Originalbeiträge

  • H. Edlund, C. Steenholdt, M.A. Ainsworth, E. Goebgen, J. Brynskov, O.Ø. Thomsen, W. Huisinga, C. Kloft.
    Magnitude of increased infliximab clearance imposed by anti-infliximab antibodies in Crohn’s disease is determined by their concentration.
    AAPS J. 19: 223-233 (2017).
    doi:10.1208/s12248-016-9989-8

  • J. Melin, S. Prothon, C. Kloft, A. Cleton, C. Johansson, C. Jorup, B. Olsson, U. Wählby Hamrén.
    Pharmacokinetics of the inhaled selective glucocorticoid receptor modulator AZD5423 following inhalation using different devices.
    AAPS J. 19: 865-874 (2017).
    doi:10.1208/s12248-016-0042-8

  • U. Neumann, D. Burau, S. Spielmann, M.J. Whitaker, R.J. Ross, C. Kloft, O. Blankenstein.
    Quality of compounded hydrocortisone capsules used in the treatment of children.
    Eur. J. Endocrinol. 177: 239-242 (2017).
    doi: 10.1530/EJE-17-0248

  • I.K. Minichmayr, A. Schaeftlein, J.L. Kuti, M. Zeitlinger, C. Kloft.
    Clinical determinants of target non-attainment of linezolid in plasma and interstitial space fluid: A pooled population pharmacokinetic analysis with focus on critically ill patients.
    Clin. Pharmacokinet. 56: 617-633 (2017).
    doi: 10.1007/s40262-016-0463-7

  • S.G. Wicha, W. Huisinga, C. Kloft.
    Translational pharmacometric evaluation of typical antibiotic broad-spectrum combination therapies against staphylococcus aureus exploiting in vitro information.
    CPT: Pharmacometrics Syst. Pharmacol.
    DOI: 10.1002/psp4.12197

  • J. Melin, Z.P Parra-Guillén, N. Hartung, W. Huisinga, R.J. Ross, M.J. Whitaker, C. Kloft.
    Predicting cortisol exposure from paediatric hydrocortisone formulation using a semi-mechanistic pharmacokinetic model established in healthy adults.
    Clin. Pharmacokinet.
    doi: 10.1007/s40262-017-0575-8

  • A. Henrich, M. Joerger, S. Kraff, U. Jaehde, W. Huisinga, C. Kloft, Z.P. Parra-Guillén.
    Semi-mechanistic bone marrow exhaustion pharmacokinetic/pharmacodynamic model for chemotherapy-induced cumulative neutropenia.
    J. Pharmacol. Exp. Ther.
    doi: 10.1124/jpet.117.240309

  • L. Klopp-Schulze, M. Joerger, S.G. Wicha, R. ter Heine, C. Csajka, Z.P. Parra-Guillen, C. Kloft.
    Exploiting pharmacokinetic models of tamoxifen and endoxifen to identify factors causing sub-therapeutic concentrations in breast cancer patients.
    Clin. Pharmacokinet.
    doi: 10.1007/s40262-017-0555-z

  • Z.P. Parra-Guillén, P.B. Berger, M. Haschke, M. Donzelli, D. Winogradova, B. Pfister, M. Früh, S. Gillessen, S. Krahenbühl, C. Kloft, M. Joerger.
    Role of cyctochrome P450 3A4 and 1A2 phenotyping in patients with advanced non-small-cell lung cancer receiving erlotinib treatment.
    Basic Clin. Pharmacol. Toxicol.
    doi: 10.1111/bcpt.12801

  • M.K. Smith, S.L. Moodie, R. Bizotti, E. Blaudez, E. Borella, L. Carrara, P. Chan,
    M. Chenel, E. Comets, R- Gieschke, K. Harling, L. Harnisch, N. Hartung, A.C. Hooker,
    M.O. Karlsson, R. Kaye, C. Kloft, N. Kokash, M. Lavielle, G. Lestini, P. Magni, A. Mari,
    F. Mentré, C. Muselle, R. Nordgren, N. H. Bjugard, Z. P. Parra-Guillen, L. Pasotti,
    N. Rode-Kristensen, M.L. Sardu, G. R. Smith, M. J. Swat, N. Terranova, G. Yngman,
    F. Yvon,N. Holford.
    Model description language (MDL): A standard for modeling and simulation.
    CPT: Pharmacometrics Syst. Pharmacol.
    doi:10.1002/psp4.12222

  • S. Fuhrman, C. Kloft, W. Huisinga.
    Impact of altered endogenous IgG on unspecific mAb cleareance.
    J. Pharmacokinet. Pharmacodyn.
    doi: 10.1007/s10928-017-9524-2

  • C. Kloft, M.N. Trame, C.A. Ritter.
    Systems pharmacology in drug development and therapeutic use - A forthcoming paradigm shift.
    Eur. J. Pharm. Sci. 94: 1-3 (2016).
    doi: 10.1016/j.ejps.2016.07.014

  • H. Saafan, S. Foerster, Z.P. Parra-Guillen, E. Hammer, M. Michaelis, J. Jr. Cinatl, U. Völker, H. Fröhlich, C. Kloft, C.A. Ritter.
    Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach.
    Eur. J. Pharmaceut. Sci. 94: 20-32 (2016).
    doi: 10.1016/j.ejps.2016.04.025

  • M. Joerger, J. von Pawel, S. Kraff, J.R. Fischer, W. Eberhardt, T.C. Gauler, L. Mueller, N. Reinmuth, M. Reck, M. Kimmich, F. Mayer, H.G. Kopp, D.M. Behringer, Y.D. Ko, R.A. Hilger, M. Roessler, C. Kloft, A. Henrich, B. Moritz, M.C. Miller, S.J. Salamone, U. Jaehde.
    Open-label, randomised study of individualized, pharmacokinetically (PK)-guided dosing of paclitaxel combined with carboplatin or cisplatin in patients with advanced non-small cell lung cancer (NSCLC).
    Ann. Oncol. 27: 1895-1902 (2016).
    doi: 10.1093/annonc/mdw290

  • J.M. Borghardt, B. Weber, A. Staab, C. Kunz, S. Formella, C. Kloft.
    Investigating pulmonary and systemic pharmacokinetics of inhaled olodaterol in healthy volunteers using a population pharmacokinetic approach.
    Br. J. Clin. Pharmacol. 81: 538–552 (2016).
    doi: 10.1111/bcp.12780

  • J.M. Borghardt, B. Weber, A. Staab, C. Kunz, C. Kloft.
    Model-based evaluation of pulmonary pharmacokinetics in asthmatic and COPD patients after oral olodaterol inhalation.
    Br. J. Clin. Pharmacol. 82: 739-753 (2016).
    doi: 10.1111/bcp.12999

  • S.G. Wicha, C. Kloft.
    Simultaneous determination and stability studies of linezolid, meropenem and vancomycin in bacterial growth medium by high-performance liquid chromatography.
    J. Chrom. B 1028: 242-248 (2016).
    doi: 10.1016/j.jchromb.2016.06.033

  • M.G. Kees, I.K. Minichmayr, S. Moritz, S. Beck, S.G. Wicha, F. Kees, C. Kloft, T. Steinke.
    Population pharmacokinetics of meropenem during continuous infusion in surgical ICU patients.
    J. Clin. Pharmacol. 56: 307-315 (2016).
    doi: 10.1002/jcph.600

  • L. Botermann, K. Monzel, K. Krueger, C. Eickhoff, C. Kloft, M. Schulz.
    Evaluating patients' comprehensibility of a standardized medication plan.
    Eur. J. Clin. Pharmacol. 72: 1229-1237 (2016).
    doi: 10.1007/s00228-016-2082-5

  • L. Botermann, K. Krueger, C. Eickhoff, C. Kloft, M. Schulz.
    Patients‘ handling of a standardized medication plan: A pilot study and method development.
    Patient. Prefer. Adherence 10: 621–30 (2016).
    doi: 10.2147/PPA.S96431

  • K. Locher, J.M. Borghardt, K.J. Frank, C. Kloft, K.G. Wagner.
    Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics.
    Eur. J. Pharm. Biopharm. 105: 166-175 (2016).
    doi: 10.1016/j.ejpb.2016.06.008

  • C. Töpper, C.L. Steinbach, C. Dorn, A. Kratzer, S.G. Wicha, M. Schleibinger, U. Liebchen, F. Kees, B. Salzberger, M.G Kees.
    Variable linezolid exposure in ICU patients – possible role of drug-drug interactions.
    Ther. Drug Monit. 38: 573-578 (2016).
    doi: 10.1097/FTD.0000000000000324

  • C. Scheerans, S.G. Wicha, J. Michael, H. Derendorf, C. Kloft.
    Concentration–response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium.
    Int. J. Antimicrob. Agents. 45: 54-60 (2015).
    doi: 10.1016/j.ijantimicag.2014.07.028

  • S.G. Wicha, M.G. Kees, J. Kuss, C. Kloft.
    Pharmacodynamic and response surface analysis of linezolid or vancomycin combined with meropenem against Staphylococcus aureus.
    Pharm. Res. 32: 2410-2418 (2015).
    doi: 10.1007/s11095-015-1632-3

  • S.G. Wicha, M.G. Kees, A. Solms, I.K. Minichmayr, A. Kratzer, C. Kloft.
    TDMx – a novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine.
    Int. J. Antimicrob. Agents. 45: 442-444 (2015).
    doi: 10.1016/j.ijantimicag.2014.12.010

  • S.G. Wicha, K. Zink, T. Haak, F. Kees, C. Kloft, M.G. Kees.
    Pharmacokinetic/pharmacodynamic analysis of moxifloxacin in patients with diabetic foot infections.
    J. Clin. Pharmacol. 55: 639-646 (2015).
    doi: 10.1002/jcph.464

  • M.J. Swat , S. Moodie, S.M. Wimalaratne, N.R. Kristensen, M. Lavielle, A. Mari, P. Magni, R. Bizzotto, M. Smith, E. Comets, C. Sarr, N. Terranova, E. Blaudez, P. Chan, J. Chard, M. Chenel, D. Edwards, C. Franklin, T. Giorgino, M. Glont, P. Girard, P. Grenon, K. Harling, A.C. Hooker, R. Kaye, R. Keizer, C. Kloft, N. Kokash, C. Laibe, C. Laveille, F. Mentre, E. Mezzalana, A. Munafo, R. Nordgren, H.B. Nyberg, Z.P. Parra-Guillen, L. Pasotti, E. Plan, B. Ribba, G. Smith, I.F. Trocóniz, F. Yvon, L. Harnisch, M. Karlsson, H. Hermjakob, N. Le Novère.
    Pharmacometrics markup language (PharmML): Opening new perspectives for model exchange in drug development.
    Clin. Pharmacol. Ther.: Pharmacomet. Syst. Pharmacol. 4: 316-319 (2015).
    doi: 10.1002/psp4.57

  • Z.P. Parra-Guillen, J.M. Cendrós, C. Peraire, R. Obach, J. Prunynosa, E. Chetaille, I.F. Trocóniz.
    Population pharmacokinetic modelling of irosustat in postmenopausal women with oestrogen-receptor positive breast cancer incorporating non-linear red blood cell uptake.
    Pharm. Res. 32: 1493-1504 (2015).
    doi: 10.1007/s11095-014-1555-4

  • C. Kirbs, C. Kloft.
    In vitro microdialysis recovery and delivery investigation of cytokines as prerequisite for potential biomarker profiling.
    Eur. J. Pharm. Sci. 57: 48-59 (2014).

  • A. Schaeftlein, I.K. Minichmayr, C. Kloft.
    Population pharmacokinetics meets microdialysis: Benefits, pitfalls and necessities of new analysis approaches for human microdialysis data.
    Eur. J. Pharm. Sci. 57: 68-73 (2014).

  • M.G. Kees, S.G. Wicha, A. Seefeld, F. Kees, C. Kloft.
    Unbound fraction of vancomycin in intensive care unit patients.
    J. Clin. Pharmacol. 54: 318-323 (2014).

  • U. Liebchen, A. Kratzer, S.G. Wicha, F. Kees, C. Kloft, M.G. Kees.
    Unbound fraction of ertapenem in intensive care unit patients.
    J. Antimicrob. Chemother. 69: 3108-3111 (2014).

  • R.B. Eslam, A. Burian, G. Vila, R. Sauermann, A. Hammer, D. Frenzel, I.K. Minichmayr, C. Kloft, P. Matzneller, Z. Oesterreicher, M. Zeitlinger.
    Target site pharmacokinetics of linezolid after single and multiple doses in diabetic patients with soft tissue infection.
    J. Clin. Pharmacol. 54: 1058-62 (2014).

  • S.S. Allemann, J.W. Foppe van Mil, L. Botermann, K. Berger, N. Griese, K.E. Hersberger
    Pharmaceutical care: the PCNE definition 2013.
    Int. J. Clin. Pharm. 36: 544-555 (2014).

  • F. Simmel, C. Kirbs, Z. Erdogan, E. Lackner, M. Zeitlinger, C. Kloft.
    Pilot investigation on long-term subcutaneous microdialysis: Proof-of-Principle in humans.
    AAPS J. 15: 95-103 (2013).

  • G. Vlasakakis, E. Comets, A. Keunecke, I. Gueorguieva, P. Magni, N. Terranova, O. Della Pasqua, E.C. de Lange, C. Kloft.
    White paper: Landscape on technical and conceptual requirements and competence framework in Drug/Disease Modeling & Simulation.
    Clin. Pharmacol. Ther.: Pharmacomet. Syst. Pharmacol. 2: e40 (2013).

  • M. Frank, A. Kunz, G. Harms, C. Kloft.
    Population pharmacokinetic analysis of a nevirapine-based HIV-1 prevention of mother-to-child transmission program in Uganda to assess the impact of different dosing regimens for newborns.
    J. Clin. Pharmacol. 53: 294-304 (2013).

  • M.G. Kees, A. Schaeftlein, H.A. Haeberle, F. Kees, C. Kloft, A. Heininger.
    Population pharmacokinetics and pharmacodynamic evaluation of intravenous and enteral moxifloxacin in surgical intensive care unit patients.
    J. Antimicrob. Chemother. 68: 1331-1337 (2013).

  • R. Stößer, W. Herrmann.
    Physical and chemical response of FeCl3/FeCl4 spin probes on the functionalizing of ionic liquids.
    J. Phys. Chem. A 117: 3960-3971 (2013).

  • R. Stößer, W. Herrmann.
    Isotope effects in ESR spectroscopy.
    Molecules. 18: 6679-6722 (2013).

  • M.G. Kees.
    Strategien zur Vermeidung von Antibiotikaresistenzen.
    Med. Klin. Intensivmed. Notfmed. 108: 125-130 (2013).

  • A. Sleinitz, C. Heyde, C. Kloft.
    Medication safety in hospitals.
    Med. Monatsschr. Pharm. 35: 140-151 (2012).

  • R. Stösser, W. Herrmann, A. Pahlke.
    Spin exchange of nitroxyl radicals in H2O and D2O.
    J. Phys. Chem. A 116: 952-961 (2012).

  • C. Justinger, M.K. Schilling, M.G. Kees, A. Kauffels, K. Hirschmann, B. Kopp, F. Kees, O. Kollmar.
    Penetration of moxifloxacin into liver tissue.
    Int. J. Antimicrob. Agents 39: 505-509 (2012).

  • R.A. Keel, A. Schaeftlein, C. Kloft, J. Pope, R. Knauft, D. Nicolau, J.L. Kuti.
    Pharmacokinetics of Intravenous and Oral Linezolid in Adults with Cystic Fibrosis.
    Antimicrob. Agents Chemother., 55: 3393-3398 (2011).

  • A. Schaeftlein, C. Kloft.
    Die Beers-Liste im klinischen Alltag. Erhöhung der Arzneimitteltherapiesicherheit geriatrischer Patienten.
    Arzneimitteltherapiekritik, 3: 219-232 (2011).

  • A. Schaeftlein, C. Kloft.
    Die Beers-Liste im klinischen Alltag. Erhöhung der Arzneimitteltherapiesicherheit geriatrischer Patienten.
    Internistische Praxis, 51/3: 617-630 (2011).

  • M. Frank, M. von Kleist, A. Kunz, G. Harms, C. Schütte, C. Kloft.
    Quantifying the Impact of Nevirapine-Based Prophylaxis Strategies To Prevent Mother-to-Child Transmission of HIV-1: a Combined Pharmacokinetic, Pharmacodynamic, and Viral Dynamic Analysis To Predict Clinical Outcomes.
    Antimicrob. Agents Chemother., 55: 5529-5540 (2011).

  • A.J. Kellermann, C. Kloft.
    Is There a Risk of Bleeding Associated with Standardized Ginkgo biloba Extract Therapy? A Systematic Review and Meta-analysis.
    Pharmacother., 31: 490-502 (2011).

  • U. Hochkirch, W. Herrmann, R. Stößer, M. Linscheid, H.-H. Borchert.
    Distribution profiles of nitroxide spin probes in human skin - a combined study using spatially resolved electron spin resonance spectroscopy and mass spectrometry.
    Anal. Bioanal. Chem., 401: 901-907 (2011).

  • R. Stösser, W. Herrmann, U. Marx, A. Brückner.
    Spin Exchange in Solutions of TEMPOL in n-Octanol and 1-Methyl-3-octylimidazolium Hexafluorophosphate in the Temperature Range from 300 to 500 K.
    J. Phys. Chem., A 115: 2939-2952 (2011).

  • R. Stösser, W. Herrmann, M.
    Feist Austauschwechselwirkung - Von der magnetischen Ordnung in Festlörpern zum Spinaustausch in Lösungen und Biosystemen.
    Humboldt-Spektrum, 18: 104-108 (2011).

  • T. Lehr, A. Staab, D. Trommeshauser, H.G. Schaefer, C. Kloft.
    Efficacy modeling of early clinical data to predict clinical outcome: Tesofensine in Alzheimer's Disease Patients.
    AAPS J., 12: 117-129 (2010).

  • T. Lehr, A. Staab, D. Trommeshauser, H.G. Schaefer, C. Kloft.
    Semi-mechanistic population pharmacokinetic drug-drug interaction modelling of a long half-life substrate and itraconazole.
    Clin. Pharmacokinet., 49: 53-66 (2010).

  • O. Schwalbe, C. Scheerans, I. Freiberg, A. Schmidt-Pokrzywniak, A. Stang, C. Kloft.
    Compliance of alzheimer patients and forgiveness of donepezil.
    BMC Health Serv. Res., 10: 232-240 (2010).

  • F. Simmel, C. Kloft.
    Microdialysis feasibility investigations with the non-hydrophilic antifungal voriconazole for successful applications in nonclinical and clinical settings.
    Int. J. Clin. Pharmacol. Ther., 48: 695-704 (2010).

  • L. Schönberg, T. Grobosch, D. Lampe, C. Kloft.
    The identification of alkaloids in urine Two intoxication cases using TOX.I.S.
    GIT Laboratory J, 14: 31-33 (2010).

  • A. Lindauer, C. Eickhoff, C. Kloft, U. Jaehde.
    Population pharmacokinetics of high-dose carboplatin in adults and children.
    Ther. Drug Monit., 32: 159-168 (2010).

  • T. Lehr, R. Narbe, O. Jöns, C. Kloft, A. Staab.
    Population pharmacokinetic modelling and simulation of single and multiple dose administration of meloxicam in cats.
    J. Vet. Pharmacol. Therap., 33: 277-286 (2010).

  • A. Kunz, M. Frank, K. Mugenyi, R. Kabasinguzi, A. Weidenhammer, M. Kurowski, C. Kloft, G. Harms.
    Persistance of nevirapine in breast milk and plasma of mothers and their children after single-dose administration.
    J. Antimicrob. Chemother., 63: 170-177 (2009).

  • T. Lehr, A. Staab, C. Tillmann, D. Trommeshauser, H.G. Schaefer, C. Kloft.
    A quantitative enterohepatic circulation model: development and evaluation with tesofensine and meloxicam.
    Clin. Pharmacokinet., 48:529-542 (2009).

  • K. Kuester, A. Kovar, C. Lüpfert, B. Brockhaus, C. Kloft.
    Refinement of the population pharmacokinetic model for the monoclonal antibody matuzumab: external model evaluation and simulations.
    Clin. Pharmacokinet., 48: 477-487 (2009).

  • B. Krippendorff, K. Kuester, C. Kloft, W. Huisinga.
    Nonlinear pharmacokinetics of therapeutic proteins resulting from receptor mediated endocytosis.
    J. Pharmacokinet. Pharmacodyn., 36: 239-260 (2009).

  • C. Scheerans, H. Derendorf, C. Kloft.
    Proposal for a standardised identification of the mono-exponential terminal phase for orally administered drugs.
    Biopharm. Drug Dispos., 29: 145-157 (2008).

  • U. Hinkel, C. Schuijt, J.F. Erckenbrecht.
    OTC laxative use of sodium picosulfate - Results of a pharmacy-based patient survey (cohort study).
    Int. J. Clin. Pharmacol. Ther., 46: 89-95 (2008).

  • L.B. Stolle, N. Plock, C. Joukhadar, M. Arpi, K.J. Emmertsen, C. Buerger, P. Riegels Nielsen, C. Kloft.
    Pharmacokinetics of linezolid in bone tissue investigated by in vivo microdialysis.
    Scand. J. Clin. Infect., 40: 24-29 (2008).

  • G. Fliss, A. Staab, C. Tillmann, D. Trommeshauser, H.G. Schaefer, C. Kloft.
    Population pharmacokinetic data analysis of cilobradine, an If channel blocker.
    Pharm. Res., 25: 359-368 (2008).

  • C. Thallinger, C. Buerger, N. Plock, S. Kljucar, S. Wuenscher, R. Sauermann, C. Kloft, C. Joukhadar.
    Effect of severity of sepsis on tissue concentrations of linezolid.
    J. Antimicrob. Chemother., 61: 173-176 (2008).

  • T. Lehr, A. Staab, C. Tillmann, E.O. Nielsen, D. Trommeshauser, H.G. Schaefer, C. Kloft.
    Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach.
    Brit. J. Pharmacol., 153: 164-167 (2008).

  • K. Kuester, A. Kovar, C. Lüpfert, B. Brockhaus, C. Kloft.
    Population pharmacokinetic data analysis of three phase I studies of matuzumab, a humanised anti-EGFR monoclonal antibody in clinical cancer development.
    Brit. J. Cancer, 98: 900-906 (2008).

  • F. Simmel, J. Soukup, A. Zoerner, J. Radke, C. Kloft.
    Development and validation of an efficient HPLC method for quantification of voriconazole in plasma and microdialysate reflecting an important target site.
    Anal. Bioanal. Chem., 392: 479-488 (2008).

  • T. Dreischulte, O. Schwalbe, S. Simons.
    Die richtige Medizin.
    Dtsch. Apoth. Ztg., 148: 4908-4913 (2008).

  • A. Dietrich, T. Mueller, R. Paschke, B. Kalinowski,T. Behlendorf, F. Reipsch, A. Fruehauf, H.-J. Schmoll, C. Kloft, W. Voigt.
    2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II): a novel platinum compound that overcomes cisplatin resistance and induces apoptosis by mechanisms different from that of cisplatin.
    J. Med. Chem., 51: 5413-5422 (2008).

  • T. Lehr, A. Staab, C. Tillmann, D. Trommeshauser, A. Raschig, H.G. Schaefer, C. Kloft.
    Population pharmacokinetic modelling of NS2330 and its major metabolite in Alzheimer's disease patients.
    Brit. J. Clin. Pharmacol., 64: 36-48 (2007).

  • A. Sauter, C. Kloft, S. Gronau, F. Bogesch¬dorfer, T. Erhardt, W. Golze, C. Schroen, A. Staab, H. Riechelmann, K. Hoermann.
    Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck.
    Int. J. Oncol., 30: 927-935 (2007).

  • L. Schönberg, T. Grobosch, D. Lampe, C. Kloft.
    Analysis of basic compounds in urine by on-line extraction-HPLC-DAD.
    Toxichem + Krimtech, 74: 64-68 (2007).

  • N. Plock, C. Buerger, C. Joukhadar, S. Kljucar, C. Kloft.
    Does linezolid inhibit its own metabolism? - Population pharmacokinetics as a tool to explain the observed nonlinearity in both healthy volunteers and septic patients.
    Drug Metab. Dispos., 35: 1816-1823 (2007).

  • D.M. Saunte, F. Simmel, N. Frimodt-Moller, L.B. Stolle, E.L. Svejgaard, M. Haedersdal, C. Kloft, M.C. Arendrup.
    In-vivo efficacy and pharmacokinetics of voriconazole in an animal model of dermatophytosis.
    Antimicrob. Agents Chemother., 51: 3317-3321 (2007).

  • L. Schönberg, T. Grobosch, D. Lampe, C. Kloft.
    Toxicological screening in urine: comparison of two automated HPLC screening systems, toxicological identification system (TOX.I.S.*) versus RemediTM-HS.
    J. Anal. Tox., 31: 321-327 (2007).

  • O. Schwalbe, I. Freiberg, C. Kloft.
    [The beers criteria - an instrument to optimise the pharmacotherapy of geriatric patients].
    Med. Monatsschr. Pharm., 30: 244-248 (2007).

  • C. Kloft, A. Henningsson, J. Wallin, E. Chatelut, M.O. Karlsson.
    Population pharmacokinetic-pharmacodynamic model for neutropenia with patient subgroup identification: comparison across anticancer drugs.
    Clin. Cancer Res., 12: 5481-5490 (2006).

  • O. Schwalbe, C. Buerger, N. Plock, C. Joukhadar, C. Kloft.
    Urea as an endogenous surrogate in human microdialysis to determine relative recovery of drugs: analytics and applications.
    J. Pharm. Biomed. Anal., 41: 233-239 (2006).

  • H. Stocker, C. Kloft, N. Plock, A. Breske, G. Kruse, C. Herzmann, H. Schulbin, P. Kreckel, C. Weber, F. Goebel, J. Roeling, S. Staszewski, A. Plettenberg, C. Moecklinghoff, K. Arasteh, M. Kurowski.
    Pharmacokinetics of enfuvirtide in patients treated in typical routine clinical settings.
    Antimicrob. Agents Chemother., 50: 667-673 (2006).

  • F. Islinger, P. Dehghanyar, R. Sauermann, C. Buerger, C. Kloft, M. Mueller, C. Joukhadar.
    The effect of food on plasma and tissue concentrations of linezolid after multiple doses.
    Int. J. Antimicrob. Agents, 27: 108-112 (2006).

  • C. Buerger, N. Plock, P. Dehghanyar, C. Joukhadar, C. Kloft.
    Pharmacokinetics of unbound linezolid in plasma and tissue interstitium of critically ill patients after multiple dosing using microdialysis.
    Antimicrob. Agents Chemother., 50: 2455-2463 (2006).

  • L. Schönberg, T. Grobosch, D. Lampe, C. Kloft.
    New screening method for basic compounds in urine by on-line extraction–high-performance liquid chromatography with photodiode-array detection.
    J. Chromatogr. A, 1134: 177-185 (2006).

  • P. Dehghanyar, C. Bürger, M. Zeitlinger, F. Islinger, F. Kovar, M. Müller, C. Kloft,
    C. Joukhadar.
    Penetration of linezolid into soft tissues after single and multiple doses to healthy volunteers.
    Antimicrob. Agents Chemother., 49: 2367-2371 (2005).

  • N. Plock, C. Buerger, C. Kloft.
    Successful management of discovered pH dependence in vancomycin recovery studies: Novel HPLC method for plasma and in vitro microdialysis samples.
    Biomed. Chromatogr., 19: 237-244 (2005).

  • C. Kloft, E.-U. Graefe, P. Tanswell, A.M. Scott, R. Hofheinz, A. Amelsberg, M.O. Karlsson.
    Population pharmacokinetics of sibrotuzumab, a novel therapeutic monoclonal antibody, in cancer patients.
    Invest. New Drugs, 22: 39-52 (2004).

  • U. Warnke, C. Rappel, H. Meier, C. Kloft, M. Galanski, C.G. Hartinger, B.K. Keppler, U. Jaehde.
    Analysis of Platinum Adducts with DNA Nucleotides and Nucleosides by Capillary Electrophoresis Coupled to ESI-MS: Indications of Guanosine 5’-Monophosphate O6–N7 Chelation.
    ChemBioChem, 5: 1543-1549 (2004).

  • C. Buerger, C. Joukhadar, M. Mueller, S. Kljucar, C. Kloft.
    Development of a new HPLC method for the determination of linezolid and its application to in vitro and human microdialysis samples.
    J. Chromatogr. B, 796:155-164 (2003).

  • C. Kloft, W. Siegert, U. Jaehde.
    Individualised dosing strategy for high-dose carboplatin in patients with germ cell cancer.
    Br. J. Cancer, 89: 787-794 (2003).

  • H. Rommelspacher, M. Meier-Henco, M. Smolka, C. Kloft.
    The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets.
    Eur. J. Pharmacol., 441: 115-125 (2002).

  • S. Reif, M.C. Nicolson, D. Bissett, M. Reid, C. Kloft, U. Jaehde, H.L. McLeod.
    Effect of grapefruit juice intake on etoposide bioavailability.
    Eur. J. Clin. Pharmacol., 58: 491-494 (2002).

  • C. Kloft, W. Siegert, J. Beyer, U. Jaehde.
    Toxicity of high-dose carboplatin: ultrafiltered and not total plasma pharmacokinetics is of clinical relevance.
    J. Clin. Pharmacol., 42: 762-773 (2002).

  • S. Reif, D. Kingreen, C. Kloft, J. Grimm, W. Siegert, W. Schunack, U. Jaehde.
    Bioequivalence investigation of high-dose etoposide and etoposide phosphate in lymphoma patients.
    Cancer Chemother. Pharmacol., 48: 134-140 (2001).

  • U. Warnke, J Gysler, B. Hofte, U.R. Tjaden, J. van der Greef, C. Kloft, W. Schunack, U. Jaehde.
    Separation and Identification of Platinum Adducts with DNA Nucleotides by Capillary Zone Electrophoresis and Capillary Zone Electrophoresis Coupled to Mass Spectrometry.
    Electrophoresis, 22: 97-103 (2001).

  • C. Kloft, C. Eickhoff, K. Schulze-Forster, H. R. Maurer, W. Schunack, U. Jaehde.
    Development and application of a simple assay to quantify cellular adducts of platinum complexes with DNA.
    Pharm. Res., 16: 470-473 (1999).

  • C. Kloft, H. Appelius, W. Siegert, W. Schunack, U. Jaehde.
    Determination of platinum complexes in clinical samples by a rapid flameless atomic absorption spectrometry assay.
    Ther. Drug Monit., 21: 631-637 (1999).

  • C. Kloft, H. Schöning, W. Siegert, U. Jaehde.
    AUC-guided dosing of carboplatin: an option for high-dose chemotherapy?
    Bone Marrow Transpl., 22 (Suppl. 3): 56-59 (1998).