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Area C: Catalytic synthesis of fluoro-organic compounds

Head: Prof. Dr. Thomas Braun

Catalytic processes are an attractive route towards the specific synthesis of fluorinated organic compounds. Homogeneous catalysis is in the center of the projects within area C to gain access to so far unknown fluorinated molecules by derivatization of fluorinated precursors. One target is the elimination of C-F bonds on a palladium centers using appropriate complexes. Based on model studies catalytic processes for the transformation of iodo- or chlorobenzene to fluorobenzene are developed.Reactive rhodium-fluoro complexes are of interest with respect to catalytic hydrofluorination reactions. The preparation of these complexes will be pursued using suitable fluorination agents such as AgF. Apart from the hydrofluorination rhodium may also serve as a suitable system to derivate fluorinated allenes and dienes by activating the C-F bond. Such investigations will focus on the substitution of fluorine by silyl groups. In close collaboration between the different participating groups methods are developed for the catalytic dehydrofluorination of fluoroallenes as well as the synthesis of hydrofluoroallenes in an enantiomer pure fashion. Enantioselective nucleophilic addition of trifluoromethyl anions/radicals or fluoride to Michael systems such as nitroalkenes or α,β-unsaturated carbonyl containing molecules is another interesting reaction, as it may offer access to fluorinated carboxylic acids and amines.

Humboldt Universität zu Berlin
DFG