name	title	fuMetaTitel	body	fuDCcreator	fuDCcreatorLinks	fuDCpublisher	fuDCpublisherLocation	fuDCSizeOrDuration	fuDCdateYear	fuDCdateMonth	fuDCdateDay	fuDCsubject	fuDCrelationPartOf	fuDCrelation	fuDClanguage	fuDCsource	fuDCcontributor	fuDCtype	fuDCformat	fuDCidentifier	fuDCcoverage	fuDCrights	fuDCdescriptionDE	fuDCdescriptionEN	fuDCIdentifierBibliographicCitation	fuBild	fuDCBibtex	fuLinksZumThema
KA886	Polyglycerol-b-polyoxazoline: A next-generation biocompatible agent for diabetic wound treatment			"Zabihi, F.; Beyranvand, S.; Mohammadi, Z.; Zeinivand, M.; Dezfoulian, O.; Farjanikish, G.; Achazi, K.; Chong, C.; Rancan, F.; Vogt, A.; Hedtrich, S.; Mohammadi, H. R.; Haag, R.; Adeli, M."		Biomaterials			2026	7		"*Biocompatible Materials/chemistry/therapeutic use/pharmacology; *Diabetes Mellitus, Experimental/complications; *Glycerol/chemistry/therapeutic use; *Oxazoles/chemistry/therapeutic use; *Polyamines/chemistry/therapeutic use; *Polymers/chemistry/therapeutic use; *Wound Healing/drug effects; Animals; Diabetic wound healing; Fibroblasts/drug effects; Foot ulcers; Humans; Male; Polyglycerol; Polyglycerol-b-poly(2-ethyl-2-oxazoline); Polyoxazoline; Rats; Rats, Sprague-Dawley"				https://doi.org/10.1016/j.biomaterials.2025.123974		journalArticle		1878-5905 (Electronic) 0142-9612 (Linking)				Diabetic wounds remain a major clinical challenge due to persistent inflammation and impaired tissue regeneration. In this study, we report the scalable synthesis of hyperbranched polyglycerol-b-poly(2-ethyl-2-oxazoline) star copolymers bearing terminal arginine groups (hPG-b-PEO-Arg), designed to self-assemble into nanoscale hydrocolloids (70-200 nm) in aqueous media, driven by the distinct hydrophilicity of the polymer blocks. These hydrophilic nanoparticles penetrate damaged wound tissue, facilitating in vivo healing of diabetic wounds in rats (n = 10). The copolymers were synthesized on a 300 g scale via ring-opening polymerization and demonstrated excellent cytocompatibility with primary human fibroblasts and keratinocytes at concentrations up to 15 mg/mL. In vivo, hPG-b-PEO-Arg treatment accelerated wound closure and promoted collagen-rich tissue regeneration without evidence of systemic toxicity, oxidative stress, or skin irritation. The combination of scalable synthesis, high biocompatibility, and intrinsic hydrocolloid-forming capability positions hPG-b-PEO-Arg as a promising platform for chronic wound management and broader biomedical applications.				
KA887	Poly(Glycerol-Sulfur) as a Functional Sustainable Nanomaterial: Synthesized by Anionic Ring Opening Polymerization of Elemental Sulfur			"Stergiou, P. S.; Cherri, M.; Nickl, P.; Quaas, E.; Achazi, K.; Dimde, M.; Adeli, M.; Haag, R."		Small			2026	7	11	"poly(glycerol-sulfur); redox-responsiveness; sulfur copolymerization; sustainable sulfur copolymers; thiol-disulfide exchange reaction"				https://doi.org/10.1002/smll.74499		journalArticle		1613-6829 (Electronic) 1613-6810 (Linking)				Elemental sulfur is an abundant by-product of the petroleum industry, yet its controlled incorporation into functional polymer architectures remains challenging. Here, we report a one-pot, moderate-temperature (120 degrees C) anionic copolymerization of elemental sulfur (S(8)) with glycidol to produce hyperbranched poly(glycerol-sulfur)s with tunable molecular weights (5-30 kDa) and sulfur contents (3-11 wt%) on the gram scale. The reaction proceeds under markedly milder conditions than conventional sulfur polymerizations, enabling precise control over polymer structure and programmable, redox-triggered backbone cleavage rates in glutathione-rich environments. Comprehensive spectroscopic characterization and control experiments provided mechanistic insights into the copolymerization of S(8) and glycidol. The method is readily scalable to tens of grams and affords structural precision unattainable by high-temperature radical routes. As a proof of concept, the copolymers were functionalized with the cytotoxic DM1 via thiol-disulfide exchange, yielding nanocarriers that release over 90% of the payload within 12 h under reductive conditions and significantly reduced the viability of MCF7 breast cancer cells.				
KA888	Redox-Responsive Self-Assembled Amphiphilic Nanosheets from Polyglycerol Sulfate-Lipoic Acid Copolymers for Targeted Cancer Drug Delivery			"Page, T. M.; Ludwig, K.; Haider, M. S.; Quaas, E.; Mavroskoufis, A.; Tang, P.; Chen, R.; Feng, J.; Bej, R.; Achazi, K.; Haag, R.; Donskyi, I. S."		Biomacromolecules			2026	1	12	"*Antineoplastic Agents/chemistry/pharmacology/administration & dosage; *Drug Delivery Systems; *Glycerol/chemistry; *Nanostructures/chemistry; *Neoplasms/drug therapy; *Polymers/chemistry; *Thioctic Acid/chemistry; Glutathione/metabolism; Humans; Hydrophobic and Hydrophilic Interactions; Oxidation-Reduction; Paclitaxel/chemistry/pharmacology/administration & dosage"				https://doi.org/10.1021/acs.biomac.5c01204		journalArticle		1526-4602 (Electronic) 1525-7797 (Print) 1525-7797 (Linking)				Targeted drug delivery systems that are stimuli-responsive offer great potential for enhancing the therapeutic activity of drugs, decreasing off-target effects, and improving bioavailability. This proof-of-concept study introduces an amphiphilic drug delivery system (DDS) capable of loading hydrophobic cargo. Elevated glutathione (GSH) levels, characteristic of certain types of cancer cells' microenvironment, degrade the nanostructures and release the cargo. Linear polyglycerol sulfate (LPGS), known for its excellent biocompatibility, is combined with lipoic acid (LA). LA facilitates the formation of cross-linked nanosheet amphiphiles sensitive to reductive conditions. Morphological changes are observed by scanning electron microscopy (SEM), cryogenic transmission electron microscopy (Cryo-TEM), and cryogenic electron tomography (Cryo-ET) upon UV irradiation (hnu), creating a stable aggregate for loading hydrophobic cargo and assembling into sheets at elevated concentrations. The resulting material displays controlled release of model dyes under increased levels of GSH, tunable by the polymer size and LPGS:LA acid ratios. This behavior enhances targeted therapy and reduced off-target effects. Further loading with paclitaxel and subsequent release, together with in vitro assays, demonstrates the system's compatibility with an anticancer drug.				
KA889	The Structure-Activity Relationship and Anticoagulation Mechanism of Polyglycerol Sulfates of Different Architectures			"Krage, C.; Weinhart, M.; Lai, B. F. L.; Stoshel, A.; Achazi, K.; Kizhakkedathu, J. N.; Haag, R."		Biomacromolecules			2026	5	11	"*Anticoagulants/chemistry/pharmacology; *Blood Coagulation/drug effects; *Glycerol/chemistry/pharmacology; *Polymers/chemistry/pharmacology; *Sulfates/chemistry/pharmacology; Animals; Heparin/chemistry/pharmacology; Humans; Protamines/pharmacology/chemistry; Structure-Activity Relationship; Thrombin/metabolism"				https://doi.org/10.1021/acs.biomac.6c00308		journalArticle		1526-4602 (Electronic) 1525-7797 (Print) 1525-7797 (Linking)				Although unfractionated heparin (UFH) remains a vital agent for rapid anticoagulation, its reliance on animal-derived sources results in batch-to-batch variability and contamination risks, and its clinical application is further restricted by the possibility of heparin-induced thrombocytopenia. Dendritic polyglycerol sulfates were investigated as heparin analogues in 2004 due to their ability to mimic its charge, which is essential for its acting mechanism, and revealed an anticoagulant activity of 15-35% compared to UFH. In the current study, we found that the anticoagulant effect of polyglycerol sulfates further increases with their flexibility, resulting in a comparable activity of linear polyglycerol sulfate to UFH. Furthermore, we comprehensively analyzed the mechanism of action and discovered an antithrombin-independent, thrombin-selective mechanism. Moreover, we confirmed that FDA-approved protamine sulfate is a viable reversal agent for polyglycerol sulfate.