name	title	fuMetaTitel	body	fuDCcreator	fuDCcreatorLinks	fuDCpublisher	fuDCpublisherLocation	fuDCSizeOrDuration	fuDCdateYear	fuDCdateMonth	fuDCdateDay	fuDCsubject	fuDCrelationPartOf	fuDCrelation	fuDClanguage	fuDCsource	fuDCcontributor	fuDCtype	fuDCformat	fuDCidentifier	fuDCcoverage	fuDCrights	fuDCdescriptionDE	fuDCdescriptionEN	fuDCIdentifierBibliographicCitation	fuBild	fuDCBibtex	fuLinksZumThema
KA890	Two-dimensional fluorinated nanomaterials for fast and selective detection of PFAS at subpicomolar concentrations			"Ghanbari, R.; Diaz, J. C.; Salahvarzi, M.; Nickl, P.; Rumpf, J.; Quaas, E.; Ludwig, K.; Junge, F.; Achazi, K.; Chong, C.; Paulus, B.; Haag, R.; Adeli, M."		Matter			2026	7	1	covalent organic frameworks				https://doi.org/10.1016/j.matt.2026.102771		journalArticle		2590-2393				Two-dimensional fluorinated nanomaterials (2DFs) possess tunable band structures and unique optoelectronic properties, but their controlled synthesis remains challenging due to the lack of mild and scalable methods. Here, we report a gram-scale, room temperature synthesis of ultra-thin 2DF sheets (1-2 nm) with micrometer-scale lateral dimensions. The approach involves nucleophilic substitution of fluorine atoms in perfluoro monomers with alkynyl groups, generating intermediates that undergo in situ [2 + 2+2] cyclotrimerization to form porous 2D networks. Experiments and computations reveal periodic pores with fluorine atoms adopting flipped conformations at pore centers. The resulting 2DFs show broad visible-near-infrared absorption (Eg approximate to 2.4 and 3.2 eV) and strong fluorescence (300-550 nm), with quantum yields up to 66%. Their emission is selectively quenched by trace PFAS, enabling rapid detection in drinking water at subpicomolar concentrations.				
KA891	Study on the Self-Assembly and Dual-Stimuli-Responsive Behavior of Multi-amphiphilic Polymeric Architectures			"Parshad, B.; Krishna; Kumari, M.; Kaushik, K.; Pan, Y.; Achazi, K.; Bottcher, C.; Haag, R.; Sharma, S. K."		Polym Sci Technol			2025	4	22	"Biocompatible; Multi-amphiphilic; Nanocarriers; Self-assembly; Stimuli-responsive"				https://doi.org/10.1021/polymscitech.5c00004		journalArticle		2997-3279 (Electronic) 2997-3279 (Linking)				"Amphiphilic polymers with self-assembling abilities and stimuli-responsive functionalities have drawn significant interest as nanotransport systems for biomedical applications. In this study, we have designed and developed dual-stimuli-responsive multi-amphiphilic polymeric architectures using easily available biocompatible starting materials. We copolymerized poly-(ethylene glycol) [bis-(carboxymethyl) ether]-diethylester (PEG-diester) and 3,3'-((2-azidopropane-1,3-diyl)-bis-(oxy))-bis-(propane-1,2-diol) (azido-triglycerol) using a biocatalyst, and the copolymer so obtained was grafted with azobenzene and polyglycerol dendron moieties to generate multi-amphiphilic polymeric architectures. The self-assembly and cargo encapsulation behaviors of the synthesized polymers were studied by encapsulating Nile red, a model hydrophobic probe. The controlled release of encapsulated Nile red was investigated by irradiation with UV light or exposure to lipase. The studied nanocarrier exhibited a slow release of Nile red, up to 72% in 10 days in the presence of lipase; however, only an insignificant release was observed in the absence of enzyme. Though the light induced release was found to proceed to a lesser extent, it was faster compared to lipase mediated release. Experimental data established the excellent capabilities of these systems as drug delivery nanocarriers by being non-cytotoxic up to a concentration of 500 mug/mL for 72 h. The cellular uptake study of the Nile red encapsulated polymers by confocal laser scanning microscopy suggested that such polymeric architectures may find potential applications as stimuli-responsive nanocarriers."				
KA892	Synthesis of Dendritic Oligo-Glycerol Amphiphiles with Different Hydrophobic Segments to Improve their Performance as Nanocarriers			"Kumari, P.; Zoister, C.; Hanheiser, N.; Makki, H.; Schade, B.; Dimde, M.; Achazi, K.; Kumar, S.; Haag, R.; Singh, A. K."		ChemistryOpen			2025	8		"Encapsulation; Hydrophilic; Hydrophobic; Oligo-glycerol amphiphiles; Supramolecular assemblies"				https://doi.org/10.1002/open.202400448		journalArticle		2191-1363 (Electronic) 2191-1363 (Linking)				A new class of non-ionic dendritic amphiphiles has been developed from biobased chemicals, in particular glycerol-based dendrons coupled to commercially available acids via the Steglich esterification process. These non-ionic amphiphiles are functionalized with different hydrophobic segments to investigate the contribution of the same towards their guest transport behaviour. Therefore, different alkyl chains i.e, C8 and C12, as well as two different aromatic units were introduced as a hydrophobic segments and G1-oligo-glycerol as a hydrophilic segment. Their physicochemical properties were characterized by different techniques such as dynamic light scattering and fluorescence measurements. The results show that these amphiphiles form a very uniform micellar supramolecular structures that is independent of the hydrophobic system. The critical micelle concentration for the prepared non-ionic amphiphiles was found to be in the range of 0.3 to 1.8 mg/mL, which depend on the type of hydrophobic units. The encapsulation capacities of the amphiphiles were tested using Nile Red and Nimodipine as model dye and drug, respectively. The encapsulation studies showed a preference for C12- and pyrene-based amphiphiles through relatively different mechanisms unraveled by molecular dynamics (MD) simulations. Further, the cytotoxicity and cellular uptake of these systems as well as the release profiles were investigated.				
KA893	Anti-Inflammatory Effects of Polyglycerol Sulfates and Natural Polyanions in Type 2 Inflammation			"Krage, C.; Malek Mohammadi Nouri, P.; Dernedde, J.; Kizhakkedathu, J. N.; Hedtrich, S.; Haag, R.; Achazi, K."		Biomacromolecules			2025	6	9	"*Anti-Inflammatory Agents/pharmacology/chemistry; *Glycerol/pharmacology/chemistry; *Inflammation/drug therapy/immunology; *Polymers/pharmacology/chemistry; *Sulfates/pharmacology/chemistry; Cytokines/metabolism; Fibronectins/metabolism; Humans; Interleukin-6/metabolism; Polyelectrolytes; Th2 Cells/immunology/drug effects; Thymic Stromal Lymphopoietin"				https://doi.org/10.1021/acs.biomac.5c00420		journalArticle		1526-4602 (Electronic) 1525-7797 (Print) 1525-7797 (Linking)				Type 2 inflammation is an essential defense mechanism of the innate and adaptive immune systems, but when dysregulated, it can cause chronic atopic diseases like allergic asthma and atopic dermatitis. Thymic stromal lymphopoietin (TSLP) helps drive type 2 inflammation by guiding T cells toward a type 2 helper cell (T(H)2) subtype and stimulating B cells' antibody production. Fibronectin (FN) has recently been found at elevated levels in the plasma of children with atopic dermatitis and shown a potential proinflammatory role in bronchial epithelium tissue models. Both proteins' surface charges suggest potential interaction with charged molecules. Seeking new strategies against type 2 inflammation, we found that negatively charged polyglycerol sulfates strongly bind to TSLP and FN. We confirmed that these molecules inhibit inflammation by reducing the TSLP-mediated type 2 polarization of CD4(+) T cells. We found that adding polyglycerol sulfate to FN-triggered inflamed bronchial epithelium models reduced TSLP expression and interleukin 6 secretion.				
KA894	Three-Dimensional Polyglycerol-PEG-Based Hydrogels as a Universal High-Sensitivity Platform for SPR Analysis			"Krage, C.; Adiguzel, S.; Thongrom, B.; Dimde, M.; Block, S.; Saeed, M.; Schulze, M.; Junge, F.; Klimek, A.; Achazi, K.; Netz, R. R.; Schedler, U.; Haag, R."		Anal Chem			2025	3	25					https://doi.org/10.1021/acs.analchem.5c00499		journalArticle		1520-6882 (Electronic) 0003-2700 (Print) 0003-2700 (Linking)				We developed a three-dimensional (3D) polyglycerol-poly(ethylene glycol)-based hydrogel as a new biosensing matrix for affinity analysis by surface plasmon resonance to enable a high loading of ligands for small molecule analysis while lacking a carbohydrate structure to reduce nonspecific binding. The hydrogel was synthesized by cross-linking a polyglycerol functionalized with carboxylate and maleimide groups with a dithiolated poly(ethylene glycol) by thiol-click chemistry. We demonstrated that the hydrogel coating enabled a high immobilization capacity of biomolecules and led to less nonspecific binding. Here, the degree of loading with carbonic anhydrase II and the resulting binding signal of acetazolamide were increased by a factor of 5 compared to standard CMD sensors (CM5), and the loading was comparable to CMD sensors specialized for maximum loading (CM7). This high loading capacity, combined with the reduced nonspecific binding due to the missing carbohydrate structure, presents an innovative matrix for a broad application range of surface plasmon resonance (SPR) experiments since no current commercial SPR biosensor combines these two key features.				
KA895	Sulfonium-based polymethacrylamides for antimicrobial use: influence of the structure and composition			"Kanwal, S.; Aziz, U. B. A.; Quaas, E.; Achazi, K.; Klinger, D."		Biomater Sci			2025	2	11	"*Acrylamides/chemistry/pharmacology; *Anti-Bacterial Agents/pharmacology/chemistry; *Anti-Infective Agents/pharmacology/chemistry; *Polymers/chemistry/pharmacology; *Sulfonium Compounds/chemistry/pharmacology; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; Hydrophobic and Hydrophilic Interactions; Microbial Sensitivity Tests; Polyethylene Glycols/chemistry; Structure-Activity Relationship"				https://doi.org/10.1039/d4bm01247j		journalArticle		2047-4849 (Electronic) 2047-4830 (Linking)				We are facing a shortage of new antibiotics to fight against increasingly resistant bacteria. As an alternative to conventional small molecule antibiotics, antimicrobial polymers (AMPs) have great potential. These polymers contain cationic and hydrophobic groups and disrupt bacterial cell membranes through a combination of electrostatic and hydrophobic interactions. While most examples focus on ammonium-based cations, sulfonium groups are recently emerging to broaden the scope of polymeric therapeutics. Here, main-chain sulfonium polymers exhibit good antimicrobial activity. In contrast, the potential of side-chain sulfonium polymers remains less explored with structure-activity relationships still being limited. To address this limitation, we thoroughly investigated key factors influencing antimicrobial activity in side-chain sulfonium-based AMPs. For this, we combined sulfonium cations with different hydrophobic (aliphatic/aromatic) and hydrophilic polyethylene glycol (PEG) groups to create a library of polymers with comparable chain lengths. For all compositions, we additionally examined the position of cationic and hydrophobic groups on the polymer backbone, i.e., we systematically compared same center and different center structures. Bactericidal tests against Gram-positive and Gram-negative bacteria suggest that same center polymers are more active than different center polymers of similar clog P. Ultimately, sulfonium-based AMPs show superior bactericidal activity and selectivity when compared to their quaternary ammonium cationic analogues.				
KA896	Chloromethane-Enabled Quaternization of Linear Polyglycerol Amines and Their Application as Antibacterial Agents			"Hanheiser, N.; Kleoff, M.; Achazi, K.; Singh, A.; Riedel, S.; Haag, R."		Macromolecular rapid communications			2025	8		"*Amines/chemistry/pharmacology; *Anti-Bacterial Agents/pharmacology/chemistry/chemical synthesis; *Glycerol/chemistry/pharmacology; *Polymers/chemistry/pharmacology; alkylation; amines; antibacterial effects; Biofilms/drug effects; biological activity; disinfectants; gas-phase reactions; Microbial Sensitivity Tests; Molecular Structure; polymer; Quaternary Ammonium Compounds/chemistry/pharmacology; Staphylococcus aureus/drug effects"				https://doi.org/10.1002/marc.202500111		journalArticle		1521-3927 (Electronic) 1022-1336 (Print) 1022-1336 (Linking)				In this study, the safe and scalable N-methylation of primary amines in a linear polyglycerol (LPG) backbone structure is reported with altering molecular weight using gaseous chloromethane for the generation of quaternary ammonium groups. All polymers are subsequently analyzed for their antibacterial and antibiofilm properties against drug-resistant Staphylococcus aureus (S. aureus), showing that the implementation of quaternary ammonium groups to a polymer backbone structure is an efficient way to generate new antimicrobial agents. Thereby, the molecular weight of the polymer backbone structure strongly correlates to its antibacterial effect and can be altered depending on the desired application.				
KA897	Modular Synthesis of Dendritic Oligo-Glycerol Cationic Surfactants for Enhanced Antibacterial Efficacy			"Hanheiser, N.; Jiang, Y.; Zoister, C.; Dimde, M.; Achazi, K.; Nie, C.; Li, Y.; Haag, R.; Singh, A. K."		Angew Chem Int Ed Engl			2025	5	26	"*Anti-Bacterial Agents/pharmacology/chemical synthesis/chemistry; *Dendrimers/chemistry/pharmacology/chemical synthesis; *Glycerol/chemistry/pharmacology; *Surface-Active Agents/chemistry/pharmacology/chemical synthesis; Animals; Antibacterial challenges; Biofilms/drug effects; Cationic surfactants; Cations/chemistry/pharmacology/chemical synthesis; Click Chemistry; Cryo-TEM; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; Humans; Microbial Sensitivity Tests; Wound healing"				https://doi.org/10.1002/anie.202425069		journalArticle		1521-3773 (Electronic) 1433-7851 (Print) 1433-7851 (Linking)				Bacterial infections and antibiotic resistance present an ever-increasing threat to human health worldwide, and medicine urgently needs new alternatives for the successful treatment of bacterial infections. Cationic surfactants have proven to be effective antibacterial agents due to their ability to disrupt bacterial membranes, inhibit biofilm formation, and combat a broad spectrum of pathogens. We employed a orthogonal click chemistry strategy for the efficient modular synthesis of six novel cationic surfactants. Our results emphasize the strong correlation between the surfactant design and its antibacterial potential. Among these six cationic surfactants we identified a prime candidate, which possessed an impressive antibacterial effect against gram-positive and gram-negative bacteria, including drug-resistant strains. We found that our surfactant can prevent biofilm formation and eradicate already existing biofilms. Cryo-TEM imaging was used to reveal the membrane-disrupting properties of the surfactant. In-vivo wound healing experiments underline the surfactants' ability to inhibit wound infections. Cationic surfactants often face the challenge of balancing strong antibacterial activity with minimal cytotoxicity. Our strategic design and orthogonal click chemistry approach have enabled precise fine-tuning of molecular structures to achieve an optimal balance between antibacterial efficacy and biocompatibility, effectively overcoming this critical limitation.				
KA898	Poly (Isobutylene-alt-Maleic Anhydride) With Pendant Benzoxaborole: Dynamic Covalent Interactions at Physiological pH and Antibacterial Properties			"Garcia Cambon, Tomas A.; Achazi, Katharina; Hanheiser, Natalie; Rivas, M. Veronica; Samaniego Lopez, Cecilia; Wolosiuk, Alejandro; Spagnuolo, Carla C."		Journal of Applied Polymer Science			2025	12	20	"biocompatibility; biomaterials; biomedical applications; boronic acids; delivery; design; field-flow fractionation; hydrogels; molecular recognition; nanoparticles; polyelectrolytes; size distribution"				https://doi.org/10.1002/app.57910		journalArticle		0021-8995 1097-4628				Boronated polymers have proven great potential and versatility for a variety of applications. In this work, poly (isobutylene-alt-maleic anhydride) (PIMA) is chemically modified with benzoxaborole to yield the anionic boronated polymer, PIMA-Bx, a bifunctional dynamic covalent material operative at physiological pH. Benzoxaborole is incorporated into the polymer backbone via a spontaneous ring opening reaction followed by basic hydrolysis. Affinity studies with model ligands and a custom synthesized glycopolymer derived from PIMA are performed using fluorescence spectroscopy and microscale thermophoresis (MST), confirming full accessibility to benzoxaborole binding sites and pH modulation of the B-O interaction. Supramolecular assemblies between complementary PIMA polymers are studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM), revealing nanosized structures modulated by pH changes in the range 5-7.4. In vitro cell experiments demonstrate excellent biocompatibility of PIMA-Bx with cultured cells even at very high concentrations. Furthermore, fluorescence confocal microscopy (CLSM) confirms successful internalization of the benzoxaborole-grafted PIMA in HeLa and A549 cells. The boronated polymer also exhibits antibacterial activity per se against typical Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus. Therefore, this new boronated polymer, which is easily prepared using cost-effective materials, is an attractive material for biomedical and pharmaceutical applications.				
KA899	The toxicity, uptake, and impact on galectin-3 mediated apoptosis of lactose functionalized PAMAM dendrimers			"Fricke, M. S.; Frometa, M. R.; Kerkhoff, Y.; Bernhard, S. P.; Tahir, R. S.; Quaas, E.; Totten, W. H.; Haag, R.; Achazi, K.; Cloninger, M. J."		Materials Advances			2025	5	19	"cells; design; glycodendrimers; lectin-binding; mammalian galectins; multivalent ligands; receptors"				https://doi.org/10.1039/d4ma00782d		journalArticle						Poly(amidoamine) (PAMAM) dendrimers functionalized with ligands that are designed to interact with biological receptors are important macromolecules for the elucidation and mediation of biological recognition processes. Specifically, carbohydrate functionalized dendrimers are useful synthetic multivalent systems for the study of multivalent protein-carbohydrate interactions. For example, lactose functionalized glycodendrimers can be used to discern the function of galectins, galactoside-binding proteins that are often over-expressed during cancer progression. In order to effectively interpret cancer cellular assays using glycodendrimers, however, their properties in the presence of cells must first be assessed. Macromolecules that are taken up by cells would be expected to have access to many different cell signaling pathways and modes of action that solely extracellular macromolecules cannot utilize. In addition, macromolecules that display cellular toxicity could not be used as drug delivery vehicles. Here, we report fundamental studies of cellular toxicity, viability, and uptake with four generations of lactose functionalized PAMAM dendrimers. In all cases, the dendrimers are readily taken up by the cells but do not display any significant cellular toxicity. The glycodendrimers also increase cellular apoptosis, suggesting that they may abrogate the antiapoptotic protections afforded by galectin-3 to cancer cells. The results reported here indicate that appropriately functionalized PAMAM dendrimers can be used as nontoxic tools for the study and mediation of both extra and intracellular cancer processes.