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(2) Multifunctional polymer-drug conjugates

PG-Doxo-PEG

PG-Doxo-PEG

We have established a platform technology for PEGylated nanoparticles based on dendritic polyglycerol. The design of this multifunctional approach allowed to fine-tune the drug-polymer conjugates with respect to drug loading and molecular weight and to prepare macromolecular prodrugs with similar surface charge and diameter, with different drugs and drug loading ratios as well as combination therapeutics that enable the release of at least two drugs. Furthermore, the multifunctional drug delivery system can easily be adapted to incorporate targeting ligands and diagnostic probes.

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