Invitation to PC-TC Colloquium
Dr. Roland L. Knorr
Interfacial Cell Biology, Integrative Research Institute for the Life Sciences, Humboldt-Universität zu Berlin, Germany
Graduate School and Faculty of Medicine, The University of Tokyo, Japan
"Intracellular interfaces and their reshaping during organelle morphogenesis"
Wednesday, January 19th 2022, 16:15 hours
Lecture Hall B (B.004), Arnimallee 22, 14195 Berlin
Compartmentalisation is essential for eukaryotic cell function, allowing the division of metabolic and regulatory processes into membrane-bound, specialised compartments, such as organelles. In recent years, intracellular phase separation has garnered much attention as a non-membrane means of organising components through the formation of droplet-like compartments with liquid-like properties, which are functionally implicated in both health and disease.
Here, we investigate the mechanism of wetting-mediated droplet sequestration during autophagy, a highly-conserved degradation system in which membrane sheets expand and bend to isolate portions of the cell interior inside autophagosomes [Nature 2020, 2021]. Further, we demonstrate that wetting also mediates embryonic plant vacuole remodelling [PNAS, JCB 2021]. I propose that formation of autophagosomes and vacuole remodelling represent a novel class of cellular processes that are driven by by interfacial phenomena