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  • For upcoming "Termine/Events" and "News" of the current month: see teasers on the right
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May 2020



24th PK/PD Expert Meeting in Saarbrücken

The 24th PK/PD Expert Meeting has been postponed to 2021 due to the COVID19 pandemic. We are looking forward to stimulating scientific interactions as part of this event next year. For more information: see link below.
http://www.pkpd-expertentreffen.de/


The AK Kloft is glad to welcome a new member

In May 2020, a new diploma student, Antonia Thomas, will join our Department. Her 6-month diploma thesis project will focus on in vitro metabolism investigations.



April 2020


Cancelled due to COVID-19: Contribution at ECCMID and ISAP annual meeting 2020

From 17 – 21 April 2020, the ISAP annual meeting and the 30th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) would have taken in Paris, France. Six members of our department, Johanna Seeger, Josefine Schulz, Luis Ilia, Dr. Robin Michelet, Ferdinand Weinelt and David Busse contributed their work during ECCMID as paper posters or ePoster talks. However, due to COVID19 the meeting was cancelled.


New scientific publication of Department

The paper “Pharmacokinetic/pharmacodynamic evaluation of hydrocortisone therapy in pediatric patients with congenital adrenal hyperplasia. “ by Melin et al. has been accepted in The Journal of Clinical Endocrinology and Metabolism, and is now available online.


Offer of internship (‘Schnupperpraktikum’) for students

Curious of what we are doing in research?
We will be offering a two-day internship for students (“Schnupperpraktikum”) in the upcoming semester break. All undergraduate pharmacy students or recent graduates who are interested in getting insight in our research projects, the methodology platform we are using and our working group are welcome to apply. Please contact Josefine Schulz (Josefine.schulz[at]fu-berlin.de) for further information and application until the 31 July 2020.


Scientific symposium on anti-infective PK/PD

Although several important conferences planned for spring 2020 were cancelled or postponed due to the COVID19 pandemic, exchanging ideas and current research results in the field of anti-infectives is still of high importance. Therefore, an online symposium will take place on 27 April, which was jointly organised together with our collaboration partners Prof. Sebastian Wicha (University of Hamburg) and Prof. Markus Zeitlinger (Medical University of Vienna). From our working group, Josefine Schulz and Luis Ilia will present their latest research results.


New scientific publication of Department

The paper “Integrated data analysis points toward model-informed precision dosing of tamoxifen“ by Klopp-Schulze, Mueller-Schoell, Neven, Koolen, Mathijssen, Joerger and Kloft has been accepted in Frontiers in Pharmacology, and is now available online.

https://doi.org/10.3389/fphar.2020.00283


The AK Kloft is glad to welcome a new member

In April 2020, Corinna Schmidt joined our Department as technical assistant. Her scientific-supporting and administrative work will focus on our experimental research pillar.



March 2020


The AK Kloft is glad to welcome a new guest researcher

Starting from March 2020, Dr. Uwe Liebchen, medical doctor at the Department of Anaesthesiology at University Hospital Munich (Ludwig-Maximilians-Universität), will join our Department as a guest researcher. As part of the Munich clinician scientist program (MCSP), he will support our research in the field of antibiotics in various projects.


The AK Kloft is glad to welcome a new member

In March 2020, a new doctoral student, Ayatallah Saleh, has joined our Department. Her doctoral project will focus on pharmacometric modelling approaches of anti-infectives.


PharMetrX Module Curriculum: Kick-off

From 09 – 13 March 2020, the PharMetrX Module Curriculum for the new PhD student year of our PhD program will start with the A1 module “Introduction to pharmacokinetics and pharmacodynamics” taking place at our Institute. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de



February 2020


Presentation at ECCO 2020

Alix Démaris, doctoral student of our working group, will present her work “Evaluation of dosing strategies of anti-TNFα monoclonal antibodies using pharmacokinetic modelling and simulation” at the 15th congress of European Crohn’s and colitis organisation (ECCO), 12-15 February 2020, in Vienna, Austria. The theme of this year’s programme is “Inflammatory Bowel Diseases beyond 2020”, including debates about the future of TNF treatment and novel tools to monitor disease activity.


Visit at the Netherlands Cancer Institute

On 18-19 February 2020, Anna Mueller-Schoell, doctoral student of our Department will visit the Netherlands Cancer Institute (NKI) on the topic of Therapeutic Drug Monitoring for oral anticancer drugs. The NKI, associated with the Antoni van Leeuwenhoek Hospital, is a national and international centre of scientific and clinical expertise and a pioneer in the field of personalised anticancer drug therapy.


New scientific publication of Department

The article “Bayesian data assimilation to support informed decision-making in individualized chemotherapy“ by Maier, Hartung, de Wiljes, Kloft and Huisinga has been accepted in CPT: Pharmacometrics and Systems Pharmacology, and is now available online.

https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/psp4.12492



January 2020


Kick-off for new EU research project FAIR

On 13-14 January 2020, the kick-off meeting for the ‘Flagellin Aerosol Therapy As An Immunomodulatory Adjunct To The Antibiotic Treatment Of Drug-Resistant Bacterial Pneumonia’ (FAIR) will take place in Paris. FAIR is a joint collaboration of 11 partners – from France, Switzerland, Denmark, Ireland, United Kingdom, The Netherlands – for the next 5 years under the Horizon 2020 - Research and Innovation Framework Programme of the European Commission.


Workshop with Prof. Bernd Meibohm, USA

On 21 January 2020, Prof. Dr. Bernd Meibohm from the College of Pharmacy, University of Tenessee Health Science Center, College of Pharmacy, Memphis (USA), will visit our Department. During the workshop, he will give insights about new aspects of PK/PD of therapeutic proteins and four of our working group members, Dr. Robin Michelet, Dr. Niklas Hartung, David Busse and Alix Démaris will present their research.


Visit of Prof. Holdenrieder’s group, TU Munich

On 27January 2020, a team led by Prof. Stefan Holdenrieder from the Institute of Laboratory Medicine, German Heart Centre, Technical University of Munich will visit our working group. The purpose is to provide insights into our group’s research activities especially the in silico modelling and simulation platform used to describe disease process and treatment-response relationships. Prof. Charlotte Kloft and three doctoral students of our group Francis Williams Ojara, Yomna N Nassar and Anna Müller-Schöll will join discussions with the visiting team on ongoing research collaborations between the two working groups.


New European project proposal (within ‘Horizon 2020’) approved

AK Kloft is proud to announce that our project proposal within the Horizon 2020 - Research and Innovation Framework Programme of the European Commission entitled ‘Flagellin Aerosol Therapy As An Immunomodulatory Adjunct To The Antibiotic Treatment Of Drug-Resistant Bacterial Pneumonia’ (FAIR) is approved for funding.
As leaders of the Work Package “Development of a translational modelling and simulation platform for flagellin PK/PD” we will quantitatively support the translation of our investigated compound towards humans. We are very much looking forward to collaborate with our 11 partners – from France, Switzerland, Denmark, Ireland, United Kingdom, The Netherlands – for the next 5 years, starting in January 2020!