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Dr. Daniel Bäcker



Freie Universität Berlin

Institut für Pharmazie

Pharmazeutische und Medizinische Chemie

Wissenschaftlicher Mitarbeiter

Institut für Pharmazie
Königin-Luise-Straße 2-4
Raum 114
14195 Berlin

05/23-dato: Wissenschaftlicher Mitarbeiter (PostDoc), Freie Universität Berlin (FU), Berlin, DE

08/22: Gastdozent, Hanoi University of Pharmacy (HUP), Hanoi, VNM

10/20-04/23: Wissenschaftlicher Mitarbeiter (PostDoc), Universität Greifswald (UG), Greifswald, DE

02/20-09/20: Wissenschaftlicher Mitarbeiter (PostDoc), Tiroler Krebsforschungsinstitut (TKFI), Medizinische Universität Innsbruck (MUI), Innsbruck, AT

01/20: Promotion zum Doctor of Philosophy (PhD), Pharmazeutische Wissenschaften

02/16-01/20: Wissenschaftlicher Mitarbeiter (PraeDoc), Leopold-Franzens-Universität (LFU), Innsbruck, AT

07/16: Allgemeine Berufsberechtigung als Apotheker, AT

12/15: Approbation als Apotheker, DE

05/15-11/15: Pharmazeut im Praktikum, Mohren-Apotheke zu St. Lorenz, Nürnberg, DE

11/14-04/15: Pharmazeut im Praktikum, University of Florida (UF), Gainesville, USA

10/10-07/14: Studium der Pharmazie, Friedrich-Alexander-Universität (FAU), Erlangen-Nürnberg, DE

[27] Alexander Weninger, Jessica Sagasser, Victoria Obermoser, Josef Egger, Susanna Wisboeck, Qianqian Qui, Miriam Ladstaetter, Andrea Cucchiaro, Klaus Wurst, Daniel Baecker*, Ronald Gust*. Development of Zeise’s salt derivatives bearing substituted acetylsalicylic acid substructures as cytotoxic COX inhibitors. Pharmaceutics, 2023, 15(6), 1573. https://doi.org/10.3390/pharmaceutics15061573

[26] Le-Quang Bao, Daniel Baecker, Do Thi Mai Dung, Nguyen Phuong Nhung, Nguyen Thi Thuan, Phuong Linh Nguyen, Phan Thi Phuong Dung, Tran Thi Lan Huong, Bakhtiyor Rasulev, Gerardo M. Casanola-Martin, Nguyen-Hai Nam*, Hai Pham-The*. Development of activity rules and chemical fragment design for in silico discovery of AChE and BACE1 dual inhibitors against Alzheimer’s disease. Molecules, 2023, 28(8), 3588. https://doi.org/10.3390/molecules28083588

[25] Fatihu Ahmad Rufa’i, Daniel Baecker, Muhammad Dauda Mukhtar*. Phytochemical screening, GC-MS analysis, and evaluating in vivo antitrypanosomal effects of a methanolic extract of Garcinia kola nuts on rats. Antibiotics, 2023, 12(4), 713. https://doi.org/10.3390/antibiotics12040713

[24] Duong Tien Anh, Nguyen Hai Nam, Brigitte Kircher*, Daniel Baecker*. The impact of fluorination on the design of histone deacetylase inhibitors. Molecules, 2023, 28(4), 1973. https://doi.org/10.3390/molecules28041973

[23] Frieda-Marie Bartz, Kristin Beirow, Konrad Wurm, Daniel Baecker, Andreas Link, Patrick J. Bednarski*. A graphite furnace-atomic absorption spectrometry-based rubidium efflux assay for screening activators of the Kv7.2/3 channel. Archiv der Pharmazie, 2023, 356(5), 2200585. https://doi.org/10.1002/ardp.202200585

[22] Benjamin N. Ma, Daniel Baecker, Hubert Descher, Philipp Brandstaetter, Martin Hermann, Brigitte Kircher*, Ronald Gust*. Synthesis and biological evaluation of salophen nickel(II) and cobalt(III) complexes as potential anticancer compounds. Archiv der Pharmazie, 2023, 356(5), 2200655. https://doi.org/10.1002/ardp.202200655

[21] Daniel Baecker*, Do Thi Mai Dung, Hai Pham-The, Nguyen Hai-Nam. Comparison of the university pharmacy education programs in Germany and Vietnam. Pharmacy, 2022, 10(6), 146. https://doi.org/10.3390/pharmacy10060146

[20] Elias Eger, Michael Schwabe, Lukas Schulig, Nils-Olaf Hübner, Jürgen A. Bohnert, Uwe T. Bornscheuer, Stefan E. Heiden, Justus U. Müller, Fazal Adnan, Karsten Becker, Carlos Correa-Martinez, Sebastian Guenther, Evgeny A. Idelevich, Daniel Baecker, Katharina Schaufler*. Extensively drug-resistant Klebsiella pneumoniae Counteracts fitness and virulence costs that accompanied Ceftazidime-Avibactam resistance acquisition. Microbiology Spectrum, 2022, 10(3), e0014822. https://doi.org/10.1128/spectrum.00148-22

[19] Daniel Baecker*. Introducing audio podcasts into a practical laboratory course for pharmacy students as a novel tool of performance assessment. Pharmacy, 2022, 10(2), 40. https://doi.org/10.3390/pharmacy10020040

[18] Daniel Baecker*, Sebastian Guenther. General applicability of high-resolution continuum-source graphite furnace molecular absorption spectrometry to the quantification of oligopeptides using the example of glutathione. Analytica, 2022, 3(1), 24-35. https://doi.org/10.3390/analytica3010003 

[17] Steven Behnisch-Cornwell, Christoph W. Grathwol, Lukas Schulig, Anika Voigt, Daniel Baecker, Andreas Link, Patrick J. Bednarski*. Correlation analysis of protein expression of 10 HDAC/sirtuin isoenzymes with sensitivities of 23 anticancer drugs in 17 cancer cell lines and potentiation of drug activity by co-treatment with HDAC inhibitors. Cancers, 2022, 14(1), 187. https://doi.org/10.3390/cancers14010187

[16] Daniel Baecker, Jessica Sagasser, Serhat Karaman, Anton A. Hörmann, Ronald Gust*. Development of methylated cobalt alkyne complexes with selective cytotoxicity against COX-positive cancer cell lines. Archiv der Pharmazie, 2021, 355(2): e2100408. https://doi.org/10.1002/ardp.202100408

[15] Lisa Wolff, Siva S. M. Bandaru, Elias Eger, Hoai-Nhi Lam, Martin Napierkowski, Daniel Baecker, Carola Schulzke*, Patrick J. Bednarski*. Comprehensive evaluation of biological effects of pentathiepins on various human cancer cell lines and insights into their mode of action. International Journal of Molecular Sciences, 2021, 22(14): 7631. https://doi.org/10.3390/ijms22147631

[14] Caroline M.Gallati, Sina K. Goetzfried, Anna Ortmeier, Jessica Sagasser, Klaus Wurst, Martin Hermann, Daniel Baecker, Brigitte Kircher, Ronald Gust*. Synthesis, characterization and biological activity of bis[3-ethyl-4-aryl-5-(2-methoxypyridin-5-yl)-1-propyl-1,3-dihydro-2H-imidazol-2-ylidene]gold(I) complexes. Dalton Transactions, 2021, 50(12): 4270-4279. https://doi.org/10.1039/D0DT03902K

[13] Daniel Baecker, Özcan Sesli, Ludwig Knabl, Silke Huber, Dorothea Orth-Höller, Ronald Gust*. Investigating the antibacterial activity of salene/salophene metal complexes: Induction of ferroptosis as part of the mode of action. European Journal of Medicinal Chemistry, 2021, 209: 112907. https://doi.org/10.1016/j.ejmech.2020.112907

[12] Daniel Baecker, Timo Kapp, Petra Schumacher, Ronald Gust, Brigitte Kircher*. Cell death-inducing properties of selected dendrimers against different breast cancer and leukemia cell lines. Archiv der Pharmazie, 2020, 353(11): e2000209. https://doi.org/10.1002/ardp.202000209

[11] Daniel Baecker, Benjamin N. Ma, Jessica Sagasser, Lukas Schultz, Carina Hörschläger, Maria Weinreich, Lucy Steiner, Brigitte Kircher, Ronald Gust*. Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(III) as necroptosis and ferroptosis inducers. Dalton Transactions, 2020, 49(20): 6842-6853. https://doi.org/10.1039/D0DT00168F

[10] Caroline M. Gallati, Sina K. Goetzfried, Marjana Ausserer, Jessica Sagasser, Matthias Plangger, Klaus Wurst, Martin Hermann, Daniel Baecker, Brigitte Kircher, Ronald Gust*. Synthesis, characterization and biological activity of bromido[3-ethyl-4-aryl-5-(2-methoxypyridin-5-yl)-1-propyl-1,3-dihydro-2H-imidazol-2-ylidene]gold(I) complexes. Dalton Transactions, 2020, 49(17): 5471-5481. https://doi.org/10.1039/C9DT04824C

[9] Julian D. Wolf, Markus Kurpiers, Roman X. Götz, Sergey Zaichik, Andrea Hupfauf, Daniel Baecker, Ronald Gust, Andreas Bernkop-Schnürch*. Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing self-emulsifying drug delivery systems (SEDDS). European Journal of Pharmaceutics and Biopharmaceutics, 2020, 150: 77-86. https://doi.org/10.1016/j.ejpb.2020.03.004

[8] Alexandra Knox, Christina Kalchschmid, Daniela Schuster, Francesca Gaggia, Claudia Manzl, Daniel Baecker, Ronald Gust*. Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators. European Journal of Medicinal Chemistry, 2020, 192: 112191. https://doi.org/10.1016/j.ejmech.2020.112191

[7] Daniel Baecker, Victoria Obermoser, Elisabeth A. Kirchner, Andrea Hupfauf, Brigitte Kircher, Ronald Gust*. Fluorination as tool to improve sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes. Dalton Transactions, 2019, 48(42): 15856-15868. https://doi.org/10.1039/C9DT03330K

[6] Jessica Sagasser, Benjamin N. Ma, Daniel Baecker, Stefan Salcher, Martin Hermann, Julia Lamprecht, Stefanie Angerer, Petra Obexer, Brigitte Kircher, Ronald Gust*. A new approach in cancer treatment: Discovery of chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes as ferroptosis inducers. Journal of Medicinal Chemistry, 2019, 62(17): 8053-8061. https://doi.org/10.1021/acs.jmedchem.9b00814

[5] Sami El Deeb, Benjamin N. Ma, Daniel Baecker, Ronald Gust*. Studies on the stability of the anticancer-active [N,N‘-bis(salicylidene)-1,2-phenylenediamine]chloridoiron(III) complex under pharmacological-like conditions. Inorganica Chimica Acta, 2019, 487: 76-80. https://doi.org/10.1016/j.ica.2018.12.002

[4] Christina Leichner, Christian Steinbring, Randi A. Baus, Daniel Baecker, Ronald Gust, Andreas Bernkop-Schnürch*. Reactive keratin derivatives: A promising strategy for covalent binding to hair. Journal of Colloid and Interface Science, 2019, 534: 533-541. https://doi.org/10.1016/j.jcis.2018.09.062

[3] Max Jelkmann, Claudia Menzel, Randi A. Baus, Philipp Ausserhofer, Daniel Baecker, Ronald Gust, Andreas Bernkop-Schnürch*. Chitosan: The one and only? Aminated cellulose as an innovative option for primary amino groups containing polymers. Biomacromolecules, 2018, 19(10): 4059-4067. 

[2] Alexander Weninger, Daniel Baecker, Victoria Obermoser, Dorothea Egger, Klaus Wurst, Ronald Gust*. Synthesis and biological evaluation of Zeise’s salt derivatives with acetylsalicylic acid substructure. International Journal of Molecular Sciences, 2018, 19(6): 1612. https://doi.org/10.3390/ijms19061612

[1] Victoria Obermoser, Daniel Baecker, Carina Schuster, Valentin Braun, Brigitte Kircher, Ronald Gust*. Chlorinated cobalt alkyne complexes derived from acetylsalicylic acid as new specific antitumor agents. Dalton Transactions, 2018, 47(12): 4341-4351. https://doi.org/10.1039/C7DT04790H