At the moment, our research focuses on the generation of linear polycationic macromolecules that selectively interact with the cell envelopes of certain bacteria while exhibiting low cytotoxicity towards eukaryotic cells. Such compounds are promising candidates as novel antibiotics that are both selective and exhibit a low tendency to trigger resistance development. Further, we are interested in the interactions of our compounds with blood components and the anticoagulation agent heparin in order to improve heparin reversal agents.

Using toolbox-like synthesis approaches, we want to combine cationic, bioinert and targeting motives to tailor our macromolecules to their specific purpose.

Current projects include:

• Development of synthetic pathways based on iterative exponential growth (IEG) towards cationic and bioinert oligomeric blocks that can be combined in the desired number and order.
• Stepwise synthesis of ABA-type macromolecules with a charged middle block.
• Depolymerization of GAGs to obtain building blocks for tailored glycosurfactants.
• Synthesis of polymer gels for the separation of blood components.

If you want to know more, contact johanna.elter@fu-berlin.de!