Engineered interfaces that control interactions between living cells and synthetic surfaces, enabling advanced cell adhesion, signaling modulation, and real-time biosensing for tissue engineering, implantable devices, and wearables.
AMPHIPHILIC BLOCK COPOLYMER AND COATING ARRANGEMENT
A universal amphiphilic block copolymer enables stable, ultrathin monolayer coatings on diverse substrates, including metals, polymers, and nanomaterials. The design combines hydrophilic, hydrophobic, catechol, and crosslinking domains for strong adhesion and antifouling performance.
A layered polymer coating with catechol-functionalized polymers provides stable, bioinert, and antifouling surfaces for diverse substrates, including metals and plastics. This architecture significantly reduces protein adsorption and cell adhesion, enhancing biocompatibility for medical and diagnostic applications.
Thermoresponsive Hydrogel for iPSC Expansion and Release
A novel thermoresponsive hydrogel, combining dendritic polyglycerol units with poly(N-isopropylacrylamide)-co-polyethylene glycol via a bioorthogonal linker, creates a dynamic microniche for robust iPSC expansion and controlled cell release. Its thermoreversible properties enable gentle, efficient harvesting by simple temperature adjustment.
