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Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems

E. Sadeghi, M. Kalantari, M. Mahmoudi, H. Hosseinkhani, M. Adeli – 2014

Pseudopolyrotaxanes (PPR) consisting of α-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.

Title
Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems
Author
E. Sadeghi, M. Kalantari, M. Mahmoudi, H. Hosseinkhani, M. Adeli
Date
2014
Identifier
10.1155/2014/829474
Citation
Journal of Nanostructured Polymers and Nanocomposites, 2005, 7, 18
Type
Text