75/
Open postdoctoral researcher position
We are recruiting a postdoctoral researcher with a focus on antimicrobial resistance. The GlobalResist project aims to forecast the evolution of antimicrobial resistance and thus take a new approach to solving a major global health problem. GlobalResist is embedded in a consortium of partners from Freie Universitaet Berlin, Charité-Universitaetsmedizin Berlin and Technische Universitaet Berlin and is funded by the Berlin University Alliance. Last day to apply 24 April 2023.
25th PK/PD Expert Meeting in Nauen
From 20-22 April 2023, the 25th PK/PD Expert Meeting will take placeunder the auspices of Arbeitsgemeinschaft für Angewandte Humanpharmakologie (AGAH) in Nauen. Presentations and discussions will focus on the topics “DDI — What is new 2023?”, “Translation to & from patients — Concepts to address the translational challenge” and “Drug development for brain diseases — New Approaches”. From our Department, Prof. Dr. Charlotte Kloft, Dr. Robin Michlet, Dr. Linda Aulin and the doctoral students Davide Bindellline, Aya Saleh, Felix Müller and Fenja Klima will attend the meeting. For more information: see link below.
https://www.pkpd-expertentreffen.de/
Brisbane meets Berlin: International TDM and MIPD exchange in antimicrobial therapy
On 21 April 2023, Amy Legg, clinical pharmacist at the Royal Brisbane and Women's Hospital and PhD candidate in the working group of Prof. Jason Roberts visited us at Charité – Universitätsmedizin Berlin. Within a fruitful meeting the in-house Antimicrobial Stewardship (AMS) Team (Miriam Stegemann, Frieder Pfäfflin, Ulrike Trost, Anja Theloe) and Franz Weber of our group were able to exchange country-specific experiences and challenges of Therapeutic Drug Monitoring and Model-informed Precision Dosing within AMS. We are looking forward to the next meeting for shaping the future of individualised antimicrobial dosing!
12th PharMetrX Symposium
On 19 – 20 April 2023, the 12th PharMetrX Symposium 2023 will take place in Berlin and Potsdam. Three PharMetrX Research+ doctoral students, Elena Pascual García, Davide Bindellini and Yomna Nassar, will present their scientific work. For more detailed information on the structured Graduate Research Training program PharMetrX, please visit our homepage https://www.pharmetrx.de/
Venue: Harnack-Haus, Berlin/Universität Potsdam
https://www.pharmetrx.de/event/12th-pharmetrx-symposium.html
Contributions to ECCMID 2023 in Copenhagen
From 15 – 18 April 2023, the 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) takes place in Copenhagen, Denmark. Five members of our Department, Dr. Linda Aulin, Malin Andersson, Amrei Konrad, Franz Weber and Nicole Zimmermann will represent our group through oral and poster presentations.
Participation at the annual ISAP Meeting
On 14 April 2023, the ISAP (International Society of Anti-Infective Pharmacology) Annual Meeting takes place in Copenhagen, Denmark, prior to the 33rd ECCMID Conference. Five members of our Department will attend the meeting and Malin Andersson will present her work through an oral presentation.
Workshop with Prof. Bernd Meibohm, University of Tennessee/USA
On 11 April 2023 our annual workshop with Prof. Bernd Meibohmn from the University of Tennessee Health Science Center, Memphis/USA takes place. We are looking forward to discussions about hot topics ranging from protein therapeutics to model-informed precision dosing with contributions by Linda Aulin, Fenja Klima and Franziska Thoma.
March 2023
“Schnupper” students are visiting the AK Kloft
During the semester break in total four students are visiting the AK Kloft for a so-called “Schnupper” Internship. With that they are given the opportunity to look over the shoulder of the daily work of our PhD students. The students get introduced to our projects and conduct some fun experimental or pharmacometric tasks. If you are interested please reach out to Amrei Konrad for further information!
PharMetrX A2 Module: “Introduction to physiologically-based pharmacokinetics”
After the successful A1 module from 13 – 17 March, we are now looking forward to the next part of the PharMetrX curriculum: From 27 – 31 March 2023, the PharMetrX A2 module “Introduction to physiologically-based pharmacokinetics” will take place at the University of Potsdam. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de.
https://www.pharmetrx.de/training/curriculum.htm
New article on target-site PK of voriconazole and its metabolite in humans
Our research article “Microdialysis of Voriconazole and its N-Oxide Metabolite: Amalgamating Knowledge of Distribution and Metabolism Processes in Humans “ by Schulz et al. has been published in the Journal Pharmaceutical Research.
https://link.springer.com/article/10.1007/s11095-022-03407-7
PharMetrX Module Curriculum: Kick-off
On 13 March 2023, the PharMetrX Module Curriculum for the new doctoral student year of our PhD program will kick off with the A1 module “Introduction to pharmacokinetics and pharmacodynamics” taking place at our Institute from 13 – 17 March 2023. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de
2nd Network Meeting of the Young Infection Medicine Network (jUNITE)
From 03-05 March 2023, the 2nd Network Meeting of the “Netzwerk Junge Infektionsmedizin”/Young Infection Medicine Network (jUNITE) will take place in Halberstadt. This year’s focus topic will be bioinformatics and digitalisation in infection medicine in the form of various interdisciplinary and interactive programme elements. From our Department, Nicole Zimmermann and Franz Weber will actively participate in the meeting. We are looking forward to an insightful scientific exchange. For more information: see link below.
https://www.netzwerk-infektionsmedizin.de/veranstaltungen
The AK Kloft is glad to welcome a new member
On 01 March 2023, a new doctoral student Marian Klose joined our Department. Marian studied Pharmacy and obtained his academic degree at FU Berlin, Germany. In his doctoral project, he will focus on the area of model-informed precision dosing in oncology.A warm WELCOME!
We celebrate 15 years of the PharMetrX Graduate Research Training Program and welcome the new PharMetrX student year 2023!
On 01March 2008 the PharMetrX Graduate Research Training Program kicked off and has qualified more than 100 young scientists in the exciting field of pharmacometrics since. Congratulations and a very happy 15th Birthday! We are very much looking forward to welcoming this year’s PharMetrX PhD students soon: Zrinka Duvnjak, Miriam Happ, Marian Klose and Johannes Tillil!
New article on the influence of maturational processes on hydrocortisone pharmacokinetics
Our manuscript “Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach “ by Michelet et al. has been published in Frontiers in Pharmacology, and is now available online
https://www.frontiersin.org/articles/10.3389/fphar.2022.1090554/full