Chloromethane-Enabled Quaternization of Linear Polyglycerol Amines and Their Application as Antibacterial Agents

"Hanheiser, Natalie; Kleoff, Merlin; Achazi, Katharina; Singh, Abhishek; Riedel, Sebastian; Haag, Rainer"

Macromolecular Rapid Communications

Abstract In this study, the safe and scalable N ?methylation of primary amines in a linear polyglycerol (LPG) backbone structure is reported with altering molecular weight using gaseous chloromethane for the generation of quaternary ammonium groups. All polymers are subsequently analyzed for their antibacterial and antibiofilm properties against drug?resistant Staphylococcus?aureus ( S. aureus ), showing that the implementation of quaternary ammonium groups to a polymer backbone structure is an efficient way to generate new antimicrobial agents. Thereby, the molecular weight of the polymer backbone structure strongly correlates to its antibacterial effect and can be altered depending on the desired application.

2025

10.1002/marc.202500111

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