Invitation to PC-TC Online Colloquium
Imperial College, London
"Theory and experiments in multivalent nanoparticles for targeted drug delivery: some recent results"
Wednesday, May 26th 2021, 16:15 hours
Access via Webex:
Meeting number:121 666 5388
Host key: 702274
One of the main promises in nanomedicine is the possibility to use nanoparticles for targeted drug delivery. Among the various systems proposed to this purpose, multivalent, ligand-coated nanoparticles are one of the leading candidates. In this system, the main idea is to impart binding selectivity by coating the particles with ligands that match receptors on the target. Whereas this simple concept is quite appealing, its application is not so straightforward as it might seem to the naive eye. In this regard, theory and simulation have been recently used to identify the sweetspots, in terms of design parameters, where this system shows selective targeting, as well as potential problems, and solutions, with multivalent targeting. Even more excitingly, theory has come out with interesting predictions in order to obtain new kinds of selectivity that can only be achieved because of the peculiar properties of multivalent interactions, predictions that can now being tested experimentally. In this talk, I will present some of our recent work along these lines, showing how theory has been used to both rationalise as well as to predict the behaviour of experiments, an integrated approach that promises to accelerate the development of multivalent nanoparticles into realistic applications.