Archiv

 

December 2016

 

PhD defense of Jens Borghardt

The PhD defense of Jens Borghardt entitled “Improving the understanding of the mechanisms determining the pulmonary and systemic pharmacokinetics of orally inhaled drugs: a pharmacometric analysis“ will take place in the Lecture Hall 406A, Institute of Pharmacy, Kelchstraße 31, 12169 Berlin, on Thursday, 15 December 2016, at 14:00. Guests are welcome!

 

PhD defense of Lea Botermann

The PhD defense of Lea Botermann with the title “Der Medikationsplan zur Verbesserung der Arzneimitteltherapie-sicherheit in Deutschland: Analyse des Status quo und Evaluation der Verständlichkeit bei Patienten mit Polymedikation“ will take place Lecture Hall 406A, Institute of Pharmacy, Kelchstraße 31, 12169 Berlin, on Tuesday, 13 December 2016, at 5 p.m.

 

New scientific publication of Department

The paper “Clinical Determinants of Target Non-Attainment of Linezolid in Plasma and Interstitial Space Fluid: A Pooled Population Pharmacokinetic Analysis with Focus on Critically Ill Patients“ has been accepted in Clinical Pharmacokinetics, and is now available online (http://link.springer.com/article/10.1007%2Fs40262-016-0463-7).

 

New scientific publication of Department

The paper “Magnitude of Increased Infliximab Clearance Imposed by Anti-infliximab Antibodies in Crohn’s Disease Is Determined by Their Concentration“ has been accepted in the American Association of Pharmaceutical Scientists Journal (AAPS J), and is now available online (http://link.springer.com/article/10.1208%2Fs12248-016-9989-8).

 

 

November 2016
 

Presentation of Prof. Ross T. Tsuyuki - Alberta University

On 02 November 2016, Prof. Ross T. Tsuyuki from Alberta University, Canada, will visit us: He will give a presentation entitled “Evidence-based cardiovascular risk reduction by pharmacists - benefits of an advanced scope of practice” within the “Pharmazeutisches Forschungskolloquium” in the lecture hall of the Botanical Museum, at 18:00 (s.t.). On 03 November 2016, we continue with presentations and discussions of research and teaching projects by our Dept. including the newly established Medication Management Centre (MMC) at the Institute. 

 

October 2016
 

"Medikations-Management-Center" officially opened

On 20 October 2016, the ceremonial opening of the “Medikations-Management-Center” (Medication Management Center, MMC) took place at the Institute of Pharmacy, Kelchstr. 31. Prof. Charlotte Kloft and two former undergraduate pharmacy students (Josefine Schulz and Steffen Loke) welcomed ~70 guests from University’s Executive Board, the Dean, Administrative Director, colleagues and members of the Faculty and Institute, colleagues from the Charité, presidents and chairs of various pharmacist/pharmacy associations, pharmacy colleagues and students and presented the innovative teaching concept followed by a reception and the opportunity to join some hands-on activites provided in the MMC. The MMC will be incorporated in the curriculum of the pharmacy undergraduate students from the first tot the last year.

 

Eva Göbgen received the Lesmüller poster price at the DPhG Meeting

We congratulate our PhD student Eva Göbgen, who received the Lesmüller poster price at the Annual Meeting of the Deutsche Pharmazeutische Gesellschaft (DPhG) in Munich for the poster contribution “Treatment of catheterised ICU patients with levofloxacin – How in silico models help to streamline in vitro investigations of treatment efficacy at the target site”. 

 

Annual meeting of the DPhG in Munich

From 05 - 07 October 2016, the annual meeting of the “Deutsche Pharmazeutische Gesellschaft” will take place in Munich. Eva Göbgen, Tamara Richter, Johanna Seeger and Christine Weiser will present their work in the field of clinical pharmacy.

 
 

September 2016
 

CESAR Annual Meeting 08 - 10 September 2016

Two PhD students of our working group, Lena Klopp-Schulze and Andrea Henrich, will present their work at the annual meeting of the Central European Society for Anticancer Drug Research (CESAR) in Munich. The main topic of the meeting this year is “Early Drug Development and Biomarkers”.

 

 

August 2016

 
Summer School Uppsala 08 - 19 August 2016

Two PhD students of our working group, Lisa Ehmann and Lena Klopp-Schulze, will attend the 6th annual Uppsala Pharmacometric Summer School (UPSS) taking place from 08. – 19.08.2016 at the Uppsala University, Sweden. Beside lectures, hands-on sessions and group works the students will present parts of their current research work.

 
 

July 2016


Day of Pharmacy

Together with the DPhG (German Pharmaceutical Society), we cordially invite you to our biyearly event „Day of Pharmacy - Shaping future pharmaceutical research: Junior scientists present”. Young investigators of our and the other Research groups of the Institute of Pharmacy will present their research in talks and on posters, followed by the Graduation Celebration and the traditional garden party organised by this year’s pharmacy graduates. We are looking forward to an exciting event and to seeing as many of you there!

 

 
June 2016

 
PAGE meeting in Lisbon

The 25th Annual Meeting of the Population Approach Group in Europe will take place in Lisbon, Portugal: 7-10 June 2016. Seven working group members will join and present their scientific research in six posters in total.

 

1st June 2016

In June 2016, a new PhD student, Franziska Kluwe, will join the AK Kloft. She will be part of the PharMetrX program, her research project will focus on the pharmacometric modelling of infectious diseases and their therapy.

 
 

May 2016

 

25 - 27 May 2016

The 8th International Symposium on Microdialysis will take place in Uppsala, Sweden: 25 - 27 May 2016. Results of our research projects will be presented as three posters and one joined oral presentation.

 

17 May 2016

Invited presentation by Dr. Sebastian Wicha

We are happy to announce a talk of our former PhD student Dr. Sebastian Wicha on “Innovative Strategies for Optimisation of Anti-Infective Therapy” within the series of the “Pharmazeutisches Forschungskolloquium” of the Institute of Pharmacy. We are looking forward to an interesting event and lively participation!

 

Jens Borghardt was awarded the Hans Günter Schäfer Award at the 20th Pharmacokinetics/Pharmacodynamics Expert Meeting in Berlin on 15 April 2016 for his PhD research work on “Investigating pulmonary and systemic pharmacokinetics of inhaled olodaterol in healthy volunteers using a population pharmacokinetic approach”, published in J.M. Borghardt, B. Weber, A. Staab, et al. Investigating pulmonary and systemic pharmacokinetics of inhaled olodaterol in healthy volunteers using a population pharmacokinetic approach. Br. J. Clin. Pharmacol. 81.: 538–52 (2016).

 

 
April 2016

 

14 - 16 April 2016

Several members of the Department of Clinical Pharmacy & Biochemistry attend the 20th Pharmacokinetics/Pharmacodynamics Expert Meeting in Berlin, which is hosted by the Association for Applied Human Pharmacology (Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V.)

 
 
14 April 2016 -PharMetrX Symposium

The annual PharMetrX Symposium will take place at the Harnack-Haus, meeting centre of the Max-Planck-Society in Berlin. Three PharMetrX students will present their work in the morning:

  • Johanna Melin: “Semi‐mechanistic modelling of the nonlinear hydrocortisone pharmacokinetics to enable extrapolation to paediatric patients”.
  • Andrea Henrich: “PK/PD model extension to characterise bone marrow exhaustion in cancer patient making use of a prior paclitaxel PK model”.
  • Christoph Hethey: “Impact of the intracellular ribosomal concentration on in vitro bacterial growth kinetics and the antibacterial effect of linezolid on S. aureus
     

 

26th ECCMID - Amsterdam

From 9 - 12 April 2016 Daniela Burau, Lisa Ehmann, Eva Göbgen, Iris Minichmayr and Christine Weiser will attend the 26th European Congress of Clinical Microbiology and Infectious Diseases, (ECCMID) in Amsterdam. As contribution to the conference, parts of their research topics will be presented as posters during one of the poster sessions.

 

 
March 2016

 
In March 2016, two new PhD students Ana-Marija Grišić and Francis Ojara Williams will join the AK Kloft. Both will have their research project within the area of pharmacometrics and will be enrolled in the PharMetrX program.


 

February 2016

 
24 - 27 February 2016

The 32. Deutscher Krebskongress 2016 (German Cancer Congress) will be hosted by the Deutsche Krebsgesellschaft (German Cancer Society) and the Deutsche Krebshilfe (German Cancer Aid) in Berlin. Prof. Dr. Charlotte Kloft will join the conference and give a talk about “Modelling of resistance phenotypes” in the category “Translational Oncology” on Thursday morning.

 

8 - 12 February 2016

The Pharmacometric Research Group, Department of Pharmaceutical Biosciences at Uppsala University, Sweden, together with the Institute of Pharmacy, Freie Universitaet Berlin, Germany, are happy to invite you to the following face-to-face course: Model-Informed Drug Development in Infectious Diseases.

 
 

January 2016

 

Thi Trong successfully defended her master thesis at the University of Gothenburg in January. The title of her thesis is: “Population pharmacokinetic/pharmacodynamics analysis of hydrocortisone in paediatric patients with congenital adrenal hyperplasia”.

The Department of Clinical Pharmacy and Biochemistry wishes Thi all the best for the future!

 

18 - 22 January 2016

DDMoRe Cardiac Safety course

The Department of Quantitative Clinical Pharmacology, AstraZeneca R&D Gothenburg, Sweden together with the Institute of Pharmacy, Freie Universitaet Berlin, Germany invites for the public Pharma lead DDMoRe course “Model-informed Drug Development in Cardiac Safety” that will take place from 18 - 22 January 2016 in Mölndal, Sweden.

 
 

November 2015

 

9 November 2015

Claudia Kirbs defends her PhD thesis entitled 'Development and application of in vitro and in vivo microdialysis methods contributing to biomarker profiling and characterisation of drug distribution processes'.

 

12 November 2015

Sebastian Wicha defends his PhD thesis entitled 'Integrated in vitro and in silico studies for optimisation of broad-spectrum antibiotic combination therapy'.

 
 
Oktober 2015

4 - 7 October 2015

DDMoRe at ACoP6

The DDMoRe Consortium will hold a stand at ACoP6 (6th American Conference on Pharmacometrics) organised at Crystal City. Dr. Zinnia Parra-Guillen will be part of the DDMoRe stand.

 
 

September 2015

 

17 - 21 September 2015

Annual CESAR-Meeting 2015 in Innsbruck  

The CESAR (Central European Society for Anticancer Drug Research) meeting 2015 with focus on "Challenge for Drug Development in Precision Oncology" will be held in Innsbruck this year. Andrea Henrich andLena Klopp-Schulze are invited to present their research work in a poster and an oral presentation.

 

23 - 25 September 2015

Annual DPhG-Meeting 2015 in Düsseldorf

In September Kristin Bartels, Lisa Ehmann, Marc-Alexander Fürtig, Eva Göbgen and Christine Weiser will attend the 13th annual meeting of the German Pharmaceutical Society (DPhG) in Düsseldorf. The focus of this year’s meeting will be: “Interactions, Integrations and Innovations”. As contribution to the conference, parts of their research topics will be presented as poster during one of the poster sessions.

 

August 2015

 

15 July 2015 - 3 August 2015

Model-informed Drug Development in Oncology (advanced) in Pavia, Italy

The DDMoRe consortium continues its series of comprehensive face-to-face courses introducing the principles of model-informed drug development, covering a range of therapeutic areas, via the newly-developed DDMoRe interoperability framework platform.

The Bioinformatics, Mathematical Modeling and Synthetic Biology (BMS) lab at Università degli Studi di Pavia, Italy and the Dept. Clinical Pharmacy & Biochemistry at the Institute of Pharmacy, Freie Universitaet Berlin, Germany are happy to invite you to the following face-to-face from 7 to 11 September 2015

 

July 2015

 

27 - 31 July 2015

2nd public DDMoRe course: MIDD in CNS diseases

On behalf of the Consortium “DDMoRe”, the Departments of Pharmacology of the Leiden Academic Centre for Drug Research (LACDR) at University of Leiden, Leiden (The Netherlands) and Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra (UNAV), Pamplona (Spain) are happy to host the 2nd public face-to-face course: “Model-informed Drug Development in Central Nervous System Diseases”.

Prof. Dr. Charlotte Kloft and Dr. Zinnia Parra (both Freie Universitaet Berlin, Germany) will contribute to the course as lecturers.

This course continuous the series of comprehensive face-to-face courses introducing the principles of model-informed drug development, covering a range of therapeutic areas, via the newly-developed DDMoRe interoperability framework platform.

On 13 July 2015, a new master student joined the AK Kloft. Thi Truong will work on characterising the pharmacokinetics/pharmacodynamics of hydrocortisone in paediatric patients with adrenal insufficiency.

 
 

June 2015


02 - 05 June 2015

24th PAGE meeting in Crete

The 24th PAGE (Population Approach Group Europe) meeting is an annual modelling and simulation conference and will this year be held in Hersonissos, Crete, Greece. Andrea Henrich, Helena Edlund, Iris Minichmayr, Jens Borghardt, Johanna Melin, Lena Klopp-Schulze and Sebastian Wicha will present parts of their research projects as posters. Additionally, Sebastian Wicha will present TDMs as software demonstration.

Link: http://www.page-meeting.org/

 
 

May 2015

 

28 - 30 May 2015

ADKA Congress

The 40th scientific congress of the ADKA (‘Bundesverband Deutscher Krankenhausapotheker’) will be held in Mannheim, Germany this year. Sebastian Wicha will present TDMx, the dosing support software from the AK Kloft in an oral and poster presentation.

Link: http://www.adka.de

 

On 23 May 2015, a new post-doc member joined the AK Kloft. Niclas Hartung will support our EU-Project DDMoRe.

 
 

April 2015

 

The 25th ECCMID (European Congress on Clinical Microbiology and Infectious Diseases) is an annually conference organised by the ESCMID (European Society of Clinical Microbiology and Infectious Diseases) and will be held in Copenhagen, Denmark this year. Eva Göbgen, Iris Minichmayr, Christine Weiser and Sebastian Wicha will present parts of their research projects, either as electronic or printed poster, there.

Link: http://www.eccmid.org/

 
 

March 2015

 

09 - 13 March 2015

PharMetrX A1 module: Introduction to PK and PD

The A1 module introduces the basic concepts in pharmacokinetics (PK) and pharmacodynamics (PD). To meet this objective, PhD students will acquire knowledge, skills and critical evaluation competencies in the understanding of (non)clinical PK concepts, (non)clinical PD concepts: Different methodological approaches of data analysis will be discussed including model diagnostics. A major focus is laid on the interpretation and assessment of clinical impact of PK, PD parameter values as well as the strength of simulation-based analysis – both for decision-making in development or therapeutic use of medicines. Finally, an introduction to the theoretical background of applied mathematics will round up the course.

The module will be complemented by multiple hands-on sessions with the software packages Phoenix/WinNonlin™, Berkeley Madonna™ and be based on case studies.

 

16 - 20 March 2015

First public DDMoRe course: MIDD in Oncology

On behalf of the European Consortium “DDMoRe”, the Department of Clinical Pharmacy & Biochemistry of the Institute of Pharmacy at the Freie Universitaet Berlin is happy to host the first public DDMoRe course “Model-informed Drug Development in Oncology (Beginners)”.

This course launches a series of comprehensive face-to-face courses introducing the principles of model-informed drug development, covering a range of therapeutic areas, via the newly-developed DDMoRe interoperability framework platform.


 
February 2015

 

26 Februar 2015

PharMetrX & Working group meeting


 
January 2015

 

7 January 2015 - 28 February 2015

TDMx (speak 'TDMetrics') is a research project to develop, maintain and advance a versatile web application to foster model-supported Therapeutic Drug Monitoring (TDM).

TDMx brings state-of-the-art pharmacometrics to Therapeutic Drug Monitoring thereby being very user-friendly. No technical pharmacometrics or modeling skills are required to use TDMx. We have developed TDMx as support tool with potential application in (i) clinical practice as well as (ii) clinical research. Further, TDMx is suitable for (iii) teaching TDM in undergraduate studies. Try TDMx under www.tdmx.eu!

 

7 - 30 January 2015

DDMoRe presents: Model-informed Drug Development in Oncology (Beginners)

 
December 2014

 

11 - 12 December 2014

At the Clinical Microdialysis Symposium in Berlin-Buch from 11 to 12 December 2014, our PhD students Iris Minichmayr and Christine Weiser will give an oral presentation about our experimental and pharmacometric research work in the microdialysis field entitled: “In vitro and in silico approaches to improve clinical drug monitoring and drug development”.

 
 

November

 

07 - 08 November 2014

 1st PharMetrX Network Meeting

Since the launch of the Structured Graduate Research Training Program PharMetrX in 2008, the group of PharMetrX PhD students is continuously growing; the past PhD students now live spread out over Germany and beyond. To maintain the connections and interactions developed in the PharMetrX program and expand these across the various PhD student years to a next level, the “PharMetrX Network” will be launched this year: On November 07-08 2014, more than 20 past and present PhD students of the PharMetrX program will meet in Berlin to share and discuss ‘hot topics’ in the world of Pharmacometrics complemented by a Keynote Lecture given by PD Dr med. Alexander Nast, Charité – Universitätsmedizin Berlin (Head of Division of Evidence based Medicine (dEBM), Member of the AWMF (Association of the Scientific Medical Societies) Permanent Commission "Guidelines", Head of Guidelines Commission of the European Dermatology Forum).

 
 

October

 
12 - 15 October 2014

At the 5th American Conference of Pharmacometrics in Las Vegas, US, our PhD student of the PharMetrX program Helena Andersson will present the results of one of her projects: “Recommendations for Dose Adjustments of Infliximab in Crohn's Disease Patients with Higher Clearance”


 

September

 
29 September 2014

Eva Göbgen - Diploma thesis defence:
'Entwicklung und Evaluierung eines elektronischen Bakterienzählverfahrens und Untersuchungen unter Linezolidexposition'

 

23 - 26 September 2014

Annual Meeting of the German Pharmaceutical Society (Deutsche Pharmazeutische Gesellschaft, DPhG) Frankfurt/Main
1 Plenary Lecture and 5 poster contributions will be presented by our working group.

 

 

August

 
29 August 2014

Robert J. Bauer, Ph.D., Vice President, ICON Development Solutions, Hanover, USA – Presentation: Estimation algorithms

 

25 - 29 August 2014

PharMetrX: A3: Population Analysis – FU Berlin
The module aims at introducing the current PhD student year to the concepts of population analysis incl. hands-on.

For further information, please see https://www.pharmetrx.de/index.php/a3-pop-ana.html

 

18 - 22 August 2014

DDMoRe F2F course, Uppsala


 

July


14 - 16 July 2014

1st DDMoRe F2F course - Leiden University, NL

The Education and Training DDMoRe work package (WP9) will run the pilot face-to-face course to evaluate the recently developed interoperability framework within the context of model-based drug development. The course will be hosted by Prof. Liesbeth de Lange at Leiden University.

 

4 July 2014 - 9:30 a.m.

Tag der Pharmazie - Institute of Pharmacy, FU

Several contributions (oral presentations, posters) will be presented by our working group.

 

 
June 2014


27 June 2014

Prof. Dr. Hartmut Derendorf, University of Florida, Gainesville, USA: presentation

What? Presentation “Clinical Pharmacy Program For International Pharmacists”

When?  1 - 3 pm

Where?  Lecture hall 1, Institute of Pharmacy, Koenigin-Luise-Str. 2, 14195 Berlin


 
10 - 13 June 2014

23rd PAGE meeting, Alicante/Spain

Annual meeting of the Population Approach Group in Europe (PAGE). www.page-meeting.org

The annual population approach group in Europe (PAGE) is taking place in Alicante (Spain). This meeting gathers one of the largest communities focus on pharmacokinetic/pharmaco- dynamic modelling. Several contributions will be presented by our working group.

 
 
May 2014


10 - 13 May 2014

ECCMID Congress Attendance

Iris Minichmayr, Daniela Kauzor, Eva Göbgen and Sebastian Wicha are presenting their research at the 24th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), held in Barcelona.