One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors
"Ahmadi, V.; Nie, C.; Mohammadifar, E.; Achazi, K.; Wedepohl, S.; Kerkhoff, Y.; Block, S.; Osterrieder, K.; Haag, R." – 2021
A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.
Title
One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors
Author
"Ahmadi, V.; Nie, C.; Mohammadifar, E.; Achazi, K.; Wedepohl, S.; Kerkhoff, Y.; Block, S.; Osterrieder, K.; Haag, R."
Publisher
Chem Commun (Camb)
Keywords
"*Antiviral Agents/pharmacology/chemical synthesis/chemistry; *Glycerol/chemistry/pharmacology/chemical synthesis; *Heparin/chemistry/pharmacology/chemical synthesis; *Herpesvirus 1, Human/drug effects; *Polymers/chemistry/pharmacology/chemical synthesis; Animals; Chlorocebus aethiops; Molecular Structure; Vero Cells"
Date
2021-11-11
Identifier
1364-548X (Electronic) 1359-7345 (Linking)
Source(s)
Type
Text