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Dendritic-based architectures

Dendrons-based macromolecular and supramolecular architectures for biomedical applications (Focus: Organic Chemistry and Physical Chemistry).


Copyright: Wiley


Past group members on the project:
PhD student: Dipl.-Chem. Soraya Taabache
Resarcher: M.Sc. Axel Baumann
Researcher: M.Sc. Jason Heier
Master student: B.Sc. Hendrik Liebe
Researcher: Dipl.-Chem. Aneta Schimanowitz


Selected publications:

[10] Vesicles from amphiphilic dumbbells and Janus dendrimers: Bioinspired self-assembled structures for biomedical applications.
S. Taabache, A. Bertin.
Polymers (invited review in special issue "Bio-inspired and Bio-based Polymers") 2017, 9, 280, doi:10.3390/polym9070280.

[9] A dendritic amphiphile for efficient control of biomimetic calcium phosphate mineralization.
D. Hentrich, S. Taabache, G. Brezesinski, N. Lange, W. Unger, C. Kuebel, A. Bertin, A. Taubert.
Macromolecular Bioscience 2017, doi: 10.1002/mabi.201600524.

[8] Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of internalized bilayers.
S. Zhang, H.-J. Sun, A. D. Hughes, R.-O. Moussodia, A. Bertin, Y. Chen., D. J. Pochan, P. A. Heiney, M. L. Klein, V. Percec.
Proceedings of the National Academy of Sciences 2014, 111, 9058-9063.

[7] “Single-single” amphiphilic Janus dendrimers self-assemble into narrow distribution dendrimersomes with predictable size.
S. Zhang, H.-J. Sun, A. D. Hughes, B. Draghici, J. Lejnieks, P. Leowanawat, A. Bertin, L. Otero De Leon, O. Kulikov, Y. Chen, D. J. Pochan, P. A. Heiney, V. Percec.
ACS Nano 2014, 8, 1554-1565.

[6] Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to biomedically relevant lectins.
V. Percec, P. Leowanawat, H.-J. Sun, O. Kulikov, C. Nusbaum, T. M. Tran M., A. Bertin, et al.
Journal of the American Chemical Society 2013, 135, 9055-9077.

[5] Predicting the size and properties of dendrimersomes from the lamellar structure of their amphiphilic Janus dendrimers.
M. Peterca, V. Percec, P. Leowanawat, A. Bertin.
Journal of the American Chemical Society 2011, 133, 20507-20520.

[4] In vitro neurotoxicity of Magnetic Resonance Imaging (MRI) contrast agents: Influence of the molecular structure and paramagnetic ion.
A. Bertin, A.-I. Michou-Gallani, J.-L. Gallani, D. Felder-Flesch.
Toxicology in Vitro, 2010, 24, 1386-1394.

[3] Synthesis and characterization of a highly stable dendritic catechol-tripod bearing Technetium-99m.
A. Bertin, A.-I. Michou-Gallani, J. Steibel, J.-L. Gallani, D. Felder-Flesch.
New Journal of Chemistry 2010, 34, 267-275.

[2] Development of a dendritic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) contrast agent: Synthesis, toxicity (in vitro) and relaxivity (in vitro, in vivo) studies.
A. Bertin, J. Steibel, A.-I. Michou-Gallani, J.-L. Gallani, D. Felder-Flesch.
Bioconjugate Chemistry 2009, 20, 760-767.

[1] Synthesis and Langmuir-film formation of new dendritic DTPA-derived gadolinium (III) complexes.
A. Bertin, T. Muller, J.-L. Gallani, D. Felder-Flesch.
Tetrahedron Letters 2007, 48, 4699-4702.