Springe direkt zu Inhalt

Alkyne Difunctionalization by Dual Gold/Photoredox Catalysis

A. Tlahuext-Aca, M. N. Hopkinson,† R. A. Garza-Sanchez,† F. Glorius* – 2016

Highly selective tandem nucleophilic addition/cross-coupling reactions of alkynes have been developed using visible-light-promoted dual gold/photoredox catalysis. The simultaneous oxidation of AuI and coordination of the coupling partner by photo-generated aryl radicals, and the use of catalytically inactive gold precatalysts allows for high levels of selectivity for the cross-coupled products without competing hydrofunctionalization or homocoupling. As demonstrated in representative arylative Meyer–Schuster and hydration reactions, this work expands the scope of dual gold/photoredox catalysis to the largest class of substrates for gold catalysts and benefits from the mild and environmentally attractive nature of visible-light activation.

Title
21. Alkyne Difunctionalization by Dual Gold/Photoredox Catalysis
Author
A. Tlahuext-Aca, M. N. Hopkinson,† R. A. Garza-Sanchez,† F. Glorius*
Publisher
Chemistry - A European Journal
Date
2016
Identifier
DOI: 10.1002/chem.201600710
Source(s)
Citation
Chem. Eur. J. 2016, 22, 5909-5913