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Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations.

Rödel, Claudia Jasmin, Otten, Cécile, Donat, Stefan, Lourenço, Fischer, Dorothea, Kuropka, Benno, Paolini, Alessio, Freund, Christian and Abdelilah-Seyfried, Salim – 2019

RATIONALE:Pathological biomechanical signaling induces vascular anomalies including cerebral cavernous malformations (CCM), which are caused by a clonal loss of CCM1/KRIT1 (Krev interaction trapped protein 1), CCM2/MGC4607, or CCM3/PDCD10. Why patients typically experience lesions only in lowly perfused venous capillaries of the cerebrovasculature is completely unknown. OBJECTIVE:In contrast, animal models with a complete loss of CCM proteins lack a functional heart and blood flow and exhibit vascular anomalies within major blood vessels as well. This finding raises the possibility that hemodynamics may play a role in the context of this vascular pathology. METHODS AND RESULTS:Here, we used a genetic approach to restore cardiac function and blood flow in a zebrafish model of CCM1. We find that blood flow prevents cardiovascular anomalies including a hyperplastic expansion within a large Ccm1-deficient vascular bed, the lateral dorsal aorta. CONCLUSIONS:This study identifies blood flow as an important physiological factor that is protective in the cause of this devastating vascular pathology.

Title
BloodFlow_Abdelilah
Author
Rödel, Claudia Jasmin, Otten, Cécile, Donat, Stefan, Lourenço, Fischer, Dorothea, Kuropka, Benno, Paolini, Alessio, Freund, Christian and Abdelilah-Seyfried, Salim
Date
2019-09-09
Identifier
10.1161/CIRCRESAHA.119.315076
Source(s)
Appeared in
Circulation Research - Volume 125 - Issue 10
Type
Text