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Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors

S. Bhatia, M. Hilsch, J. L. Cuellar-Camacho, K. Ludwig, C. Nie, B. Parshad, M. Wallert, S. Block, D. Lauster, C. Bottcher, A. Herrmann and R. Haag – 2020

Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK‐II cells.

Titel
Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Verfasser
S. Bhatia, M. Hilsch, J. L. Cuellar-Camacho, K. Ludwig, C. Nie, B. Parshad, M. Wallert, S. Block, D. Lauster, C. Bottcher, A. Herrmann and R. Haag
Datum
2020
Kennung
DOI:10.1002/anie.202006145
Zitierweise
Angew Int Ed 2020, 59 (39), 12417-12422
Sprache
eng
Art
Text