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Haltenhof

Haltenhof
Image Credit: Tom Haltenhof

CLKs are on the Cover of Molecular Cell!

https://www.cell.com/molcel/issue?pii=S1097276519X00088

https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30049-6

We show that CLKs act as evolutionarily conserved body temperature sensor that globally controls alternative splicing and gene expression. Among many functional implications we suggest a connection to temperature-dependent sex determination in reptiles. Isn't that hot? This drawing by the first author Tom Haltenhof summarizes the main findings. The style is adapted from a mural of the artist Gerhard Richter. Science meets Arts!