Publikationen

L. Grohmann, D. Becker, J. Rademann, N. Ma, M. Schäfer-Korting, G. Weindl “Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues”, Arch. Toxicol. 2017, doi: 10.1007/s00204-017-1954-5

L. Koehler, S. Samsonov, S. Rother, S. Vogel, S. Köhling, S. Moeller, M. Schnabelrauch, J. Rademann, U. Hempel, M. T. Pisabarro, D. Scharnweber, V. Hintze “Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF- β1 Signaling”, Scien. Rep. 2017, in press

S. Rother, S. Samsonov, S. Möller, M. Schnabelrauch, J. Rademann, J. Blaszkiewicz, S. Köhling, J. Waltenberger, M. T. Pisabarro, D. Scharnweber, V. Hintze, “Sulfate hyaluronan alters endothelial cell activation in vitro by controlling the biological activity of the angiogenic factors vascular endothelial growth factor-A and tissue inhibitor of metalloproteinase-3”, ACS Appl. Mater. Interfaces. 2017, doi: 10.1021/acsami.7b01300.

A. Troegeler, I. Mercier, C. Cougoule, D. Pietretti, A. Colom, C. Duval, T.-P. Vu Manh, F. Capilla, R. Poincloux, K. Pingris, J. Nigou, J. Rademann, M. Dalod, F. A. W. Verreck, T. Al Saati, G. Lugo-Villarino, B. Lepenies, D. Hudrisier, O. Neyrolles, “C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells”, Proc. Nat. Acad. Sci. U.S.A. 2017, 114, E540–E549, doi: 10.1073/pnas.1613254114.

M. Jaegle, E. L. Wong, C. Tauber, E. Nawrotzky, C. Arkona, J. Rademann, “Protein-templated fragment ligations: from molecular recognition to drug discovery”, Angew. Chem. Int. Ed. 2017, 56; Angew. Chem. 2017, 129, DOI: 10.1002/anie.201610372 and 10.1002/ange.201610372.

F. Müller, S. Hönzke, W.-O. Luthardt, E. L. Wong, M. Unbehauen, J. Bauer, R. Haag, S. Hedtrich, E. Rühl, J. Rademann, “Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery”, Eur. J. Pharm. Biopharm. 2017, DOI: 10.1016/j.ejpb.2016.12.013

M. Jaegle, T. Steinmetzer, J. Rademann, “Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction", Angew. Chem. Int. Ed. 2017, 56; Angew. Chem. 2017, 129,;DOI: 10.1002/anie.201611547 and 10.1002/ange.201611547

S. Rother, A. A. Samsonov, U. Hempel, S. Vogel, S. Moeller, J. Blaskiewicz, S. Köhling, M. Schnabelrauch, J. Rademann, M. T. Pisabarro, V. Hintze, D. Scharnweber, “Sulfated Hyaluronan Alters the Interaction Profile of TIMP-3 with the Endocytic Receptor LRP-1 Clusters II and IV and Increases the Extracellular TIMP-3 Level of Human Bone Marrow Stromal Cell” Biomacromolecules 2016, 17, 3252-3261

J. Rademann, E. L. Wong, C. Arkona, B. G. Kim, E. Nawrotzky, “Novel furazan-3-carboxylic acid derivatives and use thereof in treatment of cancer” Europäische Patentanmeldung 16192394.1

S. Köhling, M. P. Exner, S. Nojoumi, J. Schiller, N. Budisa, J. Rademann, „One-pot synthesis of anomeric glycosyl thiols from highly functionalized unprotected sugars in water for use in glycan ligation reactions“, Angew. Chem. Int. Ed. 2016, 55; Angew. Chem. Int. Ed. 2016, 55, DOI: 10.1002/anie.201607228 and 10.1002/ange.201607228

S. Rother, S. A. Samsonov, T. Hofmann, S. Köhling, J. Blaszkiewicz, S. Moeller, M. Schnabelrauch, J. Rademann, S. Kalkhof, M. von Bergen, M. T. Pisabarro, D. Scharnweber, V. Hintze, “Sulfated glycosaminoglycans modulate tissue remodeling via interaction with tissue inhibitor of metalloproteinase-3”, Acta Biomat. 2016, in press

D. Becker, Z. Kaczmarska, C. Arkona, R. Schulz, C. Tauber, G. Wolber, R. Hilgenfeld, M. Coll, J. Rademann, “Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments”, Nature Commun. 2016, 10, 12761, DOI:10.1038/ncomms12761

M. I. Fernández-Bachiller, I. Brzozowska, N. Odolczyk, U. Zielenkiewicz, P. Zielenkiewicz, J. Rademann, “Mapping Protein–Protein Interactions of the Resistance-Related Bacterial Zeta Toxin–Epsilon Antitoxin Complex (ε2ζ2) with High Affinity Peptide Ligands Using Fluorescence Polarization”, Toxins 2016, in press

N. Panitz, S. Theisgen, S. A. Samsonov, J.-P. Gehrcke, L. Baumann, K. Bellmann-Sickert, S. Köhling, M. T. Pisabarro, J. Rademann, D. Huster, A. G. Beck-Sickinger “The Structural Investigation of Glycosaminoglycan Binding to CXCL12 Displays Distinct Interaction Sites”, Glycobiology 2016, in press

M. P. Exner, S. Köhling, J. Rivollier, S. Gosling, P. Srivastava, Z. I. Palyancheva, P. Herdewijn, M.-P. Heck, J. Rademann, N. Budisa, “Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins”, Molecules 2016, 21, 287, 9 pp; doi:10.3390/molecules21030287

S. Mansour, A. S. Tocheva, C. Cave-Ayland, M. M. Machelett, B. Sander, N. M. Lissin, P. E. Molloy, M. S. Baird, G. Stübs, N. W. J. Schröder, R. R. Schumann, J. Rademann, A. D. Postle, B. K. Jakobsen, B. G. Marshall, R. Gosain, P. T. Elkington, T. Elliott, C.-K. Skylaris, J. W. Essex, I. Tews, S. D. Gadola, “Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells”, Proc. Nat. Acad. Sci. U.S.A. 2016, 113, doi: 10.1073/pnas.1519246113, in press

S. Köhling, G. Künze, K. Lemmnitzer, M. Bermudez, G. Wolber, J. Schiller, D. Huster, J. Rademann, “Chemoenzymatic synthesis of nonasulfated tetrahyaluronan with a paramagnetic tag for studying its complex with interleukin-10“, Chem. Eur. J. 2016, 22,5563-5574 doi 10.1002/chem.201504459

N. Urban, L. Wang, S. Kwiek, J. Rademann, W. M. Kübler, M. Schäfer, „Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor“, Mol. Pharmacol. 2016, 89, 197-213 doi.10.1124/mol.115.100792

G. Künze, S. Köhling, A. Vogel, J. Rademann, D. Huster, „Identification of the Glycosaminoglycan Binding Site of Interleukin-10 by NMR Spectroscopy“, J. Biol. Chem. 2016, 291, 3100-3113. doi 10.15252/embj.201489004

M. Jaegle, E. Nawrotzky, E. L. Wong, C. Arkona, and J. Rademann, “Protein-templated fragment ligation methods: emerging technologies in fragment-based drug discovery”, In: Fragment-based drug discovery (W. Jahnke, D. Erlanson, eds.), Wiley-VCH, Weinheim 2016, 292-326.

M. Bertazzon, L. Henning, C. Fischer, S. Bhatia, R.K. Uhne, J. Rademann, R. Haag, C. Freund, “Profiling and inhibition of multivalent WW domain interactions”, FEBS J. 2015, 282, 133.

L. Lan, J. D. Holland, J. Qi, S. Grosskopf, J. Rademann, R. Vogel, B. Györffy, A. Wulf-Goldenberg, W. Birchmeier, “Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice”, EMBO J. 2015, 34, 1493-1508. doi 10.15252/embj.201489004

K. Koschek, V. Durmaz, O. Krylova, M. Wieczorek, S. Gupta, M. Richter, A. Bujotzek, C. Fischer, R. Haag, C. Freund, M. Weber, J. Rademann, “Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands”, Beilstein J. Org. Chem. 2015, 11, 837–847. doi:10.3762/bjoc.11.93

S. Wagner, A. Schütz, J. Rademann, “Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic“ Bioorg. Med. Chem. 2015, 23, 2839-2847. doi: 10.1016/j.bmc.2015.03.074.

S. Grosskopf, C. Eckert, C. Arkona, S. Radetzki, K. Böhm, U. Heinemann, G. Wolber, J.-P. von Kries, W. Birchmeier, J. Rademann, „Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in-vitro and in-vivo”, ChemMedChem 2015, 10, 815-826. doi: 10.1002/cmdc.201500015.

E. Burda, J. Rademann “Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates“ Nature Comm. 2014, 5, 5170,doi:10.1038/ncomms6170.

A. Chakrabarti, J. J. Witsenburg, M. D. Sinzinger, M. Richter, R. Wallbrecher, J. C. Cluitmans, W. P.R. Verdurmen, S. Tanis, M. J. W. Adjobo-Hermans, J. Rademann, R. Brock, „Multivalent presentation of the cell-penetrating peptide nona-arginine on a linear scaffold strongly increases its membrane-perturbing capacity“ Biochem. Biophys. Ac. Biomembranes 2014, doi: 10.1016/j.bbamem.2014.08.001.

K. Holland-Nell, M. I. Fernández-Bachiller, Ahsanullah, J. Rademann, “Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3” Org. Lett. 2014, 16, 4428-4431, doi:10.1021/ol501910x.

A. El-Dahshan, S. I. Al-Gharabli, S. Radetzki, P. Kumar, T. H. Al-Tel, J. Rademann, “Divergent synthesis of sphingosine derivatives on solid phase provides ceramides with enhanced biological activity”, Biorg. Med. Chem. 2014, 22, 5506-5512, doi: 10.1016/j.bmc.2014.07.024.

J. Preidl, V.S. Gnanaprassam, M. Lisurek, J. Saupe, R. Horstkorte, J. Rademann "Fluorescent Mimetics of CMP-Neu5Ac are Highly Potent and Cell-Permeable Polarization Probes of Eukaryotic and Bacterial Sialyltransferases and Inhibit Cellular Sialylation", Angew. Chem. Int. Ed. 2014, 53, 5700-5705; Angew. Chem. 2014, 126, 5808-5813, doi: 10.1002/ange.201400394.

G. Schäfer, J. Milic, A. El-Dahshan, F. Götz, K. Zühlke, C. Schillinger, A. Kreuchwig, J. M. Elkins, K. R. A. Azeez, A. Oder, M. C. Moutty, N. Masada, M. Beerbaum, B. Schlegel, S. Niquet, P. Schmieder, G. Krause, J. P. v. Kries, D. M. F. Cooper, S. Knapp, J. Rademann, W. Rosenthal, E. Klussmann “Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP–PKA Interactions” Angew. Chem. 2013, 125, 12409-12413; Angew. Chem. Int. Ed. 2013, 52, 12187-12191, doi: 10.1002/ange.201304686.

K. Koschek, M. Dathe, J. Rademann, “Effects of Charge and Charge Distribution on the Cellular Uptake of Multivalent Arginine-Containing Peptide-Polymer Conjugates “, ChemBioChem 2013, 14, 1982-1990, doi: 10.1002/cbic.201300365.

C. Arkona, J. Rademann, “Propargyl Amides as Irreversible Inhibitors of Cysteine Proteases -- A Lesson on the Biological Reactivity of Alkynes”, Angew. Chem. 2013, 125, 8368-8370; Angew. Chem. Int. Ed. 2013, 52, 8210-8212, doi: 10.1002/anie.201303544.

M. I. Fernández-Bachiller, M. Lisurek, A. Horatscheck, J. Rademann, “Alzheimer´s disease: Identification and development of BACE-1 binding fragments and inhibitors by Dynamic Ligation Screening (DLS)”, ChemMedChem 2013, 8, 1041-1056, doi: 10.1002/cmdc.201300078.

K. Holland-Nell, J. Rademann, „Peptidyl-vinylketones as a novel class of inhibitors of the cysteine protease caspase-3“, Peptides 2012, Proc. of the 32nd European Peptide Symposium, Athens 2013, 614-615.

V. Martos, J. Rademann, “Formylglycine-peptides for the identification of novel pTyr mimetics through a fragment based dynamic ligation screening (DLS) approach”, J. Pept. Science 2012,18, S72.

J. Rademann, S. Wagner, A. Horatscheck, “Fragment-Based, Photoactive Phosphotyrosine Peptide Mimetics”, J. Pept. Science 2012, 18, S35.

B. Sina Meyer, J. Rademann, “Extra- and Intracellular Imaging of Human Matrix Metalloprotease 11 (hMMP-11) with a Cell-penetrating FRET Substrate”, J. Biol. Chem. 2012, 287, 37857-37867, doi: 10.1074/jbc.M112.371500.

A. Basters, L. Ketscher, E. Deuerling, C. Arkona, J. Rademann, K.-P. Knobeloch, G. Fritz, “High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system”, BMC Biotech. 2012, 12, 56-64, doi:10.1186/1472-6750-12-56.

R. Raz, J. Rademann, “Fmoc-Based Synthesis of Peptide Thioacids for Azide Ligations via 2-Cyanoethyl Thioesters”, Org. Lett. 2012, 14,5038–5041, doi: 10.1021/ol302247h.

A. Horatscheck, S. Wagner, J. Ortwein, M. Lisurek, B. G. Kim, S. Beligny, A. Schütz, J. Rademann, ”Benzoylphosphonate-based photoactive phosphopeptide mimetics for functional modulation of protein tyrosine phosphatases and highly specific covalent labeling of SH2-domains“, Angew. Chem. 2012, 124, 9577-9583; Angew. Chem. Int. Ed. 2012, 51, 9441-9447. (VIP-Paper), doi: 10.1002/anie.201201475.

M. I. Fernández-Bachiller, C. Pérez, L. Monjas, J. Rademann, M. I. Rodríguez-Franco, “New Tacrine – 4-Oxo-4H-Chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer´s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties”, J. Med. Chem. 2012, 55, 1303-1317, doi: 10.1021/jm201460y.

Ahsanullah, S. I. Al-Gharabli, J. Rademann „Soluble peptidyl-phosphoranes for metal-free, stereoselective ligations in organic and aqueous solution”, Org. Lett, 2012, 14, 14-17, doi:10.1021/ol202627h.

M. Richter, A. Chakrabarti, I. R. Ruttekolk, B. Wiesner, M. Beyermann, R. Brock, J. Rademann, “Multivalent Design of Apoptosis-Inducing Bid-BH3 Peptide-Oligosaccharides Boosts the Intracellular Activity at Identical Overall Peptide Concentrations”, Chem. Eur. J. 2012, 18, 16708-16715, doi: 10.1002/chem.201202276.

G. Schäfer, G. Krause, W. Rosenthal, J. Milic, J. Rademann, C. Schillinger, E. Klussmann, “Substituted Terpyridines”, EPA 11168008, 2011, owned by MDC/ FMP Berlin.

U. Kornak, S. Weinert, S. Jabs, C. Supanchart, M. Schweizer, N. Gimber, M. Richter, J. Rademann, T. Stauber, T.J. Jentsch, “Intermediate osteopetrosis upon loss of H+−driven lysosomal CL-accumulation” Bone 2011, 48, S. 136, doi.org/10.1016/j.bone.2011.03.280.

M. F. Schmidt, M. Groves, J. Rademann, “Dynamic Substrate Enhancement for the Identification of Specific, Second-Site-Binding Fragments Targeting a Set of Protein Tyrosine Phosphatases”, ChemBioChem 2011, 12, 2640-2646, doi: 10.1002/cbic.201100414.

L. Zhu, S. George, M. F. Schmidt, S. I. Al-Gharabli, J. Rademann, R. Hilgenfeld, „Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease“, Antiviral Res. 2011, 92,204-212, doi: 10.1016/j.antiviral.2011.08.001.

R. Raz, J. Rademann, “Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert-butyl thiol linker”, Org. Lett. 2011, 13, 1606-1609, doi:10.1021/ol302247h.

I. R. Ruttekolk, A. Chakrabarti,M. Richter, W. P. R. Verdurmen,F. Duchardt, H. Glauner,J. Rademann, R. Brock, „Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications”, Mol. Pharmacol. 2011, 79, 692-700, doi: 10.1124/mol.110.068296.

G. Stübs, V. Fingerle, U. Zähringer, R. R. Schumann, J. Rademann, N. W. J. Schröder, „Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato”, FEMS Immunol. Med. Microbiol. 2011, 63, 140-143, doi: org/10.1111/j.1574-695X.2011.00827. 

J. Saupe, Y. Roske, N. Kamdem, C. Schillinger, S. Radetzky, A. Diehl, H. Oschkinat, G. Krause, U. Heinemann, J. Rademann, „Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders”, ChemMedChem 2011, 6, 1411-1422, doi: 10.1002/cmdc.201100094.

A. El-Dahshan, S. Nazir, Ahsanullah, F. Ansari, J. Rademann, “Peptide-heterocycle chimera: new classes of more drug-like peptidomimetics by ligations of peptide bis-electrophiles with various bis-nucleophiles”, Eur. J. Org. Chem. 2011,730-739, doi: 10.1002/ejoc.201001206.

J. Rademann, Ahsanullah „Biocompatible Triazole Ligations via 1,3-Dipolar Cycloadditions of Peptidyl Phosphoranes and Azido Peptides” in: Tales of Peptides Copenhagen 2010, Proceedings of the 31st European Peptide Symposium, Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors), European Peptide Society, 2010, pp 30-31.

J. Rademann, S. Grosskopf, W. Birchmeier, C. Eckert, „Novel protein tyrosine phosphatase inhibitors“, EPA 10012781.

V. Fetz, S. K. Knauer, J. P. von Kries, J. Rademann, R. H. Stauber, “Targeting signal transduction cascades in disease by novel small molecule nucleo-cytoplasmic transport inhibitors”, Oncology 2010, 33, 153-153.

T. U. Mayer, J. Rademann, “Chemische Biologie – Wie kleine Moleküle große Herausforderungen meistern”, Biospektrum 2010, 589-591.

S. Weinert, S. Jabs, C. Supanchart, M. Schweizer, N. Gimber, M. Richter, J. Rademann, T. Stauber, U. Kornak, T. J. Jentsch, Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl- Accumulation, Science 2010, 328, 1401-1403.

G. Stübs, B. Rupp, R. R. Schumann, N. W. J. Schröder, J. Rademann, “Chemoenzymatic synthesis of a glycolipid antigen library and elucidation of the immunoreactive epitope for construction of a vaccine against Lyme Disease”, Chem. Eur. J. 2010, 16,3536-3544, doi: 10.1002/chem.200902205.

Ahsanullah, J. Rademann, “Cyclative cleavage of azido-peptidyl-phosphoranesdelivers locked cis-triazolyl-cyclopeptides as privileged protein binders”, Angew. Chem. 2010, 122, 5506-5510; Angew. Chem. Int. Ed. 2010, 49, 5378-5382, doi: 10.1002/anie.200904980.

A. El-Dahshan, Ahsanullah, J. Rademann, “Access to peptidylketones and –diketones via C-alkylations and C-acylations of polymer-supported phosphorus ylides followed by hydrolytic or oxidative cleavage”, Biopolymers-Peptide Science 2010, 94,220-228; doi: 10.1002/bip.21378.

A. Schreiber, S. Rolle, L. Peripelittchenko, J. Rademann, W. Schneider, F. C. Luft, R. Kettritz, „Phosphoinositol-3-kinase γ plays a fundamental role in antineutrophil cytoplasmic autoantibody (ANCA)-induced necrotizing crescentic glomerulonephritis”, Kidney Int. 2010, 77, 118–128, doi: 10.1038/ki.2009.420.

M. Lisurek, B. Rupp, J. Wichard, M. Neuenschwander, J. P. v. Kries, R. Frank, J. Rademann, R. Kühne „Design of chemical libraries with potentially bioactive compounds applying a Maximum Common Substructure (MCS) concept“, Mol. Divers. 2010, 14, 401-408, doi: 10.1007/s11030-009-9187.

M. Grättinger, P. Gribbon, J. Lenz, R. Frank, J. P. von Kries, R. Kühne, J. Rademann, „Advancing academic drug discovery“, Screening 2009, 10, 17-19.

M. Schmidt, J. Rademann, “Dynamic, template-assisted strategies in fragment-based drug discovery”, Trends in Biotechnol. 2009, 27, 512-521, doi: 10.1016/j.tibtech.2009.06.001.

M. Schmidt, A. El-Dahshan, S. Keller, J. Rademann, “Selective identification of cooperatively binding fragments in a high-throughput assay enables development of a picomolar caspase-3 inhibitor”, Angew. Chem. 2009, 121, 6464-6467; Angew. Chem. Int. Ed. 2009, 48,6346-6349, doi: 10.1002/anie.200901647.

Ahsanullah, P. Schmieder, R. Kühne, J. Rademann, “Metal-free, regioselective triazole ligations deliver locked cis-peptide mimetics”, Angew. Chem. 2009, 121, 5143-5147; Angew. Chem. Int. Ed. 2009, 48,5042-5045, doi: 10.1002/anie.200806390.

I. R. Ruttekolk, F. Duchardt, R. Fischer, K.-H. Wiesmüller, J. Rademann, R. Brock, “HPMA as a scaffold for the modular assembly of functional peptide polymers by native chemical ligation”, Bioconj. Chem. 2008, 19, 2081-2087, doi: 10.1124/mol.110.068296.

K. Hellmuth, S. Grosskopf, C. T. Lum, M. Würtele, N. Röder, J. P. von Kries, M. Rosario, J. Rademann, W. Birchmeier, “Specific Inhibitors of the Protein Tyrosine Phosphatase Shp2 Identified by High-throughput Docking”, Proc. Nat. Acad. Sci. USA 2008, 105, 7275-7280, doi: 10.1073/pnas.0710468105.

J. Rademann, "Combinatorial Chemistry – Concepts and Methods for Tasks of Molecular Optimization" in: Encyclopedic Reference of Molecular Pharmacology, S. Offermanns, W. Rosenthal (Eds.), 257-261, Springer, Heidelberg, 2008.

J. Rademann „Dynamic Ligation of Peptide Electrophiles for the Identification of Protein-Binding Fragments and Development of Protein Ligands” in: Peptides 2008, Proceedings of the 30st European Peptide Symposium, Hilkka Lankinen et al. Ed., European Peptide Society, 2010, pp 8-9.

V. Uryga-Polowy, D. Kosslick, C. Freund, J. Rademann, “Resin-bound aminofluorescein for C-terminal labeling of peptides: high affinity polarization probes binding to polyproline-specific GYF domains”, ChemBioChem 2008, 9,2452-2462, doi: 10.1002/cbic.200800329..

S. Beligny, J. Rademann “Oxidizing and reducing agents”, in: The power of functional resins in organic synthesis, J. Tulla-Puche and F. Albericio (eds.), Wiley-VCH, Weinheim, 2008,pp 83-99, doi: 10.1002/9783527626175.ch4.

M. Schmidt, A. Isidro-Llobet, A. El-Dahshan, M. Lisurek, J. Tan, R. Hilgenfeld, J. Rademann “Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by Dynamic Ligation Screening”, Angew. Chem. 2008, 120, 3319-3323;Angew. Chem. Int. Ed. 2008, 47,3275-3278, doi: 10.1002/anie.200704594.

J. Rademann, M. Schmidt: “Inhibitors of Caspase-3 identified in a dynamic ligation screen”, EP 08002534.9, 08075539.0, 2008.

 J. Rademann, M. Schmidt: „Ligandenoptimierung durch Dynamische Ligation“. EP 07076024.4 (2007).

L. M. Podust, J. P. von Kries, A. Nasser Eddine, Y. Kim, L. V. Yermalitskaya, R. Kuehne, H. Ouellet, T. Warrier, M. Alteköster, J.-S. Lee, J. Rademann, H. Oschkinat, S. H. E. Kaufmann, M. R. Waterman, “Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography”, Antimicr. Agents Chemother. 2007, 51, 3915-3923, doi: 10.1128/AAC.00311-07 .

A. El-Dahshan, S. Weik, J. Rademann „C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids” Org. Lett. 2007, 9, 949-952. doi:10.1021/ol062754+

W. Rosenthal, E. Klußmann, F. Christian, J. Rademann, S. Meyer: „Niedermolekulare Substanzen zur Hemmung der Interaktion zwischen Protein Kinase A und Protein Kinase A-Ankerprotein“ WO/2006/12254, PCT/DE2006/000897 (2006).

J. Howe, J. Bauer, J. Andrä, A. B. Schromm, M. Ernst, M. Rössle, U. Zähringer, J. Rademann, K. Brandenburg „Biophysical characterization of synthetic rhamnolipids” FEBS Journal 2006, 273, 5101-5112. doi/10.1111/j.1742-4658.2006.05507l

J. Bauer, K. Brandenburg, U. Zähringer, J. Rademann „Chemical synthesis of a glycolipid library by a solid phase strategy allows to elucidate the structural specificity of immune stimulation by rhamnolipids” Chem. Eur. J. 2006, 12, 7116-7124.doi: 10.1002/chem.200600482

S. I. Al-Gharabli, S. T. Ali Shah, S. Weik, M. Schmidt, J. R.Mesters, D. Kuhn, G. Klebe, R. Hilgenfeld, J. RademannAn efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors” ChemBioChem 2006, 7, 1048-1055. doi: 10.1002/cbic.200500533

J. Andrä, J. Rademann, J. Howe, M. H. J. Koch, H. Heine, U. Zähringer, K. Brandenburg “Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii – immune cell stimulation and biophysical characterization” Biol. Chem. 2006, 387, 301-310.

S. Weik, T. Luksch, A. Evers, J. Böttcher, A. Hasilik, H.-G. Löffler, G. Klebe, J. Rademann „The potential of P1 site alterations in peptidomimetic protease inhibitors as suggested by virtual screening and explored by the use of CC-coupling linker reagents” ChemMedChem 2006, 1,445-457.

A. El-Dahshan, J. Rademann: “C-Acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids”, In: K. Rolka, P. Rekowski, J. Silberring (eds.), Peptides 2006, Proceedings of the 29th European Peptide Symposium, Kenes Int., 2007, pp. 730-31

K. Hellmuth, W. Birchmeier, S. Grosskopf, J. Rademann: “Shp-2 inhibitors, pharmaceutical compositions comprising them and their use for treating phosphatase-mediated diseases” EP1885717, 2005

S. T. Ali Shah, P. Merkel, H. Ragge, M. Duszenko, J. Rademann, W. Voelter: “Stereospecific synthesis of chiral 2,3-dihydro-1,4-benzodithiine and methyl-2,3-dihydro-1,4-benzodithiine derivatives and their toxic effects on trypanosoma bruceiChemBioChem 2005, 6, 1438-1441.

J. Rademann, S. Weik et al. “1,2-Diamines for the treatment of Alzheimer´s disease” Patentanmeldung EP 04012182.4 der Böhringer Ingelheim International GmbH am 22.05.2004.

M. Manger, M. Scheck, H. Prinz, J.-P. von Kries, T. Langer, K. Saxena, H. Schwalbe, A. Fürstner, J. Rademann, H. Waldmann “Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase A (MptpA) Inhibitors Based on Natural Product Inspired and Fragment Based Approaches“ ChemBioChem 2005, 6, 1749-1753.

H.-J. Egelhaaf, J. Rademann „Understanding supported reactions in spherical compartments: A general algorithm to model and determine rate constants, diffusion coefficients and spatial product distributions” J. Comb. Chem. 2005, 7, 929-941.

J. Bauer, J. Rademann „Hydrophobically assisted switching phase synthesis: The flexible combination of solid-phase and solution-phase reactions employed for oligosaccharide preparation” J. Am. Chem. Soc. 2005, 127, 7296-7297.

G. Sorg, B. Thern, O. Mader, J. Rademann, G. Jung „Progress in the preparation of peptide aldehydes via polymer supported IBX oxidation and scavenging by threonyl resin” J. Pept. Science 2005, 11, 142-152.

M. Barth, R. Fischer, R. Brock, J. Rademann “Reversible cross-linking of hyperbranched polymers: A strategy for the combinatorial decoration of multivalent scaffolds” Angew. Chem. 2005, 117, 1584-1588; Angew. Chem. Int. Ed. 2005, 44, 1560-1563.

A. El-Dahshan, S. Weik, J. Rademann: “Versatile phosphoranes as linker reagents: access to various isostere structures for protease inhibition via smooth C-C-couplings on polymer support”, In: M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (eds.), Peptides 2004, Proceedings of the 28th European Peptide Symposium, Kenes Int., 2005, pp. 623-24.

S. Weik, T. Luksch, J. Böttcher, G. Klebe, J. Rademann „P1-site diversity in peptide isostere libraries via smooth CC-coupling on linker reagents”, In: M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (eds.), Peptides 2004, Proceedings of the 28th European Peptide Symposium, Kenes Int., 2005, pp. 289-90.

M. Barth, R. Fischer, R. Brock, J. Rademann “Reversible cross-linking of hyperbranched polymers: A strategy for the combinatorial decoration of multivalent scaffolds”, In: M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (eds.), Peptides 2004, Proceedings of the 28th European Peptide Symposium, Kenes Int., 2005, pp. 188-89.

S. I. A. Al-Gharabli, M. Khanfar, J. Rademann “Microwave-assisted catch and release syntheses of a peptide isostere via amino acyl ketenes”, In: M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (eds.), Peptides 2004, Proceedings of the 28th European Peptide Symposium, Kenes Int., 2005, pp. 184-185.

J. Smerdka, J. Rademann, G. Jung „Polymer-bound alkyltriazenes for mild racemization-free esterification of amino acid and peptide derivatives” J. Pept. Science 2004, 10, 603-611.

J. Rademann “Organic protein chemistry: drug discovery through the chemical modification of proteins” Angew. Chem. 2004, 116, 4654-4656; Angew. Chem. Int. Ed. 2004, 43, 4554-4556.

M. Barth, T. Ali Shah, J. Rademann, “High Loading Polymer Reagents based on Polycationic Ultragels. Polymer-Supported Reductions and Oxidations with Increased Efficiency” Tetrahedron – Combinatorial Chemistry Symposium in Print 2004, 60, 8703-8709.

M. Barth, J. Rademann, “Tailoring Ultraresins based on the cross-linking of polyethylene imines. Comparative investigation of the chemical composition, the swelling, the mobility, the chemical accessibility, and the performance in solid phase synthesis of very high-loaded resins”, J. Comb. Chem. 2004, 6, 340-349.

S. Weik, J. Rademann, "A Phosphorane as Supported Acylanion Equivalent. Linker Reagents for Smooth and Versatile C-C-Coupling Reactions", Angew. Chem. 2003, 115, 2595-2598; Angew. Chem. Int. Ed. 2003, 42, 2491-2494.

J. Bauer, J. Rademann, "Trimellitic anhydride linker (TAL) – highly orthogonal conversions of primary amines employed in the parallel synthesis of labeled carbohydrate derivatives" Tetrahedron Lett. 2003, 44, 5019 - 5023.

J. Rademann, “Inhibition of Proteases” in: Bioorganic Chemistry, H. Wennemers, C. Schmuck (Eds.), Wiley-VCH, Weinheim, 2004, 293-295.

J. Rademann, "Solid phase synthesis (SPS) and polymer-assisted solution phase (PASP) synthesis" in: Bioorganic Chemistry, H. Wennemers, C. Schmuck (Eds.), Wiley-VCH, Weinheim, 2004, 290-293.

J. Rademann, "Novel polymer- and linker reagents employed for the preparation of protease inhibitor libraries" in: Bioorganic Chemistry, H. Wennemers, C. Schmuck (Eds.), Wiley-VCH, Weinheim, 2004, 277-290.

J. Rademann, "Novel matrix-supported reaction systems for applications in synthesis and biochemistry", Habilitationsschrift, University of Tübingen, 2002.

J. Rademann, "Advanced polymer reagents based on activated reactants and reactive intermediates: Powerful novel tools in diversity-oriented synthesis" in: Methods in Enzymology, vol. 369, B. A. Bunin, G. Morales (Eds.), pp 366-390, Academic Press, San Diego, 2003.

J. Rademann, "Combinatorial Chemistry – Concepts and Methods for Tasks of Molecular Optimization" in: Encyclopedic Reference of Molecular Pharmacology, S. Offermanns, W. Rosenthal (Eds.), 257-261, Springer, Heidelberg, 2003.

L. Miranda, W. Lubbell, K. Halkes, T. Groth, M. Grötli, J. Rademann, C. Gotfredsen, M. Meldal, "SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis", J. Comb. Chem. 2002, 4, 523-539.

J. Rademann, "Polymerverbindung aufgebaut aus linearen Polymerketten", Deutsche Patentanmeldung 102 16 513.0 vom 10.04.2002.

M. Meldal, P. M. St. Hilaire, M. Willert, J. Rademann, M. Grötli, J. Buchardt, C. H. Gotfredsen, M. A. Juliano, L. Juliano, Klaus Bock, “Investigation of enzyme activity and inhibition in the interior of novel solid supports” Peptides Biology and Chemistry, Chinese Peptide Symposia 2002, pp 14-20.

J. Rademann,* M. Barth, "ULTRA-loaded resins based on the crosslinking of linear polyethylene imine. Improving the atom economy of polymer-supported chemistry", Angew. Chem. 2002, 114, 3087-3090; Angew. Chem. Int. Ed. 2002, 41, 2975-2978.

J. Rademann, G. Sorg, A. Giannis, M. Mülbauer, "Iod(V)-Verbindungen", Patentanmeldung 101 58 002.9 vom 22.11.2001.

J. Rademann, "Kombinatorische Verfahren in der medizinischen Chemie", Pharmazeutische Zeitung – Prisma 2002, 9,90-98.

K. Kröger, J. Bauer, B. Fleckenstein, J. Rademann, G. Jung, G. Gauglitz, "Epitope-mapping of transglutaminase with parallel label-free optical detection", Biosens. Bioelectron. 2002, 7, 937-944.

P. Grosche, J. Rademann, G. Jung, "Addition to Carbon-Hetero Multiple Bonds" In: Handbook of Combinatorial Chemistry, Ed. K. C. Nicolaou, Wiley-VCH, Weinheim, 2002, Vol. 1, 322-345.

G. Sorg, A. Mengel, G. Jung, J. Rademann*, "Oxidizing Polymers: A Polymer-Supported, Recyclable Hypervalent Iodine(V) Reagent for the Efficient Conversion of Alcohols, Carbonyl Compounds, and Unsaturated Carbamates in Solution", Angew. Chem. 2001, 113, 4532-4535; Angew. Chem. Int. Ed. 2001, 40, 4395-4397.

J. Rademann, S. Weik, "Oxoammonium salts and their application", Patentanmeldung beim Deutschen Patentamt, 16.03.2001, 101 13 710.9.

J. Rademann „Combinatorial Chemistry in the Commercial Jungle (Web Review)”, Angew. Chem. Int. Ed. 2001, 40, 2721.

J. Rademann „High-Throughput Synthesis. Principles and Practice. Edited by Irving Sucholeiki (Book Review)”, Angew. Chem. Int. Ed. 2001, 40, 4298.

A. Papanikos, J. Rademann, and M. Meldal, "α-Ketocarbonyl Peptides: A General Approach to Reactive Intermediates in the Synthesis of Peptide Isosteres for Protease Inhibitor Screening on Solid Support", J. Am. Chem. Soc. 2001, 123, 2176-2181.

J. Rademann, J. Smerdka, "Alkylations with triazenes", Patentanmeldung beim Deutschen Patentamt, 14.01.2001, 101 02 404.5.

J. Rademann,* M. Barth, R. Brock, H.-J. Egelhaaf, G. Jung, "Spatially and Temporally Resolved Single Bead Analysis. Homogeneity, Diffusion, and Adsorption in Cross-Linked Polystyrene", Chem. Eur. J., 2001, 7, 3884-3889.

S. Weik, G. Nicholson, G. Jung, and J. Rademann, "Oxoammonium-resins as metal-free, highly reactive, versatile polymeric oxidation reagents", Angew. Chem. 2001, 113, 1489-1492; Angew. Chem. Int. Ed. 2001, 40, 1436-1439.

J. Rademann,* J. Smerdka, G. Jung, P. Grosche, and D. Schmid, "Alkylating polymers: Resin-Released Carbenium Ions as Versatile Reactive Intermediates in Polymer-Assisted Solution Phase Synthesis", Angew. Chem. 2001, 113, 390-393; Angew. Chem. Int. Ed. 2001, 40, 381-385.

J. Rademann,* G. Jung, "Combinatorial bioassays", Transkript 2000, 6,36-38.

J. Rademann, G. Jung, "Integrating combinatorial synthesis and bioassays", Science 2000, 287, 1947-1948.

J. Rademann, B. Dörner, W. Kraas, "Polymer-assisted solution phase synthesis (PASP), Current methods in polymer-supported solution phase synthesis of compound libraries (trend report combinatorial chemistry)", Nachrichten Chem. 2000, 48, 280-283.

M. Groetli, J. Rademann, T. Groth, W. Lubell, L. Miranda and M. Meldal, "Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-based Resins in Silicon Oil; Beaded SPOCC 1500 and POEPOP 1500", J. Comb. Chem. 2001, 3, 28-33.

M. Groetli, C. Gotfredsen, J. Rademann, A. J. Clark, J. O. Duus, M. Meldal, "Physical Properties of Polyethylene Glycol (PEG)-based Resins for Combinatorial Solid Phase Organic Chemistry, A Comparison of PEG Cross-Linked and PEG Grafted Resins" J. Comb. Chem. 2000, 3, 108-119.

M. Meldal, J. Rademann, M. Groetli, K. Bock, "Identification of protease inhibitors using biocompatible resins and library synthesis" In, Current Trends in Organic Chemistry, Scolastico and Nicotra, Ed., Kluwer Academic/ Plenum, Dordrecht,1999.

J. Rademann, M. Groetli, M. Meldal, K. Bock, "SPOCC- a resin for solid phase organic chemistry and enzymatic reactions on solid phase" J. Am. Chem. Soc. 1999, 121, 5459-5465.

J. Rademann, M. Meldal, K. Bock, "Solid Phase synthesis of peptide isosters via nucleophilic reactions with N-terminal peptide aldehydes on a polar support tailored for solid phase organic chemistry" Chem. Eur. J. 1999, 5, 1218-1225.

 M. Meldal, J. Rademann, J. Buchardt, "PEG-based macromonomers, Chemically inert polymers prepared therefrom and the use of these polymers for organic synthesis and enzyme reactions" patent PCT/DK99/00508, filed 29.9.1998.

A. Heckel, E. Mross, J. Rademann, R. R. Schmidt, "Oligosaccharide synthesis on controlled-pore glass as solid phase material" Synlett 1998, 171-173.

J. Rademann, A. Geyer, R. R. Schmidt, "Solid-Phase Supported Synthesis of the Branched Pentasaccharide Moiety That Occurs in Most Complex Type N-Glycan Chains" Angew. Chem. 1998, 110, 1309-1313;Angew. Chem. Int. Ed. Engl. 1998, 37, 1241-1245.

J. Rademann, "Solid phase syntheses with carbohydrates – Synthesis of oligosaccharides, O-linked and C-linked glycopeptides", Dissertation, University of Constance 1997.

U. K. Saha, L. S. Griffith, J. Rademann, A. Geyer, R. R. Schmidt, "An N-Acetylglucosamine-containing Glycopeptide - Synthesis and Structure Assignment" Carbohydr. Res. 1997, 304, 21-28.

J. Rademann, R. R. Schmidt, "Repetitive Solid Phase Glycosylation on an Alkyl-thiol Polymer Leading to Sugar Oligomers Containing 1,2-trans- and 1,2-cis-Glycosidic Linkages" J. Org. Chem. 1997, 62, 3650-3653.

R. R. Schmidt, J. Rademann, "Carbohydrate derivatives and their synthesis on solid support", patent DE 0050/46931, filed 24.05.1996

J. Rademann, R. R. Schmidt, "A new method for the Solid phase synthesis of oligosaccharides", Tetrahedron Lett. 1996, 37, 2718-2719.

 J. Rademann, R. R. Schmidt, "Solid-phase synthesis of a glycosylated hexapeptide of human sialophorin, using the trichloroacetimidate method", Carbohydrate Res. 1995,269, 217-225.