Systematic discovery of Rab GTPases with synaptic functions in Drosophila.

Chan, C.C., Scoggin, S., Wang, D., Cherry, S., Dembo, T., Greenberg, B., Jin, E.J., Kuey, C., Lopez, A., Mehta, S.Q., Perkins, T.J., Brankatschk, M., Rothenfluh, A., Buszczak, M.*, and Hiesinger, P.R.* – 2011

Neurons require highly specialized intracellular membrane trafficking, especially at synapses. Rab GTPases are considered master regulators of membrane trafficking in all cells, and only very few Rabs have known neuron-specific functions. Here, we present the first systematic characterization of neuronal expression, subcellular localization, and function of Rab GTPases in an organism with a brain.

Title
Systematic discovery of Rab GTPases with synaptic functions in Drosophila.
Author
Chan, C.C., Scoggin, S., Wang, D., Cherry, S., Dembo, T., Greenberg, B., Jin, E.J., Kuey, C., Lopez, A., Mehta, S.Q., Perkins, T.J., Brankatschk, M., Rothenfluh, A., Buszczak, M.*, and Hiesinger, P.R.*
Publisher
Cell Press
Date
2011-10-13
Identifier
doi: 10.1016/j.cub.2011.08.058
Appeared in
Curr. Biol. 21(20): 1704-15
Language
eng
Type
Text
Rights
© 2011 Elsevier Ltd.
NeuroCure