Virucidal compounds capable of binding to and disrupting viruses represent a promising avenue for antiviral applications. In this study, we report the development of high molecular weight (approximately 300 kDa) dendronized polyglycerol-based mucin-inspired amphiphilic statistical copolymers (MIACPs) using the RAFT polymerization technique. These copolymers comprise approximately 30% repeat units containing aliphatic C11 carbon chains with terminal carboxylate (MIACP-1) and alkyl (MIACP-2) functionalities, while the remaining ~70% of the repeat units consist of dendronized polyglycerol sulfates. Structural characterization using cryo electron microscopy (cryo-EM) and small-angle neutron scattering (SANS) revealed that MIACPs form single-chain filamentous structures, similar to natural porcine gastric mucin (PGM). These biocompatible MIACPs exhibited strong, sulfate-dependent inhibition of human respiratory syncytial virus (hRSV), with exceptionally low IC₅₀ values (C= ~0.25 µg/mL). The virucidal activity was assessed using serial dilution experiments, which confirmed that MIACPs demonstrated virucidal activity, indicating a very strong binding affinity of the polymers to the hRSV. In contrast, a similar molecular weight homopolymer composed solely of sulfated dendronized repeat units exhibited comparable hRSV inhibition activity but lacked any virucidal effect. Therefore, designing a statistical copolymer with approximately 30% virucidal functionality is unique in that it renders the copolymer virucidal without compromising its inhibitory activity.