Total synthesis has changed our world profoundly by widely advancing the fields of chemistry, biology and medicine. To ensure future progress, we must explore and exploit reactivity beyond classical patterns. By finding ways to manipulate the aliphatic carbon backbone of molecules, syntheses will become possible that can provide supplies of bioactive natural products and designed analogs expediently, efficiently and economically.
Technology-driven synthesis is an important part of our work. We design and build novel reactors to enable and facilitate synthetic operations for environmentally and economically more sustainable approaches towards complex molecular entities.
Our aim is to develop robust routes to biologically relevant natural products by harnessing a framework reconstruction approach as well as C–H-functionalization chemistry. Insights into the biogenesis guide our work. The analysis of reactivity patterns also allows us to collect evidence for a speculative biogenesis.
Our design and development program focuses on novel continuous flow technology and its application in the synthesis of natural products and biologically relevant molecules. Development of new reactors, along with suitable reactions, and an understanding of their optimization potential is the basis for these endeavors.