Publications
Original publications, Reviews and Book articles:
2022
Antelmann, H*. 2023. Chapter 12: Redox signalling mechanisms during host-pathogen interactions in the human pathogen Staphylococcus aureus, Molecular Medical Microbiology, 3rd edition. Ed. Yi-Wei Tang, Dongyou Liu, Ian R. Poxton, Joseph D. Schwartzman, and Max Sussman, Academic Press.
Fritsch VN and Antelmann H*. 2022. Chapter 28 - Thiol targets in drug development to combat bacterial infections, Editor(s): Beatriz Alvarez, Marcelo A. Comini, Gustavo Salinas, Madia Trujillo, Redox Chemistry and Biology of Thiols, Academic Press, 2022, Pages 679-711, ISBN 9780323902199, https://doi.org/10.1016/B978-0-323-90219-9.00003-0.
Ashby LV, Springer R, Loi VV, Antelmann H, Hampton MB, Kettle AJ, Dickerhof N*. 2022. Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes. J Leukoc Biol. 112(4):591-605. doi: 10.1002/JLB.4HI1021-538RR.
Linzner N, Loi VV, Antelmann H*. 2022. The Catalase KatA Contributes to Microaerophilic H2O2 Priming to Acquire an Improved Oxidative Stress Resistance in Staphylococcus aureus. Antioxidants (Basel) 11(9):1793. doi: 10.3390/antiox11091793.
Fritsch VN, Linzner N, Busche T, Said N, Weise C, Kalinowski J, Wahl MC, Antelmann H*. 2022. The MerR-family regulator NmlR is involved in the defense against oxidative stress in Streptococcus pneumoniae. Mol Microbiol. 2022 Nov 8. doi: 10.1111/mmi.14999.
Fritsch VN, Loi VV, Kuropka B, Gruhlke MCH, Weise C, Antelmann H*. The MarR/DUF24-family QsrR repressor senses quinones and oxidants by thiol switch mechanisms in Staphylococcus aureus. Antioxid Redox Signal. 2022 Oct 14. doi: 10.1089/ars.2022.0090.
2021
Loi VV, Busche T, Fritsch VN, Weise C, Gruhlke MCH, Slusarenko AJ, Kalinowski J, Antelmann H*. 2021. The two-Cys-type TetR repressor GbaA confers resistance under disulfide and electrophile stress in Staphylococcus aureus. Free Radic Biol Med. 2021 Oct 19;177:120-131. doi: 10.1016/j.freeradbiomed.2021.10.024.
Mösbauer K, Fritsch VN, Adrian L, Bernhardt J, Gruhlke MCH, Slusarenko AJ, Niemeyer D and Antelmann H*. 2021. The effect of allicin on the proteome of SARS-CoV-2 infected Calu-3 cells. Front. Microbiol. 12:746795.doi: 10.3389/fmicb.2021.746795.
Linzner N and Antelmann H*. 2021. The antimicrobial activity of the AGXX® surface coating requires a small particle size to efficiently kill Staphylococcus aureus. Front. Microbiol. 12:731564. doi: 10.3389/fmicb.2021.731564
Grass LM, Wollenhaupt J, Barthel T, Parfentev I, Urlaub H, Loll B, Klauck E, Antelmann H, Wahl MC. 2021. Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2100370118. doi: 10.1073/pnas.2100370118
Troitzsch A, Loi VV, Methling K, Zühlke D, Lalk M, Riedel K, Bernhardt J, Elsayed EM, Bange G, Antelmann H, Pané-Farré J. 2021. Carbon source-dependent reprogramming of anaerobic metabolism in Staphylococcus aureus. J Bacteriol. 203(8):e00639-20. doi: 10.1128/JB.00639-20.
Borlinghaus J, Foerster Née Reiter J, Kappler U, Antelmann H, Noll U, Gruhlke MCH, Slusarenko AJ. 2021. Allicin, the odor of freshly crushed garlic: A review of recent progress in understanding allicin's effects on cells.Molecules 26(6):1505. doi: 10.3390/molecules26061505.
Linzner N, Loi VV, Fritsch VN, Antelmann H*. 2021. Thiol-based redox switches in the major pathogen Staphylococcus aureus. Biol Chem 402(3):333-361. doi: 10.1515/hsz-2020-0272.
2020
Linzner N, Fritsch VN, Busche T, Tung QN, Loi VV, Bernhardt J, Kalinowski J, Antelmann H*. 2020 The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus. Free Radic Biol Med. doi: 10.1016/j.freeradbiomed.2020.07.025.
Loi VV, Antelmann H*. 2020 Method for measurement of bacillithiol redox potential changes using the Brx-roGFP2 redox biosensor in Staphylococcus aureus. MethodsX. 7:100900. doi: 10.1016/j.mex.2020.100900.
Hartmann FSF, Clermont L, Tung QN, Antelmann H, Seibold GM. 2020 The industrial organism Corynebacterium glutamicum requires mycothiol as antioxidant to resist against oxidative stress in bioreactor cultivations. Antioxidants (Basel). 9(10):969. doi:10.3390/antiox9100969.
Fritsch VN, Loi VV, Busche T, Tung QN, Lill R, Horvatek P, Wolz C, Kalinowski J, Antelmann H*. 2020. The alarmone (p)ppGpp confers tolerance to oxidative stress during the stationary phase by maintenance of redox and iron homeostasis in Staphylococcus aureus. Free Radic Biol Med. S0891-5849(20)31596-3. doi: 10.1016/j.freeradbiomed.2020.10.322.
2019
Tung QN, Busche T, Loi VV, Kalinowski J, Antelmann H*. 2019. The redox-sensing MarR-type repressor HypS controls hypochlorite and antimicrobial resistance in Mycobacterium smegmatis. Free Rad Biol Med, 147:252-261. doi: 10.1016/j.freeradbiomed.2019.12.032.
Chi BK, Huyen NTT, Loi VV, Gruhlke MCH, Schaffer M, Mäder U, Maaß S, Becher D, Bernhardt J, Arbach M, Hamilton CJ, Slusarenko AJ, Antelmann H*. 2019. The disulfide stress response and protein S-thioallylation caused by allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics and proteomics. Antioxidants (Basel). 8(12):650. doi: 10.3390/antiox8120605.
Currier RB, Ulrich K, Leroux AE, Dirdjaja N, Deambrosi M, Bonilla M, Ahmed YL, Adrian L, Antelmann H, Jakob U, Comini MA, Krauth-Siegel RL. 2019. An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone. PLoS Pathog. 15(9):e1008065. doi: 10.1371/journal.ppat.1008065.
Reuter WH, Masuch T, Ke N, Lenon M, Radzinski M, Loi VV, Ren G, Riggs P, Antelmann H, Reichmann D, Leichert LI, and Berkmen M. 2019. Utilizing redox-sensitive GFP fusions to detect in vivo redox changes in a genetically engineered prokaryote, Redox Biology 101280, doi: https://doi.org/10.1016/j.redox.2019.101280.
Fritsch, V.N., Loi, V.V., Busche, T., Sommer, A., Nürnberg, D.J., Tedin, K., Kalinowski, J., Bernhardt, J., Fulde, M. and Antelmann, H.* 2019. The MarR-type repressor MhqR confers quinone and antimicrobial resistance in Staphylococcus aureus. Antioxid. Redox Signal. 31(16):1235-1252. doi: 10.1089/ars.2019.7750.
Linzner N, Loi VV, Fritsch VN, Tung QN, Stenzel S, Wirtz M, Hell R, Hamilton C, Tedin K, Fulde M, Antelmann H*. 2019. Staphylococcus aureususes the bacilliredoxin (BrxAB)/bacillithiol disulfide reductase (YpdA) redox pathway to defend against oxidative stress under infections, Front Microbiol. 10:1355. doi: 10.3389/fmicb.2019.01355.
Loi VV, Huyen NTT, Busche T, Tung QN, Gruhlke MCH, Kalinowski J, Bernhardt J, Slusarenko AJ, Antelmann H*.2019. Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress. Free Radic Biol Med 139: 55-69. doi: 10.1016/j.freeradbiomed.2019.05.018.
Gruhlke MCH, Antelmann H, Bernhardt J, Kloubert V, Rink L, Slusarenko AJ. 2019. The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects. Free Radic Biol Med 131:144-153. doi:10.1016/j.freeradbiomed.2018.11.022.
Tung QN, Loi VV, Busche T, Nerlich A, Mieth M, Milse J, Kalinowski J, Hocke AC, Antelmann H*. 2019. Stable integration of the Mrx1-roGFP2 biosensor to monitor dynamic changes of the mycothiol redox potential in Corynebacterium glutamicum. Redox Biology 20: 514-525. doi: 10.1016/j.redox.2018.11.012.
Imber M, Pietrzyk-Brzezinska AJ, Antelmann H*. 2019. Redox regulation by reversible protein S-thiolation in Gram-positive bacteria. Redox Biology 20:130-145. doi: 10.1016/j.redox.2018.08.017.
2018
Loi VV, Busche T, Preuß T, Kalinowski J, Bernhardt J and Antelmann H*. 2018. The AGXX® AntimicrobialCoating Causes a Thiol-Specific Oxidative Stress Response and Protein S-bacillithiolation in Staphylococcus aureus.Front. Microbiol. 9:3037. doi: 10.3389/fmicb.2018.03037.
Rossius M, Hochgräfe F, Antelmann H*. 2018.Thiol-Redox Proteomics to Study Reversible Protein Thiol Oxidations in Bacteria. Methods Mol Biol. 1841:261-275. doi: 10.1007/978-1-4939-8695-8_18.
Busche T, Hillion M, Loi VV, Berg D, Walther B, Semmler T, Strommenger B, Witte W, Cuny C, Mellmann A, Holmes MA, Kalinowski J, Adrian L, Bernhardt J, Antelmann H*. 2018. Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. Mol Cell Proteomics 17(12): 2411-2433. doi: 10.1074/mcp.RA118.001036.
Pietrzyk-Brzezinska AJ, Absmeier E, Klauck E, Wen Y, Antelmann H, Wahl MC. 2018. Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB. Structure. 2018 Aug 13. pii: S0969-2126(18)30259-4. doi: 10.1016/j.str.2018.07.013.
Antelmann H*. 2018. Unravelling the role of redox modifications. Magazine "EU Research" SUM18 pages 24-25. http://www.euresearcher.com/14/eu-research-live
Tung QN, Linzner N, Loi VV, Antelmann H*. 2018. Biosynthesis and functions of bacillithiol in Firmicutes. Book chapter no. 21, Book title “Glutathione”, Editor Leopold Flohe, CRC Press, Taylor & Francis Group, September 2018.
Tung QN, Linzner N, Loi VV, Antelmann H*. 2018. Application of genetically encoded redox biosensors to measure dynamic changes in the glutathione, bacillithiol and mycothiol redox potentials in pathogenic bacteria. Free Radic Biol Med. 128:84-96. doi: 10.1016/j.freeradbiomed.2018.02.018.
Imber M, Loi VV* Reznikov S, Fritsch VN, Pietrzyk-Brzezinska AJ, Prehn J, Hamilton CJ, Wahl MC, Bronowska AK, Antelmann H*. 2018. The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus. Redox Biol.15: 557-568. doi: 10.1016/j.redox.2018.02.001.
Loi VV, Busche T, Bernhardt J, Tedin K, Wollenhaupt J, Huyen NTT, Weise C, Kalinowski J, Wahl MC, Fulde M, Antelmann H*. 2018. Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus. Antioxid Redox Signal 29(7):615-636. doi: 10.1089/ars.2017.7354.
Imber M, Huyen NTT, Pietrzyk-Brzezinska AJ, Loi VV, Hillion M, Bernhardt J, Thärichen L, Kolšek K, Saleh M, Hamilton CJ, Adrian L, Gräter F, Wahl MC, Antelmann H*. 2018. Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress. Antioxid Redox Signal. 28: 410-430. doi: 10.1089/ars.2016.6897.
Chandrangsu P, Loi VV, Antelmann H*, Helmann JD*. 2018. The Role of Bacillithiol in Gram-Positive Firmicute. Review. Antioxid. Redox Signal. 28: 445-462. doi: 10.1089/ars.2017.7057.
2017
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, et al. 2017. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 13:94-162. doi: 10.1016/j.redox.2017.05.007. Review. PMID: 28577489.
Hillion M, Imber M, Pedre B, Bernhardt J, Saleh M, Loi VV, Maaß S, Becher D, Astolfi Rosado L, Adrian L, Weise C, Hell R, Wirtz M, Messens J, Antelmann H*. 2017. The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress. Sci Rep.7(1):5020. doi: 10.1038/s41598-017-05206-2. PMID:28694441.
Hillion M, Bernhardt J, Busche T, Rossius M, Maaß S, Becher D, Rawat M, Wirtz M, Hell R, Rückert C, Kalinowski J, Antelmann H. 2017. Monitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress. Sci Rep. 7(1):1195. doi: 10.1038/s41598-017-01179-4. PMID: 28446771.
Loi VV, Harms M, Müller M, Huyen NT, Hamilton CJ, Hochgräfe F, Pané-Farré J, Antelmann H*. 2017. Real-Time Imaging of the Bacillithiol Redox Potential in the Human Pathogen Staphylococcus aureus Using a Genetically Encoded Bacilliredoxin-Fused Redox Biosensor. Antioxid Redox Signal. 26(15):835-848. doi: 10.1089/ars.2016.6733. PMID: 27462976.
2016
Ball G, Antelmann H, Imbert PR, Gimenez MR, Voulhoux R, Ize B. Contribution of the Twin Arginine Translocation system to the exoproteome of Pseudomonas aeruginosa. Sci Rep. 2016 Jun 9;6:27675. doi: 10.1038/srep27675.
2015
Loi VV, Rossius M, Antelmann H*. 2015. Redox regulation by reversible protein S-thiolation in bacteria. Front Microbiol. 6:187. doi: 10.3389/fmicb.2015.00187. eCollection 2015. Review.
Hillion M, Antelmann H*. 2015. Thiol-based redox switches in prokaryotes. Biol Chem. 396(5):415-44. doi: 10.1515/hsz-2015-0102.
Salzberg LI, Botella E, Hokamp K, Antelmann H, Maaß S, Becher D, Noone D, Devine KM. 2015. Genome-Wide Analysis of Phosphorylated PhoP Binding to Chromosomal DNA Reveals Several Novel Features of the PhoPR-Mediated Phosphate Limitation Response in Bacillus subtilis. J Bacteriol. 197(8):1492-506. doi: 10.1128/JB.02570-14.
AbouElfetouh A, Kuhn ML, Hu LI, Scholle MD, Sorensen DJ, Sahu AK, Becher D, Antelmann H, Mrksich M, Anderson WF, Gibson BW, Schilling B, Wolfe AJ. 2015. The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites. Microbiologyopen. 4(1):66-83. doi: 10.1002/mbo3.223.
Antelmann H*. 2015. Enzyme regulation: a thiol switch opens the gate. Nat Chem Biol. 2015 Jan;11(1):4-5. doi: 10.1038/nchembio.1698.
2014
Antelmann, H. 2014. Chapter 15: "Oxidative stress responses and Redox signaling mechanisms in Bacillus subtilis and Staphylococcus aureus" in Molecular Medical Microbiology, 2nd edition, pp. 249-274. Ed. Yi-Wei Tang, Dongyou Liu, Ian R. Poxton, Joseph D. Schwartzman, and Max Sussman, Academic Press., DOI: 10.1016/B978-0-12-397169-2.00013-5
Gaballa, A., Chi, B.K., Roberts, A.A., Becher, D., Hamilton, C., Antelmann, H.* and Helmann, J.D.* 2014. Redox regulation in Bacillus subtilis: the bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE. Antioxidants & Redox Signaling, doi:10.1089/ars.2013.5327. » [link]
Chi, B. K., Busche. T., Van Laer, K., Bäsell, K., Becher, D., Clermont, L., Seibold, G., Persicke, M., Kalinowski, J., Messens, J. and Antelmann, H.* 2014. Protein S-mycothiolation functions as redox-switch and thiol protection mechanism in Corynebacterium glutamicum under hypochlorite stress. Antioxidants & Redox Signaling, doi:10.1089/ars.2013.5423. » [link]
Miranda, H. V., Antelmann, H., Hepowit, N., Krause, D. J. Pritz, J. R., Bäsell, K., Becher, D., Humbard, M.A., Brocchieri, L. and Maupin-Furlow, J.A. 2014. Archaeal sampylation: a third ubiquitin-like protein (SAMP3) is attached to proteins by isopeptide bonds via an E1-dependent mechanism. Mol. Cell. Proteomics 13: 220-39. doi:10.1074/mcp.M113.029652. » [link]
Noone, D., Salzberg, L. I., Botella, E., Bäsell, K., Becker, D., Antelmann, H. and Devine, K. M. 2014. A highly unstable transcript makes expression of the CwlO D,L-endopeptidase responsive to growth conditions in Bacillus subtilis. J. Bacteriol. 196: 237-47. » [link]
2013
Saleh, M., Bartual, S.G., Abdullah, M.R., Jensch, I., Asmat, T. M., Petruschka, L., Pribyl, T., Gellert, M., Lillig, C. H., Antelmann, H., Hermoso, J.A.* and Hammerschmidt, S.* 2013. Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence. EMBO Molecular Medicine 5:1852-1870. » [link]
Gaballa, A., Antelmann, H. and Helmann, J.D.* 2013. Regulation of Bacillus subtilis bacillithiol biosynthesis operons by Spx. Microbiology, 159: 2025-35. » [link]
Hu, L. Chi, B. K., Kuhn, M. L., Filippova, E. V., Walker-Peddakotla, A.J., Bäsell, K., Becher, D., Anderson, W.F., Antelmann, H. and Wolfe, A.J. 2013. Acetylation of the Response Regulator RcsB Controls Transcription from a Small RNA Promoter. J. Bacteriol., 195: 4174-4186.» [link]
Greiner, R., Pálinkás, Z., Bäsell, K., Becher, D., Antelmann, H., Nagy, P. and Dick, T.P.* 2013. Polysulfides link H2S to protein thiol oxidation. Antioxidants & Redox Signaling, 19: 1749-1765.» [link]
Pöther, D., Gierok, P., Harms, M., Mostertz, J., Hochgräfe, F., Antelmann, H., Hamilton, C., Borovok, I., Lalk, M., Aharonowitz, Y., and Hecker, M.* 2013. Distribution and infection-related functions of Bacillithiol in Staphylococcus aureus. Int. J. of Med. Microbiology, 303: 114-123. » [link]
Chi, B.K., Roberts, A., Huyen,T.T.T., Gronau, K., Becher, D., Albrecht, D., Hamilton, C. and Antelmann*, H. 2013. S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in Firmicutes bacteria. Antioxidants & Redox signaling 18: 1273-1295. » [link]
2012
Antelmann*, H. and Hamilton*, C.J. 2012. Bacterial mechanisms of reversible protein S-thiolation: structural and mechanistic insights into mycoredoxins. Molecular Microbiology 86:759-764. » [link]
Lima, B.P., Huyen,T.T.T., Bäsell, K., Becher, D., Antelmann, H. and Wolfe, A.J. 2012. Inhibition of Acetyl Phosphate-Dependent Transcription by an Acetylatable Lysine on RNA Polymerase. J Biol Chem, 287: 32147-60. » [link]
Tschumi, A., Grau, T., Albrecht, D., Rezwan, M., Antelmann, H. and Sander, P. 2012. Functional analyses of mycobacterial lipoprotein diacylglyceryl transferase and comparative secretome analysis of a mycobacterial lgt mutant. J. Bacteriol.194: 3938-3949.» [link]
Smaldone, G.T., Revelles, O., Gaballa, A., Sauer, U., Antelmann, H., and Helmann, J.D. 2012. A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism, J. Bacteriol.194: 2594-2605.» [link]
Smaldone, G.T., Antelmann, H., Gaballa, A., and Helmann, J.D. 2012. The FsrA sRNA and FbpB protein mediate the iron-dependent induction of the Bacillus subtilis LutABC iron-sulfur containing oxidases.J. Bacteriol., 194: 2586-2593.» [link]
Palm, G., Chi, B.K., Waack, P., Gronau, K., Becher, D., Albrecht, D., Hinrichs, W., Read, R.J. and Antelmann*, H. 2012. Structural insights into the redox-switch mechanism of the MarR/DUF24-family regulator HypR. Nucleic Acid Research 40: 4178-92.» [link]
2011
Zuber, P., Chauhan, S., Pilaka, P., Nakano, M. M., Gurumoorthy, S., Chi, B. K., Antelmann, H., and Mäder, U. 2011. Phenotype enhancement screen of a regulatory mutant to uncover function in genes of a complex regulon: Bacillus subtilis ytpQ, encoding a DUF1444 protein, affects control of iron metabolism and oxidative stress prevention. PLoS One 6, e25066.» [link]
Chi, B.K., Gronau, K., Mäder, U., Becher, D., and Antelmann*, H. 2011. S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics. Mol. Cell. Proteomics, doi: 10.1074/mcp.M111.009506.» [link]
Antelmann*, H., and Helmann*, J.D. 2011. Thiol-based redox switches and gene regulation. Forum Review Article on “Redox switches”. Antioxidants & Redox signaling, 14,1049-1063.» [link]
Lima, B.P., Antelmann, H., Gronau, K., Chi, B. K., Becher, D., Brinsmade SR, and Wolfe, A.J. 2011. Involvement of Protein Acetylation in Glucose-induced Transcription of a Stress-Responsive Promoter. Mol. Microbiol. 81, 1190-204.» [link]
Hachmann, A.-B. Sevim, E., Gaballa, A., Popham, D., Antelmann, H. and Helmann, J. D. 2011. Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis. Antimicrobial Agents and Chemotherapy 55, 4326-4337.» [link]
Fasehee, H. R., Westers, H., Bolhuis, A., Antelmann, H., Hecker, M., Quax, W. J., Mirlohi, A. F., van Dijl, J. M. and Ahmadian, G. R. 2011. Functional analysis of the sortase YhcS in Bacillus subtilis. Proteomics, 11, 3905-13.» [link]
van der Ploeg, R., Mäder, U., Homuth, G., Schaffer, M., Denham, E.L., Monteferrante, C.G., Miethke, M., Marahiel, M.A., Harwood, C.R., Winter, T., Hecker, M., Antelmann, H., and van Dijl, J.M. 2011. Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis. PLoS ONE 6, e18140.» [link]
2010
Sibbald, M.J.J.B., Winter, T., van der Kooi-Pol, M. M., Bosma, T., Schäfer, T., Ohlsen, K., Hecker, M., Antelmann, H., Engelmann, S., and van Dijl, J. M. 2010. Synthetic effects of secG and secY2 mutations on exoproteome biogenesis in Staphylococcus aureus. J. Bacteriol. 192: 3788-3800.» [link]
Gaballa, A., Newton, J., Antelmann, H., Parsonage, D., Upton, H., Rawat, M., Claiborne, A., Fahey, R., and Helmann, J.D.* 2010. Biosynthesis and functions of Bacillithiol: a major low molecular weight thiol in Bacilli, Proc. Natl. Acad. Sci. 107: 6482-6486.» [link]
Joshi, M., Mann, S., Antelmann, H., Widdick, D., Fyans, J., Chandra, G., Hutchings, M., Toth, I., Hecker, M., Loria, R. and Palmer, T. 2010. The Tat pathway exports multiple virulence factors in the plant pathogen Streptomyces scabies. Mol. Microbiol. 77: 252-71.» [link]
Chi, B.K., Kobayashi, K., Hecker, M., and Antelmann*, H. 2010. The paralogous MarR/DUF24-family repressors YodB and CatR (YvaP) control expression of the catechol dioxygenase CatE in Bacillus subtilis. J. Bacteriol. 192: 4571-4581.» [link]
Chi, B.K., Albrecht, D., Gronau, K., Becher, D. Hecker, M., and Antelmann*, H. 2010. The redox-sensing regulator YodB senses diamide and quinones via a thiol-disulfide switch in Bacillus subtilis. Proteomics 17: 3155-3164.» [link]
2009
Voigt, B. Antelmann, H., Albrecht, D., Ehrenreich, A., Maurer, K.-H., Evers, S., Gottschalk, G., van Dijl, J.M., Schweder, T., and Hecker, M. 2009. Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis. J. Mol. Microbiol. Biotechnol. 16, 53-68.» [link]
MacLellan, S.R., Helmann*, J.D. and Antelmann*, H. 2009. The YvrI alternative sigma factor is essential for acid-stress induction of oxalate decarboxylase in Bacillus subtilis. J Bacteriol. 191: 931-9.» [link]
Huyen, N.T.T., Eiamphungporn, W., Mäder, U., Liebeke, M., Lalk, M., Hecker, M., Helmann*, J.D. and Antelmann*, H. 2009. Genome wide responses to carbonyl electrophiles in Bacillus subtilis- control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the novel MerR-family regulator YraB (AdhR). Mol Microbiol. 71: 876-894.» [link]
Kouwen, T.R.H.M., Antelmann, H., van der Ploeg, R., Hecker, M., and van Dijl, J.M. 2009. MscL of Bacillus subtilis prevents selective release of cytoplasmic proteins in a hypotonic environment. Proteomics 9: 1033-1043.» [link]
Kouwen, T.R.H.M., van der Ploeg, R., Antelmann, H., Hecker, M., Homuth, G., Mäder, U., and van Dijl, J.M. 2009. Overflow of a hyper-produced secretory protein from the Bacillus Sec pathway into the Tat pathway for protein secretion. Proteomics 9: 1018-32.» [link]
Pöther, D.-C., Liebeke, M., Hochgräfe, F., Antelmann, H., Lindequist, U., Borovok, I., Cohen, G., Aharonowitz, Y., Lalk M. and Hecker M. 2009. Diamide triggers mainly S-thiolations in the cytoplasmic proteome of Bacillus subtilis and Staphylococcus aureus. J. Bacteriol. 191: 7520-7530.» [link]
2008
Antelmann*, H., Hecker, M., Zuber, P. 2008. Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis. Expert Rev Proteomics 5, 77-90. Review. » [link]
Hecker*, M., Antelmann, H., K. Büttner and Bernhardt, J. 2008. Gel-based proteomics of Gram-positive bacteria: Still a powerful tool to address physiological questions.
Proteomics
8, 4958-4975. Review » [link]
Leelakriangsak, M., Huyen, N.T.T., Töwe, S., Duy, N.V., Becher, D., Hecker, M., Antelmann* H., and Zuber*, P. 2008. Regulation of quinone detoxification by the thiol-stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis, Mol Microbiol. 67, 1108-1124. » [link]
Westers, L., Westers, H., Zanen, G. Antelmann, H., Hecker, M., Noone, D. Devine, K.M., van Dijl*, J.M., and Quax, W. 2008. Genetic or chemical protease inhibition causes significant changes in the Bacillus subtilis exoproteome. Proteomics 8, 2704-2713. » [link]
Gaballa, A., Antelmann, H., Aguilar, C., Khakh, S.-K., Song, K.-B., Smaldone, G.T, Helmann*, J.D. 2008. The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small basic proteins. Proc. Natl. Acad. Sci. 105, 11927-11932. » [link]
Liebeke, M., Pöther, D.-C., van Duy, N., Albrecht, D., Becher, D., Hochgräfe, F., Lalk, M. Hecker, M. and Antelmann*, H. 2008. Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis. Mol. Microbiol. 69, 1513 - 1529. » [link]
2007
Tam, le T., Eymann*, C., Antelmann, H., Albrecht, D., Hecker, M. 2007.Global gene expression profiling of Bacillus subtilis in response to ammonium and tryptophan starvation as revealed by transcriptome and proteome analyses. J Mol Microbiol Biotechnol. 12:121-30.» [link]
Antelmann*, H., Töwe, S., Albrecht, D., Hecker, M. 2007. The phosphorous source phytate changes the composition of the cell wall proteome in Bacillus subtilis. J. Proteome Res. 6: 897-903.» [link]
Duy, N.V., Mäder, U., Tran, N.P., Cavin, J.F., Tam, le T., Albrecht, D., Hecker, M., Antelmann*, H. 2007. The transcriptome and proteome analysis of Bacillus subtilis in response to salicylic acid. Proteomics, 7: 698-710.» [link]
Duy, N.V., Wolf, C., Mäder, U., Lalk, M., Langer, P., Lindequist, U., Hecker, M., and Antelmann*, H. 2007. Transcriptome and proteome analyses in response to 2-methylhydroquinone and 6-brom-2-vinyl-chroman-4-on reveal different degradation systems involved in the catabolism of aromatic compounds in Bacillus subtilis. Proteomics. 7: 1391-408. » [link]
Kouwen, T.R., van der Goot, A., Dorenbos, R., Winter, T., Antelmann H, Plaisier, M.C., Quax, W.J., van Dijl*, J.M., Dubois, J.Y. 2007. Thiol-disulphide oxidoreductase modules in the low-GC Gram-positive bacteria. Mol Microbiol. 64: 984-99. » [link]
Hyyrylainen, H.L., Pietiainen, M., Lunden, T., Ekman, A., Gardemeister, M., Murtomaki-Repo, S., Antelmann, H., Hecker, M., Valmu, L., Sarvas, M., Kontinen*, V.P. 2007. The density of negative charge in the cell wall influences two-component signal transduction in Bacillus subtilis. Microbiology 153:2126-36. » [link]
Töwe, S., Leelakriangsak, M., Kobayashi, K., Van Duy N., Hecker, M., Zuber, P., Antelmann* H. 2007. The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/ glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis. Mol Microbiol. 66: 40-54.» [link]
Wolff, S., Antelmann, H., Albrecht, D., Becher, D., Bernhardt, J., Bron, S., Büttner, K., van Dijl, J.M., Eymann, C., Otto, A., Tam, L.T., Hecker* M. 2007. Towards the entire proteome of the model bacterium Bacillus subtilis by gel-based and gel-free approaches. J Chromatogr B Analyt Technol Biomed Life Sci. 849: 129-40.» [link]
2006
Ollinger, J., Song, K.B., Antelmann, H., Hecker, M., Helmann*, J.D. 2006. Role of the Fur regulon in iron transport in Bacillus subtilis. J Bacteriol. 188, 3664-73.» [link]
Zanen, G., Antelmann, H., Meima, R., Jongbloed, J.D., Kolkman, M., Hecker, M., van Dijl*, J.M., Quax, W.J. 2006. Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis. Proteomics 6, 3636-48.» [link]
Tam. le T., Antelmann* H., Eymann, C., Albrecht, D., Bernhardt, J., Hecker, M. 2006. Proteome signatures for stress and starvation in Bacillus subtilis as revealed by a 2-D gel image color coding approach. Proteomics.6, 4565-85.» [link]
Lioy, V.S., Martin, M.T., Camacho, A.G., Lurz, R., Antelmann, H., Hecker, M., Hitchin, E., Ridge, Y., Wells, J.M., Alonso, J.C. 2006. pSM19035-encoded zeta toxin induces stasis followed by death in a subpopulation of cells. Microbiology. 152, 2365-79.» [link]
Tam, le T., Eymann, C., Albrecht, D., Sietmann, R., Schauer, F., Hecker, M., Antelmann* H. 2006. Differential gene expression in response to phenol and catechol reveals different metabolic activities for the degradation of aromatic compounds in Bacillus subtilis. Environ Microbiol. 8, 1408-27.» [link]
Darmon, E., Dorenbos, R., Meens, J., Freudl, R., Antelmann, H., Hecker, M., Kuipers, O. P., Bron, S., Quax, W. J., Dubois, J.-Y. F., and van Dijl*, J.M. 2006. A disulfide bond-containing alkaline phosphatase triggers a BdbC-dependent secretion stress response in Bacillus subtilis. Appl. Environ. Microbiol. 72, 6876-6885.» [link]
2005
Westers H., Braun, P.G., Westers, L., Antelmann, H., Hecker, M., Jongbloed, J.D.H., Yoshikawa, H., Tanaka, Quax, W., van Dijl*, J. M. 2005. Genes for SkfA killing factor production protect a Bacillus subtilis lipase against proteolysis. Applied Environ. Microbiol. 71, 1899-908.» [link]
Antelmann*, H., Williams, R.C., Miethke, M., Wipat, A., Albrecht, D., Harwood, C.R., and Hecker, M. 2005. The extracellular and cytoplasmic proteomes of the non-virulent Bacillus anthracis strain UM23C1-2. Proteomics 5, 3684-3695.» [link]
2004
Tjalsma, H., Antelmann, H., Jongbloed, J.D., Braun, P.G., Darmon, E., Dorenbos, R., Dubois, J.Y., Westers, H., Zanen, G., Quax, W.J., Kuipers, O.P., Bron, S., Hecker, M., J. M. van Dijl*. 2004. Proteomics of Protein Secretion by Bacillus subtilis: Separating the "Secrets" of the Secretome. Microbiol. Mol. Biol. Rev. 68:207-33.» [link]
Vitikainen M., Lappalainen, I., Seppala, R., Antelmann, H., Boer, H., Taira, S., Savilahti, H., Hecker, M., Vihinen, M., Sarvas M., and Kontinen*, V.P. 2004. Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N- and C-terminal domains in protein folding and secretion in Bacillus subtilis. J Biol Chem. 279:19302-19314.» [link]
Antelmann*, H., Sapolsky, R., Miller, B., Ferrari, E., Chotani, G., Weyler, W., Gaertner, A. and Hecker, M. 2004. Quantitative proteome profiling during the fermentation process of pleiotropic Bacillus subtilis mutants. Proteomics 4: 2408-2424.» [link]
Zanen, G, Antelmann, H., Westers, H., Hecker, M., van Dijl*, J.M., Quax, W.J. 2004. FlhF, the third signal recognition particle-GTPase of Bacillus subtilis, is dispensable for protein secretion. J Bacteriol. 186: 5956-5660.» [link]
Jongbloed, J.D.H, Grieger, U., Antelmann, H., Hecker, M. Nijland, R., Bron, S., van Dijl*, J. M. 2004. Two minimal Tat translocases in Bacillus. Mol. Microbiol., 54: 1319-1325.» [link]
2003
Rollenhagen, C., Antelmann, H., Kirstein, J., Delumeau, O., Hecker, M., Yudkin,* M.D. 2003. Binding of Sigma(A) and Sigma(B) to core RNA polymerase after environmental stress in Bacillus subtilis.J Bacteriol.185 :35-40.» [link]
Antelmann, H., Darmon, E., Noone, D., Veening, J.W., Westers, H., Bron S., Kuipers, O.P., Devin, K.M., Hecker, M., and van Dijl*, J.M. 2003. The extracellular proteome of Bacillus subtilis under secretion stress conditions. Mol. Microbiol. 49: 143-156.» [link]
Mäder, U., Antelmann, H., Buder, T., Dahl, M.K., Hecker, M., and Homuth*, G. 2003. Bacillus subtilis functional genomics: genome wide analysis of the DegS-DegU regulon by transcriptomics and proteomics. Mol. Genet. Genomics 268: 455-467.» [link]
Westers, H., Dorenbos, R., van Dijl*, J.M., Kabel, J., Flanagan, T., Devine, K.M., Jude, F., Séror, S.J., Beekman, A.C., Darmon, E., Eschevins, C., de Jong, A., Bron, S., Kuipers, O.P., Albertini, A.M., Antelmann, H., Hecker, M., Zamboni, N., Sauer, U., Bruand, C., Ehrlich, D.S., Alonso, J.C., Salas, M., and W.J. Quax. 2003. Genome engineering reveals large dispensable regions in Bacillus subtilis. Mol. Biol. Evol. 20: 2076-2090.» [link]
2002
van Dijl* J.M., Braun P.G., Robinson C., Quax W.J., Antelmann H., Hecker, M., Müller J., Tjalsma, H., Bron, S., Jongbloed, J.D. 2002. Functional genomic analysis of the Bacillus subtilis Tat pathway for protein secretion. J Biotechnol. 98: 243-54. Review.» [link]
Antelmann*, H., Yamamoto, H., Sekiguchi, J., and Hecker, M. 2002. Stabilization of cell wall proteins in Bacillus subtilis: a proteomic approach. Proteomics 2: 591-602.» [link]
Jongbloed, J.D.H., Antelmann, H., Hecker, M., Nijland, R., Pries, F., Koski, P., Quax, W.J., Bron, S., van Dijl*, J.M., and Braun, P.G. 2002. Selective contribution of the Twin-arginine translocation pathway to protein secretion in Bacillus subtilis. J. Biol. Chem. 277: 44068-44078.» [link]
2001
Antelmann, H., Tjalsma, H., Voigt, B., Ohlmeier, S., Bron, S., van Dijl,*J.M., and Hecker, M. 2001. A proteomic view on genome-based signal peptide predictions
. Genome Research 11: 14984-14502.» [link]
Büttner, K., Bernhardt, J., Scharf, C., Schmid, R., Mäder, U., Eymann, C., Antelmann,H., Völker, A., Völker, U., and Hecker*, M. 2001. A comprehensive two-dimensional map of cytosolic proteins of Bacillus subtilis. Electrophoresis 22: 2908-2935.» [link]
2000
Antelmann, H., Scharf, C. and Hecker*, M. 2000. Phosphate starvation-inducible proteins of Bacillus subtilis: proteomics and transcriptional analysis. J Bacteriol. 182, 4478-4490.» [link]
Jongbloed, J.D.H., Martin, U., Antelmann, H., Hecker, M., Tjalsma, H., Venema, G., Bron, S., van Dijl, J.M., and Müller*, J. 2000. TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway. J. Biol. Chem. 275: 41350-41357.» [link]
1999
Petersohn A, Antelmann, H., Gerth, U., and Hecker*, M. 1999. Identification and transcriptional analysis of new members of the SigmaB regulon in Bacillus subtilis. Microbiology. 145, 869-880.» [link]
1998
Völker, U., Andersen, K.K., Antelmann, H., Devine, K.M., and Hecker*, M. 1998. One of the two OsmC homologs in Bacillus subtilis
is part of the SigmaB-dependent general stress regulon.
J. Bacteriol. 180, 4212-4218.» [link]
1997
Schmid, R., Bernhardt, J., Antelmann, H., Völker, U., Mach, H., Völker, U., and Hecker*, M. 1997. Identification of vegetative proteins for a two-dimensional protein index of
Bacillus subtilis. Microbiology 143, 991-998.» [link]
Bernhardt, J., Völker, U., Völker, A., Antelmann, H., Schmid, R., Mach, H., and Hecker*, M. 1997. Specific and general stress proteins in Bacillus subtilis- a two-dimensional electrophoretical study. Microbiology 143, 999-1017.» [link]
Antelmann, H., Bernhardt, J., Schmid, R., Mach, H., Völker, U., and Hecker*, M. 1997. First steps from a two-dimensional protein index towards a response regulation map for Bacillus subtilis. Electrophoresis 18, 1451-1463.» [link]
Antelmann, H., Schmid, R., and Hecker*, M. 1997. The NAD synthetase NadE (OutB) of Bacillus subtilis is a SigmaB-dependent general stress protein. FEMS Microbiol. Lett. 153, 405-409.» [link]
Antelmann, H., Engelmann, S., Schmid, R., Sorokin, A., Lapidus, A., and Hecker*, M. 1997. Expression of a stress- and starvation-induced dps/pexB homologous gene is controlled by the alternative sigma factor SigmaB in Bacillus subtilis. J. Bacteriol. 179, 7251-7256.» [link]
1996
Antelmann, H., Engelmann, S., Schmid, R., and Hecker*, M. 1996. General and oxidative stress responses in Bacillus subtilis: Cloning , expression and mutation of the alkyl hydroperoxide reductase operon. J. Bacteriol. 178, 6571-6578.» [link]
1995
Antelmann, H., Bernhardt, J., Schmid, R., and Hecker*, M. 1995. A gene at 333° on the Bacillus subtilis chromosome encodes the newly identified sigB-dependent general stress protein GspA. J. Bacteriol. 177, 3540-3545.» [link]