Tailored materials combining biocompatibility, mechanical integrity, and functional bioactivity to support tissue repair, controlled therapeutic delivery, and next-generation implants with predictable degradation profiles.
Heteromultivalent polymers and antiviral applications thereof
A new class of linear heteromultivalent polymers bearing both hemagglutinin-binding and neuraminidase-binding ligands blocks influenza A virus attachment and release. These polymers show synergistic antiviral effects superior to monofunctional or nanoparticle analogs.
Dendritic polyglycerol cores (5–100 kDa) bearing ≥30% alkyl-carboxylate groups irreversibly inactivate a broad range of viruses, including SARS-CoV-2 and HSV-2, with low cytotoxicity.
A next-generation sulfated hydrogel engineered from dendritic polyglycerol sulfate and polyether units forms a tunable, biocompatible network with potent antiviral activity. This innovative material is designed to mimic natural tissue properties for applications in regenerative medicine and antiviral therapy.
An innovative polymeric platform consisting polyglycerol and polyoxazoline engineered for advanced wound healing and targeted gene therapy. This innovative copolymer system rapidly regenerates damaged tissue while serving as an efficient therapeutic delivery vehicle.
A sulfated hyperbranched polyester polyol selectively encapsulates hydrophobic small molecules bearing at least one amine, dramatically boosting aqueous solubility. The two-step, one-pot synthesis uses only glycidol, ε-caprolactone, and a sulfation reagent—no organic solvents—yielding a scalable solubilizing platform.
A novel amphiphilic copolymer forms micelles with a hydrophilic dendritic polyglycerol sulfate shell and hydrophobic polymer core, linked by a non-triazole hydrocarbon spacer. These micelles stably encapsulate hydrophobic anti-tumor drugs, show negligible leaching over 24 h, and release payloads in reductive or acidic tumor environments.
