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Self-degrading graphene sheets for tumor therapy

I. S. Donskyi, Y. Chen, P. Nickl, G. Guday, H. Qiao, K. Achazi, A. Lippitz, W. E. S. Unger, C. Bottcher, W. Chen, M. Adeli and R. Haag – 2020

Low biodegradability of graphene derivatives and related health risks are the main limiting factors for their in vivo biomedical applications. Here, we present the synthesis of enzyme-functionalized graphene sheets with self-degrading properties under physiological conditions and their applications in tumor therapy. The synergistic enzyme cascade glucose oxidase and myeloperoxidase are covalently conjugated to the surface of graphene sheets and two-dimensional (2D) platforms are obtained that can produce sodium hypochlorite from glucose. The enzyme-functionalized graphene sheets with up to 289 nm average size are degraded into small pieces (

Titel
Self-degrading graphene sheets for tumor therapy
Verfasser
I. S. Donskyi, Y. Chen, P. Nickl, G. Guday, H. Qiao, K. Achazi, A. Lippitz, W. E. S. Unger, C. Bottcher, W. Chen, M. Adeli and R. Haag
Datum
2020
Kennung
DOI:10.1039/d0nr02159h
Zitierweise
Nanoscale 2020, 12 (26), 14222-14229
Sprache
eng
Art
Text