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Research Group Hedtrich

We offer the possibility for master or diploma thesis in our group. For more information, please contact Prof. Dr. habil. Sarah Hedtrich!

Prof. Dr. habil. Sarah Hedtrich (née Küchler)

hedtrich

Pharmacology and Toxicology

Institute of Pharmacy

Freie Universität Berlin

Professor

Address Königin-Luise-Str. 2+4
Room VH 122
14195 Berlin
Office Petra Schmidt
Telephone (030) 838-55065
Fax (030) 838-54399
Email sarah.hedtrich@fu-berlin.de
Homepage Research Group Hedtrich

Professional Experience

since 04/2015

Professor of Pharmacology (W1)

07/2016

Habilitation, venia legendi for Pharmacology and Toxicology, Freie Universität Berlin

03/2013 - 04/2015

Junior Research Group Leader, Freie Universität Berlin, Institute for Pharmaceutical Sciences, Pharmacology & Toxicology

11/2012 – 03/2013

Visiting Scientist, Tufts University Boston, Biomedical Engineering, Prof. Dr. David Kaplan

02/2011 - 02/2013

Postdoctoral Associate, Department for Pharmaceutical Sciences, LMU München

08/2011

short-termed Lecturer, Hasanuddin Universität, Makassar (Indonesien) 

01/2011

Visiting Scientist, Wyss Institute, Harvard University

05/2009 – 01/2011

Postdoctoral Associate, Freie Universität Berlin, Institute for Pharmaceutical Sciences, Pharmacology & Toxicology

Education

02/2007 - 04/2009          

PhD Thesis, Institute for Pharmaceutical Sciences, Pharmacology & Toxicology Freie Universität Berlin
Topic: Nanoparticulate Carrier Systems for Topical Drug Delivery

12/2006

Licensed Pharmacist for Germany

06/06

German Diploma

10/2005 – 04/2006         

Diploma Thesis in collaboration with the university hospital Carl-Gustav-Carus in Dresden: „Development of a guideline for the treatment of CNS-mycoses for a hospital of maximum medical care“

2001-2006

Studies of Pharmacy, University of Leipzig

Honors and Awards

2016

Research Award on Skin Dryness Award (ROSA) in the field of atopic dermatitis, sponsored by La Roche-Posay Laboratoire Dermatologique of Germany 

2015

Astellas Forschungspreis, Dermatologie. 

2015

Galenus Support

2014

Preis für gute Lehre, Fachbereich BCP

2014

Galenus Support

2013

Galenus Support

11/2012 – 03/2013

DAAD Research Grant

2012

Galenus Support

2012

Poster Award “9th International Conference and Workshop on Biological Barriers”, Saarbrücken

2011

Travel Grant, Dr. August and Dr. Anni Lesmüller Foundation

2011

DAAD Travel and Lecturer Grant, Makassar, Indonesia

2011

Travel Grant ‚Center for International Cooperation‘, FU Berlin, for Wyss Institute, Harvard University

2010

Heinz Maurer-Award for Fundamental - Dermatological Research

2008

Poster Award “European Workshop on Particulate”, Berlin

2007-2009

Elsa-Neumann-PhD Grant

Further Activities

  • Member of the Editorial Board European Journal of Pharmaceutics and Biopharmaceutics
  • Member of Supervisory Board of the Integrated Research Training Group “Nanocarriers“ of the Collaborative Research Center 1112
  • Examiner of the 3rd state exam in Pharmacy

Scientific Reviewer for

  • European Journal of Pharmaceutics and Biopharmaceutics
  • Skin Pharmacology and Physiology
  • Phytotherapy Research
  • Advanced Drug Delivery Reviews
  • Journal of Pharmacology and Experimental Therapeutics
  • Tissue Engineering
  • Journal of Controlled Release
  • Journal of Biomedical Optics

Member of the European Epidermal Barrier Research Network (E2BRN)

Member of the ‘German Pharmaceutical Society’ (DPhG)

 

  • Dermal Drug Delivery (Nanoparticulate Carrier Systems, Smart Drug Delivery…)

  • Development and Characterization of In Vitro Skin (Disease) Models

  • Impact of Filaggrin Mutations on Skin Barrier Formation and Function

  • New Approaches for the Improvement of Wound Healing, Development of In Vitro Wound Healing Models

 
Alkaline Poly(ethylene glycol)-Based Hydrogels for a Potential Use as Bioactive Wound Dressings.

Koehler J., Wallmeyer L., Hedtrich S., Brandl F.P. and Goepferich A.M.
J Biomed Mater Res A | 2017

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents

Wallmeyer, L., Dietert, K., Sochorova, M., Gruber, A. D., Kleuser, B., Vavrova, K. and Hedtrich, S.
Sci Rep | 2017

Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis

Pischon, H., Radbruch, M., Ostrowski, A., Volz, P., Gerecke, C., Unbehauen, M., Honzke, S., Hedtrich, S., Fluhr, J. W., Haag, R., Kleuser, B., Alexiev, U., Gruber, A. D., Mundhenk, L.
Nanomedicine | 2017


Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles

Schulz, R., Yamamoto, K., Klossek, A., Flesch, R., Honzke, S., Rancan, F., Vogt, A., Blume-Peytavi, U., Hedtrich, S., Schafer-Korting, M., Ruhl, E., Netz, R. R.
Proc Natl Acad Sci U S A | 2017


NHE1 expression at wound margins increases time-dependently during physiological healing

Haverkampf, S., Heider, J., Weiss, K. T., Berneburg, M., Karrer, S., Schreml, S. and Haubner, F., Ettl, T., Schreml, J., Hedtrich, S., von Susskind-Schwendi, M., Dissemond, J.
Exp Dermatol | 2017


Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

Gerecke, C., Edlich, A., Giulbudagian, M., Schumacher, F., Zhang, N., Said, A., Yealland, G., Lohan, S. B., Neumann, F., Meinke, M. C., Ma, N., Calderon, M., Hedtrich, S., Schafer-Korting, M., Kleuser, B.
Nanotoxicology | 2017


Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium

Balzus, B., Sahle, F. F., Honzke, S., Gerecke, C., Schumacher, F., Hedtrich, S., Kleuser, B., Bodmeier, R.
Eur J Pharm Biopharm | 2017


Intradermal drug delivery by nanogel-peptide conjugates; specific and efficient transport of temoporfin

Zabihi, F., Wieczorek, S., Dimde, M., Hedtrich, S., Borner, H. G., Haag, R.
J Control Release | 2016


Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy

Yamamoto, K., Klossek, A., Flesch, R., Rancan, F., Weigand, M., Bykova, I., Bechtel, M., Ahlberg, S., Vogt, A., Blume-Peytavi, U., Schrade, P., Bachmann, S., Hedtrich, S., Schafer-Korting, M., Ruhl, E.
Eur J Pharm Biopharm | 2016


Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery

Muller, F., Honzke, S., Luthardt, W. O., Wong, E. L., Unbehauen, M., Bauer, J., Haag, R. Hedtrich, S. Ruhl, E. Rademann, J.
Eur J Pharm Biopharm | 2016


pH-Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds

Koehler, J., Wallmeyer, L., Hedtrich, S., Goepferich, A. M., Brandl, F. P.
Macromol Biosci | 2016


Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers

Doge, N., Honzke, S., Schumacher, F., Balzus, B., Colombo, M., Hadam, S., Rancan, F., Blume-Peytavi, U., Schafer-Korting, M., Schindler, A., Ruhl, E., Skov, P. S., Church, M. K., Hedtrich, S., Kleuser, B., Bodmeier, R., Vogt, A.
J Control Release | 2016


Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing

Honzke, S., Gerecke, C., Elpelt, A., Zhang, N., Unbehauen, M., Kral, V., Fleige, E., Paulus, F., Haag, R., Schafer-Korting, M., Kleuser, B., Hedtrich, S.
J Control Release | 2016


Development of biodegradable hyperbranched core-multishell nanocarriers for efficient topical drug delivery

Du, F., Honzke, S., Neumann, F., Keilitz, J., Chen, W., Ma, N., Hedtrich, S., Haag, R.
J Control Release | 2016

Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin

Edlich, A., Gerecke, C., Giulbudagian, M., Neumann, F., Hedtrich, S., Schafer-Korting, M., Ma, N., Calderon, M., Kleuser, B.
Eur J Pharm Biopharm | 2016


Influence of Th2 Cytokines on the Cornified Envelope, Tight Junction Proteins, and ss-Defensins in Filaggrin-Deficient Skin Equivalents

Honzke, S., Wallmeyer, L., Ostrowski, A., Radbruch, M., Mundhenk, L., Schafer-Korting, M., Hedtrich, S.
J Invest Dermatol | 2016


Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy

Yamamoto, K., Klossek, A., Flesch, R., Ohigashi, T., Fleige, E., Rancan, F., Frombach, J., Vogt, A., Blume-Peytavi, U., Schrade, P., Bachmann, S., Haag, R., Hedtrich, S., Schafer-Korting, M., Kosugi, N., Ruhl, E.
J Control Release | 2016


Interactions of hyaluronic Acid with the skin and implications for the dermal delivery of biomacromolecules

Witting, M., A. Boreham, R. Brodwolf, K. Vavrova, U. Alexiev, W. Friess and S. Hedtrich
Mol Pharm | 2015


Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules

Witting, M., M. Molina, K. Obst, R. Plank, K. M. Eckl, H. C. Hennies, M. Calderon, W. Friess and S. Hedtrich
Nanomedicine | 2015


The effect of endothelialization on the epidermal differentiation in human three-dimensional skin constructs - A morphological study

Khiao In, M., L. Wallmeyer, S. Hedtrich, K. C. Richardson, J. Plendl and S. Kaessmeyer
Clin Hemorheol Microcirc | 2015


Feasibility study for intraepidermal delivery of proteins using a solid microneedle array

Witting, M., K. Obst, M. Pietzsch, W. Friess and S. Hedtrich
Int J Pharm | 2015


Selective Probing of the Penetration of Dexamethasone into Human Skin by Soft X-ray Spectromicroscopy

Yamamoto, K., R. Flesch, T. Ohigashi, S. Hedtrich, A. Klossek, P. Patoka, G. Ulrich, S. Ahlberg, F. Rancan, A. Vogt, U. Blume-Peytavi, P. Schrade, S. Bachmann, M. Schafer-Korting, N. Kosugi and E. Ruhl
Anal Chem | 2015


Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

Witting, M., K. Obst, W. Friess and S. Hedtrich
Biotechnol Adv | 2015


Stimulation of PPARalpha normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin

Wallmeyer, L., D. Lehnen, N. Eger, M. Sochorova, L. Opalka, A. Kovacik, K. Vavrova and S. Hedtrich
J Dermatol Sci | 2015


Synthesis of multiarm star copolymers based on polyglycerol cores with polylactide arms and their application as nanocarriers

Adeli, M., Namazi, H., Du, F., Hönzke, S., Hedtrich, S., Keilitz, J., Haag, R.
RSC Advances | 2015


Identification of direct and indirect social network effects in the pathophysiology of insulin resistance in obese human subjects

Henning, C. H., N. Zarnekow, J. Hedtrich, S. Stark, K. Turk and M. Laudes
PLoS One | 2014


Impact of structural differences in hyperbranched polyglycerol-polyethylene glycol nanoparticles on dermal drug delivery and biocompatibility

Kumar, S., N. Alnasif, E. Fleige, I. Kurniasih, V. Kral, A. Haase, A. Luch, G. Weindl, R. Haag, M. Schafer-Korting and S. Hedtrich
Eur J Pharm Biopharm | 2014


Improving topical non-melanoma skin cancer treatment: In vitro efficacy of a novel guanosine-analog phosphonate

Ali-von Laue, C., C. Zoschke, N. Do, D. Lehnen, S. Küchler, W. Mehnert, T. Blaschke, K. D. Kramer, J. Plendl, G. Weindl, H. C. Korting, D. Hoeller Obrigkeit, H. F. Merk and M. Schäfer-Korting
Skin Pharmacol Physiol | 2014


Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair

Schreml, S., R. J. Meier, M. Kirschbaum, S. C. Kong, S. Gehmert, O. Felthaus, S. Kuchler, J. R. Sharpe, K. Woltje, K. T. Weiss, M. Albert, U. Seidl, J. Schroder, C. Morsczeck, L. Prantl, C. Duschl, S. F. Pedersen, M. Gosau, M. Berneburg, O. S. Wolfbe
Theranostics | 2014


Penetration of normal, damaged and diseased skin--an in vitro study on dendritic core-multishell nanotransporters

Alnasif, N., C. Zoschke, E. Fleige, R. Brodwolf, A. Boreham, E. Ruhl, K. M. Eckl, H. F. Merk, H. C. Hennies, U. Alexiev, R. Haag, S. Küchler and M. Schäfer-Korting
J Control Release | 2014


Increased cutaneous absorption reflects impaired barrier function of reconstructed skin models mimicking keratinisation disorders

Eckl, K. M., G. Weindl, K. Ackermann, S. Küchler, R. Casper, M. R. Radowski, R. Haag, H. C. Hennies and M. Schäfer-Korting
Exp Dermatol | 2014


Influence of Hyaluronic Acid on Dermal Drug Delivery of Biomacromolecules and the Underlying Mechanism

Witting, M., Boreham, A., Brodwolf, R., Vavrova, K., Alexiev, U., Friess, W., Küchler, S.
submitted | 2014


Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct

Vávrová, K., Henkes, D., Sochorová, M., Školová, B., Strüver, K., Witting, M., Friess, W., Schreml, S., Meier, R. J., Schäfer-Korting, M., Fluhr, J. W. and Küchler, S.
J Invest Dermatol | 2014


Targeting inflammation and wound healing by opioids

Stein, C. and Küchler, S.
Trends Pharmacol Sci | 2013


Opioid modulation of peripheral inflammation and wound healing.

Stein, C. and Küchler, S.
Trends in Pharmacological Sciences | 2013


Lyophilization of synthetic gene carriers

Kasper, J. C., Küchler, S. and Friess, W.
Methods Mol Biol | 2013


Formulation development of lyophilized, long-term stable siRNA/oligoaminoamide polyplexes

Kasper, J. C., Troiber, C., Kuchler, S., Wagner, E. and Friess, W.
Eur J Pharm Biopharm | 2013


Reconstructed skin models as emerging tools for drug absorption studies

Kuchler, S., Struver, K. and Friess, W.
Expert Opin Drug Metab Toxicol | 2013


Cytoprotective effects of opioids on irradiated oral epithelial cells

Charbaji, N., Rosenthal, P., Schäfer-Korting, M. and Küchler, S.
Wound Repair Regen | 2013


Comparison of four different particle sizing methods for siRNA polyplex characterization

Troiber, C., J. C. Kasper, S. Milani, M. Scheible, I. Martin, F. Schaubhut, S. Küchler, J. Radler, F. C. Simmel, W. Friess and E. Wagner
Eur J Pharm Biopharm | 2013


Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules

Steinhilber, D., Witting, M., Zhang, X., Staegemann, M., Paulus, F., Friess, W., Küchler, S. and Haag, R.
J Control Release | 2013


Polyglycerol coatings of glass vials for protein resistance

Hoger, K., Becherer, T., Qiang, W., Haag, R., Friess, W. and Küchler, S.
Eur J Pharm Biopharm | 2013


A thermosensitive morphine-containing hydrogel for the treatment of large-scale skin wounds

Heilmann, S., Küchler, S., Wischke, C., Lendlein, A., Stein, C. and Schäfer-Korting, M.
Int J Pharm | 2013


Magnetic Drug Targeting as New Therapeutic Option for the Treatment of Biomaterial Infections

Obermeier, A., Küchler, S., Matl, F. D., Pirzer, T., Stemberger, A., Mykhaylyk, O., Friess, W. and Burgkart, R.
J Biomater Sci Polym Ed | 2012


Morphine metabolism in human skin microsomes

Heilmann, S., Küchler, S. and Schäfer-Korting, M.
Skin Pharmacol Physiol | 2012


Peripheral opioid effects on inflammation and wound healing

Stein, C. and Küchler, S.
Curr Pharm Design | 2012


Physico-Chemical Characterization of siRNA Polyplexes: Size and Stability

Troiber, C., Kasper, J. C., Milani, S., Scheible, M., Schaubhut, F., Martin, I., Küchler, S., Rädler, J., Simmel, F. C., Friess, W. and Wagner, E.
Eur J Pharm Biopharm | 2012


Morphine stimulates cell migration of oral epithelial cells by delta-opioid receptor activation

Charbaji, N., Schäfer-Korting, M. and Küchler, S.
PLoS One | 2012


Deregulated ephrin-B2 signaling in mammary epithelial cells alters the stem cell compartment and interferes with the epithelial differentiation pathway

Kaenel, P., Antonijevic, M., Richter, S., Küchler, S., Sutter, N., Wotzkow, C., Strange, R. and Andres, A. C.
Int J Oncol | 2012


Non-analgesic effects of opioids: peripheral opioid effects on inflammation and wound healing

Stein, C and Küchler, S.
Curr Pharm Des | 2012


Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down

Küchler, S., Henkes, D., Eckl, K. M., Ackermann, K., Plendl, J., Korting, H. C., Hennies, H. C. and Schäfer-Korting, M.
Altern Lab Anim | 2011


3D-wound healing model: influence of morphine and solid lipid nanoparticles

Küchler, S., Wolf, N. B., Heilmann, S., Weindl, G., Helfmann, J., Yahya, M. M., Stein, C. and Schäfer-Korting, M.
J Biotechnol | 2010


SLN for topical application in skin diseases--characterization of drug-carrier and carrier-target interactions

Küchler, S., Herrmann, W., Panek-Minkin, G., Blaschke, T., Zoschke, C., Kramer, K. D., Bittl, R. and Schäfer-Korting, M.
Int J Pharm | 2010


Influences of opioids and nanoparticles on in vitro wound healing models

Wolf, N. B., Küchler, S., Radowski, M. R., Blaschke, T., Kramer, K. D., Weindl, G., Kleuser, B., Haag, R. and Schäfer-Korting, M.
Eur J Pharm Biopharm | 2009


Influence of nanocarrier type and size on skin delivery of hydrophilic agents

Küchler, S., Abdel-Mottaleb, M., Lamprecht, A., Radowski, M. R., Haag, R. and Schäfer-Korting, M.
Int J Pharm | 2009


Nanoparticles for skin penetration enhancement--a comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles

Küchler, S., Radowski, M. R., Blaschke, T., Dathe, M., Plendl, J., Haag, R., Schäfer-Korting, M. and Kramer, K. D.
Eur J Pharm Biopharm | 2009