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PC-TC Colloquium: Talk of Dr. Knorr

Jan 19, 2022 | 04:15 PM

Invitation to PC-TC Colloquium

Presented by

Dr. Roland L. Knorr

Interfacial Cell Biology, Integrative Research Institute for the Life Sciences, Humboldt-Universität zu Berlin, Germany

Graduate School and Faculty of Medicine, The University of Tokyo, Japan

Subject:

"Intracellular interfaces and their reshaping during organelle morphogenesis"


Wednesday, January 19th 2022, 16:15 hours

Lecture Hall B (B.004), Arnimallee 22, 14195 Berlin

Abstract

Compartmentalisation is essential for eukaryotic cell function, allowing the division of metabolic and regulatory processes into membrane-bound, specialised compartments, such as organelles. In recent years, intracellular phase separation has garnered much attention as a non-membrane means of organising components through the formation of droplet-like compartments with liquid-like properties, which are functionally implicated in both health and disease.

Here, we investigate the mechanism of wetting-mediated droplet sequestration during autophagy, a highly-conserved degradation system in which membrane sheets expand and bend to isolate portions of the cell interior inside autophagosomes [Nature 2020, 2021]. Further, we demonstrate that wetting also mediates embryonic plant vacuole remodelling [PNAS, JCB 2021]. I propose that formation of autophagosomes and vacuole remodelling represent a novel class of cellular processes that are driven by by interfacial phenomena