Prof. Dr. Sarah Hedtrich (née Küchler)

Kuechler 2

Institut für Pharmazie



Pharmakologie und Toxikologie

Adresse Freie Universität Berlin
Institut für Pharmazie
Königin-Luise-Str. 2+4
Raum VH 122
14195 Berlin
Telefon (030) 838-55065
Fax (030) 838-54399
Homepage Arbeitgruppe Hedtrich

Professional Experience

since 04/2015

Professor of Pharmacology (W1)

03/2013 - 04/2015

Junior Research Group Leader, Freie Universität Berlin, Institute for Pharmaceutical Sciences, Pharmacology & Toxicology

11/2012 – 03/2013

Visiting Scientist, Tufts University Boston, Biomedical Engineering, Prof. Dr. David Kaplan

02/2011 - 02/2013

Postdoctoral Associate, Department for Pharmaceutical Sciences, LMU München


Visiting Scientist, Wyss Institute, Harvard University

05/2009 – 01/2011

Postdoctoral Associate, Freie Universität Berlin, Institute for Pharmaceutical Sciences, Pharmacology & Toxicology


02/2007 - 04/2009          

PhD Thesis, Institute for Pharmaceutical Sciences, Pharmacology & Toxicology Freie Universität Berlin
Supervisor: Prof. Dr. Monika Schäfer-Korting
Topic: Nanoparticulate Carrier Systems for Topical Drug Delivery


Licensed Pharmacist for Germany


German Diploma

10/2005 – 04/2006         

Diploma Thesis in collaboration with the university hospital Carl-Gustav-Carus in Dresden: „Development of a guideline for the treatment of CNS-mycoses for a hospital of maximum medical care“


Studies of Pharmacy, University of Leipzig

Honors and Awards


Preis für gute Lehre, Fachbereich BCP


Galenus Support


Galenus Support

11/2012 – 03/2013

DAAD Research Grant


Galenus Support


Poster Award “9th International Conference and Workshop on Biological Barriers”, Saarbrücken


Travel Grant, Dr. August and Dr. Anni Lesmüller Foundation


DAAD Travel and Lecturer Grant, Makassar, Indonesia


Travel Grant ‚Center for International Cooperation‘, FU Berlin, for Wyss Institute, Harvard University


Heinz Maurer-Award for Fundamental - Dermatological Research


Poster Award “European Workshop on Particulate”, Berlin


Elsa-Neumann-PhD Grant

Further Activities

  • Member Editorial Board European Journal of Pharmaceutics and Biopharmaceutics

Scientific Reviewer for

  • European Journal of Pharmaceutics and Biopharmaceutics
  • Skin Pharmacology and Physiology
  • Phytotherapy Research
  • Advanced Drug Delivery Reviews
  • Journal of Pharmacology and Experimental Therapeutics
  • Tissue Engineering
  • Journal of Controlled Release
  • Journal of Biomedical Optics

Member of the European Epidermal Barrier Research Network (E2BRN)

Member of the ‘German Pharmaceutical Society’ (DPhG)


  • Dermal Drug Delivery (Nanoparticulate Carrier Systems, Smart Drug Delivery…)

  • Development and Characterization of In Vitro Skin (Disease) Models

  • Impact of Filaggrin Mutations on Skin Barrier Formation and Function

  • New Approaches for the Improvement of Wound Healing, Development of In Vitro Wound Healing Models



  •  Witting, M., Molina, M.A., Obst, K., Hennies, H.C., Calderón, M., Friess, W.,*Hedtrich, S.:Thermosensitive Dendritic Polyglycerol-Based Nanogels for Cutaneous Delivery of Biomacromolecules. Accepted, Nanomedicine: Nanotechnology, Biology, and Medicine
  • Witting, M., Obst, K., Friess, W.,*Hedtrich, S.:Recent Advances in Topical Delivery of Proteins and Peptides Mediated by Soft Matter Nanocarriers. Biotechnology Advances, doi: 10.1016/j.biotechadv.2015.01.010
  • Adeli, M., Namazi, H., Du, F., Hönzke, S., Hedtrich, S., Keilitz, J., Haag, R.:Synthesis of multiarm star copolymers based on polyglycerol cores with polylactide arms and their application as nanocarriers. RSC Advances, 5: 14958 – 14966



  •  Kumar, S., Alnasif, N., Fleige, E., Kurniasih, I., Kral, V., Haase, A., Luch, A.,Weindl, G., Haag R., Schäfer- Korting M., *Hedtrich, S.:Impact of Structural Differences in Hyperbranched Polyglycerol-Polyethylene Glycol Nanoparticles on Dermal Drug Delivery and iocompatibility. Eur J Pharm Biopharm, 88: 625-634
  • Schreml S, Meier RJ, Kirschbaum M, Kong SC, Gehmert S, Felthaus O, Küchler, S., Sharpe JR, Wöltje K, Weiß KT, Albert M, Seidl U, Schröder J, Morsczeck C, Prantl L, Duschl C, Pedersen SF, Gosau M, Berneburg M, Wolfbeis OS, Landthaler M, Babilas P.:Luminescent Dual Sensors Reveal Extracellular pH-Gradients and Hypoxia on Chronic Wounds That Disrupt Epidermal Repair. Theranostics, 4: 721-735,
  • Alnasif, N., Zoschke, C., Fleige, E., Brodwolf, R., Boreham, A., Rühl, E., Eckl, K.M., Merk, H.F., Hennies, H.C., Alexiev, U., Haag, R., Küchler, S., Schäfer-Korting, M.: Penetration of Normal, Damaged and Diseased Skin-An In Vitro Study on Dendritic Core-Multishell Nanotransporters. J Control Release, 185: 45-50
  • Ali-von Laue, C., Zoschke, C., Do, N., Lehnen, D., Küchler, S., Mehnert, W., Blaschke, T., Kramer, K.D., Plendl, J., Weindl, G., Korting, H.C., Hoeller Obrigkeit, D., Merk, H.F., Schäfer-Korting, M.:Improving Topical Non-Melanoma Skin Cancer Treatment: In vitro Efficacy of a Novel Guanosine-Analog Phosphonate. Skin Pharm Physiol, 27:173-180.
  • Eckl, K.M., Weindl, G., Ackermann, K., Küchler, S., Casper, R., Radowski, M.R., Haag, R., Hennies, H.C., Schäfer-Korting, M.:Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders. Exp Dermatol, 23: 286-288.
  • VávrováK, Henkes D, SochorováM, ŠkolováB, Strüver K, Witting M, Friess W, Schreml S, Meier R J, Schäfer-KortingM, Fluhr J W, Küchler S: Filggrin deficiency leads to impaired lipid profile and altered skin acidification pathways in a 3 D skin construct. JID; 134:746-53



  • Charbaji, N., Schäfer-Korting, M., Küchler, S.: Cytoprotective Effects of Opioids on Irradiated Oral Epithelial Cells. Wound Repair Regener; 21: 883-89.
  • Steinhilber, D., Witting, M., Zhang, X., Staegemann, M., Paulus, F., Friess, W., Küchler, S., Haag, R.: Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules. J Control Release, 169: 289-95.
  • Höger, K., Becherer, T., Qiang, W., Haag, R., Frieß, W., Küchler, S.: Polyglycerol Coatings of Glass Vials for Protein Resistance. Eur J Pharm Biopharm., 3:756-764
  • Kasper JC, Troiber C, Küchler S, Wagner E, Friess W.: Formulation development of lyophilized, long-term stable siRNA/oligoaminoamide polyplexes. Eur J Pharm Biopharm., 2: 294-305
  • Stein, C., Küchler, S.: Opioid modulation of peripheral inflammation and wound healing. Trends in Pharmacological Sciences, 34:303-12.
  • Küchler, S., Strüver, K., Friess, W.: Skin Models for Drug Absorption Studies. Accepted, Expert Opin Drug Metabol Toxicol, 9: 1255-63
  • Heilmann, S., Küchler, S., Wischke, C., Lendlein, A., Stein, C., Schäfer-Korting, M.: A thermosensitive morphine-containing hydrogel for the treatment of large-scale skin wounds. Int J Pharm, 444: 96-102.



  • Heilmann, S., Küchler, S., Schäfer-Korting, M.: Morphine Metabolism in Human Skin Microsomes. Skin Pharm Physiol, 25:319-22.
  • Troiber, C., Kasper, J. C., Milani, S., Scheible, M., Schaubhut, F., Martin, I., Küchler, S., Rädler, J., Simmel, F. C., Friess, W., Wagner, E.: Physico-Chemical Characterization of siRNA Polyplexes: Size and Stability. Eur J Pharm Biopharm, Epub doi: 10.1016/j.ejpb.2012.08.014.
  • Charbaji, N., Schäfer-Korting, M., Küchler, S.: Morphine Stimulates Cell Migration of Oral Epithelial Cells by Delta-Opioid Receptor Activation. PLoS One, doi: 10.1371/journal.pone.0042616.
  • Stein, C., Küchler, S.: Peripheral opioid effects on inflammation and wound healing. Curr Pharm Design, 18:6053-69.



  • Obermeier A, Küchler S, Matl FD, Pirzer T, Stemberger A, Mykhaylyk O, Friess W, Burgkart R: Magnetic drug targeting as new therapeutic option for the treatment of biomaterial infections. J Biomater Sci Polym Ed.;
  • Küchler S, Henkes D, Eckl KM, Ackermann K, Plendl J, Korting HC, Hennies HC, Schäfer-Korting M: Hallmarks of Atopic Skin In Vitro – Mimicked by the Means of a Skin Disease Model based on FLG Knock Down. ATLA, 39:471-80



  • Küchler S, Herrmann W, Panek-Minkin G, Blaschke T, Kramer KD, Bittl R, Schäfer-Korting M: SLN-induced Drug Delivery to the Skin - Characterization and Influences of Loading, Drug-Particle Interactions and the Composition of Skin Lipids as derived from Studies with Spin Probes. Int J Pharm, 390:225-33
  • Küchler S, Wolf NB, Heilmann S, Weindl G, Helfmann J, Yahya MM, Stein C, Schäfer-Korting M: 3D-Wound healing model: Influence of morphine and solid lipid nanoparticles. Journal of Biotechnology, 148:24-30



  • Küchler S, Wolf NB, Radowski MR, Blaschke T, Kramer KD, Weindl G, Kleuser B, Haag R, Schäfer-Korting M: Wound Healing – Influences of Opioids and Nanoparticles. Eur J Pharm Biopharm, 73:34-42
  • Küchler S, Adbel-Mottaleb M, Lamprecht A, Radowski MR, Haag R, Schäfer-Korting M: Enhanced Skin Delivery of Hydrophilic Agents by Nanoparticles – Influences of Carrier Type and Size. Int J Pharm, 377:169-72
  • Küchler S, Radowski MR, Blaschke T, Dathe M, Plendl J, Haag R, Schäfer-Korting M, Kramer KD: Nanoparticles for Skin Penetration Enhancement - A Comparison of a Dendritic Core-Multishell-Nanotransporter and Solid Lipid Nanoparticles. Eur J Pharm Biopharm, 71:243-50