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Using Rh(III)-Catalyzed C−H Activation as a Tool for the Selective Functionalization of Ketone-Containing Molecules

M. Boultadakis-Arapinis, M. N. Hopkinson, F. Glorius* – 2014

Due to the strong potential of C–H activation in many areas of organic chemistry, the use of a pre-existing carbonyl group for the installation of a directing group to enable selective and predictable α-alkenylation with activated olefins as coupling partners is described. This Heck-type reaction would then lead either to β,γ-unsaturated ketones or to variously substituted 1,4-butadienes depending on the conditions used for the cleavage of the directing group.

Title
15. Using Rh(III)-Catalyzed C−H Activation as a Tool for the Selective Functionalization of Ketone-Containing Molecules
Author
M. Boultadakis-Arapinis, M. N. Hopkinson, F. Glorius*
Publisher
Organic Letters
Date
2014
Identifier
DOI: 10.1021/ol500258q
Source(s)
Citation
Org. Lett. 2014, 16, 1630-1633