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Breaking the Barrier – Potent Anti-Inflammatory Activity following Efficient Topical Delivery of Etanercept using Thermoresponsive Nanogels

M. Giulbudagian, G. Yealland, S. Hönzke, A. Edlich, B. Geisendörfer, B. Kleuser, S. Hedtrich*, M. Calderón*.

Theranostics (2018), 8, 450-463.

Enhanced Topical Delivery of Dexamethasone by β-Cyclodextrin Decorated Thermoresponsive Nanogels

M. Giulbudagian, S. Hönzke, J. Bergueiro, D. Işık, F. Schumacher, S. Saeidpour, S. B. Lohan, M. C. Meinke, C. Teutloff, M. Schäfer-Korting, G. Yealland, B. Kleuser, S. Hedtrich, M. Calderón*.

Nanoscale (2018), 10, 469-479.

Selective cell isolation by transferrin functionalized silane-carbon soot mediated superhydrophobic micropatterns

G.P. Chate, N.R. Kale, V. Khobragade, C. Rahane, M. Calderón, S.S. Banerjee, J.J. Khandare.

Advanced Material Interfaces (2018), 2018, 5, 1701581.

Thermoresponsive nanogels with film-forming ability

A.S. Sonzogni, M.C.G. Passeggi (Jr.), S. Wedepohl, M. Calderón, L.M. Gugliotta, V.D.G. Gonzalez, R.J. Minari.

Polymer Chemistry (2018), 9, 1004–1011.

Optimizing the circulating tumor cells capture efficiency of magnetic nanogels mediated by transferrin decoration

C. Biglione, J. Bergueiro, M. Asadian-Birjand, C. Weise, V. Khobragade, G. Chate, M. Dongare, J. Khandare, M.C. Strumia, M. Calderón*.

Polymers (2018), 10, 174.

PEGylated dendritic polyglycerol conjugate targeting NCAM-expressing neuroblastoma: limitations and challenges

L.I. Vossen, E. Markovsky, A. Eldar-Boock, H.R. Tschiche, S. Wedepohl, R. Satchi-Fainaro*, M. Calderón*

Nanomedicine: Nanotechnology, Biology and Medicine (2018), 14, 1169-1179.

Comparison of Skin Penetration, Pathological and Clinical Effects of Novel Drug Transporters – Thermoresponsive Nanogels and Core Multishell Nanocarriers – in a Murine Model of Atopic Dermatitis

H. Pischon, M. Radbruch, F. Du, M. Guilbudagian, M. Calderón, M. Unbehauen, R. Haag, A.D. Gruber, L. Mundhenk

Journal of Comparative Pathology (2018), 158, 110.

A facile, one-pot, surfactant-free nanoprecipitation method for the preparation of nanogels from polyglycerol-drug conjugates that can be freely assembled for combination therapy applications

L.I. Vossen, S. Wedepohl, M. Calderón*

Polymers (2018), 10(4), 398.

Temperature-enhanced follicular penetration of thermoresponsive nanogels

S. Jung, G. Nagel, M. Giulbudgian, M. Calderón*, A. Patzelt*, F. Knorr, J. Lademann.

Zeitschrift für Physikalische Chemie (2018), DOI: https://doi.org/10.1515/zpch-2017-1080.

Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma

S. Ferber, G. Tiram, P. Ofek, A. Eldar-Boock, D. Ben-Shushan, E. Yeini, A. Krivitsky, O. Amsalem, N. Almog, J. Henkin, J.S. Lee, E. Ruppin, E. Yavin, G. Cohen, P. Lazarovici, R. Grossman, Z. Ram, M. Calderón, R. Haag, R. Satchi-Fainaro

The FASEB Journal (2018), manuscript accepted.

Crosslinked casein-based micelles as a dually responsive drug delivery system

M. Picchio, J.C. Cuggino, G. Nagel, S. Wedepohl, R. Minari, C.I. Alvarez Igarzabal, L. Gugliotta*, M. Calderón*.

Polymer Chemistry (2018), 9, 3499-3510.

Semi-interpenetrated, dendritic, dual-responsive nanogels with cytochrome c corona induce controlled apoptosis in HeLa cells

E. Miceli, S. Wedepohl, E. Rafael Osorio Blanco, G.N. Rimondino, M. Martinelli, M. Strumia, M. Molina, M. Kar, M. Calderón*

European Journal of Pharmaceutics and Biopharmaceutics (2018), 130, 115-122.

Modular approach for theranostic polymer conjugates with activatable fluorescence: impact of linker design on the stimuli-induced release of doxorubicin
G. Nagel, H.R. Tschiche, S. Wedepohl, M. Calderón*.

Journal of Controlled Release (2018), 285, 200-211.

Understanding the elusive protein corona of thermoresponsive nanogels

E. Miceli, B. Kuropka, C. Rosenauer, E.R. Osorio Blanco, L. Fechner, M. Kar, C. Weise, S. Morsbach, C. Freund, M. Calderón*.

Nanomedicine (2018), manuscript accepted.

Nanoparticles from supramolecular polylactides overcome drug resistance of cancer cells

M. Brzeziński, S. Wedepohl, B. Kost, M. Calderón*.

European Polymer Journal (2018). Manuscript accepted.

Effect of Delivery Platforms Structure on the Epidermal Antigen Transport for Topical Vaccination
A.S. Sonzogni, G. Yealland, M. Kar, S. Wedepohl, L.M.Gugliotta, V.D.G. Gonzalez, S. Hedtrich, M. Calderón*, R.J. Minari*

Biomacromolecules (2018), manuscript accepted.

Transglutaminase 1 replacement therapy successfully mitigates the ARCI phenotype in full-thickness skin disease equivalents

R. Plank, G. Yealland, E. Miceli, P. Graff, K. Eckl, D. Lima Cunha, R. Gruber, V. Moosbrugger-Martinz, M. Calderón, H.C. Hennies, S. Hedtrich

Journal of Investigative Dermatology (2018), manuscript accepted.

Critical parameters for the controlled synthesis of nanogels suitable for temperature-triggered protein delivery
L.E. Theune, R. Charbaji, M. Kar, S. Wedepohl, S. Hedtrich, M. Calderón*

A selective macromolecular probe for in vivo imaging of cathepsin B activity in the tumor microenvironment
H.-Y. Hu, H.R. Krüger, D. Vats, M. Vizovisek, A. Duro-Castano, D. Bühlmann, J. Rajkovic, S. Reichert, K.U. Wendt, M. Calderón, M. Rudin, M.J. Vicent, O. Plettenburg, B. Turk, C. Schultz, R. Haag. Manuscript submitted.

Matrix metalloproteinase-sensitive multistage nanogels promote drug transport in 3D tumor model

G. Nagel, A. Sousa-Herves, S. Wedepohl, M. Calderón*. Manuscript submitted.

Overcoming drug resistance with on-demand charged thermoresponsive dendritic nanogels by enhanced doxorubicin uptake

M. Molina, S. Wedepohl, E. Miceli, M. Calderón*

Nanomedicine (2017), 12, 117-129.

Dendritic polyglycerol and N-isopropylacrylamide based thermoresponsive nanogels as smart carriers for controlled delivery of drugs through the hair follicle

F.F. Sahle, M. Giulbudagian, J. Bergueiro, J. Lademann*, M. Calderón*

Nanoscale (2017), 9, 172-182.

Drug delivery across intact and disrupted skin barrier: identification of cell populations interacting with penetrated thermoresponsive nanogels

F. Rancan, M. Giulbudagian, J. Jurisch, U. Blume-Peytavi, M. Calderón, A. Vogt

European Journal of Pharmaceutics and Biopharmaceutics (2017), 116, 4-11.

Rational design of dendritic thermo-responsive nanogels that undergo phase transition on endolysosomal conditions

G. N. Rimondino, E. Miceli, M. Molina, S. Wedepohl, S. Thierbach, E. Rühl, M. Strumia, M. Martinelli,* M. Calderón*.

Journal of Material Chemistry B (2017), 5, 866-874.

In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio

H. Baabur-Cohen,§ L. Vossen,§ H.R. Krüger, A. Eldarboock, E. Yeini, N. Landa-Rouben, G. Tiram, S. Wedepohl, E. Markovsky, J. Leor, M. Calderón*, R. Satchi-Fainaro*. 

Journal of Controlled Release (2017), 257, 118-131.

Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin

A. Edlich, C. Gerecke, M. Giulbudagian, F. Neumann, M. Schäfer-Korting, N. Ma, M. Calderón, B. Kleuser.

European Journal of Pharmaceutics and Biopharmaceutics (2017), 116, 155-163.

Metallo-polymer chain extension controls the morphology and release kinetics of microparticles composed of terpyridine-capped polylactides and their stereocomplexes

M. Brzeziński, A. Kacprzak, M. Calderón*, S. Seiffert*. 

Macromolecular Rapid Communications (2017), 38, 1600790.

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug delivery systems and their intracellular fate in keratinocytes

C. Gerecke, A. Edlich, M. Giulbudagian, F. Schumacher, N. Zhang, A. Said, G. Yealland, S.B. Lohan, F. Neumann, M. Meinke, N. Ma, M. Calderón, S. Hedtrich, M. Schaefer-Korting, B. Kleuser.

Nanotoxicology (2017), 11, 267-277.

Formation and characterization of Langmuir and Langmuir-Blodgett films of Newkome-type dendrons in presence and absence of a therapeutic compound, for the development of surface mediated drug delivery systems
N. Dib, A. Reviglio, L. Fernandez, L. Otero, G. Morales, M. Santo, F. Alustiza, A. Liaudat, P. Bosch, M. Calderón, M. Martinelli, M. Strumia. 

Journal of Colloid and Interface Science (2017), 15, 243–253.

Interaction of organic nanoparticles with proteins in physiological conditions

E. Miceli, M. Kar, M. Calderón*.

Journal of Material Chemistry B (2017), 4393-4405.

Responsive nanogels for anticancer therapy

M. Kar, L. Fechner, G. Nagel, E. Glitscher, G.N. Rimondino, M. Calderón*

RSC Book, Smart Material Series 'Nanogels for Biomedical Applications' (2017), 210-260.

How are we applying nanogel composites in biomedicine?

M. Kar, M. Molina, M. Calderón*

Nanomedicine (2017), 12, 1627-1630.

Protein corona formation on polymeric nanoparticles possessing porous, solid and PEG-based surfaces of varied surface charge and hydrophobicity: impact on cellular uptake, toxicity, immunogenicity and drug release properties

K. Obst, G. Yealland, E. Miceli, M. Dimde, B. Balzus, C. Weise, M. Eravci, R. Bodmeier, R. Haag, M. Calderón, N. Charbaji, Sarah Hedtrich.

Biomacromolecules (2017), 18, 1762–1771.

Acid-Sensitive Doxorubicin Prodrug Nanoemulsion Impairs Tumor Growth and Prevents Distant Lung Metastasis in a Breast Cancer Mice Model

A.L. dos Santos Câmara, G. Nagel, H.R. Tschiche, C. Cardador, L.A. Muehlmann, R. Bentes Azevedo, M. Calderón, J.P. Figueiró Longo.

Nanomedicine (2017), 12, 1751-1765.

PEGylated dendritic polyglycerol conjugate delivers doxorubicin to the parasitophorous vacuole in leishmania infantum infections

C. Gutierrez Corbo, B. Dominguez Asenjo, L. I. Vossen, Y. Pérez Pertejo, M. A. Muñoz-Fenández, R. Balaña-Fouce, M. Calderón*, R. M. Reguera*.

Macromolecular Bioscience (2017), 17, 1700098.

Unexpected Chiro-Thermoresponsive Behavior of Helical Poly(phenylacetylene)s Bearing Elastin-Based Side-Chains

S. Arias, F. Freire*, M. Calderón*, J. Bergueiro*

Angewandte Chemie International Edition (2017), 56, 11420–11425.

EPR technology as sensitive method for oxidative stress detection in primary and secondary keratinocytes induced by two selected nanoparticles

S.B. Lohan, S. Ahlberg, A. Mensch, D. Höppe, M. Giulbudagian, M. Calderón, S. Grether-Beck, J. Krutmann, J. Lademann, M.C. Meinke. 

Cell Biochemistry and Biophysics (2017), 75, 359–367.

Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

S. Ferber,  G. Tiram, A. Sousa-Herves, A.Eldar-Boock, A. Krivitsky, A. Scomparin, E. Yeini, L.I. Vossen, K. Licha, R. Grossman, Z. Ram, J. Henkin, R. Haag, M. Calderón, R. Satchi-Fainaro.

eLife (2017), 6, e25281.

Transferrin Decorated Thermoresponsive Nanogels as MagneticTrap Devices for Circulating Tumor Cells

M- Asadian-Birjand, C. Biglione, J. Bergueiro, A. Cappelletti, C. Rahane, G. Chate, J. Khandare, B. Klemke, M.C. Strumia, M. Calderon*

Macromolecular Rapid Communications (2016), 37, 439-445.

New approaches from nanomedicine for treating Leishmaniasis

V. Gutiérrez, A.B. Seabra, R.M. Reguera, J. Khandare, M. Calderón*

Chemical Society Reviews (2016), 45, 152-168.

Immobilization of stimuli-responsive nanogels onto honeycomb porous surfaces and controlled release of proteins

A.S. De León, M. Molina, S. Wedepohl, A. Muñoz-Bonilla, J. Rodríguez-Hernández*, M. Calderón*.

Langmuir (2016), 32, 1854-1862.

Identification of dormancy-associated microRNAs for the design of osteosarcoma-targeted dendritic polyglycerol nanopolyplexes

G. Tiram, E. Segal, A. Krivitsky, R. Shreberk-Hassidim, P. Ofek, S. Ferber, T. Udagawa, L. Edry, N. Shomron, M. Roniger, B. Kerem, Y. Shaked, S. Aviel-Ronen, I. Barshack, M. Calderón, R. Haag, R. Satchi-Fainaro

ACS Nano (2016), 10, 2028-2045.

Bispecific Antibodies for Targeted Delivery of Dendritic Polyglycerol (dPG) Prodrug Conjugates

F. Sheikhi-Mehrabadi, J. Adelmann, S. Gupta,S. Wedepohl, M. Calderón, U. Brinkmann, Rainer Haag.

Current Cancer Drug Targets (2016), 16, 639-649.

Polymeric near-infrared absorbing dendritic nanogels for efficient in vivo photothermal cancer therapy

M. Molina, S. Wedepohl, M. Calderón*.

Nanoscale (2016), 8, 5852–5856.

Responsive nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems

J. Cuggino, M. Molina, S. Wedepohl, C. Alvarez Igarzabal, M. Calderón, L. Gugliotta.

European Polymer Journal (2016), 78, 14-24.

Effects of thermoresponsivity and softness of polyglycerol-based nanogels on skin penetration and cellular uptake

F. Rancan*, M. Asadian-Birjand, S. Dogan, C. Graf, L. Cuellar, S. Lommatzsch, U. Blume-Peytavi, M. Calderón*, A. Vogt.

Journal of Controlled Release (2016), 228, 159-169.

Near Infrared Dye Conjugated Nanogels for Combined Photodynamic and Photothermal Therapies

M. Asadian-Birjand, J. Bergueiro, S. Wedepohl, M. Calderón*.

Macromolecular Bioscience (2016), 16, 1432−1441.

Highlighted as Back Cover.

Fabrication of honeycomb films from highly functional dendritic structures: electrostatic driven immobilization of biomolecules

A.S. De León, S. Malhotra, M. Molina, M. Calderón, A. Muñoz-Bonilla, J. Rodríguez-Hernández. 

Polymer Chemistry (2016), 7, 4112-4120.

Restoring the Oncosuppressor Activity of MicroRNA-34a in Glioblastoma Using a Polyglycerol-based Polyplex

P. Ofek, M. Calderón, F. Sheikhi-Mehrabadi, R. Haag, A. Kravitsky, N. Yerushalmi, S. Kredo-Russo, Z. Shatsberg, S. Ferber, R. Grossman, Z. Ram, R. Satchi-Fainaro.

Nanomedicine: Nanotechnology, Biology and Medicine (2016), 12, 2201–2214.

Functionalized nanogels carrying an anticancer microRNA for glioblastoma therapy

Z. Shatsberg, X. Zhang, P. Ofek, S. Malhotra, A. Krivitsky, A. Scomparin‎, G. Tiram, M. Calderón, R. Haag, R. Satchi-Fainaro.

Journal of Controlled Release (2016), 239, 159-168.

Correlation between the chemical composition of thermoresponsive nanogels and their interaction with the skin barrier

M. Giulbudagian, F. Rancan*, A. Klossek, K. Yamamoto, J. Jurisch, V. Colombo Neto, P. Schrade, S. Bachmann, E. Rühl*, U. Blume-Peytavi, A. Vogt, M. Calderón*

Journal of Controlled Release (2016), 243, 323–332.

Dendritic Polyglycerol-Based Nanogels for Dermal Drug Delivery

M. Molina, M. Witting, M. Calderón*, S. Hedtrich*

Controlled Release Society Newsletter (2016), 33, 10-12.

Dendritic polymer imaging systems for the evaluation of conjugate uptake and cleavage

H. R. Krüger, G. Nagel, S. Wedepohl, M. Calderón*

Nanoscale (2015), 7, 3838-3844.

Highlighted as front cover and paper of the month

Dendritic Amphiphiles as Additives for Honeycomb-like Patterned Surfaces by Breath Figures: Role of the Molecular Characteristics on the Pore Morphology

A.S. de León, S. Malhotra, M. Molina, R. Haag, M. Calderón*, J. Rodriguez-Hernandez, A. Munoz-Bonilla*

Journal of Colloid and Interface Science (2015), 440, 263–271.

Hair Follicles as a Target Structure for Nanoparticles

J. Lademann, F. Knorr, H. Richter, S. Jung, M.M.C. Meinke, E. Ruehl, U. Alexiev, M. Calderón, A. Patzelt

Journal of Innovative Optical Health Sciences (2015), 8, 1530004.

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

A. B. Seabra, R. de Lima, M. Calderón

Current Topics in Medicinal Chemistry (2015), 15, 298-308.

Dendritic Polyglycerol Sulfate as a Novel Platform for Paclitaxel Delivery: Pitfalls of Ester Linkage

A. Sousa-Herves, P. Würfel, N. Wegner, J. Khandare, K. Licha, R. Haag, P. Welker*, and M. Calderón*

Nanoscale (2015), 7, 3923-3932.

Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
C. Biglione, A. Sousa-Herves, M. Menger, S. Wedepohl, M. Calderón*, M.C. Strumia*

RSC Advances (2015), 5, 15407-15413.

Dendritic polymers for smart drug delivery applications

J. Khandare*, M. Calderón*

Nanoscale (2015), 7, 3806-3807.

Thermoresponsive Nanodevices in Biomedical Applications

J. Bergueiro, M. Calderón*

Macromolecular Bioscience (2015), 15, 183-199.

Thermosensitive Dendritic Polyglycerol-Based Nanogels for Cutaneous Delivery of Biomacromolecules

M. Witting§, M. Molina§, K. Obst, H.C. Hennies, M. Calderón, W. Frieß, S. Küchler

Nanomedicine: Nanotechnology, Biology, and Medicine (2015), 11, 1179-1187

One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

A. Sousa-Herves, S. Wedepohl, M. Calderón*

Chemical Communications (2015), 51, 5264-5267.

First generation newkome-type dendrimer as solubility enhancer of antitumor benzimidazole carbamate
N. Dib, L. Fernández, L. Otero, M. Santo, M. Calderón, M. Martinelli, M. Strumia

Journal of Inclusion Phenomena and Macrocyclic Chemistry (2015),  82, 351-359.

Self-propelled Carbon Nanotube Based Microrockets for Rapid Capture and Isolation of Circulating Tumor Cells

S.S. Banerjee, A. Jalota-Badhwar, K.R. Zope, K.J. Todkar, R.R. Mascarenhas, G.P. Chate, G.V. Khutale, A. Bharde, M. Calderón, J.J. Khandare

Nanoscale (2015), 7, 8684-8688.

Stimuli-responsive nanogel composites for biomedical applications

M. Molina, M. Asadian-Birjand, J. Balach, J. Bergueiro, E. Miceli, M. Calderón*

Chemical Society Reviews (2015), 44, 6161-6186.

Aplicaciones biomédicas de nanogeles dendríticos termosensibles

M. Molina, J. Bergueiro, A. Sousa-Herves, M. Calderón*

Revista Iberoamericana de Polímeros (2015), 16, 164-172.

Chitosan-g-oligo(epsilon-caprolactone) polymeric micelles: Microwave-assisted synthesis and physicochemical and cytocompatibility characterization

R.J. Glisoni, S.S. Quintana, M. Molina, M. Calderón, A.G. Moglioni, A. Sosnik

Journal of Material Chemistry B (2015), 3, 4853-4864.

Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration

M. Asadian-Birjand, J.C. Cuggino, R.-C. Mutihac, K. Achazi, J. Dernedde, F. Rancan, U. Blume-Peytavi, A. Vogt, M. Calderón*

Polymer Chemistry (2015), 6, 5827-5831.

Polymeric soft nanocarriers as smart drug delivery systems: State-of-the-art and future perspectives

M. Calderón,* A. Sosnik*

Biotechnology Advances (2015), 33, 1277-1278.

Structure-activity Relationship Study of Dendritic Polyglycerolamine for Efficient siRNA Transfection

F. Sheikhi-Mehrabadi, O. Hirsch, R. Zeisig, P. Posocco, E. Laurini, S. Pricl, R. Haag, W. Kemmner*, M. Calderon*

RSC Advances (2015), 5,78760-78770.

Fabrication of Thermoresponsive Nanogels by Thermo-Nanoprecipitation and in situ Encapsulation of Bioactives

M. Giulbudagian,§ M. Asadian-Birjand,§ D. Steinhilber, K. Achazi, M. A. Molina, and M. Calderón*

Polymer Chemistry (2014), 5, 6909-6913.

Highlighted as back cover

Imaging of Doxorubicin Release from Theranostic Macromolecular Prodrugs via Fluorescence Resonance Energy Transfer

H.R. Krüger, I. Schütz, A. Justies,  K. Licha, P. Welker, V. Haucke, M. Calderón*.

Journal of Controlled Release (2014), 194, 189-196.

Positively Charged Thermoresponsive Nanogels for Anticancer Drug Delivery

M. A. Molina, M. Giulbudagian, and M. Calderón*.

Macromolecular Chemistry and Physics (2014), 215, 2414-2419.

Polyglycerol-Based Amphiphilic Dendrons as Potential siRNA Carriers for In Vivo Applications

A. Tschiche, A.M. Staedtler, S. Malhotra, H. Bauer, C. Böttcher, S. Sharbati, M. Calderón, M. Koch, T.M. Zollner, A. Barnard, D.K. Smith, R. Einspanier, N. Schmidt, R. Haag.

Journal of Material Chemistry B (2014), 2, 2153-2167.

Nanoscale Self-Assembled Multivalent (SAMul) Heparin Binders in Highly Competitive, Biologically Relevant, Aqueous Media

S.M. Bromfield, C.W. Chan, P. Posocco, S. Pricl, M. Calderon, J.E. Turnbull, D.K. Smith.

Chemical Science (2014), 5, 1484-1492.

Double-degradable responsive self-assembled multivalent arrays – temporary nanoscale recognition between dendrons and DNA

A. Barnard, P. Posocco, M. Fermeglia, A. Tschiche, M. Calderón, S. Pricl, and D.K. Smith.

Organic and Biomolecular Chemistry (2014),12, 446-455.

Receptor mediated cellular uptake of low molecular weight dendritic polyglycerols

M. Calderón*, S. Reichert, P. Welker, K. Licha, F. Kratz, R. Haag

Journal of Biomedical Nanotechnology (2014), 10, 92-99.

A Special Issue on Polymer Conjugate Based Nanotherapeutics

R. Jayakumar, J. Khandare, M. Calderón, O. Perumal
Journal of Biomedical Nanotechnology (2014), 10, 1-3.

Targeted delivery of dendritic polyglycerol-doxorubicin conjugates by scFv-SNAP fusion protein suppresses EGFR+ cancer cell growth.

A. Hussain, H.R. Krüger, F. Kampmeier, T. Weissbach, K. Licha, F. Kratz, R. Haag, M. Calderón*, S. Barth*

Biomacromolecules (2013), 14, 2510–2520.

Anionic dendritic polymers for biomedical applications

A. Sousa-Herves, D. Gröger, M. Calderón, E. Fernandez-Megia, and R. Haag

Dendrimers in Biomedical Applications, Ed. B. Klajnert, L. Peng, V. Cena, RSC Publishing, 2013, 56-72.


Hyperbranched and hyperfunctionalized materials from dendritic chemistry.

M. Calderón, M.C. Strumia

Rev. LatinAm. Metal. Mat. (2013), 33, 2-14.

Functional nanogels for biomedical applications.

M. Asadian, A. Souza, J. Cuggino, D. Steinhilber,  M. Calderón*

Current Medicinal Chemistry 19 (2012), 5029-5043.


Effects of a PEG Additive on the Biomolecular Interactions of Self-Assembled Hybrid Nanoscale Architectures.

A. Barnard, M. Calderón, A. Tschiche, R. Haag, D.K. Smith
Org. Biomol. Chem. 10 (2012), 8403-8409.


Glycin-terminated dendritic amphiphiles for nonviral gene delivery.

S. Malhotra, H. Bauer, A. Tschiche, A. Staedtler, A. Mohr, M. Calderón, V. Parmar, L. Hoeke, S. Sharbati, R. Einspanier, R. Haag,

Biomacromolecules 13 (2012),3087–3098.


Dendritic polyglyceroamine as functional antifouling coating of gold surfaces.

J.I. Paez, V. Brunetti, M.C. Strumia, T. Becherer, T. Solomun, J. Miguel, M. Calderón and R. Haag

Journal of Materials Chemistry 22 (2012), 19488-19497.


Multifunctional Dendritic Polymers in Nanomedicine: Opportunities and Challenges.

J. Khandare§, M. Calderón§, N. Dagia, R. Haag. §These authors contributed equally to this work

Chemical Society Reviews 41 (2012), 2824-2848.


Multivalent Dendritic Architectures in Theranostics.

S. Reichert, M. Calderón, K. Licha, R. Haag

Book chapter in Multifunctional Nanoparticles for Medical Applications: Imaging, Targeting, and Drug Delivery – Springer (2012), Part 4, 315-344.

Thermosensitive nanogels based in dendritic polyglycerol and N-isopropylacrylamide for biomedical applications.

J. Cuggino, C.I. Alvarez I., M. Strumia, P. Welker, K. Licha, D. Steinhilber, R.-C- Mutihac and M. Calderón*

Soft Matter 7 (2011), 11259-11266.


Degradable Self-Assembling Dendrons for Gene Delivery – Experimental and Theoretical Insights into the Barriers to Cellular Uptake.

A. Barnard, P. Posocco, S. Pricl, M. Calderón, R. Haag, M.E. Hwang, V.W. Shum, D.W. Pack, D.K. Smith

Journal of the American Chemical Society 133 (2011), 20288-20300.


Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with poly(ethylene glycol) shell.

M. Calderón, P. Welker, K. Licha, I. Fitchner, R. Graeser, R. Haag, F. Kratz.

Journal of Controlled Release151 (2011), 295–301.


Size-dependant cellular uptake of dendritic polyglycerol.

S. Reichert, M. Calderón, J. Khandare, P. Welker, D. Mangoldt, K. Licha, R.K. Kainthan, D.E. Brooks, and R. Haag

Small 7 (2011), 820-829.


Säurelabile Nanotransporter als neuartige Drug-Delivery-Systeme zur Behandlung von Krebserkrankungen.

M. Calderón, R. Haag, F. Kratz

Journal Onkologie 3 (2011), 150-153.


New dendronized polymers from acrylate Behera amine and their ability to produce visco-elastic structured fluids when mixed with CTAT worm-like micelles.

J. Cuggino, M. Calderón, C.I. Alvarez I., M. Strumia, K.N. Silva, E.K. Penott-Chang, A.J. Müller

Journal of Colloid and Interface Science 357 (2011), 147-156.


Nuevos fluidos estructurados basados en mezclas de polimeros dendronizados y un surfactante cationico capaz de formar micelas gusano.

K.N. Silva, E.K. Penott-Chang,A.J. Müller, J.C. Cuggino, M. Calderón, C.I. Alvarez, M.C. Strumia

Revista Latinamericana de Metalurgia y Materiales (2011), 56-57.


Dendritic polymers in Oncology: Facts, features, and applications.

M. A. Quadir, M. Calderón, R. Haag

Book chapter in ‘Drug Delivery in Oncology: From Basic Research to Cancer Therapy’ –Wiley (2011), 513-551.

Dendritic polyglycerols with oligoamine shells show low toxicity and high siRNA transfection efficiency in vitro.

W. Fischer, M. Calderón, A. Schulz, I. Andreou, M. Weber, R. Haag

Bioconjugate Chemistry 21 (2010), 1744-1752.


In vivo delivery of siRNA to tumors and their vasculature by novel dendritic nanocarriers.

P. Ofek, W. Fischer, M. Calderón, R. Haag and R. Satchi-Fainaro

FASEB J. 24 (2010), 3122-3134.


Synthesis and physicochemical characterization of branched poly(monomethyl itaconate).  

M. Calderón, A. Leiva, M. Martinelli, L. Gargallo, D. Radic, M. Strumia

e-polymers 91 (2010), 1-11.


Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds.

S. Malhotra, M. Calderón, W. Parmar, R. Haag

Organic and Biomolecular Chemistry, 8 (2010), 2228-2237.


Structure biocompatibility of dendritic polyglycerol derivatives.

J. Khandare, A. Mohr, M. Calderón, P. Welker, K. Licha, R. Haag

Biomaterials31 (2010), 4268-4277.


Hyperbranched polyamines for gene transfection.

W. Fischer, M. Calderón, R. Haag

Topics in Current Chemistry – Springer 296 (2010), 95-129.


Functional dendritic polymer architectures as stimuli-responsive nanocarriers.

M. Calderón, M. Quadir, M. Strumia, R. Haag

Biochimie, 92 (2010), 1242-1251.


Dendritic polyglycerol for biomedical applications.

M. Calderón, M. Quadir, S. Sharma, R. Haag

Advanced Materials 22 (2010), 190-218.


siRNA transfection by dendritic core–shell nanocarriers.

W. Fischer, M. Calderón, P. Ofek, R. Satchi-Fainaro and R. Haag

Journal of Controlled Release 148 (2010), 89.


In vivo delivery of siRNA to tumours and their vasculature by novel dendritic nanocarriers.

P. Ofek, W. Fischer, M. Calderón, R. Haag and R. Satchi-Fainaro

European Journal of Cancer Supplements 8 (2010), 53-54.


Development of efficient macromolecular prodrugs derived from dendritic polyglycerol.

M. Calderón, P. Welker, K. Licha, R. Graeser, F. Kratz., R. Haag

Journal of Controlled Release 148 (2010), 24-25.


Acid Cleavable Multifunctional Prodrugs Derived from Dendritic Polyglycerol.

M. Calderón, P. Welker, K. Licha, I. Fitchner, R. Graeser, F. Kratz , R. Haag

PMSE Preprints 103 (2010), 14143.


Design of multivalent macromolecular prodrugs derived from dendritic polyglycerol.

M. Calderón, P. Welker, K. Licha, I. Fitchner, F. Kratz, R. Haag

Macromolecular Rapid Communications 31 (2010), G106.


In vitro and in vivo studies of novel acid-sensitive prodrugs derived from dendritic polyglycerol.

M. Calderón, P. Welker, K. Licha, R. Graeser, R. Haag, F. Kratz

Proc. Amer. Assoc. Cancer Res. 51 (2010), LB 8717.

Development of enzymatically cleavable prodrugs derivated from dendritic polyglycerol.

M. Calderón, R. Graeser, F. Kratz, R. Haag

Bio-organic and Medical Letters 19 (2009), 3725-3728.


Synthesis of amphiphilic dendrons and their interaction in aqueous solutions with cetyltrimethylammonium p-toluensulfonate (CTAT).

M. Calderón, M. I. Velasco, M. C. Strumia, A. T. Lorenzo, A. J. Müller, M. R. Rojas, A. E. Sáez

Journal of Colloid & Interface Science 336 (2009), 462-469.


Drug conjugates with polyglycerol.

F. Kratz, R. Haag, M. Calderón

2009. International Patentanmeldung. PCT / EP 2009 002346, WO 2009 121564. US 2011/0117009 A1.


Development of efficient macromolecular prodrug derived from dendritic polyglycerol.

M. Calderón, P. Welker, K. Licha, R. Graeser, F. Kratz, R. Haag

Molecular Cancer Therapeutics 8 (2009), 12 (Suppl):A132.


Design, Synthesis, and Cytotoxicity: Evaluation of Dendritic Polyglycerol Architectures for Therapeutics.

 J. Khandare, A. Mohr, M. Calderón, P. Welker, K. Licha, R. Haag

Macromolecular Bioscience 9 (2) (2009).

Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous      administration of antichagasic active compounds.

L. Fernandez, M. Calderón, M. Martinelli, M. Strumia, H. Cerecetto, M. González, J.J. Silber, M. Santo

Journal of Physical Organic Chemistry. 21 (2008), 1079-1085.


Electrochemical study of a dendritic family at the water/1,2 dichloroethane interface.

M. Calderón, L. Monzón, M. Martinelli, V. Juarez, L. Yudi, M. Strumia

Langmuir 24 (2008) 6343-6350.


Dendronization: An important tool for synthesis of functional polymers.

M. Martinelli, M. Calderón, C. I. Alvarez, M. Strumia

Revista Iberoamericana de Polímeros 9(3) (2008), 148-157.


Development of enzymatically cleavable doxorubicin conjugates with polyglycerol.

M. Calderón, A. Warnecke, R. Gräser, R. Haag, Felix Kratz

Journal of Controlled Release 132 (2008), 54-55.

Synthesis and characterization of dendronized polymers.

M. Calderón, M. Martinelli, A. Leiva, L. Gargallo, D. Radic, M. Strumia

Macromolecular Symposia 258 (2007), 53-62.


Functionalized support with sugar dendritic ligand.

M. Martinelli, M. Calderón, C. I. Alvarez, M. Strumia

Reactive and functional polymers 67 (2007), 1018-1026.


Design of a polymer science course.

M. Calderón, M. Martinelli, C. I. Alvarez,  M. Strumia

Revista Iberoamericana de Polímeros 8  (2007), 64-76. 


Polyfunctional MDI oligomers through dendrimerization.

M. Martinelli, M. Calderón, E. Rodríguez, J. J. Freire, M. Strumia

European Polymer Journal 43 (2007) 1978-1985.


Functionalized polymeric materials. Part 1: Synthesis and polymerization of functionalized monomer.

M. Martinelli, P. Froimowicz, M. Calderón, M. Strumia

Revista Iberoamericana de Polímeros 4 (4) (2003), 30-47.