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Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

Rashmi, A. K. Singh, K. Achazi, B. Schade, C. Böttcher, R. Haag and S. K. Sharma – 2018

A series of four bolaamphiphiles with different hydrophilic units has been synthesised. All the amphiphiles were well characterised from their physiochemical data. The aggregation tendency of newly synthesised amphiphiles was studied using fluorescence spectroscopy, dynamic light scattering (DLS), and cryogenic electron microscopy (cryo-TEM). Furthermore, their application as nanocarriers for hydrophobic guests was demonstrated by using two established standards, i.e. the dye Nile red and the drug nimodipine. A cytotoxicity and cellular uptake study has been carried out using A549 cells. Due to the presence of an ester linkage in PEG based bolaamphiphiles, a drug release study was performed in the presence of an immobilized enzyme Novozym-435 (a lipase).

Titel
Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications
Verfasser
Rashmi, A. K. Singh, K. Achazi, B. Schade, C. Böttcher, R. Haag and S. K. Sharma
Datum
2018
Kennung
DOI: 10.1039/C8RA05921G
Zitierweise
RSC Adv 2018, 8 (55), 31777-31782
Sprache
eng
Art
Text