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Chromiumtrioxide is carcinogenic for human beings. Other chromium(VI)-compounds are at least carcinogenic in animal experiments. Most hazardous is the inhalation of dusts. Chromium(III)-salts are not carcinogenic, but have to be disposed separately as heavy metal waste. There are no general recommendations to replace the chromiumtrioxide. But often there are alternatives for specific synthetic problems, for example the oxidation of alcohols by SWERN-Oxidation. Even course books sometimes state some alternatives.