Publication in Cell reports "Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses"
We congratulate the authors on their publication in Cell reports
In Brief Fulterer et al. demonstrates that the scaffold proteins Bruchpilot and Syd-1 cluster (M)Unc13 release factor isoforms either close (BRP/Unc13A) or further away (Syd-1/Unc13B) from voltage-gated Ca2+ channels in the Drosophila olfactory system. These scaffold/release factor ‘‘modules’’ varied significantly between different synapse types, thereby tuning release features toward depression or facilitation
- Active zone scaffold proteins systematically differ between synapse types in Drosophila
- BRP localizes Unc13A 30–40 nm closer to voltage-gated Ca2+ channels than Syd-1 Unc13B
- BRP/Unc13A dominates at fast, depressing, Syd-1/Unc13B at slow, facilitating synapses