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  • For upcoming "Termine/Events" and "News" of the current month: see teasers on the right
  • For past "Termine/Events" of the current and former months: click here or see below
  • For "Termine/Events" and "News" of the last years: click on Archiv/Archive:



June


Presentation at ESDPPP Annual Meeting 2021

The work of a member of our working group, Dr. Robin Michelet, will be presented at the 18th meeting of the European Society for Developmental, Perinatal and Pediatric Pharmacology (ESDPPP), which will be held online, organised by the University of Liverpool.

https://www.esdppp.org/congresses/liverpool-2021\

 

4th PharMetrX PhD student Network Meeting

On 11-12 June 2021, the 4th PharMetrX PhD student Network Meeting will take place, where more than 80 former & present PhD students of the PharMetrX Graduate Research Training program will meet virtually to discuss ‘hot topics’ in Pharmacometrics and maintain the connections and interactions developed in the PharMetrX program and expand these across various PhD student years. The network meeting will start with a social event on Friday evening, 11 June, and having scientific and networking contents on Saturday, 12 June.

 

New article online on novel PK/PD parameters evaluating antibiotic therapy

The manuscript “Novel pharmacokinetic/pharmacodynamic parameters quantify the exposure–effect relationship of levofloxacin against fluoroquinolone-resistant Escherichia coli” by Seeger et al. has been accepted in the journal Antibiotics as part of the Special Issue Optimizing Antibiotic Treatment: Pharmacokinetics and Clinical Trials and is now available online.

https://www.mdpi.com/2079-6382/10/6/615/htm


PhD student awarded Best Presentation Award at EORTC-PAMM Spring meeting

Anna Mueller-Schoell, doctoral student of our Department, was awarded the Best Presentation Award for her presentation “A quantitative systems pharmacology model of four CAR-T cell phenotypes and CD19-positive metabolic tumour volume elucidates sources of the large pharmacokinetic variability” at the European Organisation for Research and Treatment of Cancer – Pharmacology and Molecular Mechanisms (EORTC-PAMM) Spring Meeting 2021

 

The AK Kloft is glad to welcome a new member

In May 2021, a new doctoral student Davide Bindellini joined our Department, also being enrolled in our PharMetrX program. Davide studied Pharmaceutical Biotechnology (B.Sc.) at Università degli studi di Milano, Italy, and Biomedical Sciences (M.Sc.) at Leiden University, the Netherlands. He will have his doctoral thesis project in the area of pharmacometrics: A warm welcome!



May


Research Exchange Day with FUSA

On 17 May 2021, a research Exchange Day will be organised together with Flinders University of South Australia. From our group, PhD students Alix Démaris, Anna Müller-Schöll and Franz Weber will present their research. We are looking forward to fruitful discussion and exchange!

 

Presentation at CIMT Meeting 2021

Anna Mueller-Schoell, doctoral student of our working group, will present her work entitled “Early survival prediction framework in CD19-specific CAR-T cell immunotherapy using a quantitative systems pharmacology” at the 18th Cancer Immunotherapy (CIMT) Annual Meeting 2021.

https://www.meeting.cimt.eu


New article online on the evaluation of our MeroRisk Calculator

The manuscript “Evaluation of the MeroRisk Calculator, a user-friendly tool to predict the risk of meropenem target non-attainment in critically ill patients” by Liebchen et al. has been accepted in the journal Antibiotics as part of the Special Issue TDM, Individual Dosing and Application of Antibiotics/Antiinfectives in Critically Ill Patients and is now available online.

https://www.mdpi.com/2079-6382/10/4/468

 

The AK Kloft is glad to welcome a new member

In May 2021, a new doctoral student Felix Müller joined our Department. Felix studied Pharmacy at Universitaet Greifswald. He will have his doctoral thesis project in the area of microdialysis and in vitro systems/cell culture: A warm welcome!

 

Article online on the use of pharmacometrics in immunomodulatory drug R&D

The manuscript “The use of translational modelling and Simulation to develop immunomodulatory therapy as an adjunct to antibiotic treatment in the context of pneumonia” by Michelet et al. has been accepted in the journal Pharmaceutics as part of a Special Issue The Role of Pharmacometrics in Drug Discovery and Development Process and is available online now.

https://www.mdpi.com/1999-4923/13/5/601

 

First-patient-in for our ON-TARGET study (TDM in clinical practice)

The first patient has been included in the ON-TARGET study, a non-interventional study on Therapeutic Drug Monitoring in patients with renal cell carcinoma and on the feasibility of using Volumetric Absorptive Microsampling (VAMS) for sample collection. The ON-TARGET study is the joint project of a network of clinical and academic experts in oral tumour therapy, pharmacometric data analysis, bioanalysis, and clinical studies within the framework of the Central European Society for Anticancer Drug Research (CESAR).

https://www.bcp.fu-berlin.de/en/pharmazie/faecher/klinische_pharmazie/arbeitsgruppe_kloft/on-target-studie/index.html


Scientific workshop with Prof. Meibohm, UTHSC

On 04 May 2021, Prof. Dr. Bernd Meibohm from the College of Pharmacy, University of Tenessee Health Science Center, College of Pharmacy, Memphis (USA), will join us for an online scientific workshop (part 2). He will give insights about new aspects of PK/PD of therapeutic proteins. In addition, a working group member, Dr. Robin Michelet will present his research.

www.PharMetrx.de



April 2021


The AK Kloft is glad to welcome a new member

In April 2021, a new doctoral student Franz Weber will join our Department, also being enrolled in our PharMetrX program. Franz studied Pharmacy at the Martin-Luther-Universitaet Halle-Wittenberg. He will have his doctoral thesis project in the area of pharmacometrics for optimisation of antibiotic therapy in critically ill patients: A warm welcome!

 

Article online on a PK/PD analysis of novel anti-infective combination therapy

The manuscript “A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice” by Franck, Michelet et al. has been accepted in the journal Pharmaceutics as part of a Special Issue The Role of Pharmacometrics in Drug Discovery and Development Process and is available online now.

https://www.mdpi.com/1999-4923/13/4/469

 

Defence of doctoral thesis of Ana-Marija Grišić

The defence of the doctoral thesis by Ana-Marija Grišić entitled “Pharmacometric analysis of monoclonal antibodies to support clinical decision-making” will take place online, on Friday, 23 April 2021, at 16:00. We are very much looking forward to the event!

 

Presentation at EORTC-PAMM Spring Meeting 2021

Anna Mueller-Schoell, doctoral student of our working group, will present her work entitled “A quantitative systems pharmacology model of four CAR-T cell phenotypes and CD19-positive metabolic tumour volume elucidates sources of the large pharmacokinetic variability” at the European Organisation for Research and Treatment of Cancer – Pharmacology and Molecular Mechanisms (EORTC-PAMM) Spring Meeting 2021.




March 2021


Scientific workshop with Prof. Meibohm, UTHSC

On 29 March 2021, Prof. Dr. Bernd Meibohm from the College of Pharmacy, University of Tenessee Health Science Center, College of Pharmacy, Memphis (USA), will join us for an online scientific workshop. He will give insights about new aspects of PK/PD of therapeutic proteins and Model-Informed Precision Dosing. In addition, two of our working group members, Dr. Robin Michelet and Alix Démaris will present their research.

www.PharMetrx.de

 

PharMetrX Module Curriculum continues

From 22-26 March 2021, the PharMetrX A2 module “Introduction to physiologically based pharmacokinetics” will take place online. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de

www.PharMetrx.de

 

Curious of what we are doing in research?

We will be offering an online introduction and informal dialogue for students on the 19 March 2021: All undergraduate pharmacy students or recent graduates who are interested in getting insight in our research projects, the methodology platform we are using and our working group are welcome to join. Please contact Josefine Schulz (josefine.schulz@fu-berlin.de) for further details.

 

Article on the impact of non-adherence in model-informed precision dosing

The manuscript “Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies” by Mueller-Schoell et al. has been accepted in the journal Pharmaceuticals and is available online now.

https://doi.org/10.3390/ph14020115

 

Article online on erlotinib resistance in an EGFR activating mutated lung cancer

The manuscript “Constitutive Cell Proliferation Regulating Inhibitor of Protein Phosphatase 2A (CIP2A) Mediates Drug Resistance to Erlotinib in an EGFR Activating Mutated NSCLC Cell Line” by Saafan, Alahdab, Michelet et al. has been accepted in the journal Cells and is available online now.

https://www.mdpi.com/2073-4409/10/4/716


PharMetrX Module Curriculum: Kick-off

On 01 March 2021, the PharMetrX Module Curriculum for the new doctoral student year of our PhD program will kick off with the A1 module “Introduction to pharmacokinetics and pharmacodynamics” taking place online from 01 – 05 and 12 March 2021. For more detailed information on the module and the structured Graduate Research Training program PharMetrX, please visit our homepage www.PharMetrx.de



January 2021


PharMetrX at virtual ALARM job fair in Göteborg

PharMetrX at the (virtual) ALARM job fair 2021 of the University of Gothenburg (GU): We are excited to talk to Pharmacy students of all semesters about opportunities to conduct a M.Sc. project or internship with us. We will also encourage applying to our Research, Training and Network Graduate Programme! Dr. Johanna Melin and David Busse, former and present PhD students of the program, are looking forward to getting in touch with the GU students on the 21st of January!

https://farmaci.alarmmassan.se/


Review article on Therapeutic Drug Monitoring of 71 oral anticancer drugs

The manuscript “Therapeutic Drug Monitoring of oral targeted antineoplastic drugs” by Mueller-Schoell et al. has been accepted in the European Journal of Clinical Pharmacology and is available online now.

https://doi.org/10.1007/s00228-020-03014-8