Beyond Molecular Codes: Simple Rules to Wire Complex Brain

Hassan, B.A. and Hiesinger, P.R. – 2015

Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental algorithms. We explore how molecules and mechanisms that have been considered part of a code may alternatively implement simple pattern formation rules sufficient to ensure wiring specificity in neural circuits. This analysis delineates a pattern-based framework for circuit construction that may contribute to our understanding of brain wiring.

Title
Beyond Molecular Codes: Simple Rules to Wire Complex Brain
Author
Hassan, B.A. and Hiesinger, P.R.
Publisher
Cell Press
Date
2015-10-08
Identifier
doi: 10.1016/j.cell.2015.09.031
Appeared in
Cell, 163(2):285-291
Language
eng
Type
Text
Rights
© 2015 Elsevier Inc.
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