Medical Applications of Radioactive and Non-radioactive Metal Complexes
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Our interests in medical applications focussed to radioactive compound for nuclear medical diagnostics and therapy using 99mTc, 68Ga and 188Re, but also to cytotoxic compounds for the treatment of cancer or parasitic diseases such as Chaga's diseaseThis research was done in collaboration with the nuclear medical research group of the Charite Berlin and with the groups of Prof. Pedro Ivo da Silva Maia (Universidade Federal do Triangolu Mineiro, UFTM, Brazil) and Prof. Victor Deflon (Universidade Sao Paulo, Brazil). |
Medicinal Chemistry
Alice P. Borges, Malu M. S. Obata, Silvia H. Libardi, Rafael O. Trevisan, Victor M. Deflon, Ulrich Abram,
Francis B. Ferreira, Luiz Antônio S. Costa, Antonio O. T. Patrocínio, Marcos V. da Silva, Júlio C. Borges, Pedro I. S. Maia
"Gold(I) and Silver(I) Complexes Containing Hybrid Sulfonamide/Thiourea Ligands as Potential Leishmanicidal Agents"
Radioactive Metal Complexes
Anna Baitullina, Guilhem Claude, Suelen F. Sucena, Eda Nisli, Cedric Scholz, Punita Bhardwaj,
Holger Amthauer, Winfried Brenner, Christopher Geppert, Christian Gorges, Ulrich Abram,
Pedro Ivo da Silva Maia and Sarah Spreckelmeyer
" Metallacages with 2,6‑dipicolinoylbis(N,N‑dialkylthioureas) as novel platforms in nuclear medicine for 68Ga, 177Lu and 198Au"
Technetium Chemistry
Guilhem Claude, Denis Puccio, Maximilian Roca Jungfer, Adelheid Hagenbach, Sarah Spreckelmeyer, Ulrich Abram
"Technetium complexes with an isocyano-alkyne ligand and its reaction products"
Biologically Active Gold Complexes
Federico Salsi, Gisele Bulhões Portapilla, Konstantin Schutjajew, Maximilian Roca Jungfer, Amanda Goulart, Zumira Aparecida Carneiro, Adelheid Hagenbach, Sérgio de Albuquerque, Ulrich Abram
Organometallic gold(III) complexes with tridentate, halogen-substituted thiosemicarbazones: effects of halogenation on cytotoxicity and anti-parasitic activity
Biologically Active Gold Complexes
Carla Duque Lopes, Bruna Possato, Ana Paula S. Gaspari, Ronaldo J. Oliveira, Ulrich Abram, José P. A. Almeida, Fernanda dos Reis Rocho, Andrei Leitão, Carlos A. Montanari, Pedro I. S. Maia, João S. da Silva, Sérgio de Albuquerque, Zumira A. Carneiro
Organometallic gold(III) complex [Au(Hdamp)(L14)]+ (L1 = SNS-donating thiosemicarbazone) as a candidate to new formulations against Chagas disease
Medicinal Chemistry
Arantxa Pino-Cuevas, Paula Raposinho, Célia Fernandes, António Paulo, Ulrich Abram, Rosa Carballo, Ezequiel M. Vazquez Lopez
Thiosemicarbazonate Complexes with Affinity for Amyloid-ß Fibers: Synthesis, Characterization and Biological Studies
Rhenium Chemistry
Arantxa Pino-Cuevas, Ana Graña, Ulrich Abram, Rosa Carballo, Ezequiel M. Vázquez-López
Structural Study of Mono- Di- and Tetranuclear Complexes of the {Re(CO)3}+ Fragment with Thiosemicarbazones/Thiosemicarbazonates Ligands Containing Benzothiazole or Benzoxazole Groups.
Fluorinated Ligands
F. Salsi, G. Bulhões Portapilla, K. Schutjajew, Z. Aparecida Carneiro, A. Hagenbach, S. de Albuquerque, U. Abram
Thiosemicarbazones and thiadiazines derived from fluorinated benzoylthioureas: synthesis, crystal structure and anti-Trypanosoma cruzi activity
Radioactive Tracers in Medicine
U. Abram
Innovative PET and SPECT tracers
in I. Sack, T. Schäffter, Quantification of Biophysical Parameters by Medical Imaging, Springer International, 2018.
