New Paper in Organic Letters
Our latest paper exploring benzothiazolium salts as reagents for the synthesis of fluorine containing molecules is now published in Organic Letters. In this work, tri- and difluoromethyl thioesters could be prepared directly from readily available carboxylic acids using BT-SCF3 and BT-SCF2H. DFT calculations support a concerted mechanism that avoids the generation of unstable fluoroalkylthiolate anions.
Congratulations to the joint first authors Matteo and Lili as well as Arushi, Stefan and our collaboration partner Jan! Thanks also to QoD Technologies GmbH for conducting and analysing the DFT calculations.
News from Nov 04, 2020