Speaker: Lillian Chong, University of Pittsburgh

Rare biological and chemical events often lie beyond the reach of conventional simulations. The weighted ensemble (WE) path sampling strategy overcomes this barrier, extending accessible timescales by orders of magnitude while maintaining rigorous kinetics. By directly simulating pathways and stepwise rates, WE reveals molecular mechanisms in unprecedented detail. In this talk, I will highlight recent advances in WE methodology and showcase applications to ligand unbinding and chemical reactions.