News Hopkinson Group
Our latest work exploring BT-salts as reagents for organofluorine chemistry is now out in Tetrahedron. In this work, we explore the Lewis acidity of BT-SCF 3 and related reagents and demonstrate their abiliity to activate THF. In the presence of carboxylates, ring-opening polymerisation is observed, while without a nucleophile, a remarkable α-deprotonation reaction takes place in the absence of a strong external base. Congratulations to first author Lili and to the co-authors and collaboration partners Jonas (Riedel group), Carlo, Patrick (Riedel group) and Andreas! The full text can be read here: https://www.sciencedirect.com/science/article/abs/pii/S0040402021007973 .
Oct 22, 2021
Stefan Dix has successfully defended his thesis and become the first PhD student to graduate from our group. Many congratulations Stefan - a just reward for all the hard work in the lab!
Oct 12, 2021
Our latest work exploring the combination of N-heterocyclic carbene (NHC) organocatalysis and photochemistry is now out in Tetrahedron as part of the special collection entitled "System-Oriented Development of Organocatalysis" (Editor: H. Ohmiya). In this study, acyl azolium salts of the kind formed during NHC-catalyzed reactions of carboxylic acid derivatives are shown to engage in Norrish Type II elimination reactions upon light irradiation. Moreover, in special cases, Norrish-Yang cyclizations can be observed. The full text can be read here: https://www.sciencedirect.com/science/article/abs/pii/S0040402021007821 Congratulations to the authors Andreas and Arielle!
Oct 10, 2021
A review article summarising key advances in the understanding and applications of N-heterocyclic carbenes (NHCs) over the last 6 years is now out in Nature Reviews Chemistry. This review is the result of a great collaboration with the Glorius group at the WWU Münster: https://www.uni-muenster.de/Chemie.oc/glorius/ The full text of the article can be found here: https://www.nature.com/articles/s41570-021-00321-1
Sep 05, 2021
In our latest paper published in Organic Chemistry Frontiers, we introduce BT-SeCF 2 H as the first nucleophilic reagent for introducing the SeCF 2 H group onto organic molecules. The study of this group as a constituent moiety in pharmaceuticals and agrochemicals has been limited by the lack of methods to synthesise it with previous routes involving either indirect approaches or electrophilic difluoromethylselenylating reagents. BT-SeCF 2 H, on the other hand, allows for direct nucleophilic difluoromethylselenylation of readily available carboxylic acids and benzylic alcohols. Congratulations to the first author Matteo and to Stefan! The full text can be read here: https://pubs.rsc.org/en/content/articlelanding/2021/qo/d1qo01104a
Aug 25, 2021
Congratulations to Nils, who has successfully defended his Master thesis on fluorine-specific hydrogen bonding interactions.
Aug 10, 2021
In our latest paper in collaboration with the Riedel group, bis(trifluoromethyl)peroxide (BTMP) is applied as a new reagent for the radical trifluoromethoxylation of arenes and heteroarenes. BTMP can be synthesised from the inexpensive bulk compounds CO and F 2 and serves as an attractive source of •OCF 3 radicals using either photoredox or TEMPO catalysis. The paper has been published in Chemistry - A European Journal and can be read here: Link: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202101621 Congratulations to the first author Stefan and thanks to Paul and Jonas in the Riedel group ( https://www.bcp.fu-berlin.de/en/chemie/chemie/forschung/InorgChem/agriedel/index.html ) for a great collaboration!
Jun 07, 2021
Our latest paper exploring benzothiazolium salts as reagents in organofluorine chemistry is now out in the Beilstein Journal of Organic Chemistry as part of the thematic issue "Organo-fluorine Chemistry V" (Guest Editor: D. O'Hagan). In this work, a series of BT-SR F reagents featuring long-chain perfluoroalkylthio groups were prepared and their reactivity was explored in deoxygenative substitution reactions. This led to the development of an unprecedented nucleophilic route to -SC 2 F 5 and -SC 3 F 7 -substituted compounds directly from aliphatic alcohols. Congratulations to the joint first authors Armin and Nils, as well as to contributors Ben and Stefan! The full text can be read here: https://www.beilstein-journals.org/bjoc/articles/17/8
Jan 08, 2021
We are honoured that our research has been recognised with a Thieme Chemistry Journal Award 2021! The award is presented each year by the editors of the Thieme journals Synthesis, Synlett and Synfacts to researchers worldwide who are in the early stages of their independent academic career working in chemical synthesis and catalysis or closely related areas of organic chemistry. Link: https://www.thieme.de/en/thieme-chemistry/thieme-chemistry-journals-award-107359.htm
Dec 10, 2020
Our latest paper exploring benzothiazolium salts as reagents for the synthesis of fluorine containing molecules is now published in Organic Letters. In this work, tri- and difluoromethyl thioesters could be prepared directly from readily available carboxylic acids using BT-SCF 3 and BT-SCF 2 H. DFT calculations support a concerted mechanism that avoids the generation of unstable fluoroalkylthiolate anions. Link: https://pubs.acs.org/doi/10.1021/acs.orglett.0c03328 Congratulations to the joint first authors Matteo and Lili as well as Arushi, Stefan and our collaboration partner Jan! Thanks also to QoD Technologies GmbH for conducting and analysing the DFT calculations.
Nov 04, 2020
A Synpacts article highlighting Andreas' work on the combination of NHC Organocatalysis and light activation is now out in Synlett. Photo-NHC catalysis is a conceptually novel catalysis mode that can allow synthetically important photochemical transformations of carbonyl compounds to be conducted with hitherto unsuitable substrates at the carboxylic acid oxidation level. The Synpacts article can be found here: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0040-1706472 while the original research article introducing Photo-NHC catalysis can be downloaded here: https://onlinelibrary.wiley.com/doi/10.1002/anie.201914456 .
Sep 28, 2020
Our new Concept paper highlighting catalytic reactions combining N-heterocyclic carbene (NHC) organocatalysis with light activation is out now in ChemPhotoChem. Light irradiation can open up new reactivity pathways for NHC organocatalysis either as part of a dual catalytic NHC/photoredox system or even in the absence of an additional photocatalyst. Congratulations to Andreas & Michael! You can check out their work here: http://dx.doi.org/10.1002/cptc.202000120
Jul 01, 2020
We are delighted to welcome Lilian Maas back to the group to undertake her PhD studies. After completing a successful Master project on organofluorine chemistry, Lilian will now work on the development of new methodologies for installing fluorine-containing functional groups as part of a project funded by the Daimler and Benz Foundation. Welcome Lilian!
Jun 05, 2020
Welcome to our two newest group members Arushi Garg and Michael Jakob who both begin their PhD studies on the 1st April. Arushi and Michael are both recipients of Elsa Neumann scholarships from the state of Berlin. Arushi will work on synthetic organofluorine chemistry while Michael will investigate photochemical organocatalysed reactions.
Apr 01, 2020
We are delighted that our recent work introducing Photo-NHC catalysis as a new approach enabling photoenolisation reactions of carboxylic acid derivatives is now published in Angewandte Chemie. Link: https://onlinelibrary.wiley.com/doi/10.1002/anie.201914456 Many congratulations to Andreas and former group members Keerthana, Paul and Arush! Thanks also to Vincent and Jan in the Götze group ( http://jgoetze.userpage.fu-berlin.de/ ) for a great collaboration!
Dec 09, 2019
Congratulations to Arushi for successfully completing her Master studies and defending her thesis on new applications of fluorine-containing benzothiazolium reagents.
Oct 23, 2019
Many congratulations to Stefan Dix who won a poster prize at the European Symposium on Fluorine Chemistry (ESFC 2019) in Warsaw, Poland. Stefan's poster summarized his work introducing BT-SCF 3 and BT-SeCF 3 as new reagents for organofluorine chemistry.
Sep 03, 2019
We are pleased to welcome two new members to the group. Armin Ariamajd and Nils Gerwien have joined as Student Assistants working on a project focussed on the development of new reagents for organofluorine chemistry funded by the Daimler and Benz Foundation. Welcome Armin and Nils!
Aug 01, 2019
Nils Gerwien has successfully defended his Bachelor thesis on the development of new fluorinated reagents. Many Congratulations! Congratulations also to Arushi Garg, who has completed her research internship. She has now started her Masters thesis in the group while Nils will join as a new Student Assistant.
Aug 01, 2019
You can now follow our group on Twitter under the handle @Hopkinson_Lab. Link: https://twitter.com/Hopkinson_Lab Follow us for updates on our research and other insights into our labs in Berlin.
May 07, 2019