67. Synthesis of Quinolinone Alkaloids via Aryne Insertions into Unsymmetric Imides in Flow
J. Schwan, M. Kleoff, B. Hartmayer, P. Heretsch, M. Christmann
A general strategy for the synthesis of 3,4-dioxygenated quinolin-2-one natural products is reported. The key step is a regioselective insertion of arynes into unsymmetric imides in flow.
Title
67. Synthesis of Quinolinone Alkaloids via Aryne Insertions into Unsymmetric Imides in Flow
Author
J. Schwan, M. Kleoff, B. Hartmayer, P. Heretsch, M. Christmann
Identifier
DOI: 10.1021/acs.orglett.8b03392
Citation
Org. Lett. 2018, 20, 7661–7664.