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Dscam and pancrustacean immune memory - a review of the evidence

Armitage SAO, Peuss R, Kurtz J – 2015

Evidence is accumulating for a memory-like phenomenon in the immune defence of invertebrates. Down syndrome cell adhesion molecule (Dscam) has been proposed as a key candidate for a somatically diversified receptor system in the crustaceans and insects (Pancrustacea) that could enable challenge-specific protection. However, what is the evidence for an involvement of Dscam in pancrustacean immune memory, and in particular specificity? Here we review the current state of the art, and discuss hypotheses of how Dscam could be involved in immunity. We conclude that while there is increasing evidence for the involvement of Dscam in pancrustacean immunity, crucial experiments to address whether it plays a role in specificity upon secondary encounter with a pathogen still remain to be done.

Title
Dscam and pancrustacean immune memory - a review of the evidence
Author
Armitage SAO, Peuss R, Kurtz J
Publisher
Elsevier Science
Keywords
Down syndrome cell adhesion molecule; Drosophila; Immune priming; Innate immunity; Insect immunity; Specificity
Date
2015-02
Identifier
doi: 10.1016/j.dci.2014.03.004
Appeared in
Developmental and Comparative Immunology, 48(2): 315-23
Language
eng
Type
Text
Rights
Copyright © 2014 Elsevier Ltd. All rights reserved.