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Coassembly Generates Peptide Hydrogel with Wound Dressing Material Properties

C. K. Thota, A. A. Berger, L. Elomaa, C. Nie, C. Bottcher and B. Koksch – 2020

Multicomponent self-assembly of peptides is a powerful strategy to fabricate novel functional materials with synergetic properties that can be used for several nanobiotechnological applications. In the present study, we used a coassembly strategy to generate an injectable ultrashort bioactive peptide hydrogel formed by mixing a dipeptide hydrogelator with a macrophage attracting short chemotactic peptide ligand. Coassembly does not impede hydrogelation as shown by cryo-transmission electron microscopy (cryo-TEM), scanning electron microscopy, and rheology. Biocompatibility was shown by cytotoxicity assays and confocal microscopy. The hydrogels release the entrapped skin antibiotic ciprofloxacin, among others, in a slow and continuous manner. Such bioinspired advanced functional materials can find applications as wound dressing materials to treat chronic wound conditions like diabetic foot ulcer.

Titel
Coassembly Generates Peptide Hydrogel with Wound Dressing Material Properties
Verfasser
C. K. Thota, A. A. Berger, L. Elomaa, C. Nie, C. Bottcher and B. Koksch
Datum
2020
Kennung
DOI:10.1021/acsomega.9b04371
Zitierweise
ACS Omega 2020, 5 (15), 8557-8563
Sprache
eng
Art
Text