Figure 1

The figure shows the formation, elongation and segmentation of the digits in the mouse forelimb. Left panel: whole-mount in-situ hybridization with probes showing precartilaginous condensations (Sox9), cartilage condensations (Col2a1) and joint interzones (Gdf5). Right panel: skeletal preparation of a newborn mouse hand. Digits 1-5 are indicated, m=metacarpal, p1-p3=phalanges 1-3. From Stricker and Mundlos, Developmental Dynamics 2011, 240(5), 990-1004.