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PD Dr. rer. nat. Alexander Weng

weng_groß

Institut für Pharmazie

Wissenschaftlicher Mitarbeiter

Pharmazeutische Biologie

Adresse
Freie Universität Berlin
Institut für Pharmazie
Königin-Luise-Str. 2+4
Raum 470/471
14195 Berlin
Fax
030 838 51265
  • Genetik (Vorlesung, 4. Semester)
  • Physiologie der pathogenen und arzneistoffproduzierenden Organismen (Vorlesung, 4. Semester)
  • Biologische und phytochemische Untersuchungen (Seminar und Praktikum, 6. Semester)
  • Isolation und characterization of natural products with special focus on triterpene saponins und ribosome-inactivating proteins
  • Development of siRNA- and DNA-nanocarrier
  • Tools to improve the endosomal escape process [Flyer]
  • Ribosome inactivating proteins

(2019)

Kokorin, A., Weise, C., Sama, S., Weng, A. (2019) A new type 1 ribosome-inactivating protein from the seeds of Gypsophila elegans M.Bieb. Phytochemistry. 157:121-127.

Sama S., Jerz G., Thakur M., Melzig MF. & Weng A. (2019) Structure-Activity Relationship of Transfection-Modulating Saponins - A Pursuit for the Optimal Gene Trafficker. Planta Med. (Epub ahead of print, doi: 10.1055/a-0863-4795)

(2018)

Sama, S., Jerz G., Schmieder, P., Joseph, JF., Melzig, MF., Weng, A. (2018) Plant derived triterpenes from Gypsophila elegans M.Bieb. enable non-toxic delivery of gene loaded nanoplexes. J Biotechnol. 284:131-139.

Sama, S., Woith, E., Walther, W., Jerz, G., Chen, W., Hart, S., Melzig, MF., Weng, A. (2018) Targeted suicide gene transfections reveal promising results in nu/nu mice with aggressive neuroblastoma, Journal of controlled release, accepted manuscript.

Weng, A. (2017) A novel adenine-releasing assay for ribosome-inactivating proteins. J Chromatogr B Analyt Technol Biomed Life Sci. 1072:300-304.

(2017)

Sama, S., Jerz, G., Schmieder, P., Woith, E., Melzig, MF., Weng, A. (2017) Sapofectosid - Ensuring non-toxic and effective DNA and RNA delivery. Int J Pharm. 534(1-2):195-205.

Bhargava, C., Dürkop, H., Zhao, X., Weng, A., Melzig MF., Fuchs, H. (2017) Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861. Mol Oncol. 11(11):1527-1543.

Fuchs, H., Niesler, N., Trautner, A., Sama, S., Jerz, G., Panjideh, H., Weng, A. (2017) Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies. Biomedicines. 29;5(2).

Gilabert-Oriol, R., Furness, SGB., Stringer, BW., Weng, A., Fuchs, H., Day, BW., Kourakis, A., Boyd, AW., Hare, DL., Thakur, M., Johns, TG., Wookey, PJ. (2017) Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma. Cancer Immunol Immunother. 66(9):1217-1228.


(2016)

Gilabert-Oriol, R., Thakur, M., Haussmann, K., Niesler, N., Bhargava, C., Gorick, C., Fuchs, H. & Weng, A. (2016) Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin, Planta medica. 82(18), 1525-1531.

Fuchs, H., Weng, A. & Gilabert-Oriol, R. (2016) Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers, Toxins. 8(7).

Xie, W., Weng, A. & Melzig, M. F. (2016) MicroRNAs as New Bioactive Components in Medicinal Plants, Planta medica. 82(13), 1153-1162.

 

(2015)

Weng, A., Manunta, M. D., Thakur, M., Gilabert-Oriol, R., Tagalakis, A. D., Eddaoudi, A., Munye, M. M., Vink, C. A., Wiesner, B., Eichhorst, J., Melzig, M. F. & Hart, S. L. (2015) Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides, Journal of controlled release : official journal of the Controlled Release Society. 206, 75-90.

Schrot, J., Weng, A. & Melzig, M. F. (2015) Ribosome-inactivating and related proteins, Toxins. 7, 1556-615.

Holmes, S. E., Bachran, C., Fuchs, H., Weng, A., Melzig, M. F., Flavell, S. U. & Flavell, D. J. (2015) Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent, Immunopharmacology and immunotoxicology. 37, 42-55.

Gilabert-Oriol, R., Weng, A., von Mallinckrodt, B., Stoshel, A., Nissi, L., Melzig, M. F., Fuchs, H. & Thakur, M. (2015) Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina, International journal of pharmaceutics. 487, 39-48.

Gilabert-Oriol, R., Weng, A., Trautner, A., Weise, C., Schmid, D., Bhargava, C., Niesler, N., Wookey, P. J., Fuchs, H. & Thakur, M. (2015) Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861, Biochemical pharmacology. 97, 247-55.

 

(2014)

von Mallinckrodt, B., Thakur, M., Weng, A., Gilabert-Oriol, R., Durkop, H., Brenner, W., Lukas, M., Beindorff, N., Melzig, M. F. & Fuchs, H. (2014) Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma, Future oncology. 10, 2161-75.

Thakur, M., Jerz, G., Tuwalska, D., Gilabert-Oriol, R., Wybraniec, S., Winterhalter, P., Fuchs, H. & Weng, A. (2014) High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins, Journal of chromatography B, Analytical technologies in the biomedical and life sciences. 955-956, 1-9.

Gilabert-Oriol, R., Weng, A., Mallinckrodt, B., Melzig, M. F., Fuchs, H. & Thakur, M. (2014) Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy, Current pharmaceutical design. 20, 6584-643.

Gilabert-Oriol, R., Thakur, M., von Mallinckrodt, B., Bhargava, C., Wiesner, B., Eichhorst, J., Melzig, M. F., Fuchs, H. & Weng, A. (2014) Reporter assay for endo/lysosomal escape of toxin-based therapeutics, Toxins. 6, 1644-66.

 

(2013)

Thakur, M., Weng, A., Pieper, A., Mergel, K., von Mallinckrodt, B., Gilabert-Oriol, R., Gorick, C., Wiesner, B., Eichhorst, J., Melzig, M. F. & Fuchs, H. (2013) Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge, International journal of biological macromolecules. 61, 285-94.

Thakur, M., Mergel, K., Weng, A., von Mallinckrodt, B., Gilabert-Oriol, R., Durkop, H., Melzig, M. F. & Fuchs, H. (2013) Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice, Molecular oncology. 7, 475-83.

Gilabert-Oriol, R., Thakur, M., Weise, C., Dernedde, J., von Mallinckrodt, B., Fuchs, H. & Weng, A. (2013) Small structural differences of targeted anti-tumor toxins result in strong variation of protein expression, Protein expression and purification. 91, 54-60.

Gilabert-Oriol, R., Thakur, M., von Mallinckrodt, B., Hug, T., Wiesner, B., Eichhorst, J., Melzig, M. F., Fuchs, H. & Weng, A. (2013) Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells, Molecular pharmaceutics. 10, 4347-57.

15. Gilabert-Oriol, R., Mergel, K., Thakur, M., von Mallinckrodt, B., Melzig, M. F., Fuchs, H. & Weng, A. (2013) Real-time analysis of membrane permeabilizing effects of oleanane saponins, Bioorganic & medicinal chemistry. 21, 2387-95.

 

(2012)

16. Weng, A., Thakur, M., von Mallinckrodt, B., Beceren-Braun, F., Gilabert-Oriol, R., Wiesner, B., Eichhorst, J., Bottger, S., Melzig, M. F. & Fuchs, H. (2012) Saponins modulate the intracellular trafficking of protein toxins, Journal of controlled release : official journal of the Controlled Release Society. 164, 74-86.

Weng, A., Thakur, M., Beceren-Braun, F., Bachran, D., Bachran, C., Riese, S. B., Jenett-Siems, K., Gilabert-Oriol, R., Melzig, M. F. & Fuchs, H. (2012) The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins, Molecular oncology. 6, 323-32.

Thakur, M., Mergel, K., Weng, A., Frech, S., Gilabert-Oriol, R., Bachran, D., Melzig, M. F. & Fuchs, H. (2012) Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement, Biosensors & bioelectronics. 35, 503-6.

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